Stefan Strack

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Allosteric modulation of Drp1 mechanoenzyme assembly and mitochondrial fission by the variable domain
    Stefan Strack
    Department of Pharmacology, The University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 287:10990-1001. 2012
  2. pmc N-terminal phosphorylation of protein phosphatase 2A/Bβ2 regulates translocation to mitochondria, dynamin-related protein 1 dephosphorylation, and neuronal survival
    Ronald A Merrill
    Department of Pharmacology, University of Iowa, Iowa City, IA 52242, USA
    FEBS J 280:662-73. 2013
  3. pmc Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1
    Ronald A Merrill
    Department of Pharmacology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Biol 9:e1000612. 2011
  4. pmc The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation
    Michael J Van Kanegan
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Mol Cell Biol 29:662-74. 2009
  5. pmc A calcineurin docking motif (LXVP) in dynamin-related protein 1 contributes to mitochondrial fragmentation and ischemic neuronal injury
    Andrew M Slupe
    Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 288:12353-65. 2013
  6. pmc Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons
    JASON D ULRICH
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 287:37594-609. 2012
  7. pmc Molecular determinants for PP2A substrate specificity: charged residues mediate dephosphorylation of tyrosine hydroxylase by the PP2A/B' regulatory subunit
    Amit Saraf
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Biochemistry 49:986-95. 2010
  8. pmc The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission
    Ruben K Dagda
    Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 283:36241-8. 2008
  9. pmc Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules
    Stefan Strack
    Department of Pharmacology, University of Iowa, Iowa City, IA 52246, USA
    J Cell Biol 201:1037-51. 2013
  10. ncbi Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes
    Deanna G Adams
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 280:42644-54. 2005

