Michael Strong

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Protein nanomachines
    Michael Strong
    laboratory of David Eisenberg at the Molecular Biology Institute at the University of California, Los Angeles, California, USA
    PLoS Biol 2:E73. 2004
  2. pmc Visualization and interpretation of protein networks in Mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage maps
    Michael Strong
    Howard Hughes Medical Institute, University of California at Los Angeles, Box 951570, Los Angeles, CA 90095 1570, USA
    Nucleic Acids Res 31:7099-109. 2003
  3. pmc Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach
    Michael Strong
    Howard Hughes Medical Institute, UCLA DOE Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, CA 90095 1570, USA
    Genome Biol 4:R59. 2003
  4. ncbi request reprint The protein network as a tool for finding novel drug targets
    Michael Strong
    Howard Hughes Medical Institute, UCLA DOE Institute of Genomics and Proteomics, University of California Los Angeles, USA
    Prog Drug Res 64:191, 193-215. 2007
  5. ncbi request reprint Structural proteomics and computational analysis of a deadly pathogen: combating Mycobacterium tuberculosis from multiple fronts
    Michael Strong
    UCLA DOE Institute of Genomics and Proteomics, Los Angeles, California, USA
    Methods Biochem Anal 49:245-69. 2006
  6. pmc Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis
    Michael Strong
    Howard Hughes Medical Institute, UCLA Department of Energy Institute of Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:8060-5. 2006
  7. ncbi request reprint Functional linkages can reveal protein complexes for structure determination
    Sul Min Kim
    Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA
    Structure 15:1079-89. 2007
  8. pmc Unique transcriptome signature of Mycobacterium tuberculosis in pulmonary tuberculosis
    Helmy Rachman
    Max Planck Institute for Infection, Immunology, Schumannstrasse 21 22, Berlin 10117, Germany
    Infect Immun 74:1233-42. 2006
  9. ncbi request reprint Mycobacterium tuberculosis gene expression profiling within the context of protein networks
    Helmy Rachman
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Microbes Infect 8:747-57. 2006
  10. ncbi request reprint A specific secretion system mediates PPE41 transport in pathogenic mycobacteria
    Abdallah M Abdallah
    Department of Medical Microbiology and Infection Control, VU Medical Centre, Amsterdam, The Netherlands
    Mol Microbiol 62:667-79. 2006

Collaborators

Detail Information

Publications10

  1. pmc Protein nanomachines
    Michael Strong
    laboratory of David Eisenberg at the Molecular Biology Institute at the University of California, Los Angeles, California, USA
    PLoS Biol 2:E73. 2004
  2. pmc Visualization and interpretation of protein networks in Mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage maps
    Michael Strong
    Howard Hughes Medical Institute, University of California at Los Angeles, Box 951570, Los Angeles, CA 90095 1570, USA
    Nucleic Acids Res 31:7099-109. 2003
    ....
  3. pmc Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach
    Michael Strong
    Howard Hughes Medical Institute, UCLA DOE Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, CA 90095 1570, USA
    Genome Biol 4:R59. 2003
    ....
  4. ncbi request reprint The protein network as a tool for finding novel drug targets
    Michael Strong
    Howard Hughes Medical Institute, UCLA DOE Institute of Genomics and Proteomics, University of California Los Angeles, USA
    Prog Drug Res 64:191, 193-215. 2007
    ..In this chapter we discuss methods for the identification and analysis of genome-wide protein networks, and discuss how protein networks can be used to aid the identification of novel drug targets...
  5. ncbi request reprint Structural proteomics and computational analysis of a deadly pathogen: combating Mycobacterium tuberculosis from multiple fronts
    Michael Strong
    UCLA DOE Institute of Genomics and Proteomics, Los Angeles, California, USA
    Methods Biochem Anal 49:245-69. 2006
  6. pmc Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis
    Michael Strong
    Howard Hughes Medical Institute, UCLA Department of Energy Institute of Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:8060-5. 2006
    ..Our entire procedure for the identification, characterization, and structural determination of protein complexes can be scaled to a genome-wide level...
  7. ncbi request reprint Functional linkages can reveal protein complexes for structure determination
    Sul Min Kim
    Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA
    Structure 15:1079-89. 2007
    ..We offer a database of inferred linkages corresponding to likely protein complexes for some 629,952 pairs of proteins in 154 prokaryotes and archaea...
  8. pmc Unique transcriptome signature of Mycobacterium tuberculosis in pulmonary tuberculosis
    Helmy Rachman
    Max Planck Institute for Infection, Immunology, Schumannstrasse 21 22, Berlin 10117, Germany
    Infect Immun 74:1233-42. 2006
    ..tuberculosis actively transcribes a number of genes involved in active fortification and evasion from host defense systems. These genes may provide targets for novel intervention strategies...
  9. ncbi request reprint Mycobacterium tuberculosis gene expression profiling within the context of protein networks
    Helmy Rachman
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Microbes Infect 8:747-57. 2006
    ..Our combined approach reveals certain signatures of M. tuberculosis residing within macrophage cells, including the induction of genes involved in DNA damage repair, fatty acid degradation, iron metabolism, and cell wall metabolism...
  10. ncbi request reprint A specific secretion system mediates PPE41 transport in pathogenic mycobacteria
    Abdallah M Abdallah
    Department of Medical Microbiology and Infection Control, VU Medical Centre, Amsterdam, The Netherlands
    Mol Microbiol 62:667-79. 2006
    ..This PPE secretion system is also involved in the virulence of pathogenic mycobacteria, as the ESX-5 mutant of M. marinum was affected in spreading to uninfected macrophages...