James Stringer

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Expression and loss of alleles in cultured mouse embryonic fibroblasts and stem cells carrying allelic fluorescent protein genes
    Jon S Larson
    Department of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0524, USA
    BMC Mol Biol 7:36. 2006
  2. pmc Complexity of the MSG gene family of Pneumocystis carinii
    Scott P Keely
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45220, USA
    BMC Genomics 10:367. 2009
  3. pmc Genetics of surface antigen expression in Pneumocystis carinii
    J R Stringer
    Department of Molecular Genetics, Biochemistry, and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Infect Immun 69:627-39. 2001
  4. ncbi request reprint Antigenic variation in pneumocystis
    James R Stringer
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0524, USA
    J Eukaryot Microbiol 54:8-13. 2007
  5. pmc A new name (Pneumocystis jiroveci) for Pneumocystis from humans
    James R Stringer
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0524, USA
    Emerg Infect Dis 8:891-6. 2002
  6. ncbi request reprint Pneumocystis
    James R Stringer
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45220 0524, USA
    Int J Med Microbiol 292:391-404. 2002
  7. pmc Modeling variation in tumors in vivo
    James R Stringer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH 45267 0524, USA
    Proc Natl Acad Sci U S A 102:2408-13. 2005
  8. pmc Gene arrays at Pneumocystis carinii telomeres
    Scott P Keely
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Genetics 170:1589-600. 2005
  9. ncbi request reprint Expression of the Pneumocystis carinii major surface glycoprotein epitope is correlated with linkage of the cognate gene to the upstream conserved sequence locus
    Joshua K Schaffzin
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Microbiology 150:677-86. 2004
  10. pmc Diversity at the locus associated with transcription of a variable surface antigen of Pneumocystis carinii as an index of population structure and dynamics in infected rats
    Scott P Keely
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Infect Immun 71:47-60. 2003

