Research Topics
| James StringerSummaryAffiliation: University of Cincinnati Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Expression and loss of alleles in cultured mouse embryonic fibroblasts and stem cells carrying allelic fluorescent protein genesJon S Larson
Department of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0524, USA
BMC Mol Biol 7:36. 2006..In addition, LOH caused by mitotic crossing over might be discernable in tissues because this event produces a pair of neighboring monochromatic cells that are different colors...
Complexity of the MSG gene family of Pneumocystis cariniiScott P Keely
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45220, USA
BMC Genomics 10:367. 2009..Several P. carinii MSG genes have been sequenced, which showed that genes in the family can encode distinct isoforms of MSG. The vast majority of family members have not been characterized at the sequence level...- Genetics of surface antigen expression in Pneumocystis cariniiJ R Stringer
Department of Molecular Genetics, Biochemistry, and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
Infect Immun 69:627-39. 2001.... 
Antigenic variation in pneumocystisJames R Stringer
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0524, USA
J Eukaryot Microbiol 54:8-13. 2007..Preliminary evidence suggests that gene conversion is the predominant recombination mechanism...- A new name (Pneumocystis jiroveci) for Pneumocystis from humansJames R Stringer
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0524, USA
Emerg Infect Dis 8:891-6. 2002..quot; DNA sequence variation exists among samples of P. jiroveci, a feature that allows reexamination of the relationships between host and pathogen. Instead of lifelong latency, transient colonization may be the rule... - PneumocystisJames R Stringer
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45220 0524, USA
Int J Med Microbiol 292:391-404. 2002..In a few cases, there is direct evidence of person to person transmission. In general, however, patients and their contacts have been found to have different strains of P. jiroveci... - Modeling variation in tumors in vivoJames R Stringer
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH 45267 0524, USA
Proc Natl Acad Sci U S A 102:2408-13. 2005..Although genetic instability appeared to have occurred in most tumors, large clusters were much more common than expected based on instability alone... - Gene arrays at Pneumocystis carinii telomeresScott P Keely
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA
Genetics 170:1589-600. 2005..Long mononucleotide tracts were present in some MSR genes. These unstable sequences can be expected to suffer frequent frameshift mutations, providing P. carinii with another mechanism to generate antigen variation... - Expression of the Pneumocystis carinii major surface glycoprotein epitope is correlated with linkage of the cognate gene to the upstream conserved sequence locusJoshua K Schaffzin
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Microbiology 150:677-86. 2004..Correlation of epitope expression and UCS linkage supports the hypothesis that expression of a particular MSG on the surface requires UCS linkage of the gene encoding it... - Diversity at the locus associated with transcription of a variable surface antigen of Pneumocystis carinii as an index of population structure and dynamics in infected ratsScott P Keely
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0524, USA
Infect Immun 71:47-60. 2003..By contrast, shifts in population structure occurred in rats given 10(4) P. carinii organisms, suggesting that a small fraction of these proliferated... - Evolutionary rate of ribosomal DNA in Pneumocystis species is normal despite the extraordinarily low copy-number of rDNA genesJared M Fischer
University of Cincinnati, Department of Molecular Genetics, Biochemistry and Microbiology, Cincinnati, Ohio 45267-0524, USA
J Eukaryot Microbiol 53:S156-8. 2006 - Sequence diversity of transcripts from Pneumocystis carinii gene families MSR and PRT1Scott P Keely
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0524, USA
J Eukaryot Microbiol 50:627-8. 2003 - The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preferenceEdna S Kaneshiro
Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006, USA
Mol Microbiol 44:989-99. 2002..These observations, together with the absence of SAM:SMT among mammals, further support the identification of sterol C-24 alkylation reactions as excellent targets for the development of drugs specifically directed against this pathogen... 
