Daniel O Stram

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc The potential for enhancing the power of genetic association studies in African Americans through the reuse of existing genotype data
    Gary K Chen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
    PLoS Genet 6:e1001096. 2010
  2. pmc A genome-wide scan for breast cancer risk haplotypes among African American women
    Chi Song
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    PLoS ONE 8:e57298. 2013
  3. doi request reprint Multi-SNP haplotype analysis methods for association analysis
    Daniel O Stram
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 850:423-52. 2012
  4. pmc Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs
    Boris Pasche
    Division of Hematology Oncology, The University of Alabama at Birmingham and UAB Comprehensive Cancer Center, Birmingham, AL 35203, USA
    J Exp Clin Cancer Res 29:57. 2010
  5. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
  6. pmc Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 9:257. 2009
  7. ncbi request reprint Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study
    Daniel O Stram
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, Calif 90033, USA
    Hum Hered 55:27-36. 2003
  8. ncbi request reprint Designs for studies of personal exposure to air pollution and the impact of measurement error
    Daniel O Stram
    Division of Biostatistics and Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Toxicol Environ Health A 68:1181-7. 2005
  9. pmc Age-specific effects of hormone therapy use on overall mortality and ischemic heart disease mortality among women in the California Teachers Study
    Daniel O Stram
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Menopause 18:253-61. 2011
  10. ncbi request reprint Tag SNP selection for association studies
    Daniel O Stram
    Division of Biostatistics and Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Genet Epidemiol 27:365-74. 2004

Collaborators

Detail Information

Publications95

  1. pmc The potential for enhancing the power of genetic association studies in African Americans through the reuse of existing genotype data
    Gary K Chen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
    PLoS Genet 6:e1001096. 2010
    ....
  2. pmc A genome-wide scan for breast cancer risk haplotypes among African American women
    Chi Song
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    PLoS ONE 8:e57298. 2013
    ....
  3. doi request reprint Multi-SNP haplotype analysis methods for association analysis
    Daniel O Stram
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 850:423-52. 2012
    ..We also describe the practical implementation of genome-wide haplotype risk estimation and discuss several shortcuts that can be used to speed up otherwise potentially very intensive computational requirements...
  4. pmc Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs
    Boris Pasche
    Division of Hematology Oncology, The University of Alabama at Birmingham and UAB Comprehensive Cancer Center, Birmingham, AL 35203, USA
    J Exp Clin Cancer Res 29:57. 2010
    ..This phenotype was first observed in mice, then in lymphoblastoid cell lines from patients with microsatellite stable colorectal tumors...
  5. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
    ..Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)...
  6. pmc Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 9:257. 2009
    ..We studied the association between breast cancer risk and polymorphisms in genes that code for GNRH1 and its receptor (GNRHR) in the large National Cancer Institute Breast and Prostate Cancer Cohort Consortium (NCI-BPC3)...
  7. ncbi request reprint Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study
    Daniel O Stram
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, Calif 90033, USA
    Hum Hered 55:27-36. 2003
    ..A candidate set of htSNPS of a given size is chosen so as to maximize the minimum value of R2h over the common haplotypes, h...
  8. ncbi request reprint Designs for studies of personal exposure to air pollution and the impact of measurement error
    Daniel O Stram
    Division of Biostatistics and Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Toxicol Environ Health A 68:1181-7. 2005
    ..Much emphasis is on the recent analysis of Sheppard (this issue) as a source of information concerning variations in grouped and individual air pollution...
  9. pmc Age-specific effects of hormone therapy use on overall mortality and ischemic heart disease mortality among women in the California Teachers Study
    Daniel O Stram
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Menopause 18:253-61. 2011
    ..The California Teachers Study questionnaire and mortality data were used to examine whether age modified the association between HT and the relative risk of overall mortality and ischemic heart disease deaths...
  10. ncbi request reprint Tag SNP selection for association studies
    Daniel O Stram
    Division of Biostatistics and Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Genet Epidemiol 27:365-74. 2004
    ..We use a small portion of the HapMap ENCODE data (488 common SNPs genotyped over approximately a 500 kb region of chromosome 2) as an illustrative example of this approach towards power evaluation...
