Stephen C Strom

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists
    Zofia Duniec-Dmuchowski
    Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201, USA
    Biochem Pharmacol 74:1535-40. 2007
  2. pmc Adenoviral-mediated correction of methylmalonyl-CoA mutase deficiency in murine fibroblasts and human hepatocytes
    Randy J Chandler
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Med Genet 8:24. 2007
  3. ncbi request reprint Hepatocyte transplantation: clinical experience and potential for future use
    Stephen C Strom
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell Transplant 15:S105-10. 2006
  4. pmc Placental stem cell correction of murine intermediate maple syrup urine disease
    Kristen J Skvorak
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 57:1017-23. 2013
  5. pmc Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes
    Shringi Sharma
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA
    Drug Metab Dispos 41:296-304. 2013
  6. doi request reprint Improved amino acid, bioenergetic metabolite and neurotransmitter profiles following human amnion epithelial cell transplant in intermediate maple syrup urine disease mice
    Kristen J Skvorak
    Department of Pathology, University of Pittsburgh, PA, USA
    Mol Genet Metab 109:132-8. 2013
  7. pmc Hepatic differentiation of amniotic epithelial cells
    Fabio Marongiu
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 53:1719-29. 2011
  8. doi request reprint Isolation of amniotic mesenchymal stem cells
    Fabio Marongiu
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Curr Protoc Stem Cell Biol . 2010
  9. doi request reprint Development and application of purified tissue dissociation enzyme mixtures for human hepatocyte isolation
    Roberto Gramignoli
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Cell Transplant 21:1245-60. 2012
  10. doi request reprint Isolation of amniotic epithelial stem cells
    Toshio Miki
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Curr Protoc Stem Cell Biol . 2010

Detail Information

Publications63

  1. pmc Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists
    Zofia Duniec-Dmuchowski
    Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201, USA
    Biochem Pharmacol 74:1535-40. 2007
    ..Therefore, while 24(S),25-epoxycholesterol-mediated PXR activation and CYP3A induction does not appear to be conserved from rodent to human, T0901317 is among the most potent known activators of human PXR...
  2. pmc Adenoviral-mediated correction of methylmalonyl-CoA mutase deficiency in murine fibroblasts and human hepatocytes
    Randy J Chandler
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Med Genet 8:24. 2007
    ....
  3. ncbi request reprint Hepatocyte transplantation: clinical experience and potential for future use
    Stephen C Strom
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell Transplant 15:S105-10. 2006
    ..We will briefly review the basic research that leads to clinical hepatocyte transplantation, the published clinical experience with this experimental technique, and some possible future uses of hepatocyte transplantation...
  4. pmc Placental stem cell correction of murine intermediate maple syrup urine disease
    Kristen J Skvorak
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 57:1017-23. 2013
    ..The branched chain amino acids leucine, isoleucine, valine, and alloisoleucine were significantly improved in serum and brain, as were other large neutral amino acids...
  5. pmc Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes
    Shringi Sharma
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA
    Drug Metab Dispos 41:296-304. 2013
    ..With the exception of ABCB4, all transporters examined were expressed, albeit at lower mRNA levels in fetal hepatocytes compared with adults...
  6. doi request reprint Improved amino acid, bioenergetic metabolite and neurotransmitter profiles following human amnion epithelial cell transplant in intermediate maple syrup urine disease mice
    Kristen J Skvorak
    Department of Pathology, University of Pittsburgh, PA, USA
    Mol Genet Metab 109:132-8. 2013
    ....
  7. pmc Hepatic differentiation of amniotic epithelial cells
    Fabio Marongiu
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 53:1719-29. 2011
    ..When transplanted in a syngenic animal pretreated with RS, rAECs were able to engraft and generate a progeny of cells with morphology and protein expression typical of mature hepatocytes...
  8. doi request reprint Isolation of amniotic mesenchymal stem cells
    Fabio Marongiu
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Curr Protoc Stem Cell Biol . 2010
    ..We also introduce a simple density separation technique for the purification of this cell type from possible contamination with amniotic epithelial cells...
