Stephen Strakowski

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Is depression simply a nonspecific response to brain injury?
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Curr Psychiatry Rep 15:386. 2013
  2. pmc The functional neuroanatomy of bipolar disorder: a consensus model
    Stephen M Strakowski
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 14:313-25. 2012
  3. pmc Impulsivity across the course of bipolar disorder
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0583, Cincinnati, OH 45267 0583, USA
    Bipolar Disord 12:285-97. 2010
  4. ncbi request reprint A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder
    Stephen M Strakowski
    Bipolar and Psychotic Disorders Research Program, University of Cincinnati College of Medicine, OH 45267 0583, USA
    Neuropsychopharmacology 29:1734-40. 2004
  5. ncbi request reprint Outcome following a first manic episode: cross-national US and Taiwan comparison
    Stephen M Strakowski
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:820-7. 2007
  6. ncbi request reprint Effects of co-occurring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0559, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Arch Gen Psychiatry 62:851-8. 2005
  7. pmc Characterizing impulsivity in mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Universtiy of Cincinnati College of Medicine, Cincinnati, OH, USA
    Bipolar Disord 11:41-51. 2009
  8. pmc Magnetic resonance imaging brain activation in first-episode bipolar mania during a response inhibition task
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry, and the Centefor Imaging Research, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Early Interv Psychiatry 2:225-33. 2008
  9. ncbi request reprint Abnormal FMRI brain activation in euthymic bipolar disorder patients during a counting Stroop interference task
    Stephen M Strakowski
    Center for Imaging Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0583, USA
    Am J Psychiatry 162:1697-705. 2005
  10. ncbi request reprint Effects of co-occurring cannabis use disorders on the course of bipolar disorder after a first hospitalization for mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, 2341 Albert Sabin Way, Cincinnati, OH 45267, USA
    Arch Gen Psychiatry 64:57-64. 2007

Research Grants

  1. Impulsivity as a Core Trait of Bipolar Disorder
    Stephen Strakowski; Fiscal Year: 2007
  2. Ethnicity and the Diagnosis of Affective Illness
    Stephen Strakowski; Fiscal Year: 2007
  3. U of Cincinnati Bipolar Disorder Imaging & Treatment Research Center (BITREC)
    Stephen Strakowski; Fiscal Year: 2007
  4. Anterior limbic network dysfunction in bipolar disorder
    Stephen Strakowski; Fiscal Year: 2007
  5. SUBSTANCE ABUSE IN FIRST EPISODE MANIA
    Stephen Strakowski; Fiscal Year: 2003

Detail Information

Publications77

  1. pmc Is depression simply a nonspecific response to brain injury?
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Curr Psychiatry Rep 15:386. 2013
    ....
  2. pmc The functional neuroanatomy of bipolar disorder: a consensus model
    Stephen M Strakowski
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 14:313-25. 2012
    ....
  3. pmc Impulsivity across the course of bipolar disorder
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0583, Cincinnati, OH 45267 0583, USA
    Bipolar Disord 12:285-97. 2010
    ..To determine whether abnormalities of impulse control persist across the course of bipolar disorder, thereby representing potential state markers and endophenotypes...
  4. ncbi request reprint A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder
    Stephen M Strakowski
    Bipolar and Psychotic Disorders Research Program, University of Cincinnati College of Medicine, OH 45267 0583, USA
    Neuropsychopharmacology 29:1734-40. 2004
    ..Since the differences occurred in euthymia, they may represent trait, rather than state, abnormalities of brain function in bipolar disorder...
  5. ncbi request reprint Outcome following a first manic episode: cross-national US and Taiwan comparison
    Stephen M Strakowski
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:820-7. 2007
    ..Therefore, the aim of this study was to identify differential and shared outcome predictors in first-episode manic bipolar patients in Cincinnati, OH, USA and Taipei, Taiwan...
  6. ncbi request reprint Effects of co-occurring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0559, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Arch Gen Psychiatry 62:851-8. 2005
    ..Alcohol-use disorders are common co-occurring conditions affecting bipolar patients, and this co-occurrence is negatively associated with outcome...
  7. pmc Characterizing impulsivity in mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Universtiy of Cincinnati College of Medicine, Cincinnati, OH, USA
    Bipolar Disord 11:41-51. 2009
    ....
