Research Topics
Genomes and Genes
Species | Daniel O StramSummaryAffiliation: University of Southern California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Multi-SNP haplotype analysis methods for association analysisDaniel O Stram
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Methods Mol Biol 850:423-52. 2012..We also describe the practical implementation of genome-wide haplotype risk estimation and discuss several shortcuts that can be used to speed up otherwise potentially very intensive computational requirements...
Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPsBoris Pasche
Division of Hematology Oncology, The University of Alabama at Birmingham and UAB Comprehensive Cancer Center, Birmingham, AL 35203, USA
J Exp Clin Cancer Res 29:57. 2010..This phenotype was first observed in mice, then in lymphoblastoid cell lines from patients with microsatellite stable colorectal tumors...
A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)David G Cox
Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Breast Cancer Res 8:R54. 2006..Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)...- Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)Federico Canzian
German Cancer Research Center DKFZ, Heidelberg, Germany
BMC Cancer 9:257. 2009..We studied the association between breast cancer risk and polymorphisms in genes that code for GNRH1 and its receptor (GNRHR) in the large National Cancer Institute Breast and Prostate Cancer Cohort Consortium (NCI-BPC3)... 
Designs for studies of personal exposure to air pollution and the impact of measurement errorDaniel O Stram
Division of Biostatistics and Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
J Toxicol Environ Health A 68:1181-7. 2005..Much emphasis is on the recent analysis of Sheppard (this issue) as a source of information concerning variations in grouped and individual air pollution...- Tag SNP selection for association studiesDaniel O Stram
Division of Biostatistics and Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Genet Epidemiol 27:365-74. 2004..We use a small portion of the HapMap ENCODE data (488 common SNPs genotyped over approximately a 500 kb region of chromosome 2) as an illustrative example of this approach towards power evaluation... - Age-specific effects of hormone therapy use on overall mortality and ischemic heart disease mortality among women in the California Teachers StudyDaniel O Stram
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
Menopause 18:253-61. 2011..The California Teachers Study questionnaire and mortality data were used to examine whether age modified the association between HT and the relative risk of overall mortality and ischemic heart disease deaths... - Prostate cancer incidence and intake of fruits, vegetables and related micronutrients: the multiethnic cohort study* (United States)Daniel O Stram
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Cancer Causes Control 17:1193-207. 2006..To describe the relationship between the intake of fruits, vegetables, and related vitamins and antioxidants, and the risk of prostate cancer in male participants in a large multiethnic cohort study... - Modeling and E-M estimation of haplotype-specific relative risks from genotype data for a case-control study of unrelated individualsDaniel O Stram
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Hum Hered 55:179-90. 2003..1]) the differences between the three methods are very small and in particular that the single imputation method may be expected to work extremely well... - Power and uncertainty analysis of epidemiological studies of radiation-related disease risk in which dose estimates are based on a complex dosimetry system: some observationsDaniel O Stram
Department of Preventive Medicine, School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Radiat Res 160:408-17. 2003..Uncertainty analysis (construction of confidence intervals) can be approached in the same way in simple cases. We also offer some suggestions for Monte Carlo-based confidence intervals... - Software for tag single nucleotide polymorphism selectionDaniel O Stram
Division of Biostatistics and Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Hum Genomics 2:144-51. 2005..A compromise approach which eliminates the need first to analyse block structure, but which still exploits simple relationships between SNPs, appears promising... - Beta-cryptoxanthin and lung cancer in Shanghai, China--an examination of potential confounding with cigarette smoking using urinary cotinine as a biomarker for true tobacco exposureDaniel O Stram
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Nutr Cancer 57:123-9. 2007.... - Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort StudyDaniel O Stram
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, Calif 90033, USA
Hum Hered 55:27-36. 2003..A candidate set of htSNPS of a given size is chosen so as to maximize the minimum value of R2h over the common haplotypes, h... - Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohortIona Cheng
