Jerome F Strauss

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells
    Jerome F Strauss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Mol Cell Endocrinol 202:59-65. 2003
  2. ncbi request reprint Sterols and intracellular vesicular trafficking: lessons from the study of NPC1
    Jerome F Strauss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 1354 BRB II, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Steroids 67:947-51. 2002
  3. ncbi request reprint Manuscript submissions to the journal: American sterility, foreign fertility?
    Jerome F Strauss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 77:871-2. 2002
  4. ncbi request reprint Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS
    Jerome F Strauss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 1354 BRBII, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Mol Cell Endocrinol 186:183-8. 2002
  5. ncbi request reprint Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome
    Jerome F Strauss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 1354 BRBII II, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Ann N Y Acad Sci 997:42-8. 2003
  6. pmc A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans
    Hongyan Wang
    Center for Research on Reproduction and Women s Health and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:13463-7. 2006
  7. ncbi request reprint The CARD15 2936insC mutation and TLR4 896 A>G polymorphism in African Americans and risk of preterm premature rupture of membranes (PPROM)
    Pedro E Ferrand
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Hum Reprod 8:1031-4. 2002
  8. ncbi request reprint The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis
    Jennifer R Wood
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:26380-90. 2003
  9. ncbi request reprint Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM)
    Hongyan Wang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, 421 Curie Boulevard, Philadephia, PA 19104, USA
    Hum Mol Genet 13:2659-69. 2004
  10. ncbi request reprint Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects
    Jennifer R Wood
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, USA
    Physiol Genomics 20:233-43. 2005

Collaborators

Detail Information

Publications97

  1. ncbi request reprint START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells
    Jerome F Strauss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Mol Cell Endocrinol 202:59-65. 2003
    ..The roles of StarD4, StarD5, and StarD6 in sterol movement remain to be determined. These genes have tissue-specific patterns of expression that may predict specialized roles...
  2. ncbi request reprint Sterols and intracellular vesicular trafficking: lessons from the study of NPC1
    Jerome F Strauss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 1354 BRB II, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Steroids 67:947-51. 2002
    ..NPC2, NPC1 and MLN64 may act in an ordered sequence to sense cholesterol, effect sterol movement, and consequently, influence the process of vesicular trafficking...
  3. ncbi request reprint Manuscript submissions to the journal: American sterility, foreign fertility?
    Jerome F Strauss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 77:871-2. 2002
  4. ncbi request reprint Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS
    Jerome F Strauss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 1354 BRBII, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Mol Cell Endocrinol 186:183-8. 2002
    ..The latter will be interrogated for mutations/genetic variants linked to PCOS...
  5. ncbi request reprint Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome
    Jerome F Strauss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 1354 BRBII II, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Ann N Y Acad Sci 997:42-8. 2003
    ....
  6. pmc A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans
    Hongyan Wang
    Center for Research on Reproduction and Women s Health and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:13463-7. 2006
    ..0000045) association between the -656 T allele and PPROM. The SERPINH1 -656 T allele is the first example of an ancestry-informative marker associated with preterm birth in African Americans...
  7. ncbi request reprint The CARD15 2936insC mutation and TLR4 896 A>G polymorphism in African Americans and risk of preterm premature rupture of membranes (PPROM)
    Pedro E Ferrand
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Hum Reprod 8:1031-4. 2002
    ..However, the CARD15 mutation was only detected in controls and not in PPROM cases. We conclude that the CARD15 mutation and hyporesponsive TLR4 allele do not contribute to ethnic variation in the incidence of PPROM...
  8. ncbi request reprint The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis
    Jennifer R Wood
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:26380-90. 2003
    ....
  9. ncbi request reprint Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM)
    Hongyan Wang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, 421 Curie Boulevard, Philadephia, PA 19104, USA
    Hum Mol Genet 13:2659-69. 2004
    ..52, P < 0.0002). None of the minor alleles were individually associated with PPROM. These findings demonstrate the functional significance of SNP haplotypes in the MMP8 gene and associations with obstetrical outcomes...
