Michael D Story

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Statistical methods of background correction for Illumina BeadArray data
    Yang Xie
    Division of Biostatistics, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, USA
    Bioinformatics 25:751-7. 2009
  2. pmc Distinct transcriptome profiles identified in normal human bronchial epithelial cells after exposure to γ-rays and different elemental particles of high Z and energy
    Liang Hao Ding
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    BMC Genomics 14:372. 2013
  3. doi request reprint Defining molecular and cellular responses after low and high linear energy transfer radiations to develop biomarkers of carcinogenic risk or therapeutic outcome
    Michael Story
    Department of Radiation Oncology, Division of Molecular Radiation Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Health Phys 103:596-606. 2012
  4. pmc Characterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation
    Biaoru Li
    Department Pediatrics, Georgia Health Sciences University, 1120 15th St, CN 4112, Augusta, GA 30912, USA
    BMC Genomics 13:153. 2012
  5. doi request reprint Exploring the possibility of unique molecular, biological, and tissue effects with hypofractionated radiotherapy
    Michael Story
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Semin Radiat Oncol 18:244-8. 2008
  6. pmc Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas, Southwestern Medical Centre, Dallas, TX 75390, USA
    Nucleic Acids Res 39:5474-88. 2011
  7. ncbi request reprint Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma
    Amit K Das
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Res 67:5267-74. 2007
  8. pmc DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle
    Andres I Roig
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Int J Radiat Biol 86:194-204. 2010
  9. pmc Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest
    Mayank Singh
    Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas, USA
    Mol Cell Biol 33:1210-22. 2013
  10. doi request reprint The small-molecule CDK inhibitor, SNS-032, enhances cellular radiosensitivity in quiescent and hypoxic non-small cell lung cancer cells
    Elisabeth Kodym
    Department of Radiation Oncology, Division of Molecular Radiation Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9187, USA
    Lung Cancer 66:37-47. 2009