  8. pmc Magnetic resonance imaging brain activation in first-episode bipolar mania during a response inhibition task
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry, and the Centefor Imaging Research, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Early Interv Psychiatry 2:225-33. 2008
    ..Impulsivity is common in bipolar disorder, especially during mania. Understanding the functional neuroanatomy of response inhibition, one component of impulsivity, might clarify the neural substrate of bipolar disorder...
  9. ncbi request reprint Abnormal FMRI brain activation in euthymic bipolar disorder patients during a counting Stroop interference task
    Stephen M Strakowski
    Center for Imaging Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0583, USA
    Am J Psychiatry 162:1697-705. 2005
    ..Cognitive probes, coupled with neuroimaging, provide an approach toward clarifying the neurophysiology of bipolar disorder...
  10. ncbi request reprint Effects of co-occurring cannabis use disorders on the course of bipolar disorder after a first hospitalization for mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, 2341 Albert Sabin Way, Cincinnati, OH 45267, USA
    Arch Gen Psychiatry 64:57-64. 2007
    ..Cannabis use disorders commonly co-occur in bipolar disorder; however, the effects of cannabis abuse on outcome have been minimally studied...
  11. ncbi request reprint Quality of life during treatment with haloperidol or olanzapine in the year following a first psychotic episode
    Stephen M Strakowski
    Center for Imaging Research and Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0583, Cincinnati, OH 45267 0583, USA
    Schizophr Res 78:161-9. 2005
    ..This improvement is particularly relevant early in the course of schizophrenia...
  12. pmc Functional magnetic resonance imaging brain activation in bipolar mania: evidence for disruption of the ventrolateral prefrontal-amygdala emotional pathway
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559 USA
    Biol Psychiatry 69:381-8. 2011
    ..We used functional magnetic resonance imaging (fMRI) to study manic bipolar subjects as they performed a cognitive task designed to examine the ventrolateral prefrontal emotional arousal network...
  13. pmc Neuroanatomical characterization of child offspring of bipolar parents
    Manpreet K Singh
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati, OH 45267 0559, USA
    J Am Acad Child Adolesc Psychiatry 47:526-31. 2008
    ..We hypothesized that at-risk (AR) children would exhibit abnormalities in brain regions that are involved in mood regulation...
  14. ncbi request reprint Ethnicity and diagnosis in patients with affective disorders
    Stephen M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Clin Psychiatry 64:747-54. 2003
    ..Why this occurs is unknown. Extending prior work, the authors hypothesized that first-rank symptoms distract clinicians so that they fail to identify affective disorders in African Americans...
  15. ncbi request reprint Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders
    Kim M Cecil
    Imaging Research Center, Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Child Adolesc Psychopharmacol 13:545-55. 2003
    ....
  16. ncbi request reprint The efficacy and tolerability of quetiapine versus divalproex for the treatment of impulsivity and reactive aggression in adolescents with co-occurring bipolar disorder and disruptive behavior disorder(s)
    Drew H Barzman
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    J Child Adolesc Psychopharmacol 16:665-70. 2006
    ..The aim of this study was to compare the efficacy and tolerability of quetiapine and divalproex for the treatment of impulsivity and reactive aggression in adolescents with co-occurring bipolar disorder and disruptive behavior disorders...
  17. ncbi request reprint Psychopathology in children of bipolar parents
    Manpreet K Singh
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Affect Disord 102:131-6. 2007
    ..Few studies have examined the psychopathological profiles of child offspring of bipolar parents. Such investigations are useful as a first step to identifying potential prodromal manifestations of bipolar disorder...
  18. ncbi request reprint The effect of multiple doses of cimetidine on the steady-state pharmacokinetics of quetiapine in men with selected psychotic disorders
    Stephen M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychopharmacol 22:201-5. 2002
    ..No serious adverse events were observed during quetiapine treatment. No clinically relevant alterations in quetiapine pharmacokinetics were observed after cimetidine coadministration in patients with psychotic disorders...
  19. pmc Inhibition and attention in adolescents with nonmanic mood disorders and a high risk for developing mania
    Manpreet K Singh
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati, Cincinnati, OH, USA
    J Clin Exp Neuropsychol 31:1-7. 2009
    ..75), and color naming speed (d = 0.88). The results indicate that MD participants exhibit psychomotor disinhibition, marginal cognitive slowing and cautious response biases, but no formal deficits in sustained or selective attention...
