Research Topics
| Detcho A StoyanovskySummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Effects of pH on the cytotoxicity of sodium trioxodinitrate (Angeli's salt)Detcho A Stoyanovsky
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Med Chem 47:210-7. 2004..These data suggest that the H(+)-amplified production of *OH from 1, and maybe other precursors of HNO, could be a selective mechanism for destruction cells with an acidic intra- or extracellular microenvironment...- Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiolsRajib Sengupta
Department of Surgery, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Biochemistry 46:8472-83. 2007..The data obtained are discussed within the general reaction mechanisms encompassing the cellular homeostasis of S-nitrosothiols... 
Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: role of cardiolipin remodelingYulia Y Tyurina
Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
FEBS Lett 586:235-41. 2012..This caused suppression of apoptosis induced by actinomycin D. Triacsin C, an inhibitor of acyl-CoA synthase, blocked integration of oleic acid into cardiolipin and restored cell sensitivity to apoptosis...
Protection of normal brain cells from γ-irradiation-induced apoptosis by a mitochondria-targeted triphenyl-phosphonium-nitroxide: a possible utility in glioblastoma therapyZhentai Huang
Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Neurooncol 100:1-8. 2010..Thus, TPEY-Tempo may be a promising adjunct in the treatment of glioblastoma with the potential to not only prolong survival but also to maintain quality of life and reduce treatment toxicity...- Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases NO(.) and protects mouse embryonic cells against irradiation-induced apoptosisNatalia A Belikova
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
FEBS Lett 583:1945-50. 2009..We conclude that mitochondria-targeted peroxidase-activatable NO-donors represent a new interesting class of radioprotectors... - Unusual peroxidase activity of polynitroxylated pegylated hemoglobin: Elimination of H(2)O(2) coupled with intramolecular oxidation of nitroxidesDetcho A Stoyanovsky
Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biochem Biophys Res Commun 399:139-43. 2010.... - Formation of nitroxyl and hydroxyl radical in solutions of sodium trioxodinitrate: effects of pH and cytotoxicityJuliana Ivanova
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 278:42761-8. 2003..2 than at pH 7.4. Scavengers of.OH impeded the cytotoxicity of Na2N2O3. These results suggest that the formation of HNO may be viewed as a toxicological event in tissues subjected to acidosis... - Cytochrome c/cardiolipin relations in mitochondria: a kiss of deathValerian E Kagan
Center for Free Radical and Antioxidant Health, Pittsburgh, PA 15219, USA
Free Radic Biol Med 46:1439-53. 2009..Finally, new concepts in drug discovery based on the design of mitochondria-targeted inhibitors of cyt c/CL peroxidase and CL peroxidation with antiapoptotic effects are presented... - Nitric oxide and thioredoxin type 1 modulate the activity of caspase 8 in HepG2 cellsRajib Sengupta
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Biochem Biophys Res Commun 391:1127-30. 2010..The data obtained suggest that extrinsic apoptosis can be subjected to redox regulation before induction of proteolytic damage by caspase 3... - Assessments of thiyl radicals in biosystems: difficulties and new applicationsDetcho A Stoyanovsky
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Anal Chem 83:6432-8. 2011..This Feature reviews the contemporary approaches to assessment of RS(•) using EPR spin trapping, mass spectrometric, immunological, and HPLC protocols... - A mitochondria-targeted triphenylphosphonium-conjugated nitroxide functions as a radioprotector/mitigatorJianfei Jiang
Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA
Radiat Res 172:706-17. 2009..We conclude that mitochondrial targeting of TPP-conjugated nitroxides represents a promising approach for the development of novel radioprotectors... - Activation of NO donors in mitochondria: peroxidase metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by cytochrome c releases NO and protects cells against apoptosisDetcho A Stoyanovsky
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
FEBS Lett 582:725-8. 2008.... - Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cellsRajib Sengupta
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
FEBS Lett 583:3525-30. 2009..The data obtained are discussed with focus on low molecular mass dithiols that mimic the activity of thioredoxin in reactions of protein S-denitrosation... - Studies toward the analysis of S-nitrosoproteinsRajib Sengupta
Department of Surgery, University of Pittsburgh Medical School, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
Org Biomol Chem 7:232-4. 2009..An immuno-spin trapping method for the analysis of S-nitrosoproteins based on the reaction of protein thiyl radicals with 5,5-dimethyl-1-pyrroline N-oxide has been developed... - Nitric oxide inhibits peroxidase activity of cytochrome c.cardiolipin complex and blocks cardiolipin oxidationIrina I Vlasova
Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15260, USA
J Biol Chem 281:14554-62. 2006..NO effectively inhibited 1,1'2,2'-tertalinoleoyl cardiolipin oxidation catalyzed by the peroxidase activity of cyt c. Thus, NO can act as a regulator of peroxidase activity of cyt c.CL complexes... - Nitroxyl triggers Ca2+ release from skeletal and cardiac sarcoplasmic reticulum by oxidizing ryanodine receptorsEunji Cheong
Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Cell Calcium 37:87-96. 2005..The findings indicate that HNO is a more potent activator of RyR1 than NO and that HNO activation of RyRs may contribute to NO's activation of RyRs and to the therapeutic effects of HNO-releasing prodrugs in heart failure... - A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced deathJeffrey Atkinson
Center for Free Radical and Antioxidant Health and Center for Medical Countermeasures against Radiation, University of Pittsburgh, Bridgeside Point, Pennsylvania 15219, USA
Nat Commun 2:497. 2011..Significant radioprotective/radiomitigative effects of imidazole-substituted oleic acid are observed after pretreatment of mice from 1 h before through 24 h after the irradiation... - Targeting nitroxides to mitochondria: location, location, location, and ...concentration: highlight commentary on "Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide&quValerian E Kagan
Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Bridgeside Point, 100 Technology Drive, Suite 333, Pittsburgh, PA 15219, USA
Free Radic Biol Med 43:348-50. 2007 - Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiolsDetcho A Stoyanovsky
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Am Chem Soc 127:15815-23. 2005..We conclude that both thioredoxin and dihydrolipoic acid may be involved in the regulation of cellular S-nitrosothiols... - Nitric oxide-induced inhibition of smooth muscle cell proliferation involves S-nitrosation and inactivation of RhoABrian S Zuckerbraun
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Am J Physiol Cell Physiol 292:C824-31. 2007..Nitrosation of RhoA and other proteins likely contributes to cGMP-independent effects of NO... - Comparative metabolism of N-tert-butyl-N-[1-(1-oxy-pyridin-4-yl)-ethyl]- and N-tert-butyl-N-(1-phenyl-ethyl)-nitroxide by the cytochrome P450 monooxygenase systemChristo P Novakov
Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA
Chem Res Toxicol 15:749-53. 2002..On the basis of the susceptibility of PBN/*CH(3) to undergo irreversible metabolic transformation, it is discussed that POBN may prove to be a more efficient spin-trapping agent for the in vivo detection of *OH...