Randy Strong

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice
    Randy Strong
    Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, TX, USA
    J Gerontol A Biol Sci Med Sci 68:6-16. 2013
  2. ncbi request reprint Cholinergic deficits in the septal-hippocampal pathway of the SAM-P/8 senescence accelerated mouse
    Randy Strong
    Geriatric Research, Education and Clinical Center, Audie L Murphy Memorial Veterans Hospital, San Antonio, TX 78284, USA
    Brain Res 966:150-6. 2003
  3. pmc Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
    Randy Strong
    Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    Aging Cell 7:641-50. 2008
  4. pmc Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease
    Margaret Chia Ying Wey
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e31522. 2012
  5. pmc Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling
    Smita Majumder
    Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Aging Cell 11:326-35. 2012
  6. ncbi request reprint Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy
    Florian L Muller
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 40:1993-2004. 2006
  7. pmc Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
    Smita Majumder
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 6:e25416. 2011
  8. ncbi request reprint Housing density does not influence the longevity effect of calorie restriction
    Yuji Ikeno
    Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care Systems, San Antonio, TX, USA
    J Gerontol A Biol Sci Med Sci 60:1510-7. 2005
  9. pmc Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors
    Carolina B Livi
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Aging (Albany NY) 5:100-10. 2013
  10. pmc Probing the relationship between insulin sensitivity and longevity using genetically modified mice
    James F Nelson
    Department of Physiology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245, USA
    J Gerontol A Biol Sci Med Sci 67:1332-8. 2012