Department of Epidemiology and Biostatistics and Center for Human Genetics, University of California San Francisco, San Francisco, California, USA
Cancer Epidemiol Biomarkers Prev 15:1993-7. 2006..Our results suggest that common genetic variation in the IGFBP1 and IGFBP3 genes do not substantially influence prostate and breast cancer susceptibility... - Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic CohortIona Cheng
Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
J Natl Cancer Inst 98:123-34. 2006..Insulin-like growth factor I (IGF-I) appears to play a role in prostate development and carcinogenesis. We investigated whether genetic variation at the IGF1 locus is associated with prostate cancer risk... - A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohortSulggi A Lee
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA, USA
BMC Med Genet 8:72. 2007..Prospective epidemiological studies have also shown that women with higher circulating PRL levels have an increase in risk of breast cancer, suggesting that variability in PRL may also be important in determining a woman's risk... - A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among CaucasiansFredrick R Schumacher
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Hum Mol Genet 19:3089-101. 2010.... - Association of diabetes with prostate cancer risk in the multiethnic cohortKevin M Waters
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, USA
Am J Epidemiol 169:937-45. 2009..Diabetes is a protective factor for prostate cancer across populations, suggesting shared risk factors that influence a common mechanism... - Ethnic and racial differences in the smoking-related risk of lung cancerChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9175, USA
N Engl J Med 354:333-42. 2006..There is remarkable variation in the incidence of lung cancer among ethnic and racial groups in the United States... - Characterizing genetic risk at known prostate cancer susceptibility loci in African AmericansChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America
PLoS Genet 7:e1001387. 2011..Our findings with variants at 8q24 also reinforce the importance of this region as a major risk locus for prostate cancer in men of African ancestry... - Common genetic variation at PTEN and risk of sporadic breast and prostate cancerChristopher A Haiman
University of Southern California Norris Comprehensive Cancer Center, Room 4441, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
Cancer Epidemiol Biomarkers Prev 15:1021-5. 2006..We found no strong association with any common haplotype in relation to breast or prostate cancer risk. In summary, our results show that common variants in PTEN do not substantially influence risk of these two common cancers... - Caution in generalizing known genetic risk markers for breast cancer across all ethnic/racial populationsFang Chen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Eur J Hum Genet 19:243-5. 2011..These results emphasize the need for large-scale association studies of multiple racial/ethnic groups for discovery and characterization of risk alleles relevant to all populations in the United States... - A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic CohortChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, 1441 Eastlake Ave, Rm 4441, Los Angeles, CA 90089 9175, USA
Hum Mol Genet 12:2679-92. 2003..31; 95% CI, 1.11-1.54). Our findings suggest the hypothesis that women with the long-range CYP19 haplotype 2b-3c may be carriers of a predisposing breast cancer susceptibility allele... - Igf-I genetic variation and breast cancer: the multiethnic cohortVeronica Wendy Setiawan
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Cancer Epidemiol Biomarkers Prev 15:172-4. 2006 - Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysisCeleste Leigh Pearce
Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
J Natl Cancer Inst 97:51-9. 2005..We set out to refine the association between common variation at the PGR gene locus and these two diseases... - No association of risk variants for diabetes and obesity with breast cancer: the Multiethnic Cohort and PAGE studiesFang Chen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 20:1039-42. 2011..Body mass index is an established risk factor for postmenopausal breast cancer. Epidemiologic studies have also reported a positive association between type 2 diabetes (T2D) and breast cancer risk... - Generalizability of associations from prostate cancer genome-wide association studies in multiple populationsKevin M Waters
Harlyne Norris Research Tower, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 18:1285-9. 2009..For many of these regions, fine-mapping in non-European samples may help localize causal alleles and better determine their contribution to prostate cancer risk in the population... - Breast cancer in a multiethnic cohort in Hawaii and Los Angeles: risk factor-adjusted incidence in Japanese equals and in Hawaiians exceeds that in whitesMalcolm C Pike