Research Grants

Collaborators

Detail Information

Publications30

  1. pmc Expression and loss of alleles in cultured mouse embryonic fibroblasts and stem cells carrying allelic fluorescent protein genes
    Jon S Larson
    Department of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0524, USA
    BMC Mol Biol 7:36. 2006
    ..In addition, LOH caused by mitotic crossing over might be discernable in tissues because this event produces a pair of neighboring monochromatic cells that are different colors...
  2. pmc Complexity of the MSG gene family of Pneumocystis carinii
    Scott P Keely
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45220, USA
    BMC Genomics 10:367. 2009
    ..Several P. carinii MSG genes have been sequenced, which showed that genes in the family can encode distinct isoforms of MSG. The vast majority of family members have not been characterized at the sequence level...
  3. pmc Genetics of surface antigen expression in Pneumocystis carinii
    J R Stringer
    Department of Molecular Genetics, Biochemistry, and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Infect Immun 69:627-39. 2001
    ....
  4. ncbi request reprint Antigenic variation in pneumocystis
    James R Stringer
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0524, USA
    J Eukaryot Microbiol 54:8-13. 2007
    ..Preliminary evidence suggests that gene conversion is the predominant recombination mechanism...
  5. pmc A new name (Pneumocystis jiroveci) for Pneumocystis from humans
    James R Stringer
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0524, USA
    Emerg Infect Dis 8:891-6. 2002
    ..quot; DNA sequence variation exists among samples of P. jiroveci, a feature that allows reexamination of the relationships between host and pathogen. Instead of lifelong latency, transient colonization may be the rule...
  6. ncbi request reprint Pneumocystis
    James R Stringer
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45220 0524, USA
    Int J Med Microbiol 292:391-404. 2002
    ..In a few cases, there is direct evidence of person to person transmission. In general, however, patients and their contacts have been found to have different strains of P. jiroveci...
  7. pmc Modeling variation in tumors in vivo
    James R Stringer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH 45267 0524, USA
    Proc Natl Acad Sci U S A 102:2408-13. 2005
    ..Although genetic instability appeared to have occurred in most tumors, large clusters were much more common than expected based on instability alone...
  8. pmc Gene arrays at Pneumocystis carinii telomeres
    Scott P Keely
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Genetics 170:1589-600. 2005
    ..Long mononucleotide tracts were present in some MSR genes. These unstable sequences can be expected to suffer frequent frameshift mutations, providing P. carinii with another mechanism to generate antigen variation...
  9. ncbi request reprint Expression of the Pneumocystis carinii major surface glycoprotein epitope is correlated with linkage of the cognate gene to the upstream conserved sequence locus
    Joshua K Schaffzin
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Microbiology 150:677-86. 2004
    ..Correlation of epitope expression and UCS linkage supports the hypothesis that expression of a particular MSG on the surface requires UCS linkage of the gene encoding it...
  10. pmc Diversity at the locus associated with transcription of a variable surface antigen of Pneumocystis carinii as an index of population structure and dynamics in infected rats
    Scott P Keely
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Infect Immun 71:47-60. 2003
    ..By contrast, shifts in population structure occurred in rats given 10(4) P. carinii organisms, suggesting that a small fraction of these proliferated...
  11. ncbi request reprint Evolutionary rate of ribosomal DNA in Pneumocystis species is normal despite the extraordinarily low copy-number of rDNA genes
    Jared M Fischer
    University of Cincinnati, Department of Molecular Genetics, Biochemistry and Microbiology, Cincinnati, Ohio 45267 0524, USA
    J Eukaryot Microbiol 53:S156-8. 2006
  12. ncbi request reprint Sequence diversity of transcripts from Pneumocystis carinii gene families MSR and PRT1
    Scott P Keely
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    J Eukaryot Microbiol 50:627-8. 2003
  13. ncbi request reprint The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006, USA
    Mol Microbiol 44:989-99. 2002
    ..These observations, together with the absence of SAM:SMT among mammals, further support the identification of sterol C-24 alkylation reactions as excellent targets for the development of drugs specifically directed against this pathogen...
  14. doi request reprint Stealth and opportunism: alternative lifestyles of species in the fungal genus Pneumocystis
    Melanie T Cushion
    Department of Internal Medicine, University of Cincinnati College of Medicine, Division of Infectious Diseases, Cincinnati, Ohio 45267 0560, USA
    Annu Rev Microbiol 64:431-52. 2010
    ....
  15. ncbi request reprint Evolution and speciation of Pneumocystis
    Scott P Keely
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    J Eukaryot Microbiol 50:624-6. 2003
  16. ncbi request reprint Phylogenetic identification of Pneumocystis murina sp. nov., a new species in laboratory mice
    Scott P Keely
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
    Microbiology 150:1153-65. 2004
    ..murina, the results indicated that P. murina is as old as the mouse. Taken together, these data support previous recognition of multiple species in the genus and indicate that P. murina is a phylogenetic species as well...
  17. pmc Pneumocystis murina MSG gene family and the structure of the locus associated with its transcription
    Scott P Keely
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA
    Fungal Genet Biol 44:905-19. 2007
    ..carinii, but the block of conserved sequence in P. murina is nearly five times longer than in P. carinii, and much shorter than in P. wakefieldiae. These data indicate that the P. murina expression-site locus has a distinct structure...
