Detcho A Stoyanovsky

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Effects of pH on the cytotoxicity of sodium trioxodinitrate (Angeli's salt)
    Detcho A Stoyanovsky
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Med Chem 47:210-7. 2004
  2. ncbi request reprint Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiols
    Rajib Sengupta
    Department of Surgery, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biochemistry 46:8472-83. 2007
  3. pmc Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: role of cardiolipin remodeling
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    FEBS Lett 586:235-41. 2012
  4. doi request reprint Protection of normal brain cells from γ-irradiation-induced apoptosis by a mitochondria-targeted triphenyl-phosphonium-nitroxide: a possible utility in glioblastoma therapy
    Zhentai Huang
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Neurooncol 100:1-8. 2010
  5. pmc Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases NO(.) and protects mouse embryonic cells against irradiation-induced apoptosis
    Natalia A Belikova
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    FEBS Lett 583:1945-50. 2009
  6. doi request reprint Unusual peroxidase activity of polynitroxylated pegylated hemoglobin: Elimination of H(2)O(2) coupled with intramolecular oxidation of nitroxides
    Detcho A Stoyanovsky
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biochem Biophys Res Commun 399:139-43. 2010
  7. pmc Nitric oxide and thioredoxin type 1 modulate the activity of caspase 8 in HepG2 cells
    Rajib Sengupta
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Biochem Biophys Res Commun 391:1127-30. 2010
  8. ncbi request reprint Formation of nitroxyl and hydroxyl radical in solutions of sodium trioxodinitrate: effects of pH and cytotoxicity
    Juliana Ivanova
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 278:42761-8. 2003
  9. pmc Cytochrome c/cardiolipin relations in mitochondria: a kiss of death
    Valerian E Kagan
    Center for Free Radical and Antioxidant Health, Pittsburgh, PA 15219, USA
    Free Radic Biol Med 46:1439-53. 2009
  10. doi request reprint Assessments of thiyl radicals in biosystems: difficulties and new applications
    Detcho A Stoyanovsky
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Anal Chem 83:6432-8. 2011

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Effects of pH on the cytotoxicity of sodium trioxodinitrate (Angeli's salt)
    Detcho A Stoyanovsky
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Med Chem 47:210-7. 2004
    ..These data suggest that the H(+)-amplified production of *OH from 1, and maybe other precursors of HNO, could be a selective mechanism for destruction cells with an acidic intra- or extracellular microenvironment...
  2. ncbi request reprint Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiols
    Rajib Sengupta
    Department of Surgery, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biochemistry 46:8472-83. 2007
    ..The data obtained are discussed within the general reaction mechanisms encompassing the cellular homeostasis of S-nitrosothiols...
  3. pmc Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: role of cardiolipin remodeling
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    FEBS Lett 586:235-41. 2012
    ..This caused suppression of apoptosis induced by actinomycin D. Triacsin C, an inhibitor of acyl-CoA synthase, blocked integration of oleic acid into cardiolipin and restored cell sensitivity to apoptosis...
  4. doi request reprint Protection of normal brain cells from γ-irradiation-induced apoptosis by a mitochondria-targeted triphenyl-phosphonium-nitroxide: a possible utility in glioblastoma therapy
    Zhentai Huang
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Neurooncol 100:1-8. 2010
    ..Thus, TPEY-Tempo may be a promising adjunct in the treatment of glioblastoma with the potential to not only prolong survival but also to maintain quality of life and reduce treatment toxicity...
  5. pmc Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases NO(.) and protects mouse embryonic cells against irradiation-induced apoptosis
    Natalia A Belikova
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    FEBS Lett 583:1945-50. 2009
    ..We conclude that mitochondria-targeted peroxidase-activatable NO-donors represent a new interesting class of radioprotectors...
  6. doi request reprint Unusual peroxidase activity of polynitroxylated pegylated hemoglobin: Elimination of H(2)O(2) coupled with intramolecular oxidation of nitroxides
    Detcho A Stoyanovsky
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biochem Biophys Res Commun 399:139-43. 2010
    ....
  7. pmc Nitric oxide and thioredoxin type 1 modulate the activity of caspase 8 in HepG2 cells
    Rajib Sengupta
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Biochem Biophys Res Commun 391:1127-30. 2010
    ..The data obtained suggest that extrinsic apoptosis can be subjected to redox regulation before induction of proteolytic damage by caspase 3...
  8. ncbi request reprint Formation of nitroxyl and hydroxyl radical in solutions of sodium trioxodinitrate: effects of pH and cytotoxicity
    Juliana Ivanova
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 278:42761-8. 2003
    ..2 than at pH 7.4. Scavengers of.OH impeded the cytotoxicity of Na2N2O3. These results suggest that the formation of HNO may be viewed as a toxicological event in tissues subjected to acidosis...
  9. pmc Cytochrome c/cardiolipin relations in mitochondria: a kiss of death
    Valerian E Kagan
    Center for Free Radical and Antioxidant Health, Pittsburgh, PA 15219, USA
    Free Radic Biol Med 46:1439-53. 2009
    ..Finally, new concepts in drug discovery based on the design of mitochondria-targeted inhibitors of cyt c/CL peroxidase and CL peroxidation with antiapoptotic effects are presented...
