Brian L Strom

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula
    Nicolas Stettler
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, 36th St and Civic Center Blvd, Philadelphia, PA 19104 4399, USA
    Circulation 111:1897-903. 2005
  2. ncbi request reprint The relationship between time since registration and measured incidence rates in the General Practice Research Database
    James D Lewis
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:443-51. 2005
  3. ncbi request reprint Use of nonsteroidal antiinflammatory drugs and risk of breast cancer: the Case-Control Surveillance Study revisited
    Yuqing Zhang
    Clinical Epidemiology Research and Training Unit, School of Medicine, Boston University, Boston, MA 02118, USA
    Am J Epidemiol 162:165-70. 2005
  4. pmc A comparison of change in the 0-10 numeric rating scale to a pain relief scale and global medication performance scale in a short-term clinical trial of breakthrough pain intensity
    John T Farrar
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 112:1464-72. 2010
  5. doi request reprint The Master of Science in clinical epidemiology degree program of the Perelman School of Medicine at the University of Pennsylvania: a model for clinical research training
    Brian L Strom
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    Acad Med 87:74-80. 2012
  6. doi request reprint Comparative mortality associated with ziprasidone and olanzapine in real-world use among 18,154 patients with schizophrenia: The Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC)
    Brian L Strom
    Department of Biostatistics and Epidemiology, the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, 19104 6021, USA
    Am J Psychiatry 168:193-201. 2011
  7. ncbi request reprint The Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC): design and baseline subject characteristics
    Brian L Strom
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Psychiatry 69:114-21. 2008
  8. pmc Detecting pregnancy use of non-hormonal category X medications in electronic medical records
    Brian L Strom
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    J Am Med Inform Assoc 18:i81-6. 2011
  9. ncbi request reprint Pairwise combinations of estrogen metabolism genotypes in postmenopausal breast cancer etiology
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 16:444-50. 2007
  10. ncbi request reprint Validation studies of the health improvement network (THIN) database for pharmacoepidemiology research
    James D Lewis
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 16:393-401. 2007

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula
    Nicolas Stettler
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, 36th St and Civic Center Blvd, Philadelphia, PA 19104 4399, USA
    Circulation 111:1897-903. 2005
    ..Rapid infancy weight gain is associated with childhood obesity, whereas low infancy weight is associated with coronary heart disease. Our aim was to identify during which periods in infancy weight gain is associated with adult obesity...
  2. ncbi request reprint The relationship between time since registration and measured incidence rates in the General Practice Research Database
    James D Lewis
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:443-51. 2005
    ....
  3. ncbi request reprint Use of nonsteroidal antiinflammatory drugs and risk of breast cancer: the Case-Control Surveillance Study revisited
    Yuqing Zhang
    Clinical Epidemiology Research and Training Unit, School of Medicine, Boston University, Boston, MA 02118, USA
    Am J Epidemiol 162:165-70. 2005
    ..In conclusion, long-term regular use of NSAIDs was associated with decreased risk of breast cancer. The type of NSAID used or the hormone receptor status of the tumor did not modify the effect...
  4. pmc A comparison of change in the 0-10 numeric rating scale to a pain relief scale and global medication performance scale in a short-term clinical trial of breakthrough pain intensity
    John T Farrar
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 112:1464-72. 2010
    ..The correlation of data from patients with breakthrough pain with a Pain Relief Scale and a different global outcome measures will extend our understanding of these measures...
  5. doi request reprint The Master of Science in clinical epidemiology degree program of the Perelman School of Medicine at the University of Pennsylvania: a model for clinical research training
    Brian L Strom
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    Acad Med 87:74-80. 2012
    ....
  6. doi request reprint Comparative mortality associated with ziprasidone and olanzapine in real-world use among 18,154 patients with schizophrenia: The Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC)
    Brian L Strom
    Department of Biostatistics and Epidemiology, the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, 19104 6021, USA
    Am J Psychiatry 168:193-201. 2011
    ..The authors compared 1-year mortality rates associated with ziprasidone and olanzapine in real-world use...
