Robert Stout

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi Functional plasticity of macrophages: reversible adaptation to changing microenvironments
    Robert D Stout
    Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40292, USA
    J Leukoc Biol 76:509-13. 2004
  2. ncbi Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes
    Robert D Stout
    Department of Microbiology and Immunology, University of Louisville School of Medicine, KY 40292, USA
    Immunol Rev 205:60-71. 2005
  3. ncbi Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences
    Robert D Stout
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 175:342-9. 2005
  4. ncbi Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages
    Robert D Stout
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Leukoc Biol 86:1105-9. 2009
  5. ncbi IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo
    Stephanie K Watkins
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Immunol 178:1357-62. 2007
  6. ncbi Macrophage CD40 signaling: a pivotal regulator of disease protection and pathogenesis
    Jill Suttles
    Department of Microbiology and Immunology, University of Louisville School of Medicine, 319 Abraham Flexner Way, Louisville, KY 40292, USA
    Semin Immunol 21:257-64. 2009
  7. ncbi Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    Duygu Sag
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Immunol 181:8633-41. 2008
  8. ncbi Rapid release of cytoplasmic IL-15 from tumor-associated macrophages is an initial and critical event in IL-12-initiated tumor regression
    Stephanie K Watkins
    Department of Microbiology, and James Graham Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Eur J Immunol 39:2126-35. 2009
  9. ncbi Regulation of Th17 differentiation by epidermal fatty acid-binding protein
    Bing Li
    Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    J Immunol 182:7625-33. 2009
  10. ncbi Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis
    Joseph M Reynolds
    Department of Microbiology and Immunology, School of Medicine, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40292, USA
    J Immunol 179:313-21. 2007

Research Grants

  1. Macrophage Dysfunction in Immunosenescence
    Robert Stout; Fiscal Year: 2006
  2. The impact of aging on the inflammatory response
    Robert Stout; Fiscal Year: 2007

Collaborators

  • Jill Suttles
  • N K Egilmez
  • GOKHAN HOTAMISLIGIL
  • Stephanie K Watkins
  • Bing Li
  • Joseph M Reynolds
  • Duygu Sag
  • Kimberly Head
  • Katharine S Richardson
  • Qun Zeng
  • David A Bernlohr
  • David Carling
  • Katherine C Brittingham
  • Michael Gruenthal
  • Yawei Liu
  • Cem Z Gorgun
  • Qiaohong Liu

Detail Information

Publications10

  1. ncbi Functional plasticity of macrophages: reversible adaptation to changing microenvironments
    Robert D Stout
    Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40292, USA
    J Leukoc Biol 76:509-13. 2004
    ....
  2. ncbi Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes
    Robert D Stout
    Department of Microbiology and Immunology, University of Louisville School of Medicine, KY 40292, USA
    Immunol Rev 205:60-71. 2005
    ..The macrophages appear to maintain functional plasticity during this dysregulation, making them a prime target of cytokine therapy that could enhance both innate and adaptive immune systems...
  3. ncbi Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences
    Robert D Stout
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 175:342-9. 2005
    ....
  4. ncbi Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages
    Robert D Stout
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Leukoc Biol 86:1105-9. 2009
    ....
  5. ncbi IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo
    Stephanie K Watkins
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Immunol 178:1357-62. 2007
    ..The ability of IL-12 to initiate this functional conversion may contribute to early amplification of the subsequent destructive antitumor immune response...
  6. ncbi Macrophage CD40 signaling: a pivotal regulator of disease protection and pathogenesis
    Jill Suttles
    Department of Microbiology and Immunology, University of Louisville School of Medicine, 319 Abraham Flexner Way, Louisville, KY 40292, USA
    Semin Immunol 21:257-64. 2009
    ..In this review, we discuss the role of CD40 in both protective and destructive processes, including the signaling pathways engaged and the factors capable of modulating CD40 signal transduction...
  7. ncbi Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    Duygu Sag
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Immunol 181:8633-41. 2008
    ..Thus, AMPK directs signaling pathways in macrophages in a manner that suppresses proinflammatory responses and promotes macrophage polarization to an anti-inflammatory functional phenotype...
  8. ncbi Rapid release of cytoplasmic IL-15 from tumor-associated macrophages is an initial and critical event in IL-12-initiated tumor regression
    Stephanie K Watkins
    Department of Microbiology, and James Graham Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Eur J Immunol 39:2126-35. 2009
    ..In this context, the functional plasticity and pro-immunogenic potential of TAM may constitute a significant and unappreciated target in existing cytokine therapies...
  9. ncbi Regulation of Th17 differentiation by epidermal fatty acid-binding protein
    Bing Li
    Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    J Immunol 182:7625-33. 2009
    ..Thus, taken together, our data indicate that expression of E-FABP by CD4(+) T cells contributes to the control of IL-6 stimulation of the IL-21/ROR/IL-17 pathway and to the Th17/Treg counterbalance...
  10. ncbi Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis
    Joseph M Reynolds
    Department of Microbiology and Immunology, School of Medicine, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40292, USA
    J Immunol 179:313-21. 2007
    ..This study reveals that metabolic-inflammatory pathway cross-regulation by FABPs contributes to adaptive immune responses and subsequent autoimmune inflammation...

Research Grants5

  1. Macrophage Dysfunction in Immunosenescence
    Robert Stout; Fiscal Year: 2006
    ....
  2. The impact of aging on the inflammatory response
    Robert Stout; Fiscal Year: 2007
    ..Even transient improvement in inflammatory response will not only enhance microbial clearance and wound healing, but likely will also enhance the efficacy of vaccination against infectious disease. ..