JAY STORZ

Summary

Affiliation: University of Nebraska
Country: USA

Publications

  1. pmc Expression and purification of recombinant hemoglobin in Escherichia coli
    Chandrasekhar Natarajan
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America
    PLoS ONE 6:e20176. 2011
  2. pmc Differential loss and retention of cytoglobin, myoglobin, and globin-E during the radiation of vertebrates
    Federico G Hoffmann
    School of Biological Sciences, University of Nebraska, Lincoln, USA
    Genome Biol Evol 3:588-600. 2011
  3. doi request reprint Gene duplication, genome duplication, and the functional diversification of vertebrate globins
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Mol Phylogenet Evol 66:469-78. 2013
  4. pmc Altitudinal variation at duplicated β-globin genes in deer mice: effects of selection, recombination, and gene conversion
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
    Genetics 190:203-16. 2012
  5. pmc Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Proc Natl Acad Sci U S A 106:14450-5. 2009
  6. pmc Integrating evolutionary and functional approaches to infer adaptation at specific loci
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Evolution 64:2489-509. 2010
  7. pmc Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    J Exp Biol 213:4125-36. 2010
  8. pmc Effects of spatially varying selection on nucleotide diversity and linkage disequilibrium: insights from deer mouse globin genes
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
    Genetics 180:367-79. 2008
  9. pmc Adaptive functional divergence among triplicated alpha-globin genes in rodents
    Jay F Storz
    Department of Chemistry, University of Nebraska, Lincoln, Nebraska 68588, USA
    Genetics 178:1623-38. 2008
  10. pmc Genetic differences in hemoglobin function between highland and lowland deer mice
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    J Exp Biol 213:2565-74. 2010