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Cancer Epidemiol Biomarkers Prev 11:795-800. 2002..The adjusted RR of NHs is 65% greater than that of Ws, and that of migrant Latinas is 16% lower than that of Ws. Elucidating the causes of the high rates in NHs is now a major focus of our efforts... - CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)Veronica Wendy Setiawan
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 16:2237-46. 2007..Our findings do not support the hypothesis that common germ line variation in CYP17 makes a substantial contribution to postmenopausal breast or prostate cancer susceptibility... - Comprehensive evaluation of ESR2 variation and ovarian cancer riskCeleste Leigh Pearce
USC Norris Comprehensive Cancer Center and Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 17:393-6. 2008..28-11.73; P = 0.016). Haplotype D was also reported by the BPC3 to be associated with increased risk of breast cancer. This haplotype warrants further investigation to rule out any effect with invasive ovarian cancer risk... - A systematic assessment of common genetic variation in CYP11A and risk of breast cancerVeronica Wendy Setiawan
Departments of Preventive Medicine and Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Cancer Res 66:12019-25. 2006..Based on these findings, CYP11A deserves further consideration as a candidate breast cancer susceptibility gene... - Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal womenChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
Cancer Res 67:1893-7. 2007..Thus, although genetic variation in CYP19A1 produces measurable differences in estrogen levels among postmenopausal women, the magnitude of the change was insufficient to contribute detectably to breast cancer... - Multiple regions within 8q24 independently affect risk for prostate cancerChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
Nat Genet 39:638-44. 2007..None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein... - Dietary cryptoxanthin and reduced risk of lung cancer: the Singapore Chinese Health StudyJian Min Yuan
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033 0800, USA
Cancer Epidemiol Biomarkers Prev 12:890-8. 2003..The present study lends additional credence to prior experimental and epidemiological data in support of the hypothesis that dietary beta-cryptoxanthin is a chemopreventive agent for lung cancer in humans... - No association of type 2 diabetes risk variants and prostate cancer risk: the multiethnic cohort and PAGEKevin M Waters
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Harlyne Norris Research Tower, 1450 Biggy Street, Room 1504, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 20:1979-81. 2011..We explored the hypothesis that common genetic variation may explain, in part, the inverse association between diabetes and prostate cancer... - Physical activity and colon cancer risk among women in the California Teachers StudyPhuong L Mai
Clinical Cancer Genetics Department, City of Hope National Medical Center, Duarte, CA, USA
Cancer Epidemiol Biomarkers Prev 16:517-25. 2007..One potential explanation for this inconsistency is that hormone therapy, which is associated with lower colon cancer risk, acts as a modifier of the physical activity/colon cancer relationship... - Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populationsChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Hum Mol Genet 17:825-34. 2008..The methods utilized in this study, applied to multiple populations, provide a framework for testing in association studies in diverse populations... - Risk factors for renal cell cancer: the multiethnic cohortVeronica Wendy Setiawan
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Epidemiol 166:932-40. 2007..045). Compared with nondrinkers, men who drank >or=1 drinks/day had a 31% lower risk (95% CI: 0.49, 0.96). Results show that body mass index, smoking, and hypertension are risk factors for renal cell cancer in both sexes... - A common genetic risk factor for colorectal and prostate cancerChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
Nat Genet 39:954-6. 2007..Comprehensive testing in the region uncovered variants capturing significant additional risk. Our results show that variants at 8q24 have different effects on cancer development that depend on the tissue type... - A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populationsKevin M Waters
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Cancer Epidemiol Biomarkers Prev 19:2639-46. 2010..A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer... - Correlation of dietary intake and colorectal cancer incidence among Mexican-American migrants: the multiethnic cohort studyKristine R Monroe