Research Grants

Collaborators

Detail Information

Publications36

  1. pmc Statistical methods of background correction for Illumina BeadArray data
    Yang Xie
    Division of Biostatistics, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, USA
    Bioinformatics 25:751-7. 2009
    ..However, the analysis methods for Illumina BeadArrays are far behind those for Affymetrix oligonucleotide arrays, and so need to be improved...
  2. pmc Distinct transcriptome profiles identified in normal human bronchial epithelial cells after exposure to γ-rays and different elemental particles of high Z and energy
    Liang Hao Ding
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    BMC Genomics 14:372. 2013
    ....
  3. doi request reprint Defining molecular and cellular responses after low and high linear energy transfer radiations to develop biomarkers of carcinogenic risk or therapeutic outcome
    Michael Story
    Department of Radiation Oncology, Division of Molecular Radiation Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Health Phys 103:596-606. 2012
    ..Potential biomarkers from cell lines or animal models will require validation in a human setting where possible and before being considered as a credible biomarker some understanding of the molecular mechanism is necessary...
  4. pmc Characterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation
    Biaoru Li
    Department Pediatrics, Georgia Health Sciences University, 1120 15th St, CN 4112, Augusta, GA 30912, USA
    BMC Genomics 13:153. 2012
    ....
  5. doi request reprint Exploring the possibility of unique molecular, biological, and tissue effects with hypofractionated radiotherapy
    Michael Story
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Semin Radiat Oncol 18:244-8. 2008
    ....
  6. pmc Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas, Southwestern Medical Centre, Dallas, TX 75390, USA
    Nucleic Acids Res 39:5474-88. 2011
    ..Our data suggest that downregulation of multiple DNA repair pathway genes in differentiated cells renders them vulnerable to DSBs, promoting genome instability that may lead to carcinogenesis...
  7. ncbi request reprint Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma
    Amit K Das
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Res 67:5267-74. 2007
    ....
  8. pmc DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle
    Andres I Roig
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Int J Radiat Biol 86:194-204. 2010
    ....
  9. pmc Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest
    Mayank Singh
    Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas, USA
    Mol Cell Biol 33:1210-22. 2013
    ..We propose that lamin A/C is required for maintaining genomic stability following replication fork stalling, induced by either ICL damage or replicative stress, in order to facilitate fork regression prior to DNA damage repair...
  10. doi request reprint The small-molecule CDK inhibitor, SNS-032, enhances cellular radiosensitivity in quiescent and hypoxic non-small cell lung cancer cells
    Elisabeth Kodym
    Department of Radiation Oncology, Division of Molecular Radiation Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9187, USA
    Lung Cancer 66:37-47. 2009
    ..Considering the importance of therapy resistance for the radiocurability of solid tumors, our findings may provide the basis for an improvement of the well-established treatment regimens in clinical oncology...
  11. ncbi request reprint SNS-032 prevents hypoxia-mediated glioblastoma cell invasion by inhibiting hypoxia inducible factor-1alpha expression
    M Aktar Ali
    Department of Radiation Oncology, Division of Molecular Radiation Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9187, USA
    Int J Oncol 34:1051-60. 2009
    ..Our results present an opportunity in controlling highly invasive tumors such as glioblastoma using this novel class of compounds...
  12. pmc Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks
    Cristel V Camacho
    Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Carcinogenesis 31:1889-96. 2010
    ..Indeed, we find that reexpression of p15 in tumor-derived cells significantly attenuates the tumorigenic potential of these cells, indicating that p15 loss may be a critical event in tumorigenesis triggered by complex DSBs...
  13. pmc RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN
    Seongmi Park
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8813, USA
    Cancer Res 69:4107-11. 2009
    ..Our data suggest that the RIP1-NF-kappaB status of tumors may influence response to treatments targeting the PTEN-PI3K-mTOR signaling axis...
  14. pmc Radiogenomics predicting tumor responses to radiotherapy in lung cancer
    Amit K Das
    The University of Texas Southwestern Medical Center, The Hamon Center for Therapeutic Oncology Research, Dallas, TX 75390 8593, USA
    Semin Radiat Oncol 20:149-55. 2010
    ....
  15. doi request reprint Short double-stranded RNAs of specific sequence activate ribosomal TAK1-D and induce a global inhibition of translation
    Reinhard Kodym
    Division of Molecular Radiation Biology, Department of Radiation Oncology, UT Southwestern Medical Center, 2201 Inwood Road, Dallas, TX 75390, USA
    Biol Chem 390:453-62. 2009
    ..In addition, we show that TAK1-D is also phosphorylated after the induction of ribotoxic stress. Our data indicate that TAK1-D plays a role in the signaling events triggered by selected types of ribotoxic stress...
  16. pmc Enhanced identification and biological validation of differential gene expression via Illumina whole-genome expression arrays through the use of the model-based background correction methodology
    Liang Hao Ding
    Simmons Comprehensive Cancer Center Genomics Core Facility, Department of Radiation Oncology, Division of Molecular Radiation Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Nucleic Acids Res 36:e58. 2008
    ..We conclude that MBCB is a robust background correction method that will lead to more precise determination of gene expression and better biological interpretation of Illumina BeadArray data...
  17. doi request reprint Molecular profiling to optimize treatment in non-small cell lung cancer: a review of potential molecular targets for radiation therapy by the translational research program of the radiation therapy oncology group
    Natalie L Ausborn
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Int J Radiat Oncol Biol Phys 83:e453-64. 2012
    ....
  18. doi request reprint Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Radiat Res 169:437-46. 2008