Detail Information

Publications34

  1. pmc Expression and purification of recombinant hemoglobin in Escherichia coli
    Chandrasekhar Natarajan
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America
    PLoS ONE 6:e20176. 2011
    ....
  2. pmc Differential loss and retention of cytoglobin, myoglobin, and globin-E during the radiation of vertebrates
    Federico G Hoffmann
    School of Biological Sciences, University of Nebraska, Lincoln, USA
    Genome Biol Evol 3:588-600. 2011
    ..Despite the restricted phyletic distribution of this gene, our results indicate that GbE is one of the most highly conserved globins in the avian genome...
  3. doi request reprint Gene duplication, genome duplication, and the functional diversification of vertebrate globins
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Mol Phylogenet Evol 66:469-78. 2013
    ....
  4. pmc Altitudinal variation at duplicated β-globin genes in deer mice: effects of selection, recombination, and gene conversion
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
    Genetics 190:203-16. 2012
    ..Observed patterns of diversity and haplotype structure are difficult to reconcile with expectations of a two-locus selection model with multiplicative fitness...
  5. pmc Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Proc Natl Acad Sci U S A 106:14450-5. 2009
    ..The experimental measures of O(2)-binding properties corroborated the tests of selection by demonstrating a functional difference between the products of alternative alleles...
  6. pmc Integrating evolutionary and functional approaches to infer adaptation at specific loci
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Evolution 64:2489-509. 2010
    ..Functional studies can provide corroborative evidence for positive selection at particular loci, and can potentially reveal specific molecular mechanisms of adaptation...
  7. pmc Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    J Exp Biol 213:4125-36. 2010
    ..Thus, insights into the acclimatization response of lowland animals to high-altitude hypoxia can provide a basis for predicting how altitudinal range limits might shift in response to climate change...
  8. pmc Effects of spatially varying selection on nucleotide diversity and linkage disequilibrium: insights from deer mouse globin genes
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
    Genetics 180:367-79. 2008
    ..Simulation and empirical results indicate that sliding-window analyses of Z(g) between allele classes may provide an effective means of pinpointing causal substitutions...
  9. pmc Adaptive functional divergence among triplicated alpha-globin genes in rodents
    Jay F Storz
    Department of Chemistry, University of Nebraska, Lincoln, Nebraska 68588, USA
    Genetics 178:1623-38. 2008
    ....
  10. pmc Genetic differences in hemoglobin function between highland and lowland deer mice
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    J Exp Biol 213:2565-74. 2010
    ..In conjunction with previous findings, our results demonstrate that modifications of Hb structure that alter allosteric anion sensitivity play an important role in the adaptive fine-tuning of blood-O(2) affinity...
  11. pmc Complex signatures of selection and gene conversion in the duplicated globin genes of house mice
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
    Genetics 177:481-500. 2007
    ..The alternative two-locus beta-globin haplotypes are associated with pronounced differences in intraerythrocyte glutathione and nitric oxide metabolism, suggesting a possible mechanism for selection on hemoglobin function...
  12. doi request reprint Phylogenetic diversification of the globin gene superfamily in chordates
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE
    IUBMB Life 63:313-22. 2011
    ..Finally, we discuss why the globin gene superfamily presents special challenges for phylogenetic analysis, and we describe methodological approaches that can be used to meet those challenges...
  13. pmc Oxygenation properties and oxidation rates of mouse hemoglobins that differ in reactive cysteine content
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Comp Biochem Physiol A Mol Integr Physiol 161:265-70. 2012
    ..The allelic differences in β-globin cysteine content could affect aspects of redox signaling and oxidative/nitrosative stress responses that are mediated by Hb-S-nitrosylation and Hb-S-glutathionylation pathways...
  14. pmc The molecular basis of high-altitude adaptation in deer mice
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America
    PLoS Genet 3:e45. 2007
    ....
  15. pmc Developmental regulation of hemoglobin synthesis in the green anole lizard Anolis carolinensis
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    J Exp Biol 214:575-81. 2011
    ....
  16. doi request reprint Experimental approaches to evaluate the contributions of candidate protein-coding mutations to phenotypic evolution
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE, USA
    Methods Mol Biol 772:377-96. 2011
    ....
  17. pmc Differential loss of embryonic globin genes during the radiation of placental mammals
    Juan C Opazo
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Proc Natl Acad Sci U S A 105:12950-5. 2008
    ....
  18. pmc Evolutionary and functional properties of a two-locus beta-globin polymorphism in Indian house mice
    Amy M Runck
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
    Genetics 184:1121-31. 2010
    ..If the d(minor) and p(minor) alleles are maintained as a balanced polymorphism, our results indicate that the associated fitness variance is not directly related to respiratory functions of Hb...
  19. pmc Evolution of duplicated beta-globin genes and the structural basis of hemoglobin isoform differentiation in Mus
    Amy M Runck
    School of Biological Sciences, University of Nebraska, NE, USA
    Mol Biol Evol 26:2521-32. 2009
    ....
  20. pmc Genomic evidence for independent origins of beta-like globin genes in monotremes and therian mammals