  10. ncbi request reprint Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects
    Jennifer R Wood
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, USA
    Physiol Genomics 20:233-43. 2005
    ....
  11. ncbi request reprint Deficiency of SPAG16L causes male infertility associated with impaired sperm motility
    Zhibing Zhang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Biol Reprod 74:751-9. 2006
    ..The sperm defect is consistent with the motility phenotype of the Pf20 mutants of Chlamydomonas, but morphologically different in that the mutant algal axoneme lacks the central apparatus...
  12. pmc Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome
    Kathryn G Ewens
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Fertil Steril 95:2538-41.e1-6. 2011
    ..None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function...
  13. ncbi request reprint Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins
    Eran Horowitz
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Mol Hum Reprod 11:307-17. 2005
    ..Collectively, our findings demonstrate a sequential pattern of expression of flagellar component genes, differential times of expression or rates of transcript accumulation within each class and shared promoter features within a class...
  14. ncbi request reprint Conditional response of the human steroidogenic acute regulatory protein gene promoter to sterol regulatory element binding protein-1a
    L K Christenson
    Center for Research on Reproduction and Women s Health, University of Pennsylvania L K C, J F S, Philadelphia, Pennsylvania 19104
    Endocrinology 142:28-36. 2001
    ....
  15. ncbi request reprint Regulation of transcription of the steroidogenic acute regulatory protein (StAR) gene: temporal and spatial changes in transcription factor binding and histone modification
    Hisahiko Hiroi
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 1354 BRB, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Mol Cell Endocrinol 215:119-26. 2004
    ..These observations suggest that a combinatorial code of transcription factors including reciprocal changes in histone modifications associated with active transcription and gene silencing control StAR gene expression...
  16. ncbi request reprint A polymorphism in the matrix metalloproteinase-9 promoter is associated with increased risk of preterm premature rupture of membranes in African Americans
    Pedro E Ferrand
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Mol Hum Reprod 8:494-501. 2002
    ..We conclude that there are cell host-dependent differences in MMP-9 promoter activity related to CA-repeat number and that fetal carriage of the 14 CA-repeat allele is associated with PPROM in African Americans...
  17. ncbi request reprint Increased transcription and increased messenger ribonucleic acid (mRNA) stability contribute to increased GATA6 mRNA abundance in polycystic ovary syndrome theca cells
    Clement K M Ho
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Clin Endocrinol Metab 90:6596-602. 2005
    ..The mRNA and protein levels of the transcription factor GATA6, which regulates expression of several steroidogenic enzymes, are increased in PCOS theca cells. Thus, GATA6 is a PCOS candidate gene...
  18. ncbi request reprint Steroidogenic acute regulatory protein binds cholesterol and modulates mitochondrial membrane sterol domain dynamics
    A D Petrescu
    Department of Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466 and the Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104
    J Biol Chem 276:36970-82. 2001
    ....
  19. pmc Family-based analysis of candidate genes for polycystic ovary syndrome
    Kathryn G Ewens
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 95:2306-15. 2010
    ..D19S884, a polymorphic marker in fibrillin 3 (FBN3), is one of the few association findings that has been replicated in independent sets of families...
  20. pmc The promoter of the oocyte-specific gene, Gdf9, is active in population of cultured mouse embryonic stem cells with an oocyte-like phenotype
    Lisa M Salvador
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Methods 45:172-81. 2008
    ..These findings demonstrate that a population of cultured murine ES cells contain the transcriptional machinery to drive expression of an oocyte-specific gene, and that those cells phenotypically resemble oocytes...
  21. ncbi request reprint The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling
    Jennifer R Wood
    Center for Research on Reproduction and Women s Health, 1349 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    J Reprod Immunol 63:51-60. 2004
    ..Thus, global gene expression profiling has identified potential pathways which may determine the PCOS theca cell phenotype...