  20. ncbi request reprint Severity of bipolarity in hospitalized manic adolescents with history of stimulant or antidepressant treatment
    Cesar A Soutullo
    University of Cincinnati, Department of Psychiatry, Biological Psychiatry and Psychotic and Bipolar Disorders Research Programs, PO Box 670559, 231 Bethesda Avenue, Cincinnati, OH 45267 0559, USA
    J Affect Disord 70:323-7. 2002
    ..Childhood bipolarity (BP) and ADHD frequently co-occur, these children often receive stimulants...
  21. ncbi request reprint Adjunctive topiramate in hospitalized children and adolescents with bipolar disorders
    Drew H Barzman
    Cincinnati Children s Hospital Medical Center, Division of Child and Adolescent Psychiatry, and Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267, USA
    J Child Adolesc Psychopharmacol 15:931-7. 2005
    ..The aim of this study was to assess topiramate as adjunctive treatment in children and adolescents hospitalized with bipolar disorders...
  22. ncbi request reprint Health-related quality of life in adolescents with bipolar I disorder
    Jennifer Rademacher
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Child Adolesc Psychopharmacol 17:97-103. 2007
    ..To examine abnormalities in health-related quality of life (HRQOL) and to determine whether pharmacological intervention with divalproex or quetiapine alters HRQOL abnormalities in bipolar adolescents...
  23. ncbi request reprint Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy
    Kim M Cecil
    Imaging Research Center, Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Bipolar Disord 4:357-65. 2002
    ..Patients with bipolar disorder having a manic or mixed episode were hypothesized to demonstrate metabolic abnormalities within the frontal lobe...
  24. ncbi request reprint Rates, types, and psychosocial correlates of legal charges in adolescents with newly diagnosed bipolar disorder
    Drew H Barzman
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati, OH 45229 3039, USA
    Bipolar Disord 9:339-44. 2007
    ..To examine the rates, types, and psychosocial correlates of legal charges in adolescents with newly diagnosed bipolar disorder (BD)...
  25. doi request reprint Cerebellar ataxia in youths at risk for bipolar disorder
    Lisa L Giles
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 10:733-7. 2008
    ..The present study examined cerebellar function in youths who were at familial risk for BD by comparing ataxia battery scores of youths with a bipolar parent to those of healthy youths...
  26. ncbi request reprint A retrospective chart review of intramuscular ziprasidone for agitation in children and adolescents on psychiatric units: prospective studies are needed
    Drew H Barzman
    Children s Hospital Medical Center, Division of Child and Adolescent Psychiatry, Cincinnati, Ohio 45229 3039, USA
    J Child Adolesc Psychopharmacol 17:503-9. 2007
    ..Our secondary objective was to examine demographic and clinical factors associated with treatment response...
  27. doi request reprint Meta-analysis of amygdala volumes in children and adolescents with bipolar disorder
    Jonathan C Pfeifer
    Department of Psychiatry, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Am Acad Child Adolesc Psychiatry 47:1289-98. 2008
    ..Therefore, we conducted a meta-analysis summarizing the literature examining amygdala size obtained from magnetic resonance imaging in bipolar youths and adults...
  28. doi request reprint Establishing the neurobiologic basis of treatment in children and adolescents with generalized anxiety disorder
    Jeffrey R Strawn
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Depress Anxiety 29:328-39. 2012
    ..These findings also raise the possibility that functional activity within the amygdala and VLPFC may be altered following successful treatment...
  29. pmc Lithium treatment effects on Myo-inositol in adolescents with bipolar depression
    Nick C Patel
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0004, USA
    Biol Psychiatry 60:998-1004. 2006
    ..This study used proton magnetic resonance spectroscopy (1H MRS) to identify the in vivo effects of lithium on myo-inositol (mI) concentrations in adolescent bipolar depression...
  30. ncbi request reprint Dopamine and serotonin receptor binding and antipsychotic efficacy
    Neil M Richtand
    Psychiatry Service, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH, USA
    Neuropsychopharmacology 32:1715-26. 2007
    ..2) Increasing 5-HT(2C) and 5-HT(2A) receptor-binding affinities also facilitate antipsychotic efficacy. (3) Increasing 5-HT(1A) receptor-binding affinity, in contrast, reduces antipsychotic efficacy...
