Irina A Strigo

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Further evidence of emotional allodynia in unmedicated young adults with major depressive disorder
    Alexander Ushinsky
    University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 8:e80507. 2013
  2. pmc Too hard to control: compromised pain anticipation and modulation in mild traumatic brain injury
    I A Strigo
    1 Veterans Affairs San Diego Healthcare System, San Diego, CA, USA 2 University of California San Diego, La Jolla, CA, USA 3 BioCircuits Institute, University of California San Diego, La Jolla, CA, USA
    Transl Psychiatry 4:e340. 2014
  3. pmc Decreased frontal regulation during pain anticipation in unmedicated subjects with major depressive disorder
    I A Strigo
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92161, USA
    Transl Psychiatry 3:e239. 2013
  4. pmc Altered insula activation during pain anticipation in individuals recovered from anorexia nervosa: evidence of interoceptive dysregulation
    Irina A Strigo
    Department of Psychiatry, University of California San Diego, 3350 La Jolla Village Dr, Building 13, MC 9151 B, La Jolla, CA 92161, USA
    Int J Eat Disord 46:23-33. 2013
  5. pmc The relationship between amygdala activation and passive exposure time to an aversive cue during a continuous performance task
    Irina A Strigo
    University of California San Diego, La Jolla, California, USA
    PLoS ONE 5:e15093. 2010
  6. doi request reprint Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence
    Irina A Strigo
    University of California at San Diego, La Jolla, California 92161, USA
    Biol Psychiatry 68:442-50. 2010
  7. pmc Right anterior insula hypoactivity during anticipation of homeostatic shifts in major depressive disorder
    Irina A Strigo
    Department of Psychiatry, University of California San Diego, 3350 La Jolla Village Dr, Building 13, MC 9151 B, La Jolla CA 92161, USA
    Psychosom Med 72:316-23. 2010
  8. pmc Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain
    Irina A Strigo
    Department of Psychiatry, University of California San Diego, 3350 La Jolla Village Dr, Bldg 13, MC 9151 B, La Jolla, CA 92161, USA
    Arch Gen Psychiatry 65:1275-84. 2008
  9. pmc Increased affective bias revealed using experimental graded heat stimuli in young depressed adults: evidence of "emotional allodynia"
    Irina A Strigo
    Department of Psychiatry, Laboratory of Biological Dynamics and Theoretical Medicine, University of California, San Diego, 8950 Villa La Jolla Dr, Suite C213, La Jolla, CA 92037 0985, USA
    Psychosom Med 70:338-44. 2008
  10. pmc Anxiety positive subjects show altered processing in the anterior insula during anticipation of negative stimuli
    Alan N Simmons
    Department of Psychiatry, University of California San Diego, San Diego, California 92161, USA
    Hum Brain Mapp 32:1836-46. 2011

