Research Topics
Genomes and Genes | JAY STORZSummaryAffiliation: University of Nebraska Country: USA Publications
Research Grants
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Detail Information
Publications
Gene duplication, genome duplication, and the functional diversification of vertebrate globinsJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
Mol Phylogenet Evol 66:469-78. 2013....
Altitudinal variation at duplicated β-globin genes in deer mice: effects of selection, recombination, and gene conversionJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
Genetics 190:203-16. 2012..Observed patterns of diversity and haplotype structure are difficult to reconcile with expectations of a two-locus selection model with multiplicative fitness...- Adaptive functional divergence among triplicated alpha-globin genes in rodentsJay F Storz
Department of Chemistry, University of Nebraska, Lincoln, Nebraska 68588, USA
Genetics 178:1623-38. 2008.... - Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobinJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
Proc Natl Acad Sci U S A 106:14450-5. 2009..The experimental measures of O(2)-binding properties corroborated the tests of selection by demonstrating a functional difference between the products of alternative alleles... - Complex signatures of selection and gene conversion in the duplicated globin genes of house miceJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
Genetics 177:481-500. 2007..The alternative two-locus beta-globin haplotypes are associated with pronounced differences in intraerythrocyte glutathione and nitric oxide metabolism, suggesting a possible mechanism for selection on hemoglobin function... - Integrating evolutionary and functional approaches to infer adaptation at specific lociJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
Evolution 64:2489-509. 2010..Functional studies can provide corroborative evidence for positive selection at particular loci, and can potentially reveal specific molecular mechanisms of adaptation... - The molecular basis of high-altitude adaptation in deer miceJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America
PLoS Genet 3:e45. 2007.... - Genetic differences in hemoglobin function between highland and lowland deer miceJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
J Exp Biol 213:2565-74. 2010..In conjunction with previous findings, our results demonstrate that modifications of Hb structure that alter allosteric anion sensitivity play an important role in the adaptive fine-tuning of blood-O(2) affinity... - Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebratesJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
J Exp Biol 213:4125-36. 2010..Thus, insights into the acclimatization response of lowland animals to high-altitude hypoxia can provide a basis for predicting how altitudinal range limits might shift in response to climate change... - Developmental regulation of hemoglobin synthesis in the green anole lizard Anolis carolinensisJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
J Exp Biol 214:575-81. 2011.... - Phylogenetic diversification of the globin gene superfamily in chordatesJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, NE
IUBMB Life 63:313-22. 2011..Finally, we discuss why the globin gene superfamily presents special challenges for phylogenetic analysis, and we describe methodological approaches that can be used to meet those challenges... - Experimental approaches to evaluate the contributions of candidate protein-coding mutations to phenotypic evolutionJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, NE, USA
Methods Mol Biol 772:377-96. 2011.... - Oxygenation properties and oxidation rates of mouse hemoglobins that differ in reactive cysteine contentJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
Comp Biochem Physiol A Mol Integr Physiol 161:265-70. 2012..The allelic differences in β-globin cysteine content could affect aspects of redox signaling and oxidative/nitrosative stress responses that are mediated by Hb-S-nitrosylation and Hb-S-glutathionylation pathways... - Effects of spatially varying selection on nucleotide diversity and linkage disequilibrium: insights from deer mouse globin genesJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
Genetics 180:367-79. 2008..Simulation and empirical results indicate that sliding-window analyses of Z(g) between allele classes may provide an effective means of pinpointing causal substitutions... - Differential loss of embryonic globin genes during the radiation of placental mammalsJuan C Opazo
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
Proc Natl Acad Sci U S A 105:12950-5. 2008.... - Evolutionary and functional properties of a two-locus beta-globin polymorphism in Indian house miceAmy M Runck
School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
Genetics 184:1121-31. 2010..If the d(minor) and p(minor) alleles are maintained as a balanced polymorphism, our results indicate that the associated fitness variance is not directly related to respiratory functions of Hb... - Evolution of duplicated beta-globin genes and the structural basis of hemoglobin isoform differentiation in MusAmy M Runck
School of Biological Sciences, University of Nebraska, NE, USA
Mol Biol Evol 26:2521-32. 2009.... - Genomic evidence for independent origins of beta-like globin genes in monotremes and therian mammalsJuan C Opazo
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588
Proc Natl Acad Sci U S A 105:1590-5. 2008.... 