  9. doi request reprint Development and application of purified tissue dissociation enzyme mixtures for human hepatocyte isolation
    Roberto Gramignoli
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Cell Transplant 21:1245-60. 2012
    ..These results show that purified enzymes such as CIzyme(TM) will be a safe and effective for the isolation of human hepatocytes for clinical transplants...
  10. doi request reprint Isolation of amniotic epithelial stem cells
    Toshio Miki
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Curr Protoc Stem Cell Biol . 2010
    ..We also introduce a simple density separation technique for the enrichment of the population for SSEA-4 positive cells...
  11. ncbi request reprint Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)
    Taira Wada
    Center for Pharmacogenetics, 633 Salk Hall, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Pharmacol 73:891-9. 2008
    ..Our results have revealed a novel role for RORalpha and a functional interplay between RORalpha and LXR in regulating endo- and xenobiotic genes, which may have broad implications in metabolic homeostasis...
  12. doi request reprint Production of hepatocyte-like cells from human amnion
    Toshio Miki
    Departments of Pathology and Surgery and McGowan Institute for Regenerative Medicine, University of Pittsburgh, USA
    Methods Mol Biol 481:155-68. 2009
    ..Cells isolated from the amnion may be a uniquely useful and noncontroversial stem cell source...
  13. pmc Metabolism of 17alpha-hydroxyprogesterone caproate, an agent for preventing preterm birth, by fetal hepatocytes
    Shringi Sharma
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Drug Metab Dispos 38:723-7. 2010
    ..In summary, this study demonstrates that fetal hepatocytes and, in particular, the fetal form of CYP3A (i.e., CYP3A7) can metabolize 17-OHPC...
  14. ncbi request reprint Identification of stem cell marker-positive cells by immunofluorescence in term human amnion
    Toshio Miki
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Reprod Immunol 75:91-6. 2007
    ..These data suggest that the human amnion contains stem cell-like cells at different states of differentiation. Human term amnion may be useful source of pluripotent stem cells for regenerative medicine...
  15. ncbi request reprint Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats
    Hui Tian
    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pharm Res 22:2007-15. 2005
    ....
  16. pmc Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels
    Tiffany L Sellaro
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Tissue Eng Part A 16:1075-82. 2010
    ..We conclude that like Matrigel, PLECM represents a favorable substrate for in vitro culture of human hepatocytes...
  17. pmc MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation
    Zhimin Ou
    Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 25:584-96. 2011
    ....
  18. pmc FoxO1 links hepatic insulin action to endoplasmic reticulum stress
    Adama Kamagate
    Rangos Research Center, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA
    Endocrinology 151:3521-35. 2010
    ..Excessive FoxO1 activity, resulting from a dislodged FoxO1 feedback loop in insulin resistant liver, is attributable to hepatic endoplasmic reticulum stress and metabolic abnormalities in diabetes...
  19. pmc Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity
    Stephen C Strom
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Methods Mol Biol 640:491-509. 2010
    ....
  20. pmc ATPase Class I Type 8B Member 1 and protein kinase C zeta induce the expression of the canalicular bile salt export pump in human hepatocytes
    Frank Chen
    Children s Hospital of Pittsburgh of UPMC and the Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    Pediatr Res 67:183-7. 2010
    ..Overall, these findings support the hypothesis that FIC1 enhances FXR signaling via a PKCzeta-dependent signaling pathway...
  21. doi request reprint Increased reprogramming of human fetal hepatocytes compared with adult hepatocytes in feeder-free conditions
    Marc C Hansel
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Cell Transplant 23:27-38. 2014
    ..Fetal hepatocytes reprogram much more efficiently than adult hepatocytes, although both could serve as useful sources of hiPSC-derived hepatocytes for basic research or transplantation. ..
  22. pmc A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS
    Venkateswaran C Pillai
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA
    J Pharm Biomed Anal 74:126-32. 2013
    ..Therefore, the final CYP cocktail assay consisting of five probes provides a robust method to simultaneously measure activities of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4/5 in primary cultures of human hepatocytes...
  23. pmc Mouse fetal liver cells in artificial capillary beds in three-dimensional four-compartment bioreactors
    Satdarshan P S Monga
    Department of Pathology, McGowan Institute for Regenerative Medicine, and the Department of Pharmacy, University of Pittsburgh, SOM, S421 BST, 200 Lothrop St, Pittsburgh PA 15261, USA
    Am J Pathol 167:1279-92. 2005
    ..Thus, fetal liver cells can survive, proliferate, differentiate, and function in a three-dimensional perfusion culture system while maintaining a progenitor pool, reflecting an important advance in hepatic tissue engineering...