  7. ncbi request reprint The Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC): design and baseline subject characteristics
    Brian L Strom
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Psychiatry 69:114-21. 2008
    ..Ziprasidone has been used to treat schizophrenia since 2000. It is unknown whether its modest QTc-prolonging effect increases cardiovascular event risk...
  8. pmc Detecting pregnancy use of non-hormonal category X medications in electronic medical records
    Brian L Strom
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    J Am Med Inform Assoc 18:i81-6. 2011
    ..To determine whether a rule-based algorithm applied to an outpatient electronic medical record (EMR) can identify patients who are pregnant and prescribed medications proved to cause birth defects...
  9. ncbi request reprint Pairwise combinations of estrogen metabolism genotypes in postmenopausal breast cancer etiology
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 16:444-50. 2007
    ....
  10. ncbi request reprint Validation studies of the health improvement network (THIN) database for pharmacoepidemiology research
    James D Lewis
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 16:393-401. 2007
    ..We sought to replicate in THIN well-established associations from the medical literature and to compare results from the GPRD practices to the non-GPRD practices within THIN...
  11. doi request reprint Methylphenidate and risk of serious cardiovascular events in adults
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
    Am J Psychiatry 169:178-85. 2012
    ..The authors sought to determine whether use of methylphenidate in adults is associated with elevated rates of serious cardiovascular events compared with rates in nonusers...
  12. ncbi request reprint Lack of effect modification between estrogen metabolism genotypes and combined hormone replacement therapy in postmenopausal breast cancer risk
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 16:1318-20. 2007
  13. doi request reprint Unintended effects of a computerized physician order entry nearly hard-stop alert to prevent a drug interaction: a randomized controlled trial
    Brian L Strom
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 170:1578-83. 2010
    ..The effectiveness of computerized physician order entry (CPOE) systems has been modest, largely because clinicians frequently override electronic alerts...
  14. ncbi request reprint Case-control study of postmenopausal hormone replacement therapy and endometrial cancer
    Brian L Strom
    Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, 19104 6021, USA
    Am J Epidemiol 164:775-86. 2006
    ..Thus, if HRT is to be used in women with an intact uterus, this study confirms the benefit of adding progestins to the regimen...
  15. doi request reprint Increased risk of digoxin toxicity following hospitalization
    Kevin Haynes
    Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:28-35. 2009
    ..The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin...
  16. pmc Can we predict daily adherence to warfarin?: Results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Alec B Platt
    MSCE, University of Pennsylvania School of Medicine, 707 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Chest 137:883-9. 2010
    ..Currently, no comprehensive screening tool exists to help providers assess the risk of nonadherence at the time of initiation of warfarin therapy...
  17. pmc Hormone therapy and fatal breast cancer
    Sandra A Norman
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 19:440-7. 2010
    ..Using a population-based case-control design, we estimated incidence rate ratios of fatal breast cancer in postmenopausal hormone therapy (HT) users compared to non-users by type, duration, and recency of HT use...
  18. pmc Amphetamines, atomoxetine and the risk of serious cardiovascular events in adults
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics, and Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e52991. 2013
    ..To compare the incidence rates of serious cardiovascular events in adult initiators of amphetamines or atomoxetine to rates in non-users...
  19. pmc Incidence of transaminitis among HIV-infected patients with occult hepatitis B
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Virol 43:32-6. 2008
    ..This information is needed to determine the importance of detecting and treating occult HBV in this population...
  20. ncbi request reprint Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction
    Stephen E Kimmel
    University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Ann Intern Med 142:157-64. 2005
    ..Some of these mechanisms could increase risk (for example, inhibition of prostacyclin production), and some could decrease risk (for example, inhibition of inflammation)...
  21. pmc Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Br J Clin Pharmacol 58:81-7. 2004
    ..To compare the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of thioridazine and haloperidol...