  11. ncbi request reprint Beta-cryptoxanthin and lung cancer in Shanghai, China--an examination of potential confounding with cigarette smoking using urinary cotinine as a biomarker for true tobacco exposure
    Daniel O Stram
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Nutr Cancer 57:123-9. 2007
    ....
  12. pmc Software for tag single nucleotide polymorphism selection
    Daniel O Stram
    Division of Biostatistics and Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Genomics 2:144-51. 2005
    ..A compromise approach which eliminates the need first to analyse block structure, but which still exploits simple relationships between SNPs, appears promising...
  13. ncbi request reprint Power and uncertainty analysis of epidemiological studies of radiation-related disease risk in which dose estimates are based on a complex dosimetry system: some observations
    Daniel O Stram
    Department of Preventive Medicine, School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Radiat Res 160:408-17. 2003
    ..Uncertainty analysis (construction of confidence intervals) can be approached in the same way in simple cases. We also offer some suggestions for Monte Carlo-based confidence intervals...
  14. ncbi request reprint Prostate cancer incidence and intake of fruits, vegetables and related micronutrients: the multiethnic cohort study* (United States)
    Daniel O Stram
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Causes Control 17:1193-207. 2006
    ..To describe the relationship between the intake of fruits, vegetables, and related vitamins and antioxidants, and the risk of prostate cancer in male participants in a large multiethnic cohort study...
  15. ncbi request reprint Modeling and E-M estimation of haplotype-specific relative risks from genotype data for a case-control study of unrelated individuals
    Daniel O Stram
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Hered 55:179-90. 2003
    ..1]) the differences between the three methods are very small and in particular that the single imputation method may be expected to work extremely well...
  16. ncbi request reprint Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort
    Iona Cheng
    Department of Epidemiology and Biostatistics and Center for Human Genetics, University of California San Francisco, San Francisco, California, USA
    Cancer Epidemiol Biomarkers Prev 15:1993-7. 2006
    ..Our results suggest that common genetic variation in the IGFBP1 and IGFBP3 genes do not substantially influence prostate and breast cancer susceptibility...
  17. ncbi request reprint Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort
    Iona Cheng
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Natl Cancer Inst 98:123-34. 2006
    ..Insulin-like growth factor I (IGF-I) appears to play a role in prostate development and carcinogenesis. We investigated whether genetic variation at the IGF1 locus is associated with prostate cancer risk...
  18. pmc A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort
    Sulggi A Lee
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    BMC Med Genet 8:72. 2007
    ..Prospective epidemiological studies have also shown that women with higher circulating PRL levels have an increase in risk of breast cancer, suggesting that variability in PRL may also be important in determining a woman's risk...
  19. pmc Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 7:e1001387. 2011
    ..Our findings with variants at 8q24 also reinforce the importance of this region as a major risk locus for prostate cancer in men of African ancestry...
  20. pmc Association of diabetes with prostate cancer risk in the multiethnic cohort
    Kevin M Waters
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, USA
    Am J Epidemiol 169:937-45. 2009
    ..Diabetes is a protective factor for prostate cancer across populations, suggesting shared risk factors that influence a common mechanism...
  21. pmc A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians
    Fredrick R Schumacher
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 19:3089-101. 2010
    ....
  22. ncbi request reprint Ethnic and racial differences in the smoking-related risk of lung cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9175, USA
    N Engl J Med 354:333-42. 2006
    ..There is remarkable variation in the incidence of lung cancer among ethnic and racial groups in the United States...
  23. pmc Caution in generalizing known genetic risk markers for breast cancer across all ethnic/racial populations
    Fang Chen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    Eur J Hum Genet 19:243-5. 2011
    ..These results emphasize the need for large-scale association studies of multiple racial/ethnic groups for discovery and characterization of risk alleles relevant to all populations in the United States...
  24. ncbi request reprint Common genetic variation at PTEN and risk of sporadic breast and prostate cancer
    Christopher A Haiman
    University of Southern California Norris Comprehensive Cancer Center, Room 4441, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:1021-5. 2006
    ..We found no strong association with any common haplotype in relation to breast or prostate cancer risk. In summary, our results show that common variants in PTEN do not substantially influence risk of these two common cancers...