  24. pmc Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease
    Kristen J Skvorak
    Department of Human Genetics, University of Pittsburgh, Pennsylvania, USA
    Mol Ther 17:1266-73. 2009
    ....
  25. ncbi request reprint A functional polymorphism at the transcriptional initiation site in beta2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of beta2-glycoprotein I
    Haider Mehdi
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh 15261, USA
    Eur J Biochem 270:230-8. 2003
    ....
  26. pmc Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer
    Venkateswaran C Pillai
    Department of Pharmaceutical Sciences and Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania V C P, R V Molecular Therapeutics Drug Discovery program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania R A P, S M C, J H B Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet and Hospital, Stockholm, Sweden R G, S C S and The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland M A R
    Drug Metab Dispos 41:1843-51. 2013
    ....
  27. doi request reprint Naive rat amnion-derived cell transplantation improved left ventricular function and reduced myocardial scar of postinfarcted heart
    Kazuro L Fujimoto
    Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Cell Transplant 18:477-86. 2009
    ..Our results suggest that naive ADCs are a potential cell source for cellular cardiomyoplasty...
  28. ncbi request reprint Stem cell characteristics of amniotic epithelial cells
    Toshio Miki
    Department of Pathology and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Stem Cells 23:1549-59. 2005
    ..Amnion derived from term placenta after live birth may be a useful and noncontroversial source of stem cells for cell transplantation and regenerative medicine...
  29. ncbi request reprint Amnion-derived pluripotent/multipotent stem cells
    Toshio Miki
    Department of Pathology, University of Pittsburgh, 200 Lothrop, St Pittsburgh, PA 15213, USA
    Stem Cell Rev 2:133-42. 2006
    ..In this review, we describe the unique characteristics of the AE stem cells and summarize previous work concerning the stem cell nature of cells from amnion...
  30. ncbi request reprint Pharmacokinetics of tacrolimus and mycophenolic acid are altered, but recover at different times during hepatic regeneration in rats
    Hui Tian
    718 Salk Hall, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Drug Metab Dispos 33:329-35. 2005
    ..Caution must be exercised in extrapolating in vitro data to in vivo conditions during hepatic regeneration...
  31. pmc ChREBP mediates glucose-stimulated pancreatic β-cell proliferation
    Mallikarjuna R Metukuri
    Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 61:2004-15. 2012
    ..Overexpression of ChREBP amplified glucose-stimulated proliferation in rat and human β-cells, with concomitant increases in cyclin gene expression. In conclusion, ChREBP mediates glucose-stimulated proliferation in pancreatic β-cells...
  32. pmc A whole-organ regenerative medicine approach for liver replacement
    Alejandro Soto-Gutierrez
    Transplantation Section, Department of Surgery, Children s Hospital of Pittsburgh, Center for Innovative Regenerative Therapies, University of Pittsburgh, Pennsylvania, USA
    Tissue Eng Part C Methods 17:677-86. 2011
    ..The present study investigates a new, minimally disruptive method for whole-organ liver decellularization and three different cell reseeding strategies to engineer functional liver tissue...
  33. ncbi request reprint Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures
    Bernard J Komoroski
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Drug Metab Dispos 32:512-8. 2004
    ....
  34. pmc Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases
    Zhimin Ou
    Institute of Clinical Pharmacology, Sun Yat Sen University, Guangzhou 510080, China
    Mol Endocrinol 27:106-15. 2013
    ..In summary, our results established SULT2A1 as a novel ROR target gene. The expression of RORs is a potential predictor for the expression of SULT2A1 as well as disease conditions...
  35. pmc The second extracellular loop dictates Occludin-mediated HCV entry
    Shufeng Liu
    Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Virology 407:160-70. 2010
    ..We conclude that OCLN EL2 dictates the Dynamin-dependent HCV entry. Furthermore, OCLN could function to bridge virions to Dynamin-dependent endocytic machineries...