  22. ncbi request reprint Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype
    Sami Jabara
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 88:484-92. 2003
    ..We conclude that the predominant stromal cells of the postmenopausal ovary are not a significant site of androgen biosynthesis...
  23. ncbi request reprint A polymorphism in the promoter region of TNF and bacterial vaginosis: preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth
    George A Macones
    Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women s Health, University of Pennsylvania Health System, Philadelphia, 19104 6021, USA
    Am J Obstet Gynecol 190:1504-8; discussion 3A. 2004
    ..The aim of this study was to assess if the presence of symptomatic bacterial vaginosis amplifies the risk of spontaneous preterm birth in those with a "susceptible" TNF genotype...
  24. ncbi request reprint Derivation of oocytes from mouse embryonic stem cells
    Karin Hübner
    Germline Development Group, Center for Animal Transgenesis and Germ Cell Research, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, 382 West Street Road, Kennett Square, PA 19348, USA
    Science 300:1251-6. 2003
    ..Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies on fertility treatment and germ and somatic cell interaction and differentiation...
  25. ncbi request reprint Temporal and spatial changes in transcription factor binding and histone modifications at the steroidogenic acute regulatory protein (stAR) locus associated with stAR transcription
    Hisahiko Hiroi
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 1354 Biomedical Research Building, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Mol Endocrinol 18:791-806. 2004
    ..Our findings demonstrate that increased StAR transcription can occur in the context of different patterns of transcription factor binding and histone modification...
  26. ncbi request reprint Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism
    Tatsuro Kishida
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:19276-85. 2004
    ..These observations suggest that the Mln64 START domain is largely dispensable for sterol metabolism in mice...
  27. pmc Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis
    Zhibing Zhang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:12946-51. 2004
    ..The different patterns of expression of the two PF20 proteins suggest the possibility that the Pf20 gene has multiple functions during spermatogenesis...
  28. ncbi request reprint Regulation of expression of the steroidogenic acute regulatory protein (StAR) gene: a central role for steroidogenic factor 1
    T Sugawara
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Steroids 62:5-9. 1997
    ..The distal site binds SF-1 with high affinity, whereas the proximal site binds SF-1 with lower affinities. These findings demonstrate a requirement for SF-1 for human StAR gene expression...
  29. ncbi request reprint Multiple steroidogenic factor 1 binding elements in the human steroidogenic acute regulatory protein gene 5'-flanking region are required for maximal promoter activity and cyclic AMP responsiveness
    T Sugawara
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Biochemistry 36:7249-55. 1997
    ..These findings demonstrate that multiple SF-1 response elements are required for maximal StAR promoter activity and regulation by cAMP...
  30. ncbi request reprint Dissecting the axoneme interactome: the mammalian orthologue of Chlamydomonas PF6 interacts with sperm-associated antigen 6, the mammalian orthologue of Chlamydomonas PF16
    Zhibing Zhang
    Center for Research on Reproduction and Women s Health and the Department of Ophthalmology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Proteomics 4:914-23. 2005
    ..Thus, PF6, SPAG6, and PF20 form a newly identified network that links together components of the axoneme central apparatus and presumably participates in its dynamic regulation of ciliary and flagellar beat...
  31. pmc Thrombin receptors and protease-activated receptor-2 in human placentation: receptor activation mediates extravillous trophoblast invasion in vitro
    Peter J O'Brien
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 163:1245-54. 2003
    ..Together these results support a role for PAR1, and potentially PAR2 and PAR3 in the invasive phase of human placentation...
  32. ncbi request reprint Growth differentiation factor-9 inhibits 3'5'-adenosine monophosphate-stimulated steroidogenesis in human granulosa and theca cells
    Noriko Yamamoto
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    J Clin Endocrinol Metab 87:2849-56. 2002
    ..Because GDF-9 mRNA and protein are detectable in granulosa-lutein cells after the LH surge, the concept of GDF-9 as a solely oocyte-derived luteinization inhibitor needs to be reevaluated...