Research Grants

Detail Information

Publications32

  1. pmc Further evidence of emotional allodynia in unmedicated young adults with major depressive disorder
    Alexander Ushinsky
    University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 8:e80507. 2013
    ..We hypothesized that emotional allodynia will be a robust characteristic of individuals with MDD compared to healthy controls. Thus, it would remain following acute mood induction, independent of valence...
  2. pmc Too hard to control: compromised pain anticipation and modulation in mild traumatic brain injury
    I A Strigo
    1 Veterans Affairs San Diego Healthcare System, San Diego, CA, USA 2 University of California San Diego, La Jolla, CA, USA 3 BioCircuits Institute, University of California San Diego, La Jolla, CA, USA
    Transl Psychiatry 4:e340. 2014
    ..Understanding these mechanisms of dysfunctional acute pain processing following MTBI may help shed light on the underlying causes of increased vulnerability for the development of pain-related conditions in this population...
  3. pmc Decreased frontal regulation during pain anticipation in unmedicated subjects with major depressive disorder
    I A Strigo
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92161, USA
    Transl Psychiatry 3:e239. 2013
    ..These results support and provide functional validation of the co-occurring enhanced 'bottom-up' and attenuated 'top-down' processing of salient, unpleasant emotional information in MDD...
  4. pmc Altered insula activation during pain anticipation in individuals recovered from anorexia nervosa: evidence of interoceptive dysregulation
    Irina A Strigo
    Department of Psychiatry, University of California San Diego, 3350 La Jolla Village Dr, Building 13, MC 9151 B, La Jolla, CA 92161, USA
    Int J Eat Disord 46:23-33. 2013
    ..Pain is an interoceptive process with well-characterized neuroanatomical pathways that may overlap to a large degree with neural systems that may be dysregulated in individuals with AN, such as the insula...
  5. pmc The relationship between amygdala activation and passive exposure time to an aversive cue during a continuous performance task
    Irina A Strigo
    University of California San Diego, La Jolla, California, USA
    PLoS ONE 5:e15093. 2010
    ..We suggest that amygdala activation during negative anticipatory processing depends directly on the passive exposure time to the negative cue...
  6. doi request reprint Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence
    Irina A Strigo
    University of California at San Diego, La Jolla, California 92161, USA
    Biol Psychiatry 68:442-50. 2010
    ..The aim of this study was to examine the neurobehavioral correlates of experimental pain in women with IPV-related PTSD...
  7. pmc Right anterior insula hypoactivity during anticipation of homeostatic shifts in major depressive disorder
    Irina A Strigo
    Department of Psychiatry, University of California San Diego, 3350 La Jolla Village Dr, Building 13, MC 9151 B, La Jolla CA 92161, USA
    Psychosom Med 72:316-23. 2010
    ..Although abnormal insula activity during aversive anticipation has been observed in individuals with MDD, the extent to which shifts in homeostatic state during anticipation affect insular activity in MDD subjects has not been reported...
  8. pmc Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain
    Irina A Strigo
    Department of Psychiatry, University of California San Diego, 3350 La Jolla Village Dr, Bldg 13, MC 9151 B, La Jolla, CA 92161, USA
    Arch Gen Psychiatry 65:1275-84. 2008
    ..Chronic pain and depression are highly comorbid conditions, yet little is known about the neurobiological basis of pain processing in major depressive disorder (MDD)...
  9. pmc Increased affective bias revealed using experimental graded heat stimuli in young depressed adults: evidence of "emotional allodynia"
    Irina A Strigo
    Department of Psychiatry, Laboratory of Biological Dynamics and Theoretical Medicine, University of California, San Diego, 8950 Villa La Jolla Dr, Suite C213, La Jolla, CA 92037 0985, USA
    Psychosom Med 70:338-44. 2008
    ..Existing evidence indicates that MDD may be associated with altered pain processing. However, the extent to which alterations in experimentally controlled heat pain sensations are related to increased affective bias in MDD is unknown...
  10. pmc Anxiety positive subjects show altered processing in the anterior insula during anticipation of negative stimuli
    Alan N Simmons
    Department of Psychiatry, University of California San Diego, San Diego, California 92161, USA
    Hum Brain Mapp 32:1836-46. 2011
    ..These results are consistent with the hypothesis that anxiety is related to greater anticipatory reactivity in the brain and that there may be functional asymmetries in the brain that interact with psychiatric traits...
  11. ncbi request reprint Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder
    Scott C Matthews
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, United States
    J Affect Disord 111:13-20. 2008
    ..The aim of this study was to examine the degree to which alterations in amygdala-cingulate FC relate to severity of current depressive symptoms in a group of depressed individuals without significant co-morbidities...
  12. pmc Adolescents with major depression demonstrate increased amygdala activation
    Tony T Yang
    University of California, San Diego, CA 92123, USA
    J Am Acad Child Adolesc Psychiatry 49:42-51. 2010
    ....
  13. pmc Escitalopram attenuates posterior cingulate activity during self-evaluation in healthy volunteers
    Scott C Matthews
    Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Psychiatry Res 182:81-7. 2010
    ..These results show that SSRIs change medial cortical activity and may alter self-evaluation...
  14. doi request reprint Neurosubstrates of remission following prolonged exposure therapy in veterans with posttraumatic stress disorder
    Alan N Simmons
    VA San Diego Healthcare System, University of California San Diego, La Jolla, Calif, USA
    Psychother Psychosom 82:382-9. 2013
    ..Prolonged exposure (PE) therapy is the first-line treatment for posttraumatic stress disorder (PTSD) in combat veterans. The underlying brain changes of treatment effect in PTSD are currently unknown...
  15. doi request reprint Altered insula activation in anticipation of changing emotional states: neural mechanisms underlying cognitive flexibility in Special Operations Forces personnel
    Alan N Simmons
    Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, San Diego, CA 92093, USA
    Neuroreport 23:234-9. 2012
    ..These neural changes may underlie their ability to perform well in stressful situations...
  16. pmc Initial evidence of a failure to activate right anterior insula during affective set shifting in posttraumatic stress disorder
    Alan Simmons
    Department of Psychiatry, University of California San Diego, San Diego, CA, USA
