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Genomes and Genes | Brian L StromSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formulaNicolas Stettler
Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, 36th St and Civic Center Blvd, Philadelphia, PA 19104 4399, USA
Circulation 111:1897-903. 2005..Rapid infancy weight gain is associated with childhood obesity, whereas low infancy weight is associated with coronary heart disease. Our aim was to identify during which periods in infancy weight gain is associated with adult obesity...- The relationship between time since registration and measured incidence rates in the General Practice Research DatabaseJames D Lewis
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 14:443-51. 2005.... - Use of nonsteroidal antiinflammatory drugs and risk of breast cancer: the Case-Control Surveillance Study revisitedYuqing Zhang
Clinical Epidemiology Research and Training Unit, School of Medicine, Boston University, Boston, MA 02118, USA
Am J Epidemiol 162:165-70. 2005..In conclusion, long-term regular use of NSAIDs was associated with decreased risk of breast cancer. The type of NSAID used or the hormone receptor status of the tumor did not modify the effect... 
A comparison of change in the 0-10 numeric rating scale to a pain relief scale and global medication performance scale in a short-term clinical trial of breakthrough pain intensityJohn T Farrar
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Anesthesiology 112:1464-72. 2010..The correlation of data from patients with breakthrough pain with a Pain Relief Scale and a different global outcome measures will extend our understanding of these measures...
The Master of Science in clinical epidemiology degree program of the Perelman School of Medicine at the University of Pennsylvania: a model for clinical research trainingBrian L Strom
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
Acad Med 87:74-80. 2012....- Detecting pregnancy use of non-hormonal category X medications in electronic medical recordsBrian L Strom
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
J Am Med Inform Assoc 18:i81-6. 2011..To determine whether a rule-based algorithm applied to an outpatient electronic medical record (EMR) can identify patients who are pregnant and prescribed medications proved to cause birth defects... - Comparative mortality associated with ziprasidone and olanzapine in real-world use among 18,154 patients with schizophrenia: The Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC)Brian L Strom
Department of Biostatistics and Epidemiology, the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, 19104 6021, USA
Am J Psychiatry 168:193-201. 2011..The authors compared 1-year mortality rates associated with ziprasidone and olanzapine in real-world use... - The Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC): design and baseline subject characteristicsBrian L Strom
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Psychiatry 69:114-21. 2008..Ziprasidone has been used to treat schizophrenia since 2000. It is unknown whether its modest QTc-prolonging effect increases cardiovascular event risk... - Pairwise combinations of estrogen metabolism genotypes in postmenopausal breast cancer etiologyTimothy R Rebbeck
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Cancer Epidemiol Biomarkers Prev 16:444-50. 2007.... - Validation studies of the health improvement network (THIN) database for pharmacoepidemiology researchJames D Lewis
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 16:393-401. 2007..We sought to replicate in THIN well-established associations from the medical literature and to compare results from the GPRD practices to the non-GPRD practices within THIN... - Methylphenidate and risk of serious cardiovascular events in adultsHedi Schelleman
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
Am J Psychiatry 169:178-85. 2012..The authors sought to determine whether use of methylphenidate in adults is associated with elevated rates of serious cardiovascular events compared with rates in nonusers... - Lack of effect modification between estrogen metabolism genotypes and combined hormone replacement therapy in postmenopausal breast cancer riskTimothy R Rebbeck
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA
Cancer Epidemiol Biomarkers Prev 16:1318-20. 2007 - Case-control study of postmenopausal hormone replacement therapy and endometrial cancerBrian L Strom
Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, 19104 6021, USA
Am J Epidemiol 164:775-86. 2006..Thus, if HRT is to be used in women with an intact uterus, this study confirms the benefit of adding progestins to the regimen... - Unintended effects of a computerized physician order entry nearly hard-stop alert to prevent a drug interaction: a randomized controlled trialBrian L Strom
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Arch Intern Med 170:1578-83. 2010..The effectiveness of computerized physician order entry (CPOE) systems has been modest, largely because clinicians frequently override electronic alerts... - Hormone therapy and fatal breast cancerSandra A Norman