  33. pmc Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13
    T Sugawara
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia 19104, USA
    Proc Natl Acad Sci U S A 92:4778-82. 1995
    ..A StAR pseudogene was mapped to chromosome 13. We conclude that StAR expression is restricted to tissues that carry out mitochondrial sterol oxidations subject to acute regulation by cAMP and that StAR mRNA levels are regulated by cAMP...
  34. ncbi request reprint Steroidogenic factor 1-dependent promoter activity of the human steroidogenic acute regulatory protein (StAR) gene
    T Sugawara
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Biochemistry 35:9052-9. 1996
    ..SF-1 can function at two distinct sites in the human StAR gene promoter, apparently by two different types of interaction, to control transcription...
  35. pmc Steroidogenic acute regulatory protein (StAR) retains activity in the absence of its mitochondrial import sequence: implications for the mechanism of StAR action
    F Arakane
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Proc Natl Acad Sci U S A 93:13731-6. 1996
    ..These findings imply that StAR acts via C-terminal domains on the outside of the mitochondria...
  36. pmc MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis
    H Watari
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 94:8462-7. 1997
    ..We conclude that MLN64 stimulates steroidogenesis by virtue of its homology to StAR...
  37. ncbi request reprint Structure of the human steroidogenic acute regulatory protein (StAR) gene: StAR stimulates mitochondrial cholesterol 27-hydroxylase activity
    T Sugawara
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia 19104, USA
    Biochemistry 34:12506-12. 1995
    ....
  38. pmc Activation of the control reporter plasmids pRL-TK and pRL-SV40 by multiple GATA transcription factors can lead to aberrant normalization of transfection efficiency
    Clement K M Ho
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, 1355 Biomedical Research Building II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    BMC Biotechnol 4:10. 2004
    ..To correct for variations in transfection efficiency, the Renilla luciferase encoding plasmids pRL-TK and pRL-SV40 are commonly used as normalization controls...
  39. ncbi request reprint Tumor necrosis factor-alpha suppresses the expression of steroid receptor coactivator-1 and -2: a possible mechanism contributing to changes in steroid hormone responsiveness
    Rita S Leite
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    FASEB J 18:1418-20. 2004
    ....
  40. ncbi request reprint Variation in resistin gene promoter not associated with polycystic ovary syndrome
    Margrit Urbanek
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Diabetes 52:214-7. 2003
    ..3 and PCOS. Instead, this association is most likely due to a gene or genetic element in this region that has not been identified...
  41. ncbi request reprint Mechanisms underlying "functional" progesterone withdrawal at parturition
    Amy G Brown
    III 1354 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Ann N Y Acad Sci 1034:36-49. 2004
    ..However, the specific uterine genes whose transcription is directly controlled by PR, and thus affected by "functional" progesterone withdrawal, remain to be identified...
  42. ncbi request reprint Endocrine function of the postmenopausal ovary
    Paolo Rinaudo
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Endocrinol Metab Clin North Am 33:661-74. 2004
    ..Although the current authors believe that the postmenopausal ovary has lost a clinically significant estrogenic capability, a definitive conclusion regarding androgen production cannot be forthcoming...
  43. ncbi request reprint Steroidogenic acute regulatory protein: an update on its regulation and mechanism of action
    L K Christenson
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Arch Med Res 32:576-86. 2001
    ..The models-intermembrane shuttle hypothesis, and cholesterol desorption hypothesis-are discussed with respect to the known biochemical and biophysical events associated with steroidogenesis and the structure of StAR...
  44. pmc Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization
    H Watari
    Center for Research on Reproduction and Women s Health, Departments of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 96:805-10. 1999
    ....
  45. ncbi request reprint Mechanisms of trophoblast-virus interaction
    S Parry
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Reprod Immunol 37:25-34. 1997
    ....
  46. ncbi request reprint A serum proteomics approach to the diagnosis of ectopic pregnancy
    G L Gerton
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6080, USA
    Ann N Y Acad Sci 1022:306-16. 2004
    ....