Collaborators

Detail Information

Publications24

  1. pmc Allosteric modulation of Drp1 mechanoenzyme assembly and mitochondrial fission by the variable domain
    Stefan Strack
    Department of Pharmacology, The University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 287:10990-1001. 2012
    ..This in turn modulates Arg-376-dependent OMM targeting of Drp1 via multivalent interactions with Mff...
  2. pmc N-terminal phosphorylation of protein phosphatase 2A/Bβ2 regulates translocation to mitochondria, dynamin-related protein 1 dephosphorylation, and neuronal survival
    Ronald A Merrill
    Department of Pharmacology, University of Iowa, Iowa City, IA 52242, USA
    FEBS J 280:662-73. 2013
    ..These results reveal another layer of complexity in the regulation of the mitochondrial fission-fusion equilibrium and its physiological and pathophysiological consequences in the nervous system...
  3. pmc Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1
    Ronald A Merrill
    Department of Pharmacology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Biol 9:e1000612. 2011
    ..Unopposed fusion then promotes formation of a mitochondrial reticulum, which protects neurons from diverse insults...
  4. pmc The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation
    Michael J Van Kanegan
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Mol Cell Biol 29:662-74. 2009
    ....
  5. pmc A calcineurin docking motif (LXVP) in dynamin-related protein 1 contributes to mitochondrial fragmentation and ischemic neuronal injury
    Andrew M Slupe
    Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 288:12353-65. 2013
    ..These results point to the CaN-Drp1 complex as a potential target for neuroprotective therapy of ischemic stroke...
  6. pmc Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons
    JASON D ULRICH
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 287:37594-609. 2012
    ....
  7. pmc Molecular determinants for PP2A substrate specificity: charged residues mediate dephosphorylation of tyrosine hydroxylase by the PP2A/B' regulatory subunit
    Amit Saraf
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Biochemistry 49:986-95. 2010
    ....
  8. pmc The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission
    Ruben K Dagda
    Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 283:36241-8. 2008
    ....
  9. pmc Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules
    Stefan Strack
    Department of Pharmacology, University of Iowa, Iowa City, IA 52246, USA
    J Cell Biol 201:1037-51. 2013
    ..Thus, alternative splicing generates a latent, cytoskeletal pool of Drp1 that is selectively mobilized by cyclin-dependent kinase signaling. ..
  10. ncbi Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes
    Deanna G Adams
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 280:42644-54. 2005
    ..Together these findings indicate that PP2A ABalphaC and ABdeltaC holoenzymes function as positive regulators of Raf1-MEK1/2-ERK1/2 signaling by targeting Raf1...
  11. pmc PKA/AKAP1 and PP2A/Bβ2 regulate neuronal morphogenesis via Drp1 phosphorylation and mitochondrial bioenergetics
    Audrey S Dickey
    Department of Pharmacology and Neuroscience Graduate Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 31:15716-26. 2011
    ..We propose that the bioenergetic state of mitochondria, rather than their localization or shape per se, is the key effector of Drp1, altering calcium homeostasis to modulate neuronal morphology and connectivity...
  12. pmc Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons
    Katrin Schnizler
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Neurosci 28:4904-17. 2008
    ..Together, these data suggest that PKA anchoring by AKAP150 is essential for the enhancement of TRPV1 function by activation of the PGE(2)/PKA signaling pathway...
  13. doi Functional characterization of phosphorylation sites in dynamin-related protein 1
    J Thomas Cribbs
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Methods Enzymol 457:231-53. 2009
    ..We also discuss primary astrocyte cultures as a model for regulation of cell death and mitochondrial morphology by Drp1 and present ImageJ macro source code for unbiased quantification of mitochondrial shape changes...
  14. pmc Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death
    J Thomas Cribbs
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    EMBO Rep 8:939-44. 2007
    ..Thus, Drp1 phosphorylation at Ser 656 provides a mechanism for the integration of cAMP and calcium signals in the control of mitochondrial shape, apoptosis and other aspects of mitochondrial function...
  15. ncbi Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation
    Duane D Hall
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1109, USA
    Biochemistry 45:3448-59. 2006
    ..2 is required for effective reversal of PKA-mediated channel phosphorylation. Accordingly, PKA as well as PP2A are constitutively associated with Ca(v)1.2 for its proper regulation by phosphorylation and dephosphorylation of serine 1928...
  16. ncbi Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis
    Amit Saraf
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 282:573-80. 2007
    ..In summary, we show that B'beta recruits PP2A to modulate TH activity in a tissue- and cell compartment specific fashion...
  17. pmc A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density
    Yuan Lu
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 286:26496-506. 2011
    ..However, synaptic transmission and spine density was normal at 8 weeks in KO and D36 mice. Thus AKAP150-independent mechanisms correct the aberrantly high number of active spines in juvenile AKAP150 KO and D36 mice during development...
  18. ncbi Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt
    Michael J Van Kanegan
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 280:36029-36. 2005
    ..Thus, receptor tyrosine kinase signaling cascades leading to Akt and ERK activation are modulated by PP2A holoenzymes with distinct regulatory properties...
  19. pmc CaMKII determines mitochondrial stress responses in heart
    Mei ling A Joiner
    Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Nature 491:269-73. 2012
    ....
  20. ncbi Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A
    Ruben K Dagda
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 280:27375-82. 2005
    ..This unfolding-resistant targeting to the mitochondrial translocase is necessary but not sufficient for the proapoptotic activity of Bbeta2, which also requires association with the rest of the PP2A holoenzyme...
  21. pmc Mitochondria: A kinase anchoring protein 1, a signaling platform for mitochondrial form and function
    Ronald A Merrill
    Department of Pharmacology, University of Iowa, Iowa City, USA
    Int J Biochem Cell Biol 48:92-6. 2014
    ..Recent evidence suggests that AKAP1 has critical roles in neuronal development and survival, which are mediated by inhibitory phosphorylation of Drp1 and maintenance of mitochondrial integrity. ..
  22. pmc Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15
    Elizabeth A Oberg
    Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 287:43378-89. 2012
    ..E3 ligase adaptor-mediated control of PP2A holoenzyme composition thereby adds another layer of regulation to cellular dephosphorylation events...
  23. pmc Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate
    Yunden Jinsmaa
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242, USA
    Chem Res Toxicol 22:835-41. 2009
    ....
  24. ncbi Activity-driven postsynaptic translocation of CaMKII
    Michelle A Merrill
    Department of Pharmacology, University of Iowa, Iowa City, IA 52242 1109, USA
    Trends Pharmacol Sci 26:645-53. 2005
    ..In this article, we provide an overview of recent progress in postsynaptic CaMKII anchoring and discuss its implication in synaptic plasticity and the etiology and potential treatments of neurological diseases...