    Psychosom Med 71:373-7. 2009
    ..An altered ability to monitor or modulate interoception as it relates to subjective experience may provide a mechanistic explanation for the development of some forms of psychiatric illness...
  17. doi request reprint The effects of temporal unpredictability in anticipation of negative events in combat veterans with PTSD
    Alan N Simmons
    Research Service, VA San Diego Healthcare System, San Diego, CA 92130, USA
    J Affect Disord 146:426-32. 2013
    ....
  18. doi request reprint Demand-specific alteration of medial prefrontal cortex response during an inhibition task in recovered anorexic women
    Tyson A Oberndorfer
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    Int J Eat Disord 44:1-8. 2011
    ..It is well known that individuals with anorexia nervosa (AN) are inhibited and over-controlled. This study investigated a prefrontal-cingulate network that is involved in inhibitory control...
  19. pmc Diffusion tensor imaging evidence of white matter disruption associated with loss versus alteration of consciousness in warfighters exposed to combat in Operations Enduring and Iraqi Freedom
    Scott C Matthews
    Veterans Affairs San Diego Healthcare System, La Jolla, CA 92093 0603, USA
    Psychiatry Res 204:149-54. 2012
    ..These preliminary results show that LOC is associated with detectable alterations in brain microstructure and may suggest a brain basis for psychiatric symptoms and mental illness after mTBI...
  20. pmc Altered amygdala activation during face processing in Iraqi and Afghanistani war veterans
    Alan N Simmons
    Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Biol Mood Anxiety Disord 1:6. 2011
    ..abstract:..
  21. ncbi request reprint Evidence for acute central sensitization to prolonged experimental pain in posttraumatic stress disorder
    Tobias Moeller-Bertram
    Center of Excellence for Stress and Mental Health, San Diego, California, USA VA San Diego Healthcare System, San Diego, California, USA Department of Anesthesiology, University of California San Diego, San Diego, California, USA
    Pain Med 15:762-71. 2014
    ..The aim of this psychophysical study was to investigate the behavioral response to a prolonged suprathreshold pain stimulus in subjects with combat-related PTSD and combat controls (CC) for clinical evidence of central sensitization...
  22. doi request reprint Pain and emotion in the insular cortex: evidence for functional reorganization in major depression
    Isabella Mutschler
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Neurosci Lett 520:204-9. 2012
    ..e., where pain-processing takes place in healthy subjects, may play a role in "emotional allodynia" - a notion that individuals with MDD experience pain in response to stimuli that are normally not painful...
  23. pmc The parametric, psychological, neuropsychological, and neuroanatomical properties of self and world evaluation
    Alan N Simmons
    Mental Health, VA San Diego Healthcare System, San Diego, California, United States of America
    PLoS ONE 7:e31509. 2012
    ..To fill this gap we created the Self and World Evaluation Expressions Test(SWEET)...
  24. doi request reprint A multimodal imaging study in U.S. veterans of Operations Iraqi and Enduring Freedom with and without major depression after blast-related concussion
    Scott C Matthews
    Veterans Affairs San Diego Healthcare System, USA
    Neuroimage 54:S69-75. 2011
    ....
  25. ncbi request reprint Pain and post traumatic stress disorder - review of clinical and experimental evidence
    Tobias Moeller-Bertram
    University of California San Diego, La Jolla, CA 92037, USA
    Neuropharmacology 62:586-97. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  26. pmc Voxel-based morphometry of patients with schizophrenia or bipolar I disorder: a matched control study
    Gregory G Brown
    VA San Diego Healthcare System, San Diego, CA, USA
    Psychiatry Res 194:149-56. 2011
    ..The hippocampal and amygdala findings confirm predictions derived from recent meta-analyses. These structural abnormalities may be important factors in the differential manifestations of these two functional psychotic disorders...
  27. ncbi request reprint The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects
    Irina A Strigo
    Department of Anesthesia, Centre for Research on Pain, McGill University, 3640 University Street, Rm M 19, Montreal, Que H3A 2B2, Canada
    Pain 113:255-64. 2005
    ..A decrease in the unpleasantness but not in the intensity of cutaneous pain may reflect the differential effect of NMDA-R antagonists for the two pain states observed in animal models...
  28. ncbi request reprint Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex
    Le H Hua
    Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Am J Physiol Regul Integr Comp Physiol 289:R319-R325. 2005
    ..Finally, another focus of strongly graded activation, which we interpret to represent thermoregulatory behavioral motivation elicited by dynamic cooling, was observed in the dorsal medial cortex...
  29. ncbi request reprint Visceral and cutaneous pain representation in parasylvian cortex
    Irina A Strigo
    Department of Anesthesia, McGill University, Montreal, Canada H3G 1Y6
    Neurosci Lett 384:54-9. 2005
    ..01). Our results suggest segregation of visceral esophageal and cutaneous chest afferents within parasylvian cortex, possibly implicating this region in the perceptual differentiation of visceral and cutaneous pain...
  30. ncbi request reprint Neural correlates of painful genital touch in women with vulvar vestibulitis syndrome
    Caroline F Pukall
    Department of Psychology, Queen s University, Humphrey Hall, 62 Arch Street, Kingston, Ont, Canada K7L 3N6
    Pain 115:118-27. 2005
    ....
  31. ncbi request reprint Differentiation of visceral and cutaneous pain in the human brain
    Irina A Strigo
    Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Neurophysiol 89:3294-303. 2003
    ....
  32. ncbi request reprint Psychophysical analysis of visceral and cutaneous pain in human subjects
    Irina A Strigo
    Department of Physiology McGill University, Montreal, Quebec, Canada H3G 1Y6
    Pain 97:235-46. 2002
    ..The data suggest the likelihood of both similarities and differences in the neural substrates underlying visceral and cutaneous pain...

Research Grants4

  1. The Neural Basis of Pain Modulation in Depression
    Irina Strigo; Fiscal Year: 2007
    ..Given the frequent comorbidity of pain and depression, results of this study may fundamentally alter how psychiatrists approach depression and its neurobiological underpinnings. ..
  2. Neural Processes Underlying Pain Perception in Depression
    Irina Strigo; Fiscal Year: 2007
    ..Identifying the mechanism of the aberrant response to stress in depressed individuals may identify neural substrates that predict symptom formation and can potentially serve as biomarkers for future therapeutic intervention. ..