  31. ncbi request reprint Voxel-based study of structural changes in first-episode patients with bipolar disorder
    Caleb M Adler
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Biol Psychiatry 61:776-81. 2007
    ..In this study, we used VBM to explore structural brain changes in first-episode bipolar patients...
  32. doi request reprint Wisconsin Card Sorting Test performance in bipolar disorder: effects of mood state and early course
    David E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Bipolar Disord 10:539-45. 2008
    ..However, it is unclear to what extent executive dysfunction exists (i) during syndromal remission, when mood symptoms are attenuated, and (ii) during the early course of bipolar disorder...
  33. ncbi request reprint Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode
    Melissa P DelBello
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Am J Psychiatry 164:582-90. 2007
    ..The aim of this study was to examine the 12-month outcome of bipolar adolescents following an initial hospitalization for a manic or mixed episode...
  34. ncbi request reprint Response and remission in adolescent mania: signal detection analyses of the young mania rating scale
    Nick C Patel
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0004, USA
    J Am Acad Child Adolesc Psychiatry 46:628-35. 2007
    ..The purpose of this study was to determine optimal criteria for defining response and remission in adolescents with acute mania...
  35. pmc Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study
    Robert K McNamara
    Department of Psychiatry, Center for Imaging Research, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
    Am J Clin Nutr 91:1060-7. 2010
    ..However, the effects of DHA supplementation on functional cortical activity in human subjects are unknown...
  36. pmc Temperament in child offspring of parents with bipolar disorder
    Manpreet K Singh
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati, Cincinnati, Ohio 45267 0559, USA
    J Child Adolesc Psychopharmacol 18:589-93. 2008
    ..The aim of this study was to examine the relationship between temperament and psychopathology in child offspring of parents with bipolar disorder...
  37. ncbi request reprint A 12-week single-blind trial of quetiapine for the treatment of mood symptoms in adolescents at high risk for developing bipolar I disorder
    Melissa P DelBello
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 68:789-95. 2007
    ..To investigate the effectiveness and tolerability of quetiapine for the treatment of adolescents at high risk for developing bipolar I disorder...
  38. ncbi request reprint Body mass indexes and lipid profiles in hospitalized children and adolescents exposed to atypical antipsychotics
    Nick C Patel
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, and Department of Psychiatry, Cincinnati Children s Hospital Medical Center, Ohio 45267 0004, USA
    J Child Adolesc Psychopharmacol 17:303-11. 2007
    ..The purpose of this study was to examine body mass indexes (BMI) and lipid profiles of children and adolescents hospitalized for a psychiatric illness and exposed to an atypical antipsychotic...
  39. pmc Neuroanatomic comparison of bipolar adolescents with and without cannabis use disorders
    Kelly Jarvis
    University of Cincinnati, Division of Bipolar Disorders Research, Department of Psychiatry, Cincinnati, OH 45267 0559, USA
    J Child Adolesc Psychopharmacol 18:557-63. 2008
    ..In this pilot study, we compared brain morphometry between bipolar adolescents with co-occurring cannabis use disorders (CUD) and bipolar adolescents without any substance use disorder...
  40. doi request reprint Cigarette smoking in the early course of bipolar disorder: association with ages-at-onset of alcohol and marijuana use
    Jaimee L Heffner
    Tri State Tobacco and Alcohol Research Center, University of Cincinnati Genome Research Institute, Cincinnati, OH 45237, USA
    Bipolar Disord 10:838-45. 2008
    ..e., three or more times per week for a month or more)...
  41. ncbi request reprint Concurrent tracking of alcohol use and bipolar disorder symptoms
    David E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 8:338-44. 2006
    ..The primary aim of this analysis was to examine concurrent symptom tracking and how the relative onsets of AUD and BD influence the concurrent tracking of symptoms...
  42. ncbi request reprint Obstetrical complications in children at high risk for bipolar disorder
    Manpreet K Singh
    Center for Bipolar Disorders Research, University of Cincinnati College of Medicine, and Cincinnati Children s Hospital Medical Center, Division of Child and Adolescent Psychiatry, Cincinnati, OH 45267 0559, United States
    J Psychiatr Res 41:680-5. 2007
    ..Additionally, within this "at-risk" (AR) sample, we hypothesized that obstetrical complications would be associated with the development of psychiatric disorders...