  22. doi request reprint Immunosuppressant medications and mortality in inflammatory bowel disease
    James D Lewis
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Gastroenterol 103:1428-35; quiz 1436. 2008
    ..This study examined whether treatment of Crohn's disease (CD) and ulcerative colitis (UC) with immunosuppressant medications was associated with an increased risk of death in the era prior to antitumor necrosis factor (TNF) therapies...
  23. ncbi request reprint A retrospective case-control study of the use of hormone-related supplements and association with breast cancer
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Int J Cancer 120:1523-8. 2007
    ..Additional confirmatory studies are required to determine whether black cohosh could be used to prevent breast cancer...
  24. ncbi request reprint Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugs
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Gastroenterology 129:1865-74. 2005
    ..Less is known about over-the-counter (OTC) NANSAIDs, which are typically used at lower doses and for shorter durations. This study assessed the risk of toxicity with OTC NANSAIDs...
  25. ncbi request reprint Is there cross-reactivity between penicillins and cephalosporins?
    Andrea J Apter
    Division of Pulmonary, Allergy Critical Care Medicine, Department of Medicine, Philadelphia, PA, USA
    Am J Med 119:354.e11-9. 2006
    ..We sought to determine the risk of an allergic reaction to a cephalosporin exposure in those with prior penicillin reactions...
  26. pmc Cardiovascular events and death in children exposed and unexposed to ADHD agents
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 6021, USA
    Pediatrics 127:1102-10. 2011
    ..The objective of this study was to compare the rate of severe cardiovascular events and death in children who use attention-deficit/hyperactivity disorder (ADHD) medications versus nonusers...
  27. pmc Association between longer therapy with thiazolidinediones and risk of bladder cancer: a cohort study
    Ronac Mamtani
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Natl Cancer Inst 104:1411-21. 2012
    ..In this study, we assessed the risk of bladder cancer associated with the use of TZDs and between pioglitazone and rosiglitazone, an alternative TZD...
  28. pmc Randomized clinical trial of a customized electronic alert requiring an affirmative response compared to a control group receiving a commercial passive CPOE alert: NSAID--warfarin co-prescribing as a test case
    Brian L Strom
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Pennsylvania 19104 6021, USA
    J Am Med Inform Assoc 17:411-5. 2010
    ..Studies that have looked at the effectiveness of computerized decision support systems to prevent drug-drug interactions have reported modest results because of low response by the providers to the automated alerts...
  29. doi request reprint Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicity
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:328-35. 2008
    ..This study examined the effect of medications that inhibit serotonin uptake on upper gastrointestinal toxicity...
  30. ncbi request reprint Self-reported hepatitis B and C virus infections had low sensitivity among HIV-infected patients
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 60:294-9. 2007
    ..To determine the validity of self-reported hepatitis B virus (HBV) and hepatitis C virus (HCV) in HIV-infected injection drug users (IDUs) vs. nonIDUs...
  31. pmc Impact of raloxifene or tamoxifen use on endometrial cancer risk: a population-based case-control study
    Angela DeMichele
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA
    J Clin Oncol 26:4151-9. 2008
    ....
  32. pmc Hormone-dependent effects of FGFR2 and MAP3K1 in breast cancer susceptibility in a population-based sample of post-menopausal African-American and European-American women
    Timothy R Rebbeck
    Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Carcinogenesis 30:269-74. 2009
    ..We further report that these genes confer their effects in HER2- tumors, interact with one another to confer breast cancer susceptibility in AA women and interact with hormone exposures in AA and EA women...
  33. doi request reprint Cancer incidence in The Health Improvement Network
    Kevin Haynes
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:730-6. 2009
    ..This study assessed whether the recorded incidence of cancer among patients in The Health Improvement Network (THIN) database is comparable to that expected in the UK based on national cancer registry data...
  34. pmc Validation of diagnostic codes for outpatient-originating sudden cardiac death and ventricular arrhythmia in Medicaid and Medicare claims data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 19:555-62. 2010
    ..This study examined the positive predictive value (PPV) of hospitalization and emergency department encounter diagnoses in identifying SD/VA events originating in the outpatient setting...
