Derek Strassheim

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury
    Derek Strassheim
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 174:8064-71. 2005
  2. ncbi Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils
    Derek Strassheim
    Division of Pulmonary Science and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 172:5727-33. 2004
  3. ncbi Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression
    Derek Strassheim
    Division of Pulmonary Sciences and Critical Care Medicine, Univ of Colorado Health Sciences Center, Box C272, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 286:C683-92. 2004
  4. ncbi Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B
    Karim Asehnoune
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 172:2522-9. 2004
  5. ncbi Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 170:5644-51. 2003
  6. ncbi Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:7370-7. 2004
  7. ncbi Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB
    Karim Asehnoune
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Box C272, 4200 East 9th Ave, Denver, CO 80262, USA
    Cell Signal 17:385-94. 2005
  8. ncbi Activation of gene expression in human neutrophils by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Cell Physiol 284:C870-9. 2003
  9. ncbi HMGB1 contributes to the development of acute lung injury after hemorrhage
    Jae Yeol Kim
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 288:L958-65. 2005
  10. ncbi The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with {alpha}V{beta}3 integrins
    Sang Hyun Kwak
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Leukoc Biol 78:937-45. 2005

Collaborators

Detail Information

Publications16

  1. ncbi Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury
    Derek Strassheim
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 174:8064-71. 2005
    ..These results demonstrate that SHIP has a negative regulatory role in TLR2-induced neutrophil activation and in the development of related in vivo neutrophil-dependent inflammatory processes, such as acute lung injury...
  2. ncbi Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils
    Derek Strassheim
    Division of Pulmonary Science and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 172:5727-33. 2004
    ..These results demonstrate that the PI3-K-Akt axis occupies a central role in TLR2-induced activation of neutrophils...
  3. ncbi Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression
    Derek Strassheim
    Division of Pulmonary Sciences and Critical Care Medicine, Univ of Colorado Health Sciences Center, Box C272, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 286:C683-92. 2004
    ..Such inhibitory effects on neutrophil activation may limit tissue damage produced by oxidative stress...
  4. ncbi Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B
    Karim Asehnoune
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 172:2522-9. 2004
    ....
  5. ncbi Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 170:5644-51. 2003
    ....
  6. ncbi Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:7370-7. 2004
    ..Interactions of HMGB1 with TLR 2 and TLR 4 may provide an explanation for the ability of HMGB1 to generate inflammatory responses that are similar to those initiated by LPS...
  7. ncbi Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB
    Karim Asehnoune
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Box C272, 4200 East 9th Ave, Denver, CO 80262, USA
    Cell Signal 17:385-94. 2005
    ..PKCalpha/beta can regulate NF-kappaB dependent transcription in neutrophils both by enhancing nuclear translocation of NF-kappaB and also by stimulating phosphorylation of the p65 subunit...
  8. ncbi Activation of gene expression in human neutrophils by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Cell Physiol 284:C870-9. 2003
    ..These findings indicate that HMGB1 is an effective stimulus of neutrophil activation that can contribute to development of a proinflammatory phenotype in diseases characterized by excessively high levels of HMGB1...
  9. ncbi HMGB1 contributes to the development of acute lung injury after hemorrhage
    Jae Yeol Kim
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 288:L958-65. 2005
    ..These results demonstrate that hemorrhage results in increased HMGB1 expression in the lungs, primarily through neutrophil sources, and that HMGB1 participates in hemorrhage-induced acute lung injury...
  10. ncbi The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with {alpha}V{beta}3 integrins
    Sang Hyun Kwak
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Leukoc Biol 78:937-45. 2005
    ..These results demonstrate that the KD of uPA, through interaction with alpha(V)beta(3) integrins, potentiates neutrophil activation...
  11. ncbi High mobility group box 1 protein interacts with multiple Toll-like receptors
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, Box C272, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 290:C917-24. 2006
    ....
  12. ncbi Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia
    John Arcaroli
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    J Leukoc Biol 72:571-9. 2002
    ....
  13. pmc IgM contributes to glomerular injury in FSGS
    Derek Strassheim
    Department of Medicine, School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Am Soc Nephrol 24:393-406. 2013
    ..Strategies that reduce IgM natural antibody or that prevent complement activation may slow the progression of glomerulosclerosis...
  14. pmc Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury
    Brandon Renner
    Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    Kidney Int 80:165-73. 2011
    ....
  15. ncbi Sepsis: current concepts in intracellular signaling
    Derek Strassheim
    Pulmonary Science and Critical Care, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box C272, Denver, CO 80262, USA
    Int J Biochem Cell Biol 34:1527-33. 2002
    ..Increasing understanding of the signal transduction pathways of inflammatory cells involved in the disease suggests that targeting specific kinases and transcriptional regulatory mechanisms may prove improve outcome from sepsis...
  16. pmc B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion
    Brandon Renner
    Department of Medicine, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
    J Immunol 185:4393-400. 2010
    ..However, nonperitoneal B cells attenuate renal injury after I/R, possibly through the production of IL-10...