  43. ncbi request reprint Sex, ethnicity, and antipsychotic medication use in patients with psychosis
    Lesley M Arnold
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    Schizophr Res 66:169-75. 2004
    ..There were no ethnic or sex differences in the dosing of antipsychotics for the treatment of schizophrenia spectrum disorders. There were also no ethnic or sex differences in the use of second-generation antipsychotics...
  44. ncbi request reprint Volumetric MRI studies of mood disorders: do they distinguish unipolar and bipolar disorder?
    Stephen M Strakowski
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Bipolar Disord 4:80-8. 2002
    ..This hypothesis remains speculative as much more research is needed to specifically examine how morphometric brain abnormalities translate into the neurophysiologic deficits that produce mood disorders...
  45. ncbi request reprint Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task
    Caleb M Adler
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 6:540-9. 2004
    ..We hypothesized that patients with bipolar disorder would demonstrate changes in neuronal activation in specific regions forming part of the working memory network...
  46. ncbi request reprint Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study
    Caleb M Adler
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Bipolar Disord 6:197-203. 2004
    ..In this study we utilized diffusion tensor imaging (DTI) to examine prefrontal white matter in patients with bipolar disorder...
  47. ncbi request reprint A double-blind, randomized, placebo-controlled study of quetiapine as adjunctive treatment for adolescent mania
    Melissa P DelBello
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Am Acad Child Adolesc Psychiatry 41:1216-23. 2002
    ..It was hypothesized that DVP in combination with quetiapine would be more effective than DVP alone for treating mania associated with adolescent bipolar disorder. Furthermore, it was hypothesized that quetiapine would be well tolerated...
  48. ncbi request reprint Ventricular and periventricular structural volumes in first- versus multiple-episode bipolar disorder
    Stephen M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Am J Psychiatry 159:1841-7. 2002
    ..In addition, it is unknown whether ventriculomegaly in bipolar disorder reflects acquired volume loss or underdevelopment of periventricular structures...
  49. ncbi request reprint Adjunctive topiramate treatment for pediatric bipolar disorder: a retrospective chart review
    Melissa P DelBello
    Bipolar and Psychiatric Disorders Research Program, Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267, USA
    J Child Adolesc Psychopharmacol 12:323-30. 2002
    ..The objective of this study was to evaluate the effectiveness, safety, and tolerability of the anticonvulsant agent, topiramate, as adjunctive treatment for children and adolescents with bipolar disorders...
  50. ncbi request reprint Atypical antipsychotics in the treatment of bipolar disorder
    Stephen M Strakowski
    Department of Psychiatry, University of Cincinnati College of Medicine, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Expert Opin Pharmacother 4:751-60. 2003
    ..Atypical antipsychotics offer different side effect profiles than older antipsychotics, which may be of benefit for some patients. Consequently, atypical antipsychotics provide an important treatment option for bipolar patients...
  51. ncbi request reprint Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder
    Melissa P DelBello
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Bipolar Disord 6:43-52. 2004
    ..We hypothesized that adolescents with bipolar disorder would exhibit abnormalities in brain regions that are involved in the regulation of mood including the amygdala, globus pallidus, caudate, putamen, and thalamus...
  52. ncbi request reprint Parental reports of executive dysfunction in adolescents with bipolar disorder
    Paula K Shear
    Department of Psychology, University of Cincinnati, OH 45221, USA
    Child Neuropsychol 8:285-95. 2002
    ..The findings suggest that adolescents with BPD have functional deficits on tasks requiring executive functioning skills that are not explicable solely on the basis of comorbid ADHD...
  53. ncbi request reprint Rates and predictors of developing a manic or hypomanic episode 1 to 2 years following a first hospitalization for major depression with psychotic features
    Melissa P DelBello
    The Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Child Adolesc Psychopharmacol 13:173-85. 2003
    ....
  54. ncbi request reprint Processing efficiency and sustained attention in bipolar disorder
    David E Fleck
    Center for Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Int Neuropsychol Soc 11:49-57. 2005
    ..Problems with processing efficiency are viewed as trait characteristics of bipolar disorder that may be overlooked by traditional error-based assessments...