The alphaD-globin gene originated via duplication of an embryonic alpha-like globin gene in the ancestor of tetrapod vertebratesFederico G Hoffmann
School of Biological Sciences, University of Nebraska, Lincoln, USA
Mol Biol Evol 24:1982-90. 2007..These insights into the evolutionary origin of HbD illustrate how adaptive modifications of physiological pathways may result from the retention and opportunistic co-option of ancestral protein functions...- Gene cooption and convergent evolution of oxygen transport hemoglobins in jawed and jawless vertebratesFederico G Hoffmann
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
Proc Natl Acad Sci U S A 107:14274-9. 2010.... - Mechanisms of hemoglobin adaptation to high altitude hypoxiaJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, NE
High Alt Med Biol 9:148-57. 2008..It may be the case that certain evolutionary paths are followed more often than others simply because they are subject to less stringent pleiotropic constraints... - Rapid rates of lineage-specific gene duplication and deletion in the alpha-globin gene familyFederico G Hoffmann
School of Biological Sciences, University of Nebraska, USA
Mol Biol Evol 25:591-602. 2008..The resultant variation in gene copy number among species may represent an important source of regulatory variation that affects physiologically important aspects of blood oxygen transport and aerobic energy metabolism... - New genes originated via multiple recombinational pathways in the beta-globin gene family of rodentsFederico G Hoffmann
School of Biological Sciences, University of Nebraska, USA
Mol Biol Evol 25:2589-600. 2008..Although the gamma/epsilon and beta/delta fusion genes share a similar chimeric gene structure, they originated via completely different recombinational pathways... - Origin and ascendancy of a chimeric fusion gene: the beta/delta-globin gene of paenungulate mammalsJuan C Opazo
School of Biological Sciences, University of Nebraska, Nebraska, USA
Mol Biol Evol 26:1469-78. 2009..This illustrates how the evolutionary fates of chimeric fusion genes can be strongly influenced by their recombinational mode of origin... - Natural selection on protein polymorphism in the rodent genus Peromyscus: evidence from interlocus contrastsJay F Storz
Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson, Arizona 85721, USA
Evolution 57:2628-35. 2003..Interestingly, the albumin locus was implicated as a candidate gene for local adaptation in four different species of Peromyscus. The results also demonstrate that selection can severely bias marker-based estimates of neutral parameters... - Natural selection drives altitudinal divergence at the albumin locus in deer mice, Peromyscus maniculatusJay F Storz
Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson, Arizona 85721, USA
Evolution 58:1342-52. 2004..We conclude that clinal variation at the Alb locus reflects a balance between gene flow and diversifying selection that results from elevational changes in fitness rankings among alternative genotypes... - Using genome scans of DNA polymorphism to infer adaptive population divergenceJay F Storz
Department of Biology, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA 94132, USA
Mol Ecol 14:671-88. 2005..Finally, I consider the evolutionary and functional insights that might be gained by conducting genome scans for loci involved in adaptive population divergence... - Estimation of genetically effective breeding numbers using a rejection algorithm approachUma Ramakrishnan
0116, Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
Mol Ecol 13:3283-92. 2004..These analyses demonstrate that the rejection algorithm provides accurate estimates of Nebm across a broad range of demographic scenarios, except when the true Nebm is high... - Genome scans of DNA variability in humans reveal evidence for selective sweeps outside of AfricaJay F Storz
Department of Ecology and Evolutionary Biology, Biosciences West, University of Arizona, AZ, USA
Mol Biol Evol 21:1800-11. 2004..A disproportionate number of these loci exhibited reduced levels of relative variability in non-African populations alone, suggesting that recent episodes of positive selection have been more prevalent outside of sub-Saharan Africa... - Contrasting patterns of divergence in quantitative traits and neutral DNA markers: analysis of clinal variationJay F Storz
Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson, AZ 85721, USA
Mol Ecol 11:2537-51. 2002..sphinx. The geographical patterning of pairwise QST is most likely attributable to spatially varying selection and/or the direct influence of latitudinally ordered environmental effects... - Genetic effective size of a wild primate population: influence of current and historical demographyJay F Storz
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
Evolution 56:817-29. 2002..Thus, observed levels of genetic diversity may primarily reflect the population's prebottleneck history rather than its current demography... - Testing for genetic evidence of population expansion and contraction: an empirical analysis of microsatellite DNA variation using a hierarchical Bayesian modelJay F Storz
Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson 85721, USA
Evolution 56:154-66. 2002..Genetic evidence for population decline may reflect the consequences of habitat destruction on a more recent time scale...
Research Grants
- Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude RodentsJAY STORZ; Fiscal Year: 2009....
- Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude RodentsJAY STORZ; Fiscal Year: 2009..abstract_text> ..
- Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude RodentsJay F Storz; Fiscal Year: 2010....
- Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude RodentsJay F Storz; Fiscal Year: 2010....