  35. doi request reprint Proton pump inhibitors and traditional nonsteroidal anti-inflammatory drugs and the risk of acute interstitial nephritis and acute kidney injury
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 21:1155-72. 2012
    ....
  36. ncbi request reprint Longitudinal trends in fluoroquinolone resistance among Enterobacteriaceae isolates from inpatients and outpatients, 1989-2000: differences in the emergence and epidemiology of resistance across organisms
    Ebbing Lautenbach
    Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Clin Infect Dis 38:655-62. 2004
    ..Efforts to elucidate the epidemiology of FQ resistance and identify targets for intervention must recognize and account for the variability of FQ resistance across organisms and clinical settings...
  37. ncbi request reprint Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    J Natl Cancer Inst 98:1311-20. 2006
    ..To investigate the mechanism of this association, we evaluated whether risk of endometrial cancer was associated with the genotypes involved in steroid hormone metabolism and the duration of exogenous hormone use...
  38. ncbi request reprint Prevalence, risk factors, and outcomes for occult hepatitis B virus infection among HIV-infected patients
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 44:315-20. 2007
    ..The prevalence of occult HBV in HIV-infected patients remains controversial, and the risk factors and clinical significance are unknown...
  39. ncbi request reprint Predictors of recall of over-the-counter and prescription non-steroidal anti-inflammatory drug exposure
    James D Lewis
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 15:39-45. 2006
    ..Because of the difficulty in establishing a gold standard, data on accuracy of recall of over-the-counter (OTC) medication use are sparse...
  40. ncbi request reprint Diagnostic accuracy of CD4 cell count increase for virologic response after initiating highly active antiretroviral therapy
    Gregory P Bisson
    Department of Medicine, Division of Infectious Diseases, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania19104 6021, USA
    AIDS 20:1613-9. 2006
    ..To derive and internally validate a clinical prediction rule for virologic response based on CD4 cell count increase after initiation of HAART in a resource-limited setting...
  41. pmc Patient reported receipt of medication instructions for warfarin is associated with reduced risk of serious bleeding events
    Joshua P Metlay
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Gen Intern Med 23:1589-94. 2008
    ..Adverse drug events are an important cause of preventable hospitalizations...
  42. ncbi request reprint Represcription of penicillin after allergic-like events
    Andrea J Apter
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 113:764-70. 2004
    ..We sought to determine the frequency of represcription of penicillin to individuals with penicillin allergy and the risk of a second reaction in those who had a previous reaction...
  43. ncbi request reprint Cigarette yield and the risk of myocardial infarction in smokers
    William H Sauer
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Intern Med 162:300-6. 2002
    ..Although cigarette smoking is a major risk factor for acute myocardial infarction (MI), cigarette tar yield has not been clearly demonstrated to affect MI risk...
  44. pmc The Effects of a Problem Solving-Based Intervention on Depressive Symptoms and HIV Medication Adherence Are Independent
    Robert Gross
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America Center for Pharmacoepidemiology Research and Training, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America Division of Infectious Diseases, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e84952. 2014
    ..Thus, interventions for medication adherence may not need to address depressive symptoms in order to impact both adherence and depression; this remains to be confirmed, however, in other data. ..
  45. doi request reprint Safety of saxagliptin: rationale for and design of a series of postmarketing observational studies
    Vincent Lo Re
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 21:1202-15. 2012
    ..To describe the design and rationale of a series of postmarketing studies to examine the safety of saxagliptin, an oral dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus, in real-world settings...
  46. pmc Risk factors for nonadherence to warfarin: results from the IN-RANGE study
    Alec B Platt
    Department of Medicine, University of Pennsylvania School of Medicine, PA, USA
    Pharmacoepidemiol Drug Saf 17:853-60. 2008
    ..Warfarin is widely used to prevent stroke and venous thromboembolism despite its narrow therapeutic window. Warfarin nonadherence is a substantial problem, but risk factors have not been well elucidated...
  47. ncbi request reprint Evaluating health information technology's clinical effects
    Brian L Strom
    Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA 19104, USA
    LDI Issue Brief 16:1-4. 2011
    ..This rigorous test of a specific CPOE intervention shows that an electronic alert system can be effective in changing prescribing, but may also have unintended consequences for patient safety...