  55. ncbi request reprint Working memory and inhibitory control among manic and euthymic patients with bipolar disorder
    Eric R Larson
    Center for Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
    J Int Neuropsychol Soc 11:163-72. 2005
    ..These results indicated that patients in the present sample had relatively normal working memory abilities, but had a deficit in behavioral self-regulation, which was evident across mood states...
  56. ncbi request reprint The neurophysiology of childhood and adolescent bipolar disorder
    Melissa P DelBello
    Division of Bipolar Disorder Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    CNS Spectr 11:298-311. 2006
    ....
  57. ncbi request reprint Open-label lithium for the treatment of adolescents with bipolar depression
    Nick C Patel
    College of Pharmacy and Department of Psychiatry, University of Cincinnati, OH 45267 0004, USA
    J Am Acad Child Adolesc Psychiatry 45:289-97. 2006
    ..We hypothesized that patients receiving open-label treatment with lithium during a 6-week period would experience a statistically and clinically significant decrease in depressive symptoms and tolerate lithium treatment fairly well...
  58. ncbi request reprint Processing efficiency and directed forgetting in bipolar disorder
    David E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Int Neuropsychol Soc 11:871-80. 2005
    ..Problems with processing efficiency are viewed as trait characteristics of bipolar disorder that may be overlooked by traditional error-based assessments...
  59. ncbi request reprint Ethnic differences in symptom presentation of youths with bipolar disorder
    Nick C Patel
    The College of Pharmacy, University of Cincinnati, OH 45267 0004, USA
    Bipolar Disord 8:95-9. 2006
    ..To compare symptom profiles of African-American and white adolescents with a diagnosis of bipolar disorder...
  60. ncbi request reprint Phenomenology associated with age at onset in patients with bipolar disorder at their first psychiatric hospitalization
    Nick C Patel
    College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267 0004, USA
    Bipolar Disord 8:91-4. 2006
    ..To compare the clinical presentation of patients with early-onset (age <18 years) and typical-onset (age 20-30 years) bipolar disorder at the time of first hospitalization...
  61. ncbi request reprint Comorbid ADHD is associated with altered patterns of neuronal activation in adolescents with bipolar disorder performing a simple attention task
    Caleb M Adler
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Bipolar Disord 7:577-88. 2005
    ..In this study we utilized functional magnetic resonance imaging (fMRI) to compare activation patterns during performance of a simple attention task between bipolar adolescents with and without ADHD...
  62. ncbi request reprint Ethnic differences in maintenance antipsychotic prescription among adolescents with bipolar disorder
    Nick C Patel
    Department of Psychiatry, University of Cincinnati, and the General Clinical Research Center and Mental Health Service Line, Cincinnati Veterans Affairs Medical Center, Ohio 45267 0004, USA
    J Child Adolesc Psychopharmacol 15:938-46. 2005
    ..The aim of this study was to compare the longitudinal use of psychotropic medications in African-American and Caucasian adolescents with a diagnosis of bipolar disorder following their first psychiatric hospitalization...
  63. ncbi request reprint Neuroanatomic characterization of schizoaffective disorder using MRI: a pilot study
    Glen E Getz
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Schizophr Res 55:55-9. 2002
    ..Patients diagnosed with SCA exhibited regional abnormalities on the striatum that resemble those seen in BPD. This study suggests that SCA has some neuroanatomical characteristics similar to BPD...
  64. ncbi request reprint MRI analysis of cerebellar vermal abnormalities in bipolar disorder
    Neil P Mills
    Center for Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Am J Psychiatry 162:1530-2. 2005
    ..The authors sought to expand previous findings of vermal abnormalities in bipolar disorder patients...
  65. ncbi request reprint Verbal memory in mania: effects of clinical state and task requirements
    David E Fleck
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 5:375-80. 2003
    ..Manic patients exhibit impaired verbal learning and memory, particularly following longstanding illness. However, it is unclear whether recognition and recall performance are differentially influenced by a manic mood state...
  66. ncbi request reprint Brain network dysfunction in bipolar disorder
    Caleb M Adler
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    CNS Spectr 11:312-20; quiz 323-4. 2006
    ..As neuroimaging techniques continue to improve, the underlying neural basis of bipolar disorder will be clarified...
  67. doi request reprint Neurochemical alteration in the caudate: implications for the pathophysiology of bipolar disorder
    Nasrin Shahana
    Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States
    Psychiatry Res 193:107-12. 2011
    ..While speculative, these results suggest that AAP do not cause oxidative injury to neuronal membranes...