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 19:440-7. 2010..Using a population-based case-control design, we estimated incidence rate ratios of fatal breast cancer in postmenopausal hormone therapy (HT) users compared to non-users by type, duration, and recency of HT use... - Increased risk of digoxin toxicity following hospitalizationKevin Haynes
Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 18:28-35. 2009..The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin... - Can we predict daily adherence to warfarin?: Results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) StudyAlec B Platt
MSCE, University of Pennsylvania School of Medicine, 707 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
Chest 137:883-9. 2010..Currently, no comprehensive screening tool exists to help providers assess the risk of nonadherence at the time of initiation of warfarin therapy... - Incidence of transaminitis among HIV-infected patients with occult hepatitis BVincent Lo Re
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Virol 43:32-6. 2008..This information is needed to determine the importance of detecting and treating occult HBV in this population... - Comparative cardiac safety of low-dose thioridazine and low-dose haloperidolSean Hennessy
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Br J Clin Pharmacol 58:81-7. 2004..To compare the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of thioridazine and haloperidol... - Immunosuppressant medications and mortality in inflammatory bowel diseaseJames D Lewis
Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Gastroenterol 103:1428-35; quiz 1436. 2008..This study examined whether treatment of Crohn's disease (CD) and ulcerative colitis (UC) with immunosuppressant medications was associated with an increased risk of death in the era prior to antitumor necrosis factor (TNF) therapies... - A retrospective case-control study of the use of hormone-related supplements and association with breast cancerTimothy R Rebbeck
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Int J Cancer 120:1523-8. 2007..Additional confirmatory studies are required to determine whether black cohosh could be used to prevent breast cancer... - Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarctionStephen E Kimmel
University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
Ann Intern Med 142:157-64. 2005..Cardiovascular effects among the COX-2 inhibitors seem different, but further studies, preferably randomized trials, are needed to fully understand the spectrum of effects of COX-2 inhibitors and potential differences among them... - Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugsJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Gastroenterology 129:1865-74. 2005..Less is known about over-the-counter (OTC) NANSAIDs, which are typically used at lower doses and for shorter durations. This study assessed the risk of toxicity with OTC NANSAIDs... - Is there cross-reactivity between penicillins and cephalosporins?Andrea J Apter
Division of Pulmonary, Allergy Critical Care Medicine, Department of Medicine, Philadelphia, PA, USA
Am J Med 119:354.e11-9. 2006..We sought to determine the risk of an allergic reaction to a cephalosporin exposure in those with prior penicillin reactions... - Cardiovascular events and death in children exposed and unexposed to ADHD agentsHedi Schelleman
Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 6021, USA
Pediatrics 127:1102-10. 2011..The objective of this study was to compare the rate of severe cardiovascular events and death in children who use attention-deficit/hyperactivity disorder (ADHD) medications versus nonusers... - Association between longer therapy with thiazolidinediones and risk of bladder cancer: a cohort studyRonac Mamtani
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Natl Cancer Inst 104:1411-21. 2012..In this study, we assessed the risk of bladder cancer associated with the use of TZDs and between pioglitazone and rosiglitazone, an alternative TZD... - Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicityJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 17:328-35. 2008..This study examined the effect of medications that inhibit serotonin uptake on upper gastrointestinal toxicity... - Self-reported hepatitis B and C virus infections had low sensitivity among HIV-infected patientsVincent Lo Re
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Epidemiol 60:294-9. 2007..To determine the validity of self-reported hepatitis B virus (HBV) and hepatitis C virus (HCV) in HIV-infected injection drug users (IDUs) vs. nonIDUs... - Cancer incidence in The Health Improvement NetworkKevin Haynes
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 18:730-6. 2009..This study assessed whether the recorded incidence of cancer among patients in The Health Improvement Network (THIN) database is comparable to that expected in the UK based on national cancer registry data... - Impact of raloxifene or tamoxifen use on endometrial cancer risk: a population-based case-control studyAngela DeMichele
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA
J Clin Oncol 26:4151-9. 2008.... - Randomized clinical trial of a customized electronic alert requiring an affirmative response compared to a control group receiving a commercial passive CPOE alert: NSAID--warfarin co-prescribing as a test caseBrian L Strom
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Pennsylvania 19104 6021, USA
J Am Med Inform Assoc 17:411-5. 2010..Studies that have looked at the effectiveness of computerized decision support systems to prevent drug-drug interactions have reported modest results because of low response by the providers to the automated alerts... - Hormone-dependent effects of FGFR2 and MAP3K1 in breast cancer susceptibility in a population-based sample of post-menopausal African-American and European-American womenTimothy R Rebbeck
Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Carcinogenesis 30:269-74. 2009..We further report that these genes confer their effects in HER2- tumors, interact with one another to confer breast cancer susceptibility in AA women and interact with hormone exposures in AA and EA women... - Validation of diagnostic codes for outpatient-originating sudden cardiac death and ventricular arrhythmia in Medicaid and Medicare claims dataSean Hennessy
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 19:555-62. 2010..This study examined the positive predictive value (PPV) of hospitalization and emergency department encounter diagnoses in identifying SD/VA events originating in the outpatient setting... - Proton pump inhibitors and traditional nonsteroidal anti-inflammatory drugs and the risk of acute interstitial nephritis and acute kidney injuryCharles E Leonard
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 21:1155-72. 2012.... - Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer riskTimothy R Rebbeck
Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
J Natl Cancer Inst 98:1311-20. 2006..To investigate the mechanism of this association, we evaluated whether risk of endometrial cancer was associated with the genotypes involved in steroid hormone metabolism and the duration of exogenous hormone use... - Longitudinal trends in fluoroquinolone resistance among Enterobacteriaceae isolates from inpatients and outpatients, 1989-2000: differences in the emergence and epidemiology of resistance across organismsEbbing Lautenbach
Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Clin Infect Dis 38:655-62. 2004..Efforts to elucidate the epidemiology of FQ resistance and identify targets for intervention must recognize and account for the variability of FQ resistance across organisms and clinical settings... - Represcription of penicillin after allergic-like eventsAndrea J Apter
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA
J Allergy Clin Immunol 113:764-70. 2004..72%). Represcription of penicillin to such patients is more frequent than anticipated... - Predictors of recall of over-the-counter and prescription non-steroidal anti-inflammatory drug exposureJames D Lewis
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 15:39-45. 2006..Because of the difficulty in establishing a gold standard, data on accuracy of recall of over-the-counter (OTC) medication use are sparse... - Diagnostic accuracy of CD4 cell count increase for virologic response after initiating highly active antiretroviral therapyGregory P Bisson
Department of Medicine, Division of Infectious Diseases, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104 6021, USA
AIDS 20:1613-9. 2006..To derive and internally validate a clinical prediction rule for virologic response based on CD4 cell count increase after initiation of HAART in a resource-limited setting... - Patient reported receipt of medication instructions for warfarin is associated with reduced risk of serious bleeding eventsJoshua P Metlay
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Gen Intern Med 23:1589-94. 2008..Adverse drug events are an important cause of preventable hospitalizations... - Cigarette yield and the risk of myocardial infarction in smokersWilliam H Sauer
Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Arch Intern Med 162:300-6. 2002..001 for the trend). CONCLUSIONS: Smoking higher-yield cigarettes is associated with an increased risk of MI, and there is a dose-response relationship between total tar consumption per day and MI... - Safety of saxagliptin: rationale for and design of a series of postmarketing observational studiesVincent Lo Re
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 21:1202-15. 2012..To describe the design and rationale of a series of postmarketing studies to examine the safety of saxagliptin, an oral dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus, in real-world settings... - Amphetamines, atomoxetine and the risk of serious cardiovascular events in adultsHedi Schelleman
Center for Clinical Epidemiology and Biostatistics, and Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 8:e52991. 2013..To compare the incidence rates of serious cardiovascular events in adult initiators of amphetamines or atomoxetine to rates in non-users... - Evaluating health information technology's clinical effectsBrian L Strom