  48. pmc Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    BMJ 325:1070. 2002
    ..To examine the rates of cardiac arrest and ventricular arrhythmia in patients with treated schizophrenia and in non-schizophrenic controls...
  49. doi request reprint Managed problem solving for antiretroviral therapy adherence: a randomized trial
    Robert Gross
    Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104 6021, USA
    JAMA Intern Med 173:300-6. 2013
    ..We sought to determine whether an intervention derived from problem solving theory, Managed Problem Solving (MAPS), would improve antiretroviral outcomes...
  50. doi request reprint Validation of 6-minute walk distance as a surrogate end point in pulmonary arterial hypertension trials
    Nicole B Gabler
    Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA, USA
    Circulation 126:349-56. 2012
    ..We aimed to validate the difference in Δ6MWD against the probability of a clinical event in pulmonary arterial hypertension trials...
  51. ncbi request reprint Reacting to antibiotic allergies
    Andrea J Apter
    Center for Clinical Epidemiology and Biostatistics, Center for Education and Research on Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    LDI Issue Brief 11:1-4. 2006
    ....
  52. ncbi request reprint Epidemiologic studies of adverse effects of anti-retroviral drugs: how well is statistical power reported
    Scott D Halpern
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:155-61. 2005
    ..To determine whether there is a difference in average statistical power between pharmacoepidemiologic studies of anti-retroviral adverse drug effects (ADEs) sponsored by for-profit versus non-profit organizations...
  53. doi request reprint Cardiovascular safety of ADHD medications: rationale for and design of an investigator-initiated observational study
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 19:934-41. 2010
    ....
  54. ncbi request reprint Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics
    Brian L Strom
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    N Engl J Med 349:1628-35. 2003
    ..The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic reactions to sulfonamide antibiotics...
  55. ncbi request reprint Absence of an effect of injectable and implantable progestin-only contraceptives on subsequent risk of breast cancer
    Brian L Strom
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, 824 Blockley Hall, 423 Guardian Drive, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Contraception 69:353-60. 2004
    ..This study does not support an increased risk of breast cancer associated with the use of injectable or implantable progestin-only contraceptives in women aged 35 to 64...
  56. ncbi request reprint The risk of mortality in patients with psoriasis: results from a population-based study
    Joel M Gelfand
    MSCE, Department of Dermatology, University of Pennsylvania School of Medicine, 2 Maloney Bldg, 3600 Spruce St, Philadelphia, PA 19104, USA
    Arch Dermatol 143:1493-9. 2007
    ..To determine the risk of mortality in patients with psoriasis...
  57. pmc Identifying and quantifying medication errors: evaluation of rapidly discontinued medication orders submitted to a computerized physician order entry system
    Ross Koppel
    Department of Sociology, University of Pennsylvania, Philadelphia, PA, USA
    J Am Med Inform Assoc 15:461-5. 2008
    ..This measure offers a rapid, constant, inexpensive, and objective method to identify medication orders with a high probability of error. It may also serve as a screening and teaching mechanism for physicians-in-training...
  58. ncbi request reprint Neither panacea nor black box: responding to three Journal of Biomedical Informatics papers on computerized physician order entry systems
    Ross Koppel
    Department of Sociology and Center for Clinical Epidemiology and Biostatistics of the School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biomed Inform 38:267-9. 2005
  59. ncbi request reprint Preevent vaccination against smallpox: a survey of pediatric emergency health care providers
    Worth W Everett
    Department of Emergency Medicine, Hospital of the University of Pennsylvania, Centers for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Pediatr Infect Dis J 23:332-7. 2004
    ..In January 2003, smallpox vaccinations were offered to health care workers to create hospital-based teams prepared to care for patients with smallpox as part of national bioterrorism preparedness activities...
  60. ncbi request reprint Out-of-pocket costs of HAART limit HIV treatment responses in Botswana's private sector
    Gregory P Bisson
    Division of Infectious Disease, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    AIDS 20:1333-6. 2006
    ..001]. HAART costs should be minimized as scale-up efforts in sub-Saharan Africa progress...