  25. pmc Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 9:e1003419. 2013
    ..Very large sample sizes will be required to better define the role of rare and less penetrant coding variation in prostate and breast cancer disease genetics...
  26. pmc Levels of beta-microseminoprotein in blood and risk of prostate cancer in multiple populations
    Christopher A Haiman
    Harlyne Norris Research Tower, 1450 Biggy St, Rm 1504, Los Angeles, CA 90033, USA
    J Natl Cancer Inst 105:237-43. 2013
    ..Whether MSP levels are predictive of prostate cancer risk has not been evaluated...
  27. ncbi request reprint A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, 1441 Eastlake Ave, Rm 4441, Los Angeles, CA 90089 9175, USA
    Hum Mol Genet 12:2679-92. 2003
    ..31; 95% CI, 1.11-1.54). Our findings suggest the hypothesis that women with the long-range CYP19 haplotype 2b-3c may be carriers of a predisposing breast cancer susceptibility allele...
  28. ncbi request reprint Igf-I genetic variation and breast cancer: the multiethnic cohort
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Cancer Epidemiol Biomarkers Prev 15:172-4. 2006
  29. doi request reprint No association of risk variants for diabetes and obesity with breast cancer: the Multiethnic Cohort and PAGE studies
    Fang Chen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 20:1039-42. 2011
    ..Body mass index is an established risk factor for postmenopausal breast cancer. Epidemiologic studies have also reported a positive association between type 2 diabetes (T2D) and breast cancer risk...
  30. pmc Generalizability of associations from prostate cancer genome-wide association studies in multiple populations
    Kevin M Waters
    Harlyne Norris Research Tower, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 18:1285-9. 2009
    ..For many of these regions, fine-mapping in non-European samples may help localize causal alleles and better determine their contribution to prostate cancer risk in the population...
  31. ncbi request reprint Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis
    Celeste Leigh Pearce
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    J Natl Cancer Inst 97:51-9. 2005
    ..We set out to refine the association between common variation at the PGR gene locus and these two diseases...
  32. ncbi request reprint Breast cancer in a multiethnic cohort in Hawaii and Los Angeles: risk factor-adjusted incidence in Japanese equals and in Hawaiians exceeds that in whites
    Malcolm C Pike
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 11:795-800. 2002
    ..The adjusted RR of NHs is 65% greater than that of Ws, and that of migrant Latinas is 16% lower than that of Ws. Elucidating the causes of the high rates in NHs is now a major focus of our efforts...
  33. pmc Dietary patterns and breast cancer risk in the California Teachers Study cohort
    Lilli B Link
    From Cancer Epidemiology, Mailman School of Public Health, Columbia University, New York, NY LBL the Cancer Prevention Institute of California, Fremont, CA AJC, CAC, and PLH R the Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA CAC and PLH R the Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA LB the Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA DOS and GU the Cancer Registry of Norway, Oslo, Norway GU and the Department of Nutrition, University of Oslo, Oslo, Norway GU
    Am J Clin Nutr 98:1524-32. 2013
    ..Evidence that diet is associated with breast cancer risk is inconsistent. Most studies have examined risks associated with specific foods and nutrients, rather than measures of overall diet...
  34. ncbi request reprint CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Veronica Wendy Setiawan
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 16:2237-46. 2007
    ..Our findings do not support the hypothesis that common germ line variation in CYP17 makes a substantial contribution to postmenopausal breast or prostate cancer susceptibility...
  35. pmc A genome-wide association study of breast cancer in women of African ancestry
    Fang Chen
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Hum Genet 132:39-48. 2013
    ..Identification of novel risk variants for breast cancer in women of African ancestry will demand testing of a substantially larger set of markers from stage 1 in a larger replication sample...
  36. doi request reprint Comprehensive evaluation of ESR2 variation and ovarian cancer risk
    Celeste Leigh Pearce
    USC Norris Comprehensive Cancer Center and Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 17:393-6. 2008
    ..28-11.73; P = 0.016). Haplotype D was also reported by the BPC3 to be associated with increased risk of breast cancer. This haplotype warrants further investigation to rule out any effect with invasive ovarian cancer risk...