Research Grants

Collaborators

Detail Information

Publications27

  1. pmc Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice
    Randy Strong
    Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, TX, USA
    J Gerontol A Biol Sci Med Sci 68:6-16. 2013
    ....
  2. ncbi request reprint Cholinergic deficits in the septal-hippocampal pathway of the SAM-P/8 senescence accelerated mouse
    Randy Strong
    Geriatric Research, Education and Clinical Center, Audie L Murphy Memorial Veterans Hospital, San Antonio, TX 78284, USA
    Brain Res 966:150-6. 2003
    ..The results suggest that a compromised septal-hippocampal cholinergic pathway may contribute to the previously reported early onset of impaired learning and memory in the SAM-P/8 mouse strain...
  3. pmc Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
    Randy Strong
    Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    Aging Cell 7:641-50. 2008
    ..Further studies are warranted to find whether NDGA or aspirin, over a range of doses,might prove to postpone death and various age-related outcomes reproducibly in mice...
  4. pmc Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease
    Margaret Chia Ying Wey
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e31522. 2012
    ..These results support the hypothesis that impaired detoxification of biogenic aldehydes may be important in the pathophysiology of PD and suggest that Aldh1a1(-/-)×Aldh2(-/-) mice may be a useful animal model of PD...
  5. pmc Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling
    Smita Majumder
    Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Aging Cell 11:326-35. 2012
    ..This is the first evidence to show that a small molecule known to increase lifespan also ameliorates age-dependent learning and memory deficits...
  6. ncbi request reprint Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy
    Florian L Muller
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 40:1993-2004. 2006
    ..Thus, the absence of CuZnSOD imposes elevated oxidative stress, loss of muscle mass, and physiological consequences that resemble an acceleration of normal age-related sarcopenia...
  7. pmc Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
    Smita Majumder
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 6:e25416. 2011
    ..In conclusion, we show that autophagy induction via rapamycin may represent a valid therapeutic strategy in AD when administered early in the disease progression...
  8. ncbi request reprint Housing density does not influence the longevity effect of calorie restriction
    Yuji Ikeno
    Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care Systems, San Antonio, TX, USA
    J Gerontol A Biol Sci Med Sci 60:1510-7. 2005
    ..These results indicate that CR can extend life span as effectively in multiply as in singly housed mice, even though housing density can differentially affect the cancer-reducing effect of CR...
  9. pmc Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors
    Carolina B Livi
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Aging (Albany NY) 5:100-10. 2013
    ..In this model, eRapa appears to act differently than DR, suggesting diverse mechanisms of action on survival and anti-tumor effects. In particular the beneficial effects of rapamycin did not depend on the dose of Rb1...
  10. pmc Probing the relationship between insulin sensitivity and longevity using genetically modified mice
    James F Nelson
    Department of Physiology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245, USA
    J Gerontol A Biol Sci Med Sci 67:1332-8. 2012
    ..These results show that insulin sensitivity in some murine genotypes is inversely related to longevity and provide further evidence for evolutionary conservation of this pathway as a modulator of longevity...
  11. ncbi request reprint Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice
    Elizabeth Fernandez
    Research Service and Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, Texas, USA
    Alcohol Clin Exp Res 30:1650-8. 2006
    ..Therefore, we examined the hypothesis that altered brain monoamine metabolism is related to the influence of ALDH2 on behavioral responses to ethanol...
  12. ncbi request reprint Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity
    Qitao Ran
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Neurosci Res 84:202-8. 2006
    ..Our data demonstrate that overexpression of Gpx4 protects neurons against oxidative injury and beta-amyloid-induced cytotoxicity...
  13. pmc WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    David A Price
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA
    Eur J Neurosci 29:2177-86. 2009
    ....
  14. pmc Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
    Patricia Spilman
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 5:e9979. 2010
    ..Whether inhibition of the mTOR pathway would delay or prevent age-associated disease such as AD remained to be determined...
  15. pmc Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments
    Antonella Caccamo
    Department of Physiology, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 285:13107-20. 2010
    ..The results presented here provide a molecular basis for the Abeta-induced cognitive deficits and, moreover, show that rapamycin, an FDA approved drug, improves learning and memory and reduces Abeta and Tau pathology...
  16. ncbi request reprint Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta
    Lily Q Dong
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biochem Biophys Res Commun 294:136-44. 2002
    ..The specific expression of mPDK-1 beta in mouse testis and brains of aged mice also suggests potential involvement of this kinase in regulating animal spermatogenesis and aging...
  17. pmc Cognitive dysfunction precedes the onset of motor symptoms in the MitoPark mouse model of Parkinson's disease
    Xiuhua Li
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas, United States of America Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, P R China
    PLoS ONE 8:e71341. 2013
    ..Together, these data establish that mild cognitive impairment precedes the loss of motor function in a novel rodent model of PD, which may provide unique opportunities for therapeutic development. ..
  18. ncbi request reprint Exogenous prenatal corticosterone exposure mimics the effects of prenatal stress on adult brain stress response systems and fear extinction behavior
    Brian C Bingham
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States
    Psychoneuroendocrinology 38:2746-57. 2013
    ..The data further suggest that adverse prenatal environments constitute a risk factor for PTSD-like symptomatology, especially when combined with chronic stressors later in life...
  19. pmc Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease
    Ai Ling Lin
    Research Imaging Institute, San Antonio, TX, USA
    J Cereb Blood Flow Metab 33:1412-21. 2013
    ..Drugs that inhibit the TOR pathway may have promise as a therapy for AD and possibly for vascular dementias. ..
  20. ncbi request reprint Genetic mouse models of extended lifespan
    Hanyu Liang
    Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MSC 7762, San Antonio, TX 78229 3900, USA
    Exp Gerontol 38:1353-64. 2003
    ..However, these mouse models are already providing new information about the mechanism underlying mammalian aging...
  21. doi request reprint Effects of anabolic androgenic steroids and social subjugation on behavior and neurochemistry in male rats
    Krystle A Frahm
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Pharmacol Biochem Behav 97:416-22. 2011
    ..5HIAA was significantly increased in the prefrontal cortex of all experimental groups. We conclude that AAS and SS differentially affect behavior towards females as well as neurotransmitter levels...
  22. doi request reprint Evolutionary conservation of an atypical glucocorticoid-responsive element in the human tyrosine hydroxylase gene
    C S Sheela Rani
    Department of Pharmacology and the Barshop Institute for Longevity and Aging Studies, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, USA
    J Neurochem 126:19-28. 2013
    ..Thus, our studies have clearly identified a glucocorticoid-responsive element in a 7 bp AP-1-like motif in the promoter region at -7.24 kb of the human TH gene...
  23. ncbi request reprint Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress
    Holly Van Remmen
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284 7762, USA
    Free Radic Biol Med 36:1625-34. 2004
    ....
  24. pmc Effects of chronic plus acute prolonged stress on measures of coping style, anxiety, and evoked HPA-axis reactivity
    Megan K Roth
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Neuropharmacology 63:1118-26. 2012
    ....
  25. ncbi request reprint Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
    Holly Van Remmen
    Department of Cellular and Structural Biology at the University of Texas Health Science Center at San Antonio, San Antonio 78229 3900, USA
    Physiol Genomics 16:29-37. 2003
    ..Thus life-long reduction of MnSOD activity leads to increased levels of oxidative damage to DNA and increased cancer incidence but does not appear to affect aging...
  26. ncbi request reprint An Aging Interventions Testing Program: study design and interim report
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor VA Medical Center, Ann Arbor, MI 48109 2200, USA
    Aging Cell 6:565-75. 2007
    ..More data will be needed to determine if any of these compounds can extend maximal lifespan, but the current data show that NDGA reduces early life mortality risks in genetically heterogeneous mice at multiple test sites...
  27. ncbi request reprint Plasma glucose and the action of calorie restriction on aging
    Roger McCarter
    The Pennsylvania State University, Center for Developmental and Health Genetics, Gardner House, University Park, PA 16802, USA
    J Gerontol A Biol Sci Med Sci 62:1059-70. 2007
    ..We conclude that decreased plasma glucose over the life span is not an important factor in the action of calorie restriction on aging processes...

Research Grants3

  1. Center for Testing Potential Anti-Aging Interventions
    Randy Strong; Fiscal Year: 2007
    ..To conduct Phase I1 longevity and age-sensitive trait determinations for Phase I studies to have potential anti-aging action. ..