  18. doi request reprint Mutation in aging mice occurs in diverse cell types that proliferate postmutation
    Jared M Fischer
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA
    Aging Cell 7:667-80. 2008
    ..These data show that age-associated accumulation of mutant cells occurs in diverse cell types and is due to both new mutation and proliferation of mutant cells, even in cell types that tend to not proliferate...
  19. ncbi request reprint The sequence of the erg11 gene in form 1 and form 6 of Pneumocystis carinii are identical
    Stephenson W Nkinin
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221 0006, USA
    J Eukaryot Microbiol 53:S147-8. 2006
  20. ncbi request reprint Increased mutation in mice genetically predisposed to oxidative damage in the brain
    James R Stringer
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA
    Mutat Res 556:127-34. 2004
    ..PLAP+ cells were observed in all areas of the brain. No increase in the number of PLAP+ cells was seen in three other tissues, suggesting that the effect of Aif deficiency on mutation was specific to brain...
  21. pmc Embryonic stem cells and somatic cells differ in mutation frequency and type
    Rachel B Cervantes
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Vontz Center for Molecular Studies, Cincinnati, OH 45267 052, USA
    Proc Natl Acad Sci U S A 99:3586-90. 2002
    ..Because UPD leads to reduction to homozygosity at multiple recessive disease loci, including tumor suppressor loci, in the affected chromosome, the increased risk of tumor formation after stem cell therapy should be viewed with concern...
  22. ncbi request reprint Co-mutagenic activity of arsenic and benzo[a]pyrene in mouse skin
    Jared M Fischer
    University of Cincinnati, Department of Molecular Genetics, Biochemistry and Microbiology, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
    Mutat Res 588:35-46. 2005
    ..Whereas combined treatment produced more PLAP+ cells, stable BaP adduct levels and arsenic burdens were not higher in mice exposed to both agents compared to mice exposed to either one agent or the other...
  23. ncbi request reprint Impact of mismatch repair deficiency on genomic stability in the maternal germline and during early embryonic development
    Jon S Larson
    Department of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0524, USA
    Mutat Res 556:45-53. 2004
    ..These data suggest that the paternally derived Pms2 gene provided normal levels of PMS2 protein to embryos by the time they reached the eight-cell stage, but that smaller embryos formed from PMS2-deficient eggs lacked PMS2 function...
  24. ncbi request reprint Visualization of mosaicism in tissues of normal and mismatch-repair-deficient mice carrying a microsatellite-containing transgene
    Megan N Hersh
    Department of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, OH 45267 0524, USA
    Mutat Res 505:51-62. 2002
    ..The reason for the different results in the liver is not clear. Cells in the liver were shown to be capable of expressing of PLAP enzyme and PLAP mRNA was present in this organ...
  25. doi request reprint Visualizing loss of heterozygosity in living mouse cells and tissues
    Jared M Fischer
    University of Cincinnati, Department of Molecular Genetics, Biochemistry and Microbiology, Cincinnati, OH 45267 0524, USA
    Mutat Res 645:1-8. 2008
    ..These data demonstrate that this approach can detect LOH and suggest that it will allow detection of LOH in a broad array of tissues and cell types in transgenic mice made from shYFP cells...
  26. ncbi request reprint Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation
    Christy M Caudill
    Department of Pathology, University of Cincinnati, 231 Albert Sabin Way, P O Box 670529, Cincinnati, Ohio 45267 0529, USA
    J Clin Endocrinol Metab 90:2364-9. 2005
    ..1-10 Gy gamma-radiation. This provides additional evidence for a direct link between this genetic event and radiation exposure and offers a powerful experimental system for studying radiation-induced carcinogenesis in the thyroid gland...
  27. ncbi request reprint Exposure of mice to arsenic and/or benzo[a]pyrene does not increase the frequency of Aprt-deficient cells recovered from explanted skin of Aprt heterozygous mice
    Jared M Fischer
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Ohio, USA
    Environ Mol Mutagen 47:334-44. 2006
    ..Analysis of DNA from DAP(r) colonies suggested that mitotic recombination contributed to the loss of wild-type Aprt allele. Whether arsenic or BaP enhanced or diminished the frequency of this process could not be deduced from these data...
  28. ncbi request reprint Pneumocystis oryctolagi sp. nov., an uncultured fungus causing pneumonia in rabbits at weaning: review of current knowledge, and description of a new taxon on genotypic, phylogenetic and phenotypic bases
    Eduardo Dei-Cas
    ECOPA EA 3609, Lille Pasteur Institute, Lille, France
    FEMS Microbiol Rev 30:853-71. 2006
    ..The present work focuses on Pneumocystis oryctolagi sp. nov. from Old-World rabbits. This new species has been described on the basis of both biological and phylogenetic species concepts...
  29. ncbi request reprint Pneumocystis and Trypanosoma cruzi: nomenclature and typifications
    Scott A Redhead
    National Program on Environmental Health Biodiversity, Agriculture and Agri Food Canada, Central Experimental Farm, KW Neatby Building, 960 Carling Avenue, Ottawa, Ontario K1A 0C6, Canada
    J Eukaryot Microbiol 53:2-11. 2006
    ..The classification and nomenclature of Pneumocystis is reviewed and guidelines given for the publication of new species...
  30. ncbi request reprint Has the name really been changed? It has for most researchers
    Melanie T Cushion
    Clin Infect Dis 41:1756-8. 2005

Research Grants13

  1. STRUCTURE AND EXPRESSION OF PNEUMOCYSTIS ANTIGEN GENES
    James Stringer; Fiscal Year: 2004
    ..carinii. Human P. carinii will be obtained from patients. Molecular genetic and immunohistochemical tools will be used to study expression of MSG genes and proteins. ..
  2. STRUCTURE AND EXPRESSION OF PNEUMOCYSTIS ANTIGEN GENES
    James Stringer; Fiscal Year: 2009
    ..abstract_text> ..