Stealth and opportunism: alternative lifestyles of species in the fungal genus PneumocystisMelanie T Cushion
Department of Internal Medicine, University of Cincinnati College of Medicine, Division of Infectious Diseases, Cincinnati, Ohio 45267 0560, USA
Annu Rev Microbiol 64:431-52. 2010....- Evolution and speciation of PneumocystisScott P Keely
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0524, USA
J Eukaryot Microbiol 50:624-6. 2003 - Phylogenetic identification of Pneumocystis murina sp. nov., a new species in laboratory miceScott P Keely
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
Microbiology 150:1153-65. 2004..murina, the results indicated that P. murina is as old as the mouse. Taken together, these data support previous recognition of multiple species in the genus and indicate that P. murina is a phylogenetic species as well... - Pneumocystis murina MSG gene family and the structure of the locus associated with its transcriptionScott P Keely
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA
Fungal Genet Biol 44:905-19. 2007..carinii, but the block of conserved sequence in P. murina is nearly five times longer than in P. carinii, and much shorter than in P. wakefieldiae. These data indicate that the P. murina expression-site locus has a distinct structure... - Mutation in aging mice occurs in diverse cell types that proliferate postmutationJared M Fischer
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA
Aging Cell 7:667-80. 2008..These data show that age-associated accumulation of mutant cells occurs in diverse cell types and is due to both new mutation and proliferation of mutant cells, even in cell types that tend to not proliferate... - The sequence of the erg11 gene in form 1 and form 6 of Pneumocystis carinii are identicalStephenson W Nkinin
Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221-0006, USA
J Eukaryot Microbiol 53:S147-8. 2006 - Increased mutation in mice genetically predisposed to oxidative damage in the brainJames R Stringer
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA
Mutat Res 556:127-34. 2004..PLAP+ cells were observed in all areas of the brain. No increase in the number of PLAP+ cells was seen in three other tissues, suggesting that the effect of Aif deficiency on mutation was specific to brain... - Embryonic stem cells and somatic cells differ in mutation frequency and typeRachel B Cervantes
Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Vontz Center for Molecular Studies, Cincinnati, OH 45267-052, USA
Proc Natl Acad Sci U S A 99:3586-90. 2002..Because UPD leads to reduction to homozygosity at multiple recessive disease loci, including tumor suppressor loci, in the affected chromosome, the increased risk of tumor formation after stem cell therapy should be viewed with concern... - Co-mutagenic activity of arsenic and benzo[a]pyrene in mouse skinJared M Fischer
University of Cincinnati, Department of Molecular Genetics, Biochemistry and Microbiology, 231 Albert Sabin Way, Cincinnati, OH 45267-0524, USA
Mutat Res 588:35-46. 2005..Whereas combined treatment produced more PLAP+ cells, stable BaP adduct levels and arsenic burdens were not higher in mice exposed to both agents compared to mice exposed to either one agent or the other... - Impact of mismatch repair deficiency on genomic stability in the maternal germline and during early embryonic developmentJon S Larson
Department of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0524, USA
Mutat Res 556:45-53. 2004..These data suggest that the paternally derived Pms2 gene provided normal levels of PMS2 protein to embryos by the time they reached the eight-cell stage, but that smaller embryos formed from PMS2-deficient eggs lacked PMS2 function... - Visualization of mosaicism in tissues of normal and mismatch-repair-deficient mice carrying a microsatellite-containing transgeneMegan N Hersh
Department of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, OH 45267-0524, USA
Mutat Res 505:51-62. 2002..The reason for the different results in the liver is not clear. Cells in the liver were shown to be capable of expressing of PLAP enzyme and PLAP mRNA was present in this organ... - Visualizing loss of heterozygosity in living mouse cells and tissuesJared M Fischer
University of Cincinnati, Department of Molecular Genetics, Biochemistry and Microbiology, Cincinnati, OH 45267 0524, USA
Mutat Res 645:1-8. 2008..These data demonstrate that this approach can detect LOH and suggest that it will allow detection of LOH in a broad array of tissues and cell types in transgenic mice made from shYFP cells... - Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiationChristy M Caudill
Department of Pathology, University of Cincinnati, 231 Albert Sabin Way, P.O. Box 670529, Cincinnati, Ohio 45267-0529, USA
J Clin Endocrinol Metab 90:2364-9. 2005..1-10 Gy gamma-radiation. This provides additional evidence for a direct link between this genetic event and radiation exposure and offers a powerful experimental system for studying radiation-induced carcinogenesis in the thyroid gland... - Exposure of mice to arsenic and/or benzo[a]pyrene does not increase the frequency of Aprt-deficient cells recovered from explanted skin of Aprt heterozygous miceJared M Fischer
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Ohio, USA
Environ Mol Mutagen 47:334-44. 2006..Analysis of DNA from DAP(r) colonies suggested that mitotic recombination contributed to the loss of wild-type Aprt allele. Whether arsenic or BaP enhanced or diminished the frequency of this process could not be deduced from these data... - Pneumocystis oryctolagi sp. nov., an uncultured fungus causing pneumonia in rabbits at weaning: review of current knowledge, and description of a new taxon on genotypic, phylogenetic and phenotypic basesEduardo Dei-Cas
ECOPA EA 3609, Lille Pasteur Institute, Lille, France
FEMS Microbiol Rev 30:853-71. 2006..The present work focuses on Pneumocystis oryctolagi sp. nov. from Old-World rabbits. This new species has been described on the basis of both biological and phylogenetic species concepts... - Pneumocystis and Trypanosoma cruzi: nomenclature and typificationsScott A Redhead
National Program on Environmental Health-Biodiversity, Agriculture and Agri-Food Canada, Central Experimental Farm, KW Neatby Building, 960 Carling Avenue, Ottawa, Ontario K1A 0C6, Canada
J Eukaryot Microbiol 53:2-11. 2006..The classification and nomenclature of Pneumocystis is reviewed and guidelines given for the publication of new species... - Has the name really been changed? It has for most researchersMelanie T Cushion
Clin Infect Dis 41:1756-8. 2005
Research Grants
- STRUCTURE AND EXPRESSION OF PNEUMOCYSTIS ANTIGEN GENESJames Stringer; Fiscal Year: 2004..carinii. Human P. carinii will be obtained from patients. Molecular genetic and immunohistochemical tools will be used to study expression of MSG genes and proteins. ..
- STRUCTURE AND EXPRESSION OF PNEUMOCYSTIS ANTIGEN GENESJames Stringer; Fiscal Year: 2009..abstract_text> ..