  61. ncbi request reprint Descriptive analyses of the integrity of a US Medicaid claims database
    Sean Hennessy
    Center for Clinical Epidemiology, Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 12:103-11. 2003
    ..To examine the integrity of six Medicaid databases for use in pharmacoepidemiology research...
  62. doi request reprint Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension
    Nicole B Gabler
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiolog, Perelman School of Medicine, University of Pennsylvania, 723 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Chest 141:20-6. 2012
    ..Differences in endothelin-1 biology between sexes and between whites and blacks may lead to differences in patients' responses to treatment with endothelin receptor antagonists (ERAs)...
  63. ncbi request reprint Hospitalization and mortality rates from peptic ulcer disease and GI bleeding in the 1990s: relationship to sales of nonsteroidal anti-inflammatory drugs and acid suppression medications
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Am J Gastroenterol 97:2540-9. 2002
    ..This study examines trends in hospitalization and mortality rates from GI toxicity during the 1990s...
  64. ncbi request reprint Combined effect of oral contraceptive use and hormone replacement therapy on breast cancer risk in postmenopausal women
    Sandra A Norman
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Cancer Causes Control 14:933-43. 2003
    ..We examined breast cancer risk related to lifetime exposure to oral contraceptives (OCs) and hormone replacement therapy (HRT) in postmenopausal women...
  65. ncbi request reprint Parenteral ketorolac and risk of myocardial infarction
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pharmacoepidemiol Drug Saf 11:113-9. 2002
    ..To examine the effects of ketorolac, a non-aspirin non-steroidal anti-inflammatory drug (NANSAID) with antiplatelet properties, on the risk of in-hospital myocardial infarction (MI)...
  66. doi request reprint Validity and comparison of two measures of days supply in Medicaid claims data
    Robert Gross
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 17:1029-32. 2008
    ..The two measures should yield the same duration, but if not, the preferred method is unknown...
  67. ncbi request reprint The effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirin
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Am Coll Cardiol 43:985-90. 2004
    ....
  68. ncbi request reprint Seasonal variation in flares of inflammatory bowel disease
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics and Department of Medicine, University of Pennsylvania Centers for Education and Research on Therapeutics, Philadelphia, 19104 6021, USA
    Gastroenterology 126:665-73. 2004
    ..The purpose of this study was to determine whether relapse of inflammatory bowel disease follows a seasonal pattern either across a cohort of patients or within individual patients...
  69. ncbi request reprint Retrospective drug utilization review, prescribing errors, and clinical outcomes
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    JAMA 290:1494-9. 2003
    ..However, it has not been shown to improve clinical outcomes or reduce the rate of potential prescribing errors, known as "exceptions."..
  70. pmc Effectiveness of an information technology intervention to improve prophylactic antibacterial use in the postoperative period
    Kevin Haynes
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Med Inform Assoc 18:164-8. 2011
    ..Electronic order sets have shown promise as a means of integrating guideline information with electronic order entry systems and facilitating safer, more effective care...
  71. pmc Temporal and within practice variability in the health improvement network
    Kevin Haynes
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 20:948-55. 2011
    ..However, little is known about the consistency within practices across observation years and among practices within a given year, in THIN or other large medical record databases...
  72. ncbi request reprint Practical aspects of sharing controls between case-control studies
    Greta R Bunin
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:523-30. 2005
    ..We discuss the practical advantages and challenges of sharing controls among two or more concurrently conducted case-control studies...
  73. ncbi request reprint Incidence and risk factors for weight loss during dual HIV/hepatitis C virus therapy
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 44:344-50. 2007
    ..Clinical observations suggest that patients with HIV/hepatitis C virus (HCV) may lose body weight during dual therapy, but this has not been confirmed analytically...
  74. pmc Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort study
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes Care 34:916-22. 2011
    ..This is an interim report of an ongoing cohort study examining the association between pioglitazone therapy and the risk of bladder cancer in patients with diabetes...
