Affiliation: University of California
- Protein nanomachinesMichael Strong
laboratory of David Eisenberg at the Molecular Biology Institute at the University of California, Los Angeles, California, USA
PLoS Biol 2:E73. 2004
- Visualization and interpretation of protein networks in Mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage mapsMichael Strong
Howard Hughes Medical Institute, University of California at Los Angeles, Box 951570, Los Angeles, CA 90095 1570, USA
Nucleic Acids Res 31:7099-109. 2003....
- Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approachMichael Strong
Howard Hughes Medical Institute, UCLA DOE Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, CA 90095 1570, USA
Genome Biol 4:R59. 2003....
- The protein network as a tool for finding novel drug targetsMichael Strong
Howard Hughes Medical Institute, UCLA DOE Institute of Genomics and Proteomics, University of California Los Angeles, USA
Prog Drug Res 64:191, 193-215. 2007..In this chapter we discuss methods for the identification and analysis of genome-wide protein networks, and discuss how protein networks can be used to aid the identification of novel drug targets...
- Structural proteomics and computational analysis of a deadly pathogen: combating Mycobacterium tuberculosis from multiple frontsMichael Strong
UCLA DOE Institute of Genomics and Proteomics, Los Angeles, California, USA
Methods Biochem Anal 49:245-69. 2006
- Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosisMichael Strong
Howard Hughes Medical Institute, UCLA Department of Energy Institute of Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 103:8060-5. 2006..Our entire procedure for the identification, characterization, and structural determination of protein complexes can be scaled to a genome-wide level...
- Functional linkages can reveal protein complexes for structure determinationSul Min Kim
Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA
Structure 15:1079-89. 2007..We offer a database of inferred linkages corresponding to likely protein complexes for some 629,952 pairs of proteins in 154 prokaryotes and archaea...
- Unique transcriptome signature of Mycobacterium tuberculosis in pulmonary tuberculosisHelmy Rachman
Max Planck Institute for Infection, Immunology, Schumannstrasse 21 22, Berlin 10117, Germany
Infect Immun 74:1233-42. 2006..tuberculosis actively transcribes a number of genes involved in active fortification and evasion from host defense systems. These genes may provide targets for novel intervention strategies...
- Mycobacterium tuberculosis gene expression profiling within the context of protein networksHelmy Rachman
Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, 10117 Berlin, Germany
Microbes Infect 8:747-57. 2006..Our combined approach reveals certain signatures of M. tuberculosis residing within macrophage cells, including the induction of genes involved in DNA damage repair, fatty acid degradation, iron metabolism, and cell wall metabolism...
- A specific secretion system mediates PPE41 transport in pathogenic mycobacteriaAbdallah M Abdallah
Department of Medical Microbiology and Infection Control, VU Medical Centre, Amsterdam, The Netherlands
Mol Microbiol 62:667-79. 2006..This PPE secretion system is also involved in the virulence of pathogenic mycobacteria, as the ESX-5 mutant of M. marinum was affected in spreading to uninfected macrophages...