  36. ncbi request reprint A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development
    Ying Mu
    Center for Pharmacogenetics, Salk Hall 656, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Pharmacol 68:403-13. 2005
    ..The stereoselectivity may be used to guide the development of safer drugs to avoid drug-drug interactions or to achieve human-specific therapeutic effects when a xenobiotic receptor is being used as a drug target...
  37. pmc Side population cells derived from adult human liver generate hepatocyte-like cells in vitro
    Sunny Zaheed Hussain
    Division of Gastroenterology, Children s National Medical Center, Washington, DC, USA
    Dig Dis Sci 50:1755-63. 2005
    ....
  38. pmc Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes
    Stephanie M Zamule
    Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 101 Life Sciences Building, University Park, PA 16802, USA
    Chem Biol Interact 173:179-86. 2008
    ....
  39. ncbi request reprint Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures
    Bernard J Komoroski
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pennsylvania 15213 1863, USA
    Clin Cancer Res 11:6972-9. 2005
    ..Because docetaxel is inactivated by CYP3A, we studied the effects of the St. John's wort constituent hyperforin on docetaxel metabolism in a human hepatocyte model...
  40. ncbi request reprint Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes
    Seva E Kostrubsky
    Department of Safety Science, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Toxicol Sci 87:146-55. 2005
    ..Our findings suggest that, in multiple drug therapy, an inhibitory complex between UGT and one of the drugs can lead to decreased glucuronidation and increased systemic exposure and toxicity of a coadministered drug...
  41. ncbi request reprint Effects of green tea compounds on irinotecan metabolism
    Snezana Mirkov
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Drug Metab Dispos 35:228-33. 2007
    ..Catechins do not induce CYP3A4 activity. The effect of acute and prolonged use of green tea on the pharmacokinetics of irinotecan in patients remains to be evaluated...
  42. pmc Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues
    Katy M Olsavsky
    Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Toxicol Appl Pharmacol 222:42-56. 2007
    ....
  43. ncbi request reprint Induction of cyp3a in primary cultures of human hepatocytes by ginkgolides a and B
    Nu He
    Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Clin Exp Pharmacol Physiol 34:632-5. 2007
    ..05 for ginkgolide A; P > 0.05 for ginkgolide B). Quercetin had no apparent induction. 4. Ginkgolide A and ginkgolide B can induce CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes at higher doses...
  44. ncbi request reprint Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor
    Hai lin Fang
    Institute of Environmental Health Sciences, Wayne State University, 2727 Second Ave, Room 4000, Detroit, MI 48201, USA
    Mol Pharmacol 67:1257-67. 2005
    ..Results also indicate that important species differences govern the transactivation of SULT2A gene transcription by nuclear receptors...
  45. ncbi request reprint Regulation of the human cathepsin E gene by the constitutive androstane receptor
    Jeanine L Page
    Center for Molecular Toxicology and Carcinogenesis and the Department of Veterinary and Biomedical Sciences, 101 Life Sciences Building, The Pennsylvania State University, University Park, PA 16802, USA
    Arch Biochem Biophys 467:132-8. 2007
    ..Thus, these studies demonstrate CAR-mediated regulation of CTSE within primary hepatocyte cultures from several individual donors and suggest that elevated CTSE activity may play a functional role in the etiology of hepatocarcinogenesis...
  46. ncbi request reprint In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging
    Henning Wege
    Transplant Research Institute, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Cell Transplant 12:897-906. 2003
    ..In this study, telomere stabilization extended the proliferative capacity of in vitro proliferating human neonatal hepatocytes. Therefore, telomere attrition needs to be addressed when developing techniques to expand human hepatocytes...
  47. doi request reprint To be or not to be: generation of hepatocytes from cells outside the liver
    Ira J Fox
    Gastroenterology 134:878-81. 2008
  48. ncbi request reprint Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats
    Vsevolod E Kostrubsky
    Department of Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Toxicol Sci 76:220-8. 2003
    ..These results provide methods to evaluate inhibitory effects of potentially cholestatic compounds on bile-acid transport, and to rank compounds according to their hepatotoxic potential...
  49. ncbi request reprint Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes
    Trisha L Noreault
    Department of Pharmacology Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Drug Metab Dispos 33:993-1003. 2005
    ..These results suggest that arsenite inhibits both untreated and induced CYP3A4 transcription in primary human hepatocytes by decreasing the activity of PXR, as well as expression of the nuclear receptor RXRalpha...