  75. ncbi request reprint The role of academia and the research community in assisting the Food and Drug Administration to ensure U.S. drug safety
    Vincent Lo Re
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 16:818-25. 2007
    ..We sought to examine ways that academia could expand its role in U.S. drug safety...
  76. ncbi request reprint Statins and over-the-counter availability
    Brian L Strom
    University of Pennsylvania School of Medicine, Philadelphia, USA
    N Engl J Med 352:1403-5. 2005
  77. ncbi request reprint Methodologic challenges to studying patient safety and comparative effectiveness
    Brian L Strom
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Med Care 45:S13-5. 2007
    ..This article provides a conceptual overview of these methodologic issues...
  78. pmc Antidiabetic action of bezafibrate in a large observational database
    James H Flory
    1Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 32:547-51. 2009
    ..The purpose of this study was to test the hypothesis that bezafibrate, an approved fibrate, can prevent or delay type 2 diabetes...
  79. ncbi request reprint The ineffectiveness of retrospective drug utilization review
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Center for Education and Research on Therapeutics, University of Pennsylvania, USA
    LDI Issue Brief 9:1-4. 2003
    ..This Issue Brief summarizes a landmark study that suggests that retrospective DUR has had no measurable effects on outpatient drug use or clinical outcomes in the Medicaid program...
  80. ncbi request reprint PDUFA reauthorization--drug safety's golden moment of opportunity?
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    N Engl J Med 356:1703-4. 2007
  81. ncbi request reprint Participants and refusers in a telephone interview about hormone replacement therapy were equally likely to be taking it
    Brian L Strom
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 824 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 57:624-6. 2004
    ..To address a major concern in pharmacoepidemiology studies related to whether the characteristics of responders are different from those who refuse to participate...
  82. ncbi request reprint An interview strategy was critical for obtaining valid information on the use of hormone replacement therapy
    Brian L Strom
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 57:1210-3. 2004
    ..We compared telephone reports of hormone replacement therapy (HRT) use to claims for drugs dispensed...
  83. ncbi request reprint Role of computerized physician order entry systems in facilitating medication errors
    Ross Koppel
    Department of Sociology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 USA
    JAMA 293:1197-203. 2005
    ..Published studies report that CPOE reduces medication errors up to 81%. Few researchers, however, have focused on the existence or types of medication errors facilitated by CPOE...
  84. ncbi request reprint Clinically important changes in acute pain outcome measures: a validation study
    John T Farrar
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pain Symptom Manage 25:406-11. 2003
    ..This provides support for the usefulness of these values in future clinical trials of pain therapy...
  85. ncbi request reprint Agreement between patient self-report and a Veterans Affairs national pharmacy database for identifying recent exposures to antibiotics
    Joshua P Metlay
    Philadelphia Veterans Affairs Medical Center, Division of General Internal Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, Univ of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 12:9-15. 2003
    ..The authors compared self-report with pharmacy dispensing data to determine the accuracy of self-reported antibiotic exposure...
  86. ncbi request reprint Potential for conflict of interest in the evaluation of suspected adverse drug reactions: a counterpoint
    Brian L Strom
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    JAMA 292:2643-6. 2004
  87. ncbi request reprint The incidence and prevalence of pressure ulcers among elderly patients in general medical practice
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Epidemiol 12:321-5. 2002
    ..The objective of this study was to estimate the period prevalence and incidence of pressure ulcer among those 65 years of age and older...
  88. ncbi request reprint Validity and completeness of the General Practice Research Database for studies of inflammatory bowel disease
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania School of Medicine, 9th Floor Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 11:211-8. 2002
    ..The objective of this study was to evaluate the validity and completeness of the General Practice Research Database (GPRD) as a tool for research into inflammatory bowel disease epidemiology...
  89. pmc Association between serious ischemic cardiac outcomes and medications used to treat diabetes
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:753-9. 2008
    ..Data on cardiovascular outcomes among treated diabetics have been inconsistent. Our goal was to compare cardiovascular outcomes associated with different treatments for diabetes...