  37. ncbi request reprint Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1893-7. 2007
    ..Thus, although genetic variation in CYP19A1 produces measurable differences in estrogen levels among postmenopausal women, the magnitude of the change was insufficient to contribute detectably to breast cancer...
  38. ncbi request reprint A systematic assessment of common genetic variation in CYP11A and risk of breast cancer
    Veronica Wendy Setiawan
    Departments of Preventive Medicine and Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Res 66:12019-25. 2006
    ..Based on these findings, CYP11A deserves further consideration as a candidate breast cancer susceptibility gene...
  39. pmc Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans
    Fang Chen
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Hum Mol Genet 20:4491-503. 2011
    ..04, P = 6.1 × 10(-5)]. In this detailed analysis of the known breast cancer risk loci, we have validated and improved upon markers of risk that better characterize their association with breast cancer in women of African ancestry...
  40. pmc Multiple regions within 8q24 independently affect risk for prostate cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Nat Genet 39:638-44. 2007
    ..None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein...
  41. doi request reprint Hormone metabolism genes and mammographic density in Singapore Chinese women
    Eunjung Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Cancer Epidemiol Biomarkers Prev 22:984-6. 2013
    ..We investigated the association between genetic variation in the hormone metabolism and signaling pathway and mammographic density, a strong predictor of breast cancer risk...
  42. ncbi request reprint Dietary cryptoxanthin and reduced risk of lung cancer: the Singapore Chinese Health Study
    Jian Min Yuan
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033 0800, USA
    Cancer Epidemiol Biomarkers Prev 12:890-8. 2003
    ..The present study lends additional credence to prior experimental and epidemiological data in support of the hypothesis that dietary beta-cryptoxanthin is a chemopreventive agent for lung cancer in humans...
  43. pmc No association of type 2 diabetes risk variants and prostate cancer risk: the multiethnic cohort and PAGE
    Kevin M Waters
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Harlyne Norris Research Tower, 1450 Biggy Street, Room 1504, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 20:1979-81. 2011
    ..We explored the hypothesis that common genetic variation may explain, in part, the inverse association between diabetes and prostate cancer...
  44. ncbi request reprint Physical activity and colon cancer risk among women in the California Teachers Study
    Phuong L Mai
    Clinical Cancer Genetics Department, City of Hope National Medical Center, Duarte, CA, USA
    Cancer Epidemiol Biomarkers Prev 16:517-25. 2007
    ..One potential explanation for this inconsistency is that hormone therapy, which is associated with lower colon cancer risk, acts as a modifier of the physical activity/colon cancer relationship...
  45. ncbi request reprint Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Hum Mol Genet 17:825-34. 2008
    ..The methods utilized in this study, applied to multiple populations, provide a framework for testing in association studies in diverse populations...
  46. ncbi request reprint Risk factors for renal cell cancer: the multiethnic cohort
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Epidemiol 166:932-40. 2007
    ..045). Compared with nondrinkers, men who drank >or=1 drinks/day had a 31% lower risk (95% CI: 0.49, 0.96). Results show that body mass index, smoking, and hypertension are risk factors for renal cell cancer in both sexes...
  47. pmc A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations
    Kevin M Waters
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 19:2639-46. 2010
    ..A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer...
  48. pmc A common genetic risk factor for colorectal and prostate cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Nat Genet 39:954-6. 2007
    ..Comprehensive testing in the region uncovered variants capturing significant additional risk. Our results show that variants at 8q24 have different effects on cancer development that depend on the tissue type...
  49. ncbi request reprint Correlation of dietary intake and colorectal cancer incidence among Mexican-American migrants: the multiethnic cohort study
    Kristine R Monroe
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Nutr Cancer 45:133-47. 2003
    ....
  50. pmc Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese women
    Eunjung Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Norris Cancer Center, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 21:635-44. 2012
    ..We investigated the interrelations of soy, PPARγ, and mammographic density, a biomarker of breast cancer risk in a cross-sectional study of 2,038 women who were members of the population-based Singapore Chinese Health Study Cohort...
  51. pmc Recent breast cancer incidence trends according to hormone therapy use: the California Teachers Study cohort
    Sarah F Marshall
    Department of Epidemiology, School of Medicine, University of California, Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 12:R4. 2010
    ..Few data sources can address breast cancer incidence trends according to pertinent characteristics like hormone therapy use history...