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA 19104, USA
LDI Issue Brief 16:1-4. 2011..This rigorous test of a specific CPOE intervention shows that an electronic alert system can be effective in changing prescribing, but may also have unintended consequences for patient safety... - Risk factors for nonadherence to warfarin: results from the IN-RANGE studyAlec B Platt
Department of Medicine, University of Pennsylvania School of Medicine, PA, USA
Pharmacoepidemiol Drug Saf 17:853-60. 2008..Warfarin is widely used to prevent stroke and venous thromboembolism despite its narrow therapeutic window. Warfarin nonadherence is a substantial problem, but risk factors have not been well elucidated... - Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative dataSean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
BMJ 325:1070. 2002..To examine the rates of cardiac arrest and ventricular arrhythmia in patients with treated schizophrenia and in non-schizophrenic controls... - Prevalence, risk factors, and outcomes for occult hepatitis B virus infection among HIV-infected patientsVincent Lo Re
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
J Acquir Immune Defic Syndr 44:315-20. 2007..The prevalence of occult HBV in HIV-infected patients remains controversial, and the risk factors and clinical significance are unknown... - Managed problem solving for antiretroviral therapy adherence: a randomized trialRobert Gross
Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104 6021, USA
JAMA Intern Med 173:300-6. 2013..Implementation of MAPS should be strongly considered where resources are available. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00130273... - Validation of 6-minute walk distance as a surrogate end point in pulmonary arterial hypertension trialsNicole B Gabler
Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA, USA
Circulation 126:349-56. 2012..We aimed to validate the difference in Δ6MWD against the probability of a clinical event in pulmonary arterial hypertension trials... - Reacting to antibiotic allergiesAndrea J Apter
Center for Clinical Epidemiology and Biostatistics, Center for Education and Research on Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
LDI Issue Brief 11:1-4. 2006.... - Absence of an effect of injectable and implantable progestin-only contraceptives on subsequent risk of breast cancerBrian L Strom
Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, 824 Blockley Hall, 423 Guardian Drive, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Contraception 69:353-60. 2004..This study does not support an increased risk of breast cancer associated with the use of injectable or implantable progestin-only contraceptives in women aged 35 to 64... - Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibioticsBrian L Strom
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
N Engl J Med 349:1628-35. 2003..The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic reactions to sulfonamide antibiotics... - Out-of-pocket costs of HAART limit HIV treatment responses in Botswana's private sectorGregory P Bisson
Division of Infectious Disease, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
AIDS 20:1333-6. 2006..001]. HAART costs should be minimized as scale-up efforts in sub-Saharan Africa progress... - Identifying and quantifying medication errors: evaluation of rapidly discontinued medication orders submitted to a computerized physician order entry systemRoss Koppel
Department of Sociology, University of Pennsylvania, Philadelphia, PA, USA
J Am Med Inform Assoc 15:461-5. 2008..This measure offers a rapid, constant, inexpensive, and objective method to identify medication orders with a high probability of error. It may also serve as a screening and teaching mechanism for physicians-in-training... - Epidemiologic studies of adverse effects of anti-retroviral drugs: how well is statistical power reportedScott D Halpern
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 14:155-61. 2005..Future research is needed to determine whether the observed paucity of industry-sponsored observational studies of anti-retroviral ADEs extends to other clinical areas, and if so, to identify the causes of this phenomenon... - Cardiovascular safety of ADHD medications: rationale for and design of an investigator-initiated observational studySean Hennessy
Center for Clinical Epidemiology and Biostatistics, and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 19:934-41. 2010.... - The risk of mortality in patients with psoriasis: results from a population-based studyJoel M Gelfand
MSCE, Department of Dermatology, University of Pennsylvania School of Medicine, 2 Maloney Bldg, 3600 Spruce St, Philadelphia, PA 19104, USA
Arch Dermatol 143:1493-9. 2007..To determine the risk of mortality in patients with psoriasis... - Neither panacea nor black box: responding to three Journal of Biomedical Informatics papers on computerized physician order entry systemsRoss Koppel
Department of Sociology and Center for Clinical Epidemiology and Biostatistics of the School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Biomed Inform 38:267-9. 2005 - Preevent vaccination against smallpox: a survey of pediatric emergency health care providersWorth W Everett