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Nutr Cancer 45:133-47. 2003.... - Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese womenEunjung Lee
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Norris Cancer Center, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 21:635-44. 2012..We investigated the interrelations of soy, PPARγ, and mammographic density, a biomarker of breast cancer risk in a cross-sectional study of 2,038 women who were members of the population-based Singapore Chinese Health Study Cohort... - Recent breast cancer incidence trends according to hormone therapy use: the California Teachers Study cohortSarah F Marshall
Department of Epidemiology, School of Medicine, University of California, Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
Breast Cancer Res 12:R4. 2010..Few data sources can address breast cancer incidence trends according to pertinent characteristics like hormone therapy use history... - BRCA1 variants in a family study of African-American and Latina womenRoberta McKean-Cowdin
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue MS 44, Los Angeles, CA 90089 9175, USA
Hum Genet 116:497-506. 2005..We believe this to be the largest study of high-risk African-American and Latina women sequenced for variants in the BRCA1 gene to date... - Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populationsJing He
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, Harlyne Norris Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 20:70-81. 2011..Genome-wide association studies (GWAS) in populations of European ancestry have identified several loci that confer an increased risk of colorectal cancer (CRC)... - A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancerChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, USA
Nat Genet 43:1210-4. 2011..25, P = 1.1 × 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations... - A genome-wide association study of breast cancer in women of African ancestryFang Chen
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Hum Genet 132:39-48. 2013..Identification of novel risk variants for breast cancer in women of African ancestry will demand testing of a substantially larger set of markers from stage 1 in a larger replication sample... - Bayesian spatial modeling of haplotype associationsDuncan C Thomas
University of Southern California, Los Angeles, CA 90089 9011, USA
Hum Hered 56:32-40. 2003..We conclude with a discussion of the implications of these methods for modeling cryptic relatedness, haplotype blocks, and haplotype tagging SNPs, and suggest a Bayesian framework for the HapMap project... - Comparison of prostate-specific antigen and hormone levels among men in Singapore and the United StatesIona Cheng
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA, 90089 9175, USA
Cancer Epidemiol Biomarkers Prev 14:1692-6. 2005..Given that the overall mortality rate of prostate cancer in Singapore is low, these undiagnosed cancers may be of nonaggressive type. Alternatively, PSA may be a poor marker of prostate cancer in this low-risk population... - Long-term recreational physical activity and risk of invasive and in situ breast cancer: the California teachers studyCher M Dallal
Keck School of Medicine and USC Norris Cancer Center, University of Southern California, Los Angeles, USA
Arch Intern Med 167:408-15. 2007..Long-term physical activity may affect breast cancer risk. Few prospective studies have evaluated in situ or invasive breast cancer risk, or breast cancer receptor subtypes, in relation to long-term activity... - Genome-wide association study identifies new prostate cancer susceptibility lociFredrick R Schumacher
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Hum Mol Genet 20:3867-75. 2011..72 and P= 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes... - Utilizing HapMap and tagging SNPsChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Methods Mol Med 141:37-54. 2008.... - Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer riskCeleste Leigh Pearce
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
Hum Mol Genet 20:2263-72. 2011..25). IGF2 is emerging as an important gene for ovarian cancer; additional genotyping is warranted to further confirm these associations with IGF2 and to narrow down the region harboring the causal SNP... - Population genetic structure and origins of native hawaiians in the multiethnic cohort studySung K Kim
Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America Sequenom, Incorporated, San Diego, California, United States of America
PLoS ONE 7:e47881. 2012..By providing important insight into the underlying population structure of Native Hawaiians, this study lays the foundation for future genetic association studies of this U.S. minority population... - Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African AmericansFang Chen