  52. ncbi request reprint BRCA1 variants in a family study of African-American and Latina women
    Roberta McKean-Cowdin
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue MS 44, Los Angeles, CA 90089 9175, USA
    Hum Genet 116:497-506. 2005
    ..We believe this to be the largest study of high-risk African-American and Latina women sequenced for variants in the BRCA1 gene to date...
  53. pmc Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations
    Jing He
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, Harlyne Norris Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 20:70-81. 2011
    ..Genome-wide association studies (GWAS) in populations of European ancestry have identified several loci that confer an increased risk of colorectal cancer (CRC)...
  54. pmc Population genetic structure and origins of Native Hawaiians in the multiethnic cohort study
    Sung K Kim
    Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e47881. 2012
    ..By providing important insight into the underlying population structure of Native Hawaiians, this study lays the foundation for future genetic association studies of this U.S. minority population...
  55. pmc Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women
    Eunjung Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Cancer Res 73:1876-82. 2013
    ..Our data support that TGFB1 genetic variation may be an important genetic determinant of mammographic density measure that predicts breast cancer risk, particularly in nulliparous women...
  56. pmc A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, USA
    Nat Genet 43:1210-4. 2011
    ..25, P = 1.1 × 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations...
  57. ncbi request reprint Bayesian spatial modeling of haplotype associations
    Duncan C Thomas
    University of Southern California, Los Angeles, CA 90089 9011, USA
    Hum Hered 56:32-40. 2003
    ..We conclude with a discussion of the implications of these methods for modeling cryptic relatedness, haplotype blocks, and haplotype tagging SNPs, and suggest a Bayesian framework for the HapMap project...
  58. ncbi request reprint Comparison of prostate-specific antigen and hormone levels among men in Singapore and the United States
    Iona Cheng
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA, 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 14:1692-6. 2005
    ..Given that the overall mortality rate of prostate cancer in Singapore is low, these undiagnosed cancers may be of nonaggressive type. Alternatively, PSA may be a poor marker of prostate cancer in this low-risk population...
  59. ncbi request reprint Long-term recreational physical activity and risk of invasive and in situ breast cancer: the California teachers study
    Cher M Dallal
    Keck School of Medicine and USC Norris Cancer Center, University of Southern California, Los Angeles, USA
    Arch Intern Med 167:408-15. 2007
    ..Long-term physical activity may affect breast cancer risk. Few prospective studies have evaluated in situ or invasive breast cancer risk, or breast cancer receptor subtypes, in relation to long-term activity...
  60. pmc A kinship-based modification of the armitage trend test to address hidden population structure and small differential genotyping errors
    Cyril S Rakovski
    Department of Mathematics and Computer Science, Chapman University, Orange, California, United States of America
    PLoS ONE 4:e5825. 2009
    ..We propose a modification of the well-known Armitage trend test to address the problems associated with hidden population structure and hidden relatedness in genome-wide case-control association studies...
  61. pmc Genome-wide association study identifies new prostate cancer susceptibility loci
    Fredrick R Schumacher
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Hum Mol Genet 20:3867-75. 2011
    ..72 and P= 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes...
  62. pmc Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk
    Celeste Leigh Pearce
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 20:2263-72. 2011
    ..25). IGF2 is emerging as an important gene for ovarian cancer; additional genotyping is warranted to further confirm these associations with IGF2 and to narrow down the region harboring the causal SNP...
  63. ncbi request reprint Utilizing HapMap and tagging SNPs
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Methods Mol Med 141:37-54. 2008
    ....
  64. pmc Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California, USA
    Nat Genet 43:570-3. 2011
    ..Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations...
  65. ncbi request reprint Exploring genetic susceptibility to cancer in diverse populations
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine and the Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Curr Opin Genet Dev 20:330-5. 2010
    ..Challenges to multiethnic studies relating to study power, control for hidden population structure, imputation, and use of shared controls for multiple cancer endpoints are discussed...
  66. ncbi request reprint Optimal two-stage genotyping designs for genome-wide association scans
    Hansong Wang
    Division of Biostatistics and Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Genet Epidemiol 30:356-68. 2006
    ....