  47. ncbi request reprint The extra domain A of fibronectin activates Toll-like receptor 4
    Y Okamura
    Center for Research on Reproduction and Women's Health, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Biol Chem 276:10229-33. 2001
    ..These observations provided a mechanism by which EDA-containing fibronectin fragments promote expression of genes involved in the inflammatory response...
  48. ncbi request reprint Allelic variants of the follistatin gene in polycystic ovary syndrome
    M Urbanek
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    J Clin Endocrinol Metab 85:4455-61. 2000
    ..We conclude that contributions to the etiology of PCOS from the follistatin gene, if any, are likely to be small...
  49. ncbi request reprint Steroidogenic acute regulatory protein (StAR) and the intramitochondrial translocation of cholesterol
    L K Christenson
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 1355 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Biochim Biophys Acta 1529:175-87. 2000
    ..StAR gene expression is regulated primarily at the transcriptional level, and the roles of transcription factors that govern basal and cAMP-dependent StAR expression including SF-1, C/EBP beta, Sp1 and GATA-4 are reviewed...
  50. pmc Transduction of human trophoblastic cells by replication-deficient recombinant viral vectors. Promoting cellular differentiation affects virus entry
    S Parry
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, USA
    Am J Pathol 152:1521-9. 1998
    ..Additionally, trophoblast differentiation leads to alterations in the mechanisms of virus uptake that may affect maternal-to-fetus transmission...
  51. pmc PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1
    A M Ishov
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 147:221-34. 1999
    ..Our findings identify the basic requirements for ND10 formation and suggest a dynamic mechanism for protein recruitment to these nuclear domains controlled by the SUMO-1 modification state of PML...
  52. ncbi request reprint CCAAT/enhancer-binding proteins regulate expression of the human steroidogenic acute regulatory protein (StAR) gene
    L K Christenson
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 274:26591-8. 1999
    ....
  53. pmc Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin
    M Urbanek
    Departments of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 96:8573-8. 1999
    ..Our study shows how a systematic screen of candidate genes can provide strong evidence for genetic linkage in complex diseases and can identify those genes that should have high (or low) priority for further study...
  54. ncbi request reprint Quantitative analysis of the hormone-induced hyperacetylation of histone H3 associated with the steroidogenic acute regulatory protein gene promoter
    L K Christenson
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6142, USA
    J Biol Chem 276:27392-9. 2001
    ..The union of the chromatin immunoprecipitation assay with quantitative real-time polymerase chain reaction described and validated here should enhance the analysis of gene expression...
  55. ncbi request reprint Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions
    L K Christenson
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 273:30729-35. 1998
    ....
  56. ncbi request reprint A hemoglobin fragment found in cervicovaginal fluid from women in labor potentiates the action of agents that promote contraction of smooth muscle cells
    Amy G Brown
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical School, Biomedical Research Building II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Peptides 27:1794-800. 2006
    ..This peptide may promote vasoconstriction and augment normal labor through enhancing the action of uterotonins...
  57. ncbi request reprint Syncytiotrophoblast is a barrier to maternal-fetal transmission of herpes simplex virus
    Hideki Koi
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 67:1572-9. 2002
    ..Thus, the decreased expression of herpesvirus entry mediators in villous syncytiotrophoblast prevents placental villous infection, thereby limiting maternal-fetal transmission of HSV...
  58. pmc Induction of the hyaluronic acid-binding protein, tumor necrosis factor-stimulated gene-6, in cervical smooth muscle cells by tumor necrosis factor-alpha and prostaglandin E(2)
    Toshio Fujimoto
    Center for Research on Reproduction and Women sHealth, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Am J Pathol 160:1495-502. 2002
    ....
  59. ncbi request reprint Association of anti-mullerian hormone levels with obesity in late reproductive-age women
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 87:101-6. 2007
    ..To describe anti-mullerian hormone (AMH) levels in healthy late reproductive age women and test the hypothesis that AMH levels are lower in obese compared to non-obese women...