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Hum Mol Genet 20:4491-503. 2011..04, P = 6.1 × 10(-5)]. In this detailed analysis of the known breast cancer risk loci, we have validated and improved upon markers of risk that better characterize their association with breast cancer in women of African ancestry... - Optimal two-stage genotyping designs for genome-wide association scansHansong Wang
Division of Biostatistics and Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Genet Epidemiol 30:356-68. 2006.... - Exploring genetic susceptibility to cancer in diverse populationsChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine and the Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Curr Opin Genet Dev 20:330-5. 2010..Challenges to multiethnic studies relating to study power, control for hidden population structure, imputation, and use of shared controls for multiple cancer endpoints are discussed... - Regression calibration when foods (measured with error) are the variables of interest: markedly non-Gaussian data with many zeroesGary E Fraser
Department of Epidemiology and Biostatistics, School of Public Health, Loma Linda University, California, USA
Am J Epidemiol 175:325-31. 2012..Irrespective of fit, linear regression calibration in this situation at least approximately corrects bias. More complex linear calibration equations that improve fit may increase power over that of uncalibrated regressions... - Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21Christopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California, USA
Nat Genet 43:570-3. 2011..Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations... - Is residual confounding a reasonable explanation for the apparent protective effects of beta-carotene found in epidemiologic studies of lung cancer in smokers?Daniel O Stram
Department of Preventive Medicine, School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Epidemiol 155:622-8. 2002..Appropriate cohort studies of lung cancer in smokers, utilizing biomarkers of smoking, are needed and are presently ongoing... - A controlled 2-mo dietary fat reduction and soy food supplementation study in postmenopausal womenAnna H Wu
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90089 9175, USA
Am J Clin Nutr 81:1133-41. 2005..Low intake of dietary fat and high intake of soy foods have been suggested to partly explain the lower breast cancer rates in Asia, perhaps because of lower endogenous estrogens... - Bone marrow transplantation versus prolonged intensive chemotherapy for children with acute lymphoblastic leukemia and an initial bone marrow relapse within 12 months of the completion of primary therapy: Children's Oncology Group study CCG-1941Paul S Gaynon
Division of Hematology Oncology, Children s Hospital Los Angeles, Los Angeles, CA, USA
J Clin Oncol 24:3150-6. 2006..To compare conventional sibling bone marrow transplantation (CBMT), BMT with alternative donor (ABMT), and chemotherapy (CT) for children with acute lymphoblastic leukemia (ALL) and an early first marrow relapse... - Enlarged and prominent nucleoli may be indicative of MYCN amplification: a study of neuroblastoma (Schwannian stroma-poor), undifferentiated/poorly differentiated subtype with high mitosis-karyorrhexis indexChie Kobayashi
Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles/Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA
Cancer 103:174-80. 2005..The results of the current study indicate that nucleolar enlargement in neuroblastic cells may be a sign of MYCN amplification... - Common variation in BRCA2 and breast cancer risk: a haplotype-based analysis in the Multiethnic CohortMatthew L Freedman
The Broad Institute of MIT and Harvard, Cambridge, MA, USA
Hum Mol Genet 13:2431-41. 2004..However, a significant elevation in risk was observed among approximately 6% of women who carried a specific haplotype pattern and may harbor a susceptibility allele at the BRCA2 locus... - Re: Beta-carotene and lung cancer: a lesson for future chemoprevention investigations?Daniel O Stram
J Natl Cancer Inst 95:E4. 2003 - A haplotype-based case-control study of BRCA1 and sporadic breast cancer riskMatthew L Freedman
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Cancer Res 65:7516-22. 2005.... - Impact of radiotherapy for high-risk neuroblastoma: a Children's Cancer Group studyDaphne A Haas-Kogan
Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA
Int J Radiat Oncol Biol Phys 56:28-39. 2003..To assess the effect of local radiation administered to primary disease sites in children with high-risk neuroblastoma... - Genetic variation in the HSD17B1 gene and risk of prostate cancerPeter Kraft
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS Genet 1:e68. 2005..These results suggest that the germline variants in HSD17B1 characterized by these htSNPs do not substantially influence the risk of prostate cancer in U.S. and European whites... - Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studiesHeather Spencer Feigelson
Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, Georgia 30329, USA
Cancer Res 66:2468-75. 2006..Although the probability that these ER-negative findings are false-positive results is high, these findings were consistent across each cohort examined and warrant further study... - Breast-feeding and neuroblastoma, USA and CanadaJulie L Daniels
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Cancer Causes Control 13:401-5. 2002..Researchers have suggested an inverse association between breast-feeding and risk of childhood cancer. We investigated the association between breast-feeding and neuroblastoma in a large case-control study in the United States and Canada... - Asymptotic equivalence between two score tests for haplotype-specific risk in general linear modelsRongrong Xie
Genet Epidemiol 29:166-70. 2005 - An utter refutation of the "Fundamental Theorem of the HapMap" by Terwilliger and HiekkalinnaDuncan C Thomas
Eur J Hum Genet 14:1238-9. 2006 - Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort ConsortiumYen Ching Chen
Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 16:1973-81. 2007..Estrogen receptor beta (ESR2) may play a role in modulating prostate carcinogenesis through the regulation of genes related to cell proliferation and apoptosis... - Calcium, vitamin D, and dairy product intake and prostate cancer risk: the Multiethnic Cohort StudySong Yi Park
Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
Am J Epidemiol 166:1259-69. 2007.... - Re: the use of inferred haplotypes in downstream analysisPeter Kraft
Am J Hum Genet 81:863-5; author reply 865-6. 2007 - Hypothesis testing, statistical power, and confidence limits in the presence of epistemic uncertaintyDaniel O Stram
Health Phys 93:326-7; author reply 327-8. 2007 - Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristicsMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
PLoS Genet 4:e1000054. 2008..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment... - Dietary patterns and risk of ovarian cancer in the California Teachers Study cohortEllen T Chang
Northern California Cancer Center, Fremont, California 94538, USA
Nutr Cancer 60:285-91. 2008..Overall, our results show no convincing associations between dietary patterns and ovarian cancer risk... - Dietary fiber and colorectal cancer risk: the multiethnic cohort studyAbraham M Y Nomura
Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
Cancer Causes Control 18:753-64. 2007..To investigate the association of dietary fiber with colorectal cancer.. - IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)Alpa V Patel
Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
PLoS ONE 3:e2578. 2008..In summary, the impact of genetic variation in IGF1 and IGFBP3 on circulating IGF levels does not appear to substantially influence breast cancer risk substantially among primarily Caucasian postmenopausal women... - A common 8q24 variant in prostate and breast cancer from a large nested case-control studyFredrick R Schumacher
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Cancer Res 67:2951-6. 2007..590). Although the gene responsible has yet to be identified, the validation of this marker in this large sample of prostate cancer cases leaves little room for the possibility of a false-positive result... - Exploiting gene-environment interaction to detect genetic associationsPeter Kraft
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Hum Hered 63:111-9. 2007..This makes the joint test an attractive tool for large-scale association scans where the true gene-environment interaction model is unknown... - Diet and risk of ovarian cancer in the California Teachers Study cohortEllen T Chang
Northern California Cancer Center, Fremont, CA 94538, USA
Am J Epidemiol 165:802-13. 2007..Although dietary consumption of isoflavones may be associated with decreased ovarian cancer risk, most dietary factors are unlikely to play a major role in ovarian cancer development... - Wine and other alcohol consumption and risk of ovarian cancer in the California Teachers Study cohortEllen T Chang
Northern California Cancer Center, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA
Cancer Causes Control 18:91-103. 2007..Whether alcohol consumption influences ovarian cancer risk is unclear. Therefore, we investigated the association between alcohol intake at various ages and risk of ovarian cancer... - Transferability of tag SNPs in genetic association studies in multiple populationsPaul I W de Bakker
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts, 02142, USA
Nat Genet 38:1298-303. 2006..These results demonstrate that the HapMap DNA samples can be used to select tags for genome-wide association studies in many samples around the world... - Haplotypes of the estrogen receptor beta gene and breast cancer riskDavid G Cox
Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
Int J Cancer 122:387-92. 2008..These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women...