  67. pmc Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer
    Hui Shen
    USC Epigenome Center, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA
    Nat Commun 4:1628. 2013
    ..These findings underscore distinct mechanisms driving different epithelial ovarian cancer histological subtypes...
  68. pmc Regression calibration when foods (measured with error) are the variables of interest: markedly non-Gaussian data with many zeroes
    Gary E Fraser
    Department of Epidemiology and Biostatistics, School of Public Health, Loma Linda University, California, USA
    Am J Epidemiol 175:325-31. 2012
    ..Irrespective of fit, linear regression calibration in this situation at least approximately corrects bias. More complex linear calibration equations that improve fit may increase power over that of uncalibrated regressions...
  69. ncbi request reprint Is residual confounding a reasonable explanation for the apparent protective effects of beta-carotene found in epidemiologic studies of lung cancer in smokers?
    Daniel O Stram
    Department of Preventive Medicine, School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Epidemiol 155:622-8. 2002
    ..Appropriate cohort studies of lung cancer in smokers, utilizing biomarkers of smoking, are needed and are presently ongoing...
  70. ncbi request reprint A controlled 2-mo dietary fat reduction and soy food supplementation study in postmenopausal women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90089 9175, USA
    Am J Clin Nutr 81:1133-41. 2005
    ..Low intake of dietary fat and high intake of soy foods have been suggested to partly explain the lower breast cancer rates in Asia, perhaps because of lower endogenous estrogens...
  71. ncbi request reprint Enlarged and prominent nucleoli may be indicative of MYCN amplification: a study of neuroblastoma (Schwannian stroma-poor), undifferentiated/poorly differentiated subtype with high mitosis-karyorrhexis index
    Chie Kobayashi
    Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA
    Cancer 103:174-80. 2005
    ..Nonetheless, certain tumors possessing these histologic characteristics contain a nonamplified MYCN gene (NA-MYCN)...
  72. ncbi request reprint Bone marrow transplantation versus prolonged intensive chemotherapy for children with acute lymphoblastic leukemia and an initial bone marrow relapse within 12 months of the completion of primary therapy: Children's Oncology Group study CCG-1941
    Paul S Gaynon
    Division of Hematology Oncology, Children s Hospital Los Angeles, Los Angeles, CA, USA
    J Clin Oncol 24:3150-6. 2006
    ..To compare conventional sibling bone marrow transplantation (CBMT), BMT with alternative donor (ABMT), and chemotherapy (CT) for children with acute lymphoblastic leukemia (ALL) and an early first marrow relapse...
  73. ncbi request reprint Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies
    Heather Spencer Feigelson
    Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, Georgia 30329, USA
    Cancer Res 66:2468-75. 2006
    ..Although the probability that these ER-negative findings are false-positive results is high, these findings were consistent across each cohort examined and warrant further study...
  74. ncbi request reprint Common variation in BRCA2 and breast cancer risk: a haplotype-based analysis in the Multiethnic Cohort
    Matthew L Freedman
    The Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Hum Mol Genet 13:2431-41. 2004
    ..However, a significant elevation in risk was observed among approximately 6% of women who carried a specific haplotype pattern and may harbor a susceptibility allele at the BRCA2 locus...
  75. pmc Re: the use of inferred haplotypes in downstream analysis
    Peter Kraft
    Am J Hum Genet 81:863-5; author reply 865-6. 2007
  76. ncbi request reprint Hypothesis testing, statistical power, and confidence limits in the presence of epistemic uncertainty
    Daniel O Stram
    Health Phys 93:326-7; author reply 327-8. 2007
  77. ncbi request reprint Re: Beta-carotene and lung cancer: a lesson for future chemoprevention investigations?
    Daniel O Stram
    J Natl Cancer Inst 95:E4. 2003
  78. pmc Haplotypes of the estrogen receptor beta gene and breast cancer risk
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 122:387-92. 2008
    ..These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women...
  79. ncbi request reprint Impact of radiotherapy for high-risk neuroblastoma: a Children's Cancer Group study
    Daphne A Haas-Kogan
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA
    Int J Radiat Oncol Biol Phys 56:28-39. 2003
    ..To assess the effect of local radiation administered to primary disease sites in children with high-risk neuroblastoma...
