Research Topics
Species | Wolfgang StreitSummaryAffiliation: University of Florida Country: USA Publications
Research Grants
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Publications
Alpha-tocopherol (vitamin E) induces rapid, nonsustained proliferation in cultured rat microgliaBarry E Flanary
Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, Gainesville, 32610-0244, USA
Glia 53:669-74. 2006..Our findings provide an impetus to investigate potential benefits of vitamin E supplementation on microglial renewal capacity in vivo during aging or after brain injury...- Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase geneSarah E Fendrick
Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, Gainesville, FL 32611, USA
J Neuroinflammation 4:9. 2007..The purpose of this study was to provide a histopathological evaluation of the microglial neuroinflammatory response in a rodent model of ALS, the SOD1G93A transgenic rat... - Microglial activation in the hippocampus of hypercholesterolemic rabbits occurs independent of increased amyloid productionQing Shan Xue
Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, 100 Newell Drive, Gainesville FL 32611, USA
J Neuroinflammation 4:20. 2007..The purpose of this study was to survey microglial activation in rabbits fed cholesterol in the presence or absence of copper or other metal ions, such as zinc and aluminum... - Role of microglia in the central nervous system's immune responseWolfgang J Streit
Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, Gainesville, FL 32610, USA
Neurol Res 27:685-91. 2005..In addition, we provide an overview of the neuroinflammation associated with primary brain tumors and how microglial tumor cytotoxicity could be targeted for immunotherapeutic approaches designed to treat these lesions... - Microglia and neuroprotection: implications for Alzheimer's diseaseWolfgang J Streit
Department of Neuroscience, University of Florida College of Medicine, Gainesville, 32610 0244, USA
Brain Res Brain Res Rev 48:234-9. 2005.... - Role of fractalkine (CX3CL1) in regulating neuron-microglia interactions: development of viral-based CX3CR1 antagonistsWolfgang J Streit
Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA
Curr Alzheimer Res 2:187-9. 2005..The results from these studies will guide future development of therapeutic agents designed to modulate microglial activation with the goal of preventing or slowing the progression of AD... - Microglial senescence: does the brain's immune system have an expiration date?Wolfgang J Streit
Department of Neuroscience, PO Box 100244, University of Florida College of Medicine, Gainesville, FL 32610, USA
Trends Neurosci 29:506-10. 2006..Such attrition of the brain's immune system could contribute to the development of neurodegenerative disease by diminishing glial neuroprotection... - Microglia and Alzheimer's disease pathogenesisWolfgang J Streit
Department of Neuroscience, University of Florida College of Medicine, Gainesville, Florida 32610 0244, USA
J Neurosci Res 77:1-8. 2004..The microglial dysfunction theory offers a different perspective on the identity of activated microglia and their role in AD pathogenesis taking into account the most recent insights gained from studying basic microglial biology... - Dystrophic microglia in the aging human brainWolfgang J Streit
Department of Neuroscience, PO Box 100244, University of Florida College of Medicine, Building 59, 100 Newell Drive, Gainesville, FL 32610, USA
Glia 45:208-12. 2004..Thus, we conclude that microglial dystrophy is a sign of microglial cell senescence. We hypothesize that microglial senescence could be important for understanding age-related declines in cognitive function... - Microglia as neuroprotective, immunocompetent cells of the CNSWolfgang J Streit
Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, Gainesville, Florida 32611, USA
Glia 40:133-9. 2002..Future studies along these lines may provide novel insights into microglial involvement in neurodegenerative disease pathogenesis... - Microglial degeneration in the aging brain--bad news for neurons?Wolfgang J Streit
Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA
Front Biosci 13:3423-38. 2008.... - Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's diseaseWolfgang J Streit
Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610 0244, USA
Acta Neuropathol 118:475-85. 2009..The results have far-reaching implications in terms of reevaluating current treatment approaches towards AD... - Life and death of microgliaWolfgang J Streit
Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA
J Neuroimmune Pharmacol 4:371-9. 2009.... - Effects of axotomy on telomere length, telomerase activity, and protein in activated microgliaBarry E Flanary
Department of Neuroscience, University of Florida College of Medicine, Gainesville, Florida 32610, USA
J Neurosci Res 82:160-71. 2005..We conclude that molecular mechanisms pertaining to telomere maintenance are active in the injured CNS... - The facial motor nucleus transcriptional program in response to peripheral nerve injury identifies Hn1 as a regeneration-associated geneVioletta Zujovic
Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610 0267, USA
J Neurosci Res 82:581-91. 2005..These findings identify Hn1 as a gene associated with nervous system development and nerve regeneration... - TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microgliaShuzhen Chen
Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610 0267, USA
J Neuroimmunol 133:46-55. 2002..TGF-beta1 may shift fractalkine-dependent signaling away from activation of ERK1/2 towards other pathways and/or may provide a mechanism for microglia to more strongly adhere to neurons... - Endogenous T lymphocytes and microglial reactivity in the axotomized facial motor nucleus of mice: effect of genetic background and the RAG2 geneGrace K Ha
McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
J Neuroimmunol 172:1-8. 2006.... - Evidence that aging and amyloid promote microglial cell senescenceBarry E Flanary
Department of Neuroscience, University of Florida College of Medicine, McKnight Brain Institute, Gainesville, Florida 32610 0244, USA
Rejuvenation Res 10:61-74. 2007..They suggest that degeneration of microglia is a factor in the pathogenesis of AD... - CX3CL1 and CX3CR1 in the GL261 murine model of glioma: CX3CR1 deficiency does not impact tumor growth or infiltration of microglia and lymphocytesChe Liu
Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL 32610 0267, USA