Department of Emergency Medicine, Hospital of the University of Pennsylvania, Centers for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
Pediatr Infect Dis J 23:332-7. 2004..A greater understanding of the knowledge, attitudes and beliefs of pediatric health care workers toward preevent smallpox vaccination will assist in the development of future bioterrorism preparedness programs... - Descriptive analyses of the integrity of a US Medicaid claims databaseSean Hennessy
Center for Clinical Epidemiology, Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 12:103-11. 2003..To examine the integrity of six Medicaid databases for use in pharmacoepidemiology research... - Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertensionNicole B Gabler
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiolog, Perelman School of Medicine, University of Pennsylvania, 723 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
Chest 141:20-6. 2012..Differences in endothelin-1 biology between sexes and between whites and blacks may lead to differences in patients' responses to treatment with endothelin receptor antagonists (ERAs)... - Hospitalization and mortality rates from peptic ulcer disease and GI bleeding in the 1990s: relationship to sales of nonsteroidal anti-inflammatory drugs and acid suppression medicationsJames D Lewis
Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
Am J Gastroenterol 97:2540-9. 2002..Changing rates of peptic ulcer disease morbidity and mortality were temporally related to increasing sales of antiulcerants but not to change in sales of NSAIDs... - Combined effect of oral contraceptive use and hormone replacement therapy on breast cancer risk in postmenopausal womenSandra A Norman
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Cancer Causes Control 14:933-43. 2003..We examined breast cancer risk related to lifetime exposure to oral contraceptives (OCs) and hormone replacement therapy (HRT) in postmenopausal women... - Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort studyJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Diabetes Care 34:916-22. 2011..This is an interim report of an ongoing cohort study examining the association between pioglitazone therapy and the risk of bladder cancer in patients with diabetes... - Temporal and within practice variability in the health improvement networkKevin Haynes
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 20:948-55. 2011..However, little is known about the consistency within practices across observation years and among practices within a given year, in THIN or other large medical record databases... - The effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirinStephen E Kimmel
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
J Am Coll Cardiol 43:985-90. 2004.... - Validity and comparison of two measures of days supply in Medicaid claims dataRobert Gross
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 17:1029-32. 2008..The two measures should yield the same duration, but if not, the preferred method is unknown... - Practical aspects of sharing controls between case-control studiesGreta R Bunin
Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 14:523-30. 2005..We discuss the practical advantages and challenges of sharing controls among two or more concurrently conducted case-control studies... - The role of academia and the research community in assisting the Food and Drug Administration to ensure U.S. drug safetyVincent Lo Re
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 16:818-25. 2007..We sought to examine ways that academia could expand its role in U.S. drug safety... - Effectiveness of an information technology intervention to improve prophylactic antibacterial use in the postoperative periodKevin Haynes
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Am Med Inform Assoc 18:164-8. 2011..Electronic order sets have shown promise as a means of integrating guideline information with electronic order entry systems and facilitating safer, more effective care... - Retrospective drug utilization review, prescribing errors, and clinical outcomesSean Hennessy
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
JAMA 290:1494-9. 2003..However, it has not been shown to improve clinical outcomes or reduce the rate of potential prescribing errors, known as "exceptions.".. - Parenteral ketorolac and risk of myocardial infarctionStephen E Kimmel
Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Pharmacoepidemiol Drug Saf 11:113-9. 2002..To examine the effects of ketorolac, a non-aspirin non-steroidal anti-inflammatory drug (NANSAID) with antiplatelet properties, on the risk of in-hospital myocardial infarction (MI)... - Incidence and risk factors for weight loss during dual HIV/hepatitis C virus therapyVincent Lo Re
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
J Acquir Immune Defic Syndr 44:344-50. 2007..Clinical observations suggest that patients with HIV/hepatitis C virus (HCV) may lose body weight during dual therapy, but this has not been confirmed analytically... - Seasonal variation in flares of inflammatory bowel diseaseJames D Lewis