  60. ncbi request reprint Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region
    M Kiriakidou
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    DNA Cell Biol 16:1289-98. 1997
    ..The location of the Daxx gene, which is implicated in the pathway for deletion of autoreactive lymphocytes, in the MHC region may shed light on the genetic basis of autoimmune diseases...
  61. ncbi request reprint The steroidogenic acute regulatory protein (StAR): a window into the complexities of intracellular cholesterol trafficking
    J F Strauss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Recent Prog Horm Res 54:369-94; discussion 394-5. 1999
    ....
  62. ncbi request reprint Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene
    K F Kozarsky
    Institute for Human Gene Therapy, Department of Molecular and Cellular Engineering, University of Pennsylvania, Philadelphia, USA
    Nat Genet 13:54-62. 1996
    ..Infusion of recombinant adenoviruses containing the VLDL receptor gene corrected the dsylipidaemia in the FH mouse and circumvented immune responses to the transgene leading to a more prolonged metabolic correction...
  63. ncbi request reprint Viral infection of the trophoblast: time to take a serious look at its role in abnormal implantation and placentation?
    Fabian Arechavaleta-Velasco
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 1354 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    J Reprod Immunol 55:113-21. 2002
    ..We conclude that there is sufficient evidence linking placental infection by common viruses, including viruses thought to be non-pathogenic or to have low pathogenicity, to indicate that this effect contributes to poor pregnancy outcome...
  64. ncbi request reprint Sperm antigen 6 is the murine homologue of the Chlamydomonas reinhardtii central apparatus protein encoded by the PF16 locus
    R Sapiro
    Center for Research on Reproduction and Women s Health, Center for Neurobiology and Behavior, and Molecular Genetics in Psychology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Biol Reprod 62:511-8. 2000
    ..Mutations in the Chlamydomonas PF16 gene cause flagellar paralysis. The presence of a highly conserved mammalian PF16 homologue (Spag6) raises the possibility that Spag6 plays an important role in sperm flagellar function...
  65. ncbi request reprint Multiple signal transduction pathways regulate ovarian steroidogenesis
    Jennifer R Wood
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Rev Endocr Metab Disord 3:33-46. 2002
  66. ncbi request reprint A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes
    Toshio Fujimoto
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:6296-302. 2002
    ..We conclude that the 2G allele has stronger promoter activity in amnion cells, that it confers increased responsiveness of amnion cells to stimuli that induce MMP-1, and that this polymorphism contributes to the risk of PPROM...
  67. ncbi request reprint Waiting for the second coming
    Jerome F Strauss
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6142, USA
    Nature 432:43-5. 2004
  68. ncbi request reprint Fine mapping of genetic susceptibility to polycystic ovary syndrome on chromosome 19p13.2 and tests for regulatory activity
    D R Stewart
    Department of Genetics, Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, USA
    J Clin Endocrinol Metab 91:4112-7. 2006
    ..We previously found linkage and association of PCOS with the dinucleotide marker D19S884 in two independent sets of families; allele 8 of D19S884 confers increased risk...
  69. ncbi request reprint Localization of the steroidogenic acute regulatory protein in human tissues
    S E Pollack
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Clin Endocrinol Metab 82:4243-51. 1997
    ....
  70. ncbi request reprint Induction of matrix metalloproteinases and collagenolysis in chick embryonic membranes before hatching
    H Lei
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Biol Reprod 60:183-9. 1999
    ....
  71. ncbi request reprint Amniotic fluid matrix metalloproteinase-8 indicates intra-amniotic infection
    S R Angus
    Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia 19104-6142, USA
    Am J Obstet Gynecol 185:1232-8. 2001
    ....
  72. ncbi request reprint Differential expression of the coxsackievirus and adenovirus receptor regulates adenovirus infection of the placenta
    H Koi
    Center for Research on Reproduction and Women's Health, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 64:1001-9. 2001
    ....