  50. ncbi request reprint Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder
    Simon P Horslen
    Section of Pediatric Gastroenterology, University of Nebraska Medical Center, Omaha, Nebraska 68198 3285, USA
    Pediatrics 111:1262-7. 2003
    ....
  51. ncbi request reprint Isolated hepatocyte transplantation for Crigler-Najjar syndrome type 1
    Giovanni Ambrosino
    Department of Surgery and Gastroenterological Science, University of Padova, Padova, Italy
    Cell Transplant 14:151-7. 2005
    ..Isolated AHT, though effective and safe, is not sufficient to correct CN1. Maintenance of adequate immunosuppression and family compliance are the main factors hampering the success of this procedure...
  52. ncbi request reprint Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes
    Yuan Hua Wen
    Department of Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Drug Metab Dispos 30:977-84. 2002
    ..These results suggest that bergamottin causes both inhibition of CYP3A and CYP1A1/2 enzymatic activities and induction of correspondent proteins and mRNAs...
  53. pmc Mapping the genetic architecture of gene expression in human liver
    Eric E Schadt
    Rosetta Inpharmatics, Seattle, Washington, United States of America
    PLoS Biol 6:e107. 2008
    ..We also identify SORT1 and CELSR2 as candidate susceptibility genes for a locus recently associated with coronary artery disease and plasma low-density lipoprotein cholesterol levels in the process...
  54. ncbi request reprint Bigger may not be better when it comes to hepatocytes
    Stephen C Strom
    Liver Transpl 12:16-8. 2006
  55. pmc Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures
    Katy M O Goyak
    Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA
    Toxicol Appl Pharmacol 231:216-24. 2008
    ....
  56. ncbi request reprint Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells
    Ornella Parolini
    Centro di Ricerca E Menni, Fondazione Poliambulanza, Istituto Ospedaliero, Via Bissolati 57, 25124 Brescia, Italy
    Stem Cells 26:300-11. 2008
    ....
  57. ncbi request reprint Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites
    Seva E Kostrubsky
    Department of Safety Science and Pharmacokinetics, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Chem Res Toxicol 20:1503-12. 2007
    ..The data also suggest a possible drug-drug interaction between flutamide and APAP, resulting in inhibition of flutamide metabolism and increased APAP bioactivation and toxicity...
  58. ncbi request reprint Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor
    Hai lin Fang
    Institute of Environmental Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
    J Pharmacol Exp Ther 323:586-98. 2007
    ..By contrast, the rifampicin-inducible SULT2A1 expression that occurs in many human hepatocyte preparations seems to be mediated through a PXR-independent mechanism...
  59. pmc Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites
    Matthew A Stoner
    Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA
    Nucleic Acids Res 35:2177-90. 2007
    ....
  60. ncbi request reprint Human hepatocyte transplantation: worldwide results
    Robert A Fisher
    Department of Surgery, Transplantation Division, Virginia Commonwealth University, Medical College of Virginia Hospitals, Richmond, VA, USA
    Transplantation 82:441-9. 2006
    ..The human cell infusion experiences are categorized by liver disease treated (metabolic, chronic, and acute liver failure), and these are accompanied by seminal in vitro and in vivo experimental data...
  61. ncbi request reprint Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes
    Jacqueline Ramirez
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Pharmacogenet Genomics 16:79-86. 2006
    ..The indel at -53 affects the basal phenotype and appears to limit the hepatocyte capability of maximal induction after phenobarbital. However, variants at -53, -3156 and -3279 are not associated with variability in UGT1A1 inducibility...
  62. ncbi request reprint Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone
    Seva E Kostrubsky
    Department of Safety Science and Pharmacokinetics, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Toxicol Sci 90:451-9. 2006
    ..Our findings are consistent with the clinical experience and suggest that described methodology can be applied in the selection of nonhepatotoxic drug candidates...
  63. ncbi request reprint Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes
    Thomas A Kocarek
    Institute of Environmental Health Sciences, Wayne State University, Detroit 48201, Michigan, USA
    Drug Metab Dispos 30:1400-5. 2002
    ....