    Juan C Opazo
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588
    Proc Natl Acad Sci U S A 105:1590-5. 2008
    ....
  21. ncbi request reprint The alphaD-globin gene originated via duplication of an embryonic alpha-like globin gene in the ancestor of tetrapod vertebrates
    Federico G Hoffmann
    School of Biological Sciences, University of Nebraska, Lincoln, USA
    Mol Biol Evol 24:1982-90. 2007
    ..These insights into the evolutionary origin of HbD illustrate how adaptive modifications of physiological pathways may result from the retention and opportunistic co-option of ancestral protein functions...
  22. pmc Gene cooption and convergent evolution of oxygen transport hemoglobins in jawed and jawless vertebrates
    Federico G Hoffmann
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Proc Natl Acad Sci U S A 107:14274-9. 2010
    ....
  23. pmc Mechanisms of hemoglobin adaptation to high altitude hypoxia
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE
    High Alt Med Biol 9:148-57. 2008
    ..It may be the case that certain evolutionary paths are followed more often than others simply because they are subject to less stringent pleiotropic constraints...
  24. ncbi request reprint Rapid rates of lineage-specific gene duplication and deletion in the alpha-globin gene family
    Federico G Hoffmann
    School of Biological Sciences, University of Nebraska, USA
    Mol Biol Evol 25:591-602. 2008
    ..The resultant variation in gene copy number among species may represent an important source of regulatory variation that affects physiologically important aspects of blood oxygen transport and aerobic energy metabolism...
  25. pmc New genes originated via multiple recombinational pathways in the beta-globin gene family of rodents
    Federico G Hoffmann
    School of Biological Sciences, University of Nebraska, USA
    Mol Biol Evol 25:2589-600. 2008
    ..Although the gamma/epsilon and beta/delta fusion genes share a similar chimeric gene structure, they originated via completely different recombinational pathways...
  26. pmc Origin and ascendancy of a chimeric fusion gene: the beta/delta-globin gene of paenungulate mammals
    Juan C Opazo
    School of Biological Sciences, University of Nebraska, Nebraska, USA
    Mol Biol Evol 26:1469-78. 2009
    ..This illustrates how the evolutionary fates of chimeric fusion genes can be strongly influenced by their recombinational mode of origin...
  27. ncbi request reprint Using genome scans of DNA polymorphism to infer adaptive population divergence
    Jay F Storz
    Department of Biology, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA 94132, USA
    Mol Ecol 14:671-88. 2005
    ..Finally, I consider the evolutionary and functional insights that might be gained by conducting genome scans for loci involved in adaptive population divergence...
  28. ncbi request reprint Natural selection drives altitudinal divergence at the albumin locus in deer mice, Peromyscus maniculatus
    Jay F Storz
    Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson, Arizona 85721, USA
    Evolution 58:1342-52. 2004
    ..We conclude that clinal variation at the Alb locus reflects a balance between gene flow and diversifying selection that results from elevational changes in fitness rankings among alternative genotypes...
  29. ncbi request reprint Natural selection on protein polymorphism in the rodent genus Peromyscus: evidence from interlocus contrasts
    Jay F Storz
    Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson, Arizona 85721, USA
    Evolution 57:2628-35. 2003
    ..Interestingly, the albumin locus was implicated as a candidate gene for local adaptation in four different species of Peromyscus. The results also demonstrate that selection can severely bias marker-based estimates of neutral parameters...
  30. ncbi request reprint Genetic effective size of a wild primate population: influence of current and historical demography
    Jay F Storz
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
    Evolution 56:817-29. 2002
    ..Thus, observed levels of genetic diversity may primarily reflect the population's prebottleneck history rather than its current demography...
  31. ncbi request reprint Contrasting patterns of divergence in quantitative traits and neutral DNA markers: analysis of clinal variation
    Jay F Storz
    Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson, AZ 85721, USA
    Mol Ecol 11:2537-51. 2002
    ..sphinx. The geographical patterning of pairwise QST is most likely attributable to spatially varying selection and/or the direct influence of latitudinally ordered environmental effects...
  32. ncbi request reprint Genome scans of DNA variability in humans reveal evidence for selective sweeps outside of Africa
    Jay F Storz
    Department of Ecology and Evolutionary Biology, Biosciences West, University of Arizona, AZ, USA
    Mol Biol Evol 21:1800-11. 2004
    ..A disproportionate number of these loci exhibited reduced levels of relative variability in non-African populations alone, suggesting that recent episodes of positive selection have been more prevalent outside of sub-Saharan Africa...
  33. ncbi request reprint Estimation of genetically effective breeding numbers using a rejection algorithm approach
    Uma Ramakrishnan
    0116, Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Ecol 13:3283-92. 2004
    ..These analyses demonstrate that the rejection algorithm provides accurate estimates of Nebm across a broad range of demographic scenarios, except when the true Nebm is high...
  34. ncbi request reprint Testing for genetic evidence of population expansion and contraction: an empirical analysis of microsatellite DNA variation using a hierarchical Bayesian model
    Jay F Storz
    Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson 85721, USA
    Evolution 56:154-66. 2002
    ..Genetic evidence for population decline may reflect the consequences of habitat destruction on a more recent time scale...