  73. doi request reprint Cholesterol interaction with the related steroidogenic acute regulatory lipid-transfer (START) domains of StAR (STARD1) and MLN64 (STARD3)
    Julian Reitz
    Institute of Biochemistry, Gutenberg University Mainz, Becherweg 30, Mainz, Germany
    FEBS J 275:1790-802. 2008
    ..Overall, our results provide evidence for differential cholesterol binding of the two most closely related START domain proteins STARD1 and STARD3...
  74. ncbi request reprint Ultrastructural and biochemical evidence for the presence of mature steroidogenic acute regulatory protein (StAR) in the cytoplasm of human luteal cells
    Walter D Sierralta
    Laboratorio de Estructuras, INTA Universidad de Chile, Macul 5540, PO Box 138, Santiago 11, Chile
    Mol Cell Endocrinol 242:103-10. 2005
    ....
  75. ncbi request reprint Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome
    Jessica K Wickenheisser
    Department of Cellular and Molecular Physiology, Pennsylvania State Hershey College of Medicine, 500 University Drive, C4723, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 90:4858-65. 2005
    ..Recent experiments have suggested that several genes involved in retinoic acid synthesis may be differentially expressed in PCOS theca cells and may contribute to excessive theca-derived androgen production...
  76. ncbi request reprint Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein
    Volker Wiegand
    Institute of Biochemistry, Johannes Gutenberg University of Mainz, Germany
    FASEB J 17:782-4. 2003
    ..Our data show that NPC1 has an essential role in the distribution of plasma membrane-derived cholesterol by maintaining the small size of cholesterol-containing lipid droplets in the cell...
  77. ncbi request reprint Control of human luteal steroidogenesis
    Luigi Devoto
    Departamento de Obstetricia y Ginecologia, Facultad de Medicina, Instituto de Investigaciones Materno Infantil, IDIMI y Universidad de Chile, PO Box 226 3, Santiago, Chile
    Mol Cell Endocrinol 186:137-41. 2002
    ....
  78. ncbi request reprint Valproate potentiates androgen biosynthesis in human ovarian theca cells
    Velen L Nelson-Degrave
    Department of Cellular and Molecular Physiology, Pennsylvania State Hershey College of Medicine, 500 University Drive, C4723, Hershey, PA 17033, USA
    Endocrinology 145:799-808. 2004
    ..These studies provide the first biochemical evidence to support a role for VPA in the genesis of polycystic ovary syndrome-like symptoms, and establish a direct link between VPA treatment and increased ovarian androgen biosynthesis...
  79. ncbi request reprint MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria
    Mei Zhang
    Lipid Cell Biology Section and Cell Biochemistry Section, Laboratory of Cell Biochemistry and Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:33300-10. 2002
    ..We conclude that MLN64 participates in mobilization and utilization of lysosomal cholesterol by virtue of the START domain's role in cholesterol transport...
  80. ncbi request reprint Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome
    Velen L Nelson-Degrave
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine 500 University Drive H166, Hershey, Pennsylvania 17033, USA
    Mol Endocrinol 19:379-90. 2005
    ..These findings implicate alterations in the MAPK pathway in the pathogenesis of excessive ovarian androgen production in PCOS...
  81. pmc Phosphorylation of mouse sperm axoneme central apparatus protein SPAG16L by a testis-specific kinase, TSSK2
    Zhibing Zhang
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Biol Reprod 79:75-83. 2008
    ..SPAG16L can be phosphorylated by TSSK2 in vitro. Finally, TSSK2 is absent or markedly reduced from the testes in most of the SPAG16L-null mice. These data support the conclusion that SPAG16L is a TSSK2 substrate...
  82. ncbi request reprint Lipopolysaccharide induces interleukin-8 production by human cervical smooth muscle cells
    Michiko Watari
    Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido, Japan
    J Soc Gynecol Investig 10:110-7. 2003
    ....
  83. doi request reprint A 12-bp deletion in the 5'-flanking region of the SERPINH1 gene affects promoter activity and protects against preterm premature rupture of membranes in African Americans
    Hongyan Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University School of Life Science, Shanghai, China
    Hum Mutat 29:332. 2008
    ..These studies define a new haplotype in the SERPINH1 gene that modifies risk of an adverse obstetrical outcome...