J Neuroimmunol 198:98-105. 2008..These data indicate that CX3CR1 has little or no effects on either gliomagenesis or the migration of microglia and lymphocytes into GL261 tumors... - Rejection of RG-2 gliomas is mediated by microglia and T lymphocytesChristopher L Mariani
Department of Neuroscience, College of Medicine, University of Florida, P O Box 100244, Gainesville, FL 32611, USA
J Neurooncol 79:243-53. 2006..Our findings suggest that the combined mobilization of peripheral and CNS endogenous immune cells is required for eradicating large intracranial tumors... - Microglial response to murine leukemia virus-induced encephalopathy is a good indicator of neuronal perturbationsQing Shan Xue
Department of Neuroscience, PO Box 100244, University of Florida College of Medicine, McKnight Brain Institute, Gainesville, FL 32610 0244, USA
Brain Res 1319:131-41. 2010..We conclude that the visualization of microglial activation is a more sensitive measure of neuronal perturbations than direct detection of neuronal pathology which may be subtle and not produce overt degenerative changes... - IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neuronsJohn M Petitto
Department of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610 0256, USA
J Neuroimmunol 134:95-103. 2003..Further study of IL-2's complex actions in neuronal injury may provide greater understanding of key variables that determine whether or not immunological processes in the brain are proregenerative... - Effect of aging on the microglial response to peripheral nerve injuryJessica R Conde
Department of Neuroscience, University of Florida College of Medicine, McKnight Brain Institute, P O Box 100244, Gainesville, FL 32610 0244, USA
Neurobiol Aging 27:1451-61. 2006..We propose that aging-related changes in morphology in conjunction with a less regulated proliferative response in the aged facial nucleus may be a reflection of microglial senescence... - Minocycline does not inhibit microglia proliferation or neuronal regeneration in the facial nucleus following crush injurySarah E Fendrick
Department of Neuroscience, University of Florida, P.O. Box 100244, Gainesville, FL 32610, USA
Neurosci Lett 385:220-3. 2005..The findings show that microglia maintain the ability to become activated in vivo even in the presence of high levels of minocycline... - In situ hybridization analysis of chemokines and chemokine receptors in the central nervous systemJeffrey K Harrison
Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610 0267, USA
Methods 29:312-8. 2003..As such, methods that are compatible with the in situ hybridization procedure are included for staining astrocytes and microglia... - Axonally transported peripheral signals regulate alpha-internexin expression in regenerating motoneuronsTanya S McGraw
Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, Gainesville, Florida 32611, USA
J Neurosci 22:4955-63. 2002..We conclude that alpha-internexin upregulation in injured motoneurons suggests a role for this IF protein in neuronal regeneration... - Nonspecific immunotherapy with intratumoral lipopolysaccharide and zymosan A but not GM-CSF leads to an effective anti-tumor response in subcutaneous RG-2 gliomasChristopher L Mariani
Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA
J Neurooncol 85:231-40. 2007..In this study we examined the response of syngeneic rat gliomas to treatment with several nonspecific stimulators of dendritic cells and macrophages alone or in combination with radiation therapy... - Bromodeoxyuridine inhibits cancer cell proliferation in vitro and in vivoLindsay H Levkoff
Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA
Neoplasia 10:804-16. 2008..These results suggest that BrdU may have an important role as an adjunctive therapeutic for a wide variety of cancers based on new insights into its effect as a negative regulator of cell cycle progression... - Microglia in the aging brainJessica R Conde
Department of Neuroscience, University of Florida College of Medicine, Gainesville, 32610, USA
J Neuropathol Exp Neurol 65:199-203. 2006..The concept of microglial senescence offers a novel perspective on aging-related neurodegeneration, namely that neurodegeneration could also occur secondary to microglial degeneration... - Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivityKryslaine O Lopes
Department of Neuroscience, University of Florida College of Medicine, Gainesville, Florida 32610 0244, USA
Glia 56:1048-60. 2008..We conclude that ferritin immunohistochemistry may be a useful method for detecting degenerating microglia in the human brain... - Transforming growth factor-beta1 increases CXCR4 expression, stromal-derived factor-1alpha-stimulated signalling and human immunodeficiency virus-1 entry in human monocyte-derived macrophagesShuzhen Chen
Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610-0267, USA
Immunology 114:565-74. 2005..The results suggest that increased expression of CXCR4 on macrophages may contribute to the emergence of dual-tropic X4 viral variants at later stages of HIV-1 infection... - Telomeres shorten with age in rat cerebellum and cortex in vivoBarry E Flanary
Department of Neuroscience, University of Florida College of Medicine, Gainesville, Florida 32610, USA
J Anti Aging Med 6:299-308. 2003..Our findings provide an impetus to further investigate the pattern of telomere length and telomerase activity that emerges with further aging in the rat brain... - Progressive telomere shortening occurs in cultured rat microglia, but not astrocytesBarry E Flanary
Department of Neuroscience, University of Florida College of Medicine, McKnight Brain Institute, Gainesville, Florida 32610-0244, USA
Glia 45:75-88. 2004..Our findings provide an impetus to investigate the possibility that microglial telomere shortening may occur in vivo... - IntroductionBianca Marchetti
Department of Pharmacology, University of Sassari, Medical School, Italy
Brain Res Brain Res Rev 48:129-32. 2005
Research Grants
- Microglia: Role in Motoneuron Degeneration/RegenerationWolfgang Streit; Fiscal Year: 2005..e. that dystrophy and dysfunction of microglia may be involved. In addition, the minocycline experiments will help to further assess the usefulness of this drug for possible treatment of ALS. ..
- Microglial Dysfunction in Aged and Alzheimers's BrainWolfgang Streit; Fiscal Year: 2007..Preliminary studies suggest that microglial degeneration is much more pronounced in AD compared to non-demented individuals, and thus microglial dysfunction could be an important factor in AD pathogenesis. ..