  10. doi request reprint Assessments of thiyl radicals in biosystems: difficulties and new applications
    Detcho A Stoyanovsky
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Anal Chem 83:6432-8. 2011
    ..This Feature reviews the contemporary approaches to assessment of RS(•) using EPR spin trapping, mass spectrometric, immunological, and HPLC protocols...
  11. pmc A mitochondria-targeted triphenylphosphonium-conjugated nitroxide functions as a radioprotector/mitigator
    Jianfei Jiang
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA
    Radiat Res 172:706-17. 2009
    ..We conclude that mitochondrial targeting of TPP-conjugated nitroxides represents a promising approach for the development of novel radioprotectors...
  12. pmc Activation of NO donors in mitochondria: peroxidase metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by cytochrome c releases NO and protects cells against apoptosis
    Detcho A Stoyanovsky
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    FEBS Lett 582:725-8. 2008
    ....
  13. pmc Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells
    Rajib Sengupta
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    FEBS Lett 583:3525-30. 2009
    ..The data obtained are discussed with focus on low molecular mass dithiols that mimic the activity of thioredoxin in reactions of protein S-denitrosation...
  14. doi request reprint Studies toward the analysis of S-nitrosoproteins
    Rajib Sengupta
    Department of Surgery, University of Pittsburgh Medical School, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Org Biomol Chem 7:232-4. 2009
    ..An immuno-spin trapping method for the analysis of S-nitrosoproteins based on the reaction of protein thiyl radicals with 5,5-dimethyl-1-pyrroline N-oxide has been developed...
  15. ncbi request reprint Nitric oxide inhibits peroxidase activity of cytochrome c.cardiolipin complex and blocks cardiolipin oxidation
    Irina I Vlasova
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15260, USA
    J Biol Chem 281:14554-62. 2006
    ..NO effectively inhibited 1,1'2,2'-tertalinoleoyl cardiolipin oxidation catalyzed by the peroxidase activity of cyt c. Thus, NO can act as a regulator of peroxidase activity of cyt c.CL complexes...
  16. ncbi request reprint Nitroxyl triggers Ca2+ release from skeletal and cardiac sarcoplasmic reticulum by oxidizing ryanodine receptors
    Eunji Cheong
    Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cell Calcium 37:87-96. 2005
    ..The findings indicate that HNO is a more potent activator of RyR1 than NO and that HNO activation of RyRs may contribute to NO's activation of RyRs and to the therapeutic effects of HNO-releasing prodrugs in heart failure...
  17. pmc A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death
    Jeffrey Atkinson
    Center for Free Radical and Antioxidant Health and Center for Medical Countermeasures against Radiation, University of Pittsburgh, Bridgeside Point, Pennsylvania 15219, USA
    Nat Commun 2:497. 2011
    ..Significant radioprotective/radiomitigative effects of imidazole-substituted oleic acid are observed after pretreatment of mice from 1 h before through 24 h after the irradiation...
  18. ncbi request reprint Targeting nitroxides to mitochondria: location, location, location, and ...concentration: highlight commentary on "Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide&qu
    Valerian E Kagan
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Bridgeside Point, 100 Technology Drive, Suite 333, Pittsburgh, PA 15219, USA
    Free Radic Biol Med 43:348-50. 2007
  19. ncbi request reprint Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols
    Detcho A Stoyanovsky
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Chem Soc 127:15815-23. 2005
    ..We conclude that both thioredoxin and dihydrolipoic acid may be involved in the regulation of cellular S-nitrosothiols...
  20. ncbi request reprint Nitric oxide-induced inhibition of smooth muscle cell proliferation involves S-nitrosation and inactivation of RhoA
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Physiol Cell Physiol 292:C824-31. 2007
    ..Nitrosation of RhoA and other proteins likely contributes to cGMP-independent effects of NO...
  21. doi request reprint Glutathione and thioredoxin type 1 cooperatively denitrosate HepG2 cells-derived cytosolic S-nitrosoproteins
    Detcho A Stoyanovsky
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Org Biomol Chem 11:4433-7. 2013
    ..In this study, we present experimental evidence that glutathione acts in concert with human thioredoxin type 1 in the denitrosation of cytosolic S-nitrosoproteins (PSNOs) from HepG2 cells...
  22. ncbi request reprint Comparative metabolism of N-tert-butyl-N-[1-(1-oxy-pyridin-4-yl)-ethyl]- and N-tert-butyl-N-(1-phenyl-ethyl)-nitroxide by the cytochrome P450 monooxygenase system
    Christo P Novakov
    Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA
    Chem Res Toxicol 15:749-53. 2002
    ..On the basis of the susceptibility of PBN/*CH(3) to undergo irreversible metabolic transformation, it is discussed that POBN may prove to be a more efficient spin-trapping agent for the in vivo detection of *OH...