  84. ncbi request reprint Molecular progress in infertility: polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Fertil Steril 78:569-76. 2002
    ..To review the evidence that polycystic ovary syndrome is a genetic disease...
  85. doi request reprint Genetic and epigenetic mechanisms combine to control MMP1 expression and its association with preterm premature rupture of membranes
    Hongyan Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University School of Life Science, Shanghai 200433, China
    Hum Mol Genet 17:1087-96. 2008
    ..We conclude that in addition to genetic variation, DNA methylation plays a role in controlling MMP1 expression and risk of an adverse obstetrical outcome...
  86. ncbi request reprint A heterozygous mutation disrupting the SPAG16 gene results in biochemical instability of central apparatus components of the human sperm axoneme
    Zhibing Zhang
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Biol Reprod 77:864-71. 2007
    ....
  87. ncbi request reprint Genetic approaches to polycystic ovarian syndrome
    Marie Nam Menke
    Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Curr Opin Obstet Gynecol 19:355-9. 2007
    ..This review clarifies the challenges facing investigators in the search for polycystic ovarian syndrome candidate genes...
  88. ncbi request reprint Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins
    Zhibing Zhang
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Cell Motil Cytoskeleton 64:360-76. 2007
    ..The findings also demonstrate that SPAG6 and SPAG16L have related roles in controlling the function of cilia in the brain and lung...
  89. ncbi request reprint Genetics of polycystic ovarian syndrome
    Marie Nam Menke
    Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Clin Obstet Gynecol 50:188-204. 2007
    ..A concerted effort will be necessary to conclusively rule in or rule out candidate genes...
  90. ncbi request reprint The accelerated pace of pharma abandonment of research and development in family planning and fertility: will reproductive health technology be frozen in time?
    Jerome F Strauss
    Fertil Steril 87:717-8. 2007
  91. ncbi request reprint The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phase
    Paulina Kohen
    Instituto de Investigaciones Materno Infantil y Departamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Chile, Hospital Clinico San Borja Arriaran, Santiago
    J Clin Endocrinol Metab 88:3421-30. 2003
    ....
  92. ncbi request reprint Mechanisms of gonadotropin desensitization
    Abraham Amsterdam
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Mol Cell Endocrinol 187:69-74. 2002
    ....
  93. ncbi request reprint Contact sites from human placental mitochondria: characterization and role in progesterone synthesis
    Aida Uribe
    Departamento de Bioquimica, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Apdo Postal 70 159, 04510 Mexico, DF, Mexico
    Arch Biochem Biophys 413:172-81. 2003
    ..This organization may facilitate the metabolism of cholesterol delivered to the outer mitochondrial membrane into steroid hormones by the inner mitochondrial membrane cholesterol side chain cleavage system...
  94. ncbi request reprint Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal
    Karla J Saner
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9032, USA
    Mol Endocrinol 19:184-97. 2005
    ..Both SF1 and GATA-6 were positive regulators of SULT2A1 promoter constructs. These data support the hypothesis that adrenal SULT2A1 expression is regulated by SF1 and GATA-6...
  95. ncbi request reprint National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development
    Pushpa V Thadani
    Division of Neuroscience and Behavioral Research National Institute on Drug Abuse NIDA, National Institutes of Health, 6001 Executive Boulevard, Room 4282, MSC 9555, Bethesda, MD 20892 9555, USA
    Am J Obstet Gynecol 191:1858-62. 2004
    ..This report summarizes the presentations and research recommendations resulting from the workshop discussions...
  96. ncbi request reprint Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis
    Jennifer R Wood
    Department of Animal Science, University of Nebraska Lincoln, 3800 Fair Street, Lincoln, Nebraska 68583 0908, USA
    J Clin Endocrinol Metab 92:705-13. 2007
    ..These PCOS phenotypes are associated with exaggerated ovarian responsiveness to FSH and increased pregnancy loss...