Center for Clinical Epidemiology and Biostatistics and Department of Medicine, University of Pennsylvania Centers for Education and Research on Therapeutics, Philadelphia, 19104 6021, USA
Gastroenterology 126:665-73. 2004..The purpose of this study was to determine whether relapse of inflammatory bowel disease follows a seasonal pattern either across a cohort of patients or within individual patients... - Statins and over-the-counter availabilityBrian L Strom
University of Pennsylvania School of Medicine, Philadelphia, USA
N Engl J Med 352:1403-5. 2005 - Methodologic challenges to studying patient safety and comparative effectivenessBrian L Strom
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Med Care 45:S13-5. 2007..This article provides a conceptual overview of these methodologic issues... - Antidiabetic action of bezafibrate in a large observational databaseJames H Flory
1Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Diabetes Care 32:547-51. 2009..The purpose of this study was to test the hypothesis that bezafibrate, an approved fibrate, can prevent or delay type 2 diabetes... - The ineffectiveness of retrospective drug utilization reviewSean Hennessy
Center for Clinical Epidemiology and Biostatistics, Center for Education and Research on Therapeutics, University of Pennsylvania, USA
LDI Issue Brief 9:1-4. 2003..This Issue Brief summarizes a landmark study that suggests that retrospective DUR has had no measurable effects on outpatient drug use or clinical outcomes in the Medicaid program... - PDUFA reauthorization--drug safety's golden moment of opportunity?Sean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
N Engl J Med 356:1703-4. 2007 - Participants and refusers in a telephone interview about hormone replacement therapy were equally likely to be taking itBrian L Strom
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 824 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
J Clin Epidemiol 57:624-6. 2004..To address a major concern in pharmacoepidemiology studies related to whether the characteristics of responders are different from those who refuse to participate... - Role of computerized physician order entry systems in facilitating medication errorsRoss Koppel
Department of Sociology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 USA
JAMA 293:1197-203. 2005..Published studies report that CPOE reduces medication errors up to 81%. Few researchers, however, have focused on the existence or types of medication errors facilitated by CPOE... - An interview strategy was critical for obtaining valid information on the use of hormone replacement therapyBrian L Strom
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Epidemiol 57:1210-3. 2004..We compared telephone reports of hormone replacement therapy (HRT) use to claims for drugs dispensed... - Potential for conflict of interest in the evaluation of suspected adverse drug reactions: a counterpointBrian L Strom
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
JAMA 292:2643-6. 2004 - Association between serious ischemic cardiac outcomes and medications used to treat diabetesDavid J Margolis
Department of Dermatology, University of Pennsylvania School of Medicine, PA 19104, USA
Pharmacoepidemiol Drug Saf 17:753-9. 2008..Data on cardiovascular outcomes among treated diabetics have been inconsistent. Our goal was to compare cardiovascular outcomes associated with different treatments for diabetes... - Agreement between patient self-report and a Veterans Affairs national pharmacy database for identifying recent exposures to antibioticsJoshua P Metlay
Philadelphia Veterans Affairs Medical Center, Division of General Internal Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, Univ of Pennsylvania, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 12:9-15. 2003..The authors compared self-report with pharmacy dispensing data to determine the accuracy of self-reported antibiotic exposure... - Clinically important changes in acute pain outcome measures: a validation studyJohn T Farrar
University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Pain Symptom Manage 25:406-11. 2003..This provides support for the usefulness of these values in future clinical trials of pain therapy... - Validity and completeness of the General Practice Research Database for studies of inflammatory bowel diseaseJames D Lewis
Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania School of Medicine, 9th Floor Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 11:211-8. 2002..The objective of this study was to evaluate the validity and completeness of the General Practice Research Database (GPRD) as a tool for research into inflammatory bowel disease epidemiology... - Smallpox vaccination: a national survey of emergency health care providersWorth W Everett
Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