  90. ncbi request reprint Smallpox vaccination: a national survey of emergency health care providers
    Worth W Everett
    Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Acad Emerg Med 10:606-11. 2003
    ..Although emergency health care providers are among the first targeted for vaccination, little is known about how these providers view the risks and benefits of SP vaccination...
  91. ncbi request reprint Hormone replacement therapy regimens and breast cancer risk(1)
    Linda K Weiss
    Population Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University, Detroit, Michigan, USA
    Obstet Gynecol 100:1148-58. 2002
    ..Progestin administered in an uninterrupted regimen may be a contributing factor. Risk dissipates once use is discontinued...
  92. ncbi request reprint Relation of regimens of combined hormone replacement therapy to lobular, ductal, and other histologic types of breast carcinoma
    Janet R Daling
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer 95:2455-64. 2002
    ..However, the use of combined (estrogen and progestin) hormone replacement therapy (CHRT) also has increased during the last decade and may account in part for the increase in invasive lobular breast carcinoma...
  93. ncbi request reprint Estrogen replacement therapy and risk of lung cancer
    Janine A Blackman
    Department of Family Practice, Franklin Square Hospital Center, Baltimore, MD, USA
    Pharmacoepidemiol Drug Saf 11:561-7. 2002
    ..We assessed the relation of the use of estrogen replacement therapy (ERT) to the risk of lung cancer in our hospital-based Case-Control Surveillance Study, conducted in four US centers during 1976 to 2001...
  94. ncbi request reprint The FDA and drug safety: a proposal for sweeping changes
    Curt D Furberg
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Arch Intern Med 166:1938-42. 2006
    ....
  95. ncbi request reprint Statin use and the risk of 10 cancers
    Patricia F Coogan
    Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
    Epidemiology 18:213-9. 2007
    ..The purpose of the present study was to evaluate the association between statin use and various types of cancer in our hospital-based case-control surveillance study...
  96. ncbi request reprint Oral contraceptives and the risk of breast cancer
    Polly A Marchbanks
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 346:2025-32. 2002
    ..We conducted a population-based, case-control study to determine the risk of breast cancer among former and current users of oral contraceptives...
  97. ncbi request reprint The NICHD Women's Contraceptive and Reproductive Experiences Study: methods and operational results
    Polly A Marchbanks
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Ann Epidemiol 12:213-21. 2002
    ..This paper presents methods and operational results of a population-based case-control study examining the effects of oral contraceptive use on breast cancer risk among white and black women aged 35-64 years in five U.S. locations...
  98. pmc Vitamin D receptor polymorphisms and breast cancer risk in a large population-based case-control study of Caucasian and African-American women
    Britton Trabert
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Fairview Ave N, Seattle, Washington 98109 1024, USA
    Breast Cancer Res 9:R84. 2007
    ..The involvement of vitamin D receptor (VDR), which is a key mediator in the vitamin D pathway, in breast cancer etiology has long been of interest...
  99. ncbi request reprint Breast cancer risk estimates for relatives of white and African American women with breast cancer in the Women's Contraceptive and Reproductive Experiences Study
    Michael S Simon
    Division of Hematology and Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, MI 48201, USA
    J Clin Oncol 24:2498-504. 2006
    ..The purpose of this report is to update breast cancer risk estimates associated with a family history of breast cancer for white and AA women...
  100. ncbi request reprint Risk of breast cancer associated with short-term use of oral contraceptives
    Suzanne G Folger
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Cancer Causes Control 18:189-98. 2007
    ..To estimate breast cancer risk associated with short-term (<6 months) oral contraceptive use, and explore variation in estimates by use characteristics and medical, menstrual, and reproductive history...
  101. ncbi request reprint Lung cancer and regular use of aspirin and nonaspirin nonsteroidal anti-inflammatory drugs
    Judith P Kelly
    Slone Epidemiology Center of Boston University, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 17:322-7. 2008
    ..Our objective was to examine the association of regular use of ASA and NANSAIDs with lung cancer...