  80. ncbi request reprint Breast-feeding and neuroblastoma, USA and Canada
    Julie L Daniels
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Causes Control 13:401-5. 2002
    ..Researchers have suggested an inverse association between breast-feeding and risk of childhood cancer. We investigated the association between breast-feeding and neuroblastoma in a large case-control study in the United States and Canada...
  81. ncbi request reprint Transferability of tag SNPs in genetic association studies in multiple populations
    Paul I W de Bakker
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts, 02142, USA
    Nat Genet 38:1298-303. 2006
    ..These results demonstrate that the HapMap DNA samples can be used to select tags for genome-wide association studies in many samples around the world...
  82. ncbi request reprint Dietary fiber and colorectal cancer risk: the multiethnic cohort study
    Abraham M Y Nomura
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Causes Control 18:753-64. 2007
    ..To investigate the association of dietary fiber with colorectal cancer..
  83. ncbi request reprint Calcium, vitamin D, and dairy product intake and prostate cancer risk: the Multiethnic Cohort Study
    Song Yi Park
    Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Am J Epidemiol 166:1259-69. 2007
    ....
  84. pmc IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2578. 2008
    ..In summary, the impact of genetic variation in IGF1 and IGFBP3 on circulating IGF levels does not appear to substantially influence breast cancer risk substantially among primarily Caucasian postmenopausal women...
  85. ncbi request reprint Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Yen Ching Chen
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1973-81. 2007
    ..Estrogen receptor beta (ESR2) may play a role in modulating prostate carcinogenesis through the regulation of genes related to cell proliferation and apoptosis...
  86. pmc Dietary patterns and risk of ovarian cancer in the California Teachers Study cohort
    Ellen T Chang
    Northern California Cancer Center, Fremont, California 94538, USA
    Nutr Cancer 60:285-91. 2008
    ..Overall, our results show no convincing associations between dietary patterns and ovarian cancer risk...
  87. ncbi request reprint A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk
    Matthew L Freedman
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Cancer Res 65:7516-22. 2005
    ....
  88. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment...
  89. pmc Diet and risk of ovarian cancer in the California Teachers Study cohort
    Ellen T Chang
    Northern California Cancer Center, Fremont, CA 94538, USA
    Am J Epidemiol 165:802-13. 2007
    ..Although dietary consumption of isoflavones may be associated with decreased ovarian cancer risk, most dietary factors are unlikely to play a major role in ovarian cancer development...
  90. ncbi request reprint Asymptotic equivalence between two score tests for haplotype-specific risk in general linear models
    Rongrong Xie
    Genet Epidemiol 29:166-70. 2005
  91. pmc Genetic variation in the HSD17B1 gene and risk of prostate cancer
    Peter Kraft
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 1:e68. 2005
    ..These results suggest that the germline variants in HSD17B1 characterized by these htSNPs do not substantially influence the risk of prostate cancer in U.S. and European whites...
  92. ncbi request reprint An utter refutation of the "Fundamental Theorem of the HapMap" by Terwilliger and Hiekkalinna
    Duncan C Thomas
    Eur J Hum Genet 14:1238-9. 2006
  93. ncbi request reprint Exploiting gene-environment interaction to detect genetic associations
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Hered 63:111-9. 2007
    ..This makes the joint test an attractive tool for large-scale association scans where the true gene-environment interaction model is unknown...
  94. ncbi request reprint A common 8q24 variant in prostate and breast cancer from a large nested case-control study
    Fredrick R Schumacher
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 67:2951-6. 2007
    ..590). Although the gene responsible has yet to be identified, the validation of this marker in this large sample of prostate cancer cases leaves little room for the possibility of a false-positive result...
  95. pmc Wine and other alcohol consumption and risk of ovarian cancer in the California Teachers Study cohort
    Ellen T Chang
    Northern California Cancer Center, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA
    Cancer Causes Control 18:91-103. 2007
    ..Whether alcohol consumption influences ovarian cancer risk is unclear. Therefore, we investigated the association between alcohol intake at various ages and risk of ovarian cancer...