Acad Emerg Med 10:606-11. 2003..Although emergency health care providers are among the first targeted for vaccination, little is known about how these providers view the risks and benefits of SP vaccination... - The incidence and prevalence of pressure ulcers among elderly patients in general medical practiceDavid J Margolis
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Ann Epidemiol 12:321-5. 2002..They are most likely to occur in those over 85 years of age. Preventative strategies within the general practice setting should concentrate on the oldest of the elderly... - Oral contraceptives and the risk of breast cancerPolly A Marchbanks
Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, USA
N Engl J Med 346:2025-32. 2002..CONCLUSIONS: Among women from 35 to 64 years of age, current or former oral-contraceptive use was not associated with a significantly increased risk of breast cancer... - Estrogen replacement therapy and risk of lung cancerJanine A Blackman
Department of Family Practice, Franklin Square Hospital Center, Baltimore, MD, USA
Pharmacoepidemiol Drug Saf 11:561-7. 2002..There were non-significant increases for non-small cell types other than squamous, but there was no consistent pattern across duration of use. CONCLUSION: Our data do not support an increased risk of lung cancer among women who use ERT... - Relation of regimens of combined hormone replacement therapy to lobular, ductal, and other histologic types of breast carcinomaJanet R Daling
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer 95:2455-64. 2002..However, the use of combined (estrogen and progestin) hormone replacement therapy (CHRT) also has increased during the last decade and may account in part for the increase in invasive lobular breast carcinoma... - Do thyroid disorders increase the risk of breast cancer?Michael S Simon
Division of Hematology and Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, Michigan, USA
Cancer Epidemiol Biomarkers Prev 11:1574-8. 2002..There was no statistical interaction between thyroid disorders, thyroid treatments, and race, menopausal status, or parity. We found no association between thyroid disorders or their associated treatments and the risk of breast cancer... - Hormone replacement therapy regimens and breast cancer risk(1)Linda K Weiss
Population Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University, Detroit, Michigan, USA
Obstet Gynecol 100:1148-58. 2002..Progestin administered in an uninterrupted regimen may be a contributing factor. Risk dissipates once use is discontinued... - The NICHD Women's Contraceptive and Reproductive Experiences Study: methods and operational resultsPolly A Marchbanks
Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Ann Epidemiol 12:213-21. 2002..5% and 78.6%, respectively, with lower rates for black women and older women. CONCLUSIONS: The methodologic details of this large collaboration may assist researchers conducting similar investigations... - Infertility drugs and the risk of breast cancer: findings from the National Institute of Child Health and Human Development Women's Contraceptive and Reproductive Experiences StudyRonald T Burkman
National Cancer Institute Surveillance, Epidemiology, and End Results Registry, Department of Obstetrics and Gynecology, Henry Ford Health System, Detroit, Michigan, USA
Fertil Steril 79:844-51. 2003..To determine the association between infertility drug use and invasive breast cancer in a population-based case-control study... - Breast cancer risk estimates for relatives of white and African American women with breast cancer in the Women's Contraceptive and Reproductive Experiences StudyMichael S Simon
Division of Hematology and Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, MI 48201, USA
J Clin Oncol 24:2498-504. 2006..The purpose of this report is to update breast cancer risk estimates associated with a family history of breast cancer for white and AA women... - Relationship between established breast cancer risk factors and risk of seven different histologic types of invasive breast cancerChristopher I Li
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 C308, P O Box 19024, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 15:946-54. 2006.... - Risk of breast cancer associated with short-term use of oral contraceptivesSuzanne G Folger
Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Cancer Causes Control 18:189-98. 2007..To estimate breast cancer risk associated with short-term (<6 months) oral contraceptive use, and explore variation in estimates by use characteristics and medical, menstrual, and reproductive history... - Lifetime recreational exercise activity and breast cancer risk among black women and white womenLeslie Bernstein
Department of Preventive Medicine, Keck School of Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
J Natl Cancer Inst 97:1671-9. 2005.... - Use of selective serotonin reuptake inhibitors and the risk of breast cancerPatricia F Coogan
Slone Epidemiology Center, Boston University, Boston, MA 02215, USA
Am J Epidemiol 162:835-8. 2005..7 (95% confidence interval: 0.4, 1.5) for use of 4 or more years. Odds ratios were not elevated for any specific SSRI. These data provide some assurance that the use of SSRIs does not increase the risk of breast cancer...