  68. ncbi request reprint The McLean-Harvard First-Episode Mania Study: prediction of recovery and first recurrence
    Mauricio Tohen
    Lilly Research Laboratories, Brougher Building, 525 South Meridian, Indianapolis, IN 46225, USA
    Am J Psychiatry 160:2099-107. 2003
    ..Since improved prediction of illness course early in bipolar disorder is required to guide treatment planning, the authors evaluated recovery, first recurrence, and new illness onset following first hospitalization for mania...
  69. ncbi request reprint Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol
    Robert B Zipursky
    Schizophrenia Programme, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Br J Psychiatry 187:537-43. 2005
    ..Substantial weight gain is common with many atypical antipsychotics...
  70. ncbi request reprint Parametric neurocognitive task design: a pilot study of sustained attention in adolescents with bipolar disorder
    Melissa P DelBello
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Bethesda Ave, P O Box 670559, Cincinnati, OH 45267 0559, USA
    J Affect Disord 82:S79-88. 2004
    ..Additionally, we hypothesized that the groups would exhibit a similar decline in task performance as level of task difficulty increased and that within each level of task difficulty there would be similar performance among groups...
  71. ncbi request reprint Memantine normalizes brain activity in the inferior frontal gyrus: a controlled pilot fMRI study
    Michael A Cerullo
    Schizophr Res 97:294-6. 2007
  72. ncbi request reprint Anterior cingulate subregion volumes and executive function in bipolar disorder
    Molly E Zimmerman
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02912, USA
    Bipolar Disord 8:281-8. 2006
    ....
  73. doi request reprint Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium
    Nick C Patel
    College of Pharmacy, University of Georgia, Medical College of Georgia, Augusta, Georgia 30912 2450, USA
    J Child Adolesc Psychopharmacol 18:132-9. 2008
    ..This proton magnetic resonance spectroscopy (1H MRS) study identified the in vivo effects of lithium on N-acetyl-aspartate (NAA) concentrations in adolescent bipolar depression...
  74. ncbi request reprint First episode schizophrenia-related psychosis and substance use disorders: acute response to olanzapine and haloperidol
    Alan I Green
    Commonwealth Research Center and the Massachusetts Mental Health Center, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 66:125-35. 2004
    ..We report on rates of co-occurring substance use disorders in patients within their first episode of schizophrenia-related psychosis from a multicenter, international treatment trial of olanzapine vs. haloperidol...
  75. ncbi request reprint Selective attention in schizoaffective disorder: pilot data
    David E Fleck
    Schizophr Res 68:109-10. 2004
  76. ncbi request reprint Ethnicity and first-rank symptoms in patients with psychosis
    Lesley M Arnold
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Schizophr Res 67:207-12. 2004
    ..These findings indicate that psychotic symptom presentation should be evaluated in the context of other symptoms (e.g., affective symptoms) in diagnostic assessments in order to prevent misdiagnoses of schizophrenia...
  77. doi request reprint Hyperthermia and rhabdomyolysis in an adolescent treated with topiramate and olanzapine
    Jeffrey R Strawn
    J Child Adolesc Psychopharmacol 18:116-8. 2008

Research Grants22

  1. Impulsivity as a Core Trait of Bipolar Disorder
    Stephen Strakowski; Fiscal Year: 2007
    ....
  2. Ethnicity and the Diagnosis of Affective Illness
    Stephen Strakowski; Fiscal Year: 2007
    ..The final objective is to determine whether Latinos are at risk for similar problems in diagnostic assessments and treatment assignment. ..
  3. U of Cincinnati Bipolar Disorder Imaging & Treatment Research Center (BITREC)
    Stephen Strakowski; Fiscal Year: 2007
    ....
  4. Anterior limbic network dysfunction in bipolar disorder
    Stephen Strakowski; Fiscal Year: 2007
    ..Finally, this work will provide a neurophysiologic substrate to inform additional investigations aimed at identify mechanisms underlying anterior limbic dysfunction both in human and animal models. ..
  5. SUBSTANCE ABUSE IN FIRST EPISODE MANIA
    Stephen Strakowski; Fiscal Year: 2003
    ..The results of this study could have immediate impact on how treatment of this patient population is developed. ..