    ..Collectively, these data demonstrate that the inability of cells to rejoin DSBs within clustered DNA lesions likely contributes to the greater biological effectiveness of HZE particles...
  19. pmc Cells lacking IKKα show nuclear cyclin D1 overexpression and a neoplastic phenotype: role of IKKα as a tumor suppressor
    Youn Tae Kwak
    Department of Medicine, Division of Hematology Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Mol Cancer Res 9:341-9. 2011
    ..These results suggest that IKKα may function as a tumor suppressor gene. Absence of IKKα may induce tumorigenicity by nuclear localization of cyclin D1 and modulating the expression of genes involved in neoplastic transformation...
  20. pmc An orthotopic lung tumor model for image-guided microirradiation in rats
    Debabrata Saha
    Department of Radiation Oncology, Division of Molecular Radiation Biology and Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas 75390 9187, USA
    Radiat Res 174:62-71. 2010
    ....
  21. ncbi request reprint Optimizing dose and fractionation for stereotactic body radiation therapy. Normal tissue and tumor control effects with large dose per fraction
    Robert Timmerman
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9183, USA
    Front Radiat Ther Oncol 40:352-65. 2007
    ..Hopefully, it will serve as a motivation for more sophisticated biological research into the effects of SBRT...
  22. ncbi request reprint Stereotactic body radiation therapy: a treatment in need of basic biological research
    Robert D Timmerman
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9183, USA
    Cancer J 12:19-20. 2006
  23. doi request reprint Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy
    Clint Park
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9183, USA
    Int J Radiat Oncol Biol Phys 70:847-52. 2008
    ....
  24. ncbi request reprint Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation
    Amit K Das
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, NC 7 208, Mail Code 9187, Dallas, TX 75390, USA
    Cancer Res 66:9601-8. 2006
    ....
  25. doi request reprint High dose-per-fraction irradiation of limited lung volumes using an image-guided, highly focused irradiator: simulating stereotactic body radiotherapy regimens in a small-animal model
    Jaeho Cho
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75093, USA
    Int J Radiat Oncol Biol Phys 77:895-902. 2010
    ..Here, we describe such an irradiation system and use it to examine normal tissue toxicity in a small-animal model at lung volumes similar to those associated with human therapy...
  26. pmc An athymic rat model of cutaneous radiation injury designed to study human tissue-based wound therapy
    Lucas H Rifkin
    1Department of Plastic and Reconstructive Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Radiat Oncol 7:68. 2012
    ..To describe a pilot study for a novel preclinical model used to test human tissue-based therapies in the setting of cutaneous radiation injury...
  27. doi request reprint 2'-5'-Oligoadenylate synthetase is activated by a specific RNA sequence motif
    Reinhard Kodym
    Division of Molecular Radiation Biology, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX 75390 9187, USA
    Biochem Biophys Res Commun 388:317-22. 2009
    ....
  28. pmc DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy
    Benjamin J Moeller
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 17:2035-43. 2011
    ..We examined whether differential expression of double-strand DNA break (DSB) repair proteins in HNSCC, the chief mediators of DNA repair following irradiation, predict for treatment outcomes...
  29. doi request reprint Gene expression changes in cervical squamous cell carcinoma after initiation of chemoradiation and correlation with clinical outcome
    Ann H Klopp
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 71:226-36. 2008
    ..In addition we aimed to identify a gene expression profile that was associated with clinical outcome...
  30. pmc Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation
    Xin Huang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94025, USA
    Mol Cell 35:856-67. 2009
    ..Taken together, these data implicate an important role for mir-210 in regulating the hypoxic response of tumor cells and tumor growth...
  31. ncbi request reprint Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2
    Thomas A Buchholz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 97:557-61. 2002
    ..This phenotype could possibly predispose to an increased risk of radiation-induced mutagenesis and carcinogenesis...
  32. ncbi request reprint Predicting radiosensitivity using DNA end-binding complex analysis
    Sheikh M Ismail
    Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:1226-34. 2004
    ..45). These data indicate that DNA-EBC analysis may be a practical, clinically relevant predictor of tumor and primary cell radiosensitivity...
  33. ncbi request reprint Chromosomal fragility syndrome and family history of radiosensitivity as indicators for radiotherapy dose modification
    Ghazi Alsbeih
    Experimental Radiation Oncology, Box 66, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Radiother Oncol 66:341-4. 2003
    ..While an accurate laboratory test for radiosensitivity is still lacking, assessments of chromosomal fragility, cell survival and clinical medicine will continue to be useful for a small number of patients...
  34. ncbi request reprint Adenoviral-mediated mda-7 expression suppresses DNA repair capacity and radiosensitizes non-small-cell lung cancer cells
    Takashi Nishikawa
    Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 23:7125-31. 2004
    ..Based on these results, we hypothesize that Ad-mda7 sensitizes NSCLC cells to ionizing radiation by suppressing the activity of NHEJ, a pathway essential for repair of radiation-induced DSBs...
  35. ncbi request reprint Cyclin B1 overexpression and resistance to radiotherapy in head and neck squamous cell carcinoma
    Khaled A Hassan
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:6414-7. 2002
    ..01). Our results indicate that tumors overexpressing cyclin B1 may be resistant to RT, and cyclin B1 may be an indicator of the risk of locoregional recurrence and metastasis in patients having HNSCC receiving RT...
  36. pmc Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    Doug W Chan
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Genes Dev 16:2333-8. 2002
    ..Mutation of Thr2609 to Ala leads to radiation sensitivity and impaired DSB rejoining. These findings establish that Ku-dependent phosphorylation of DNA-PKcs at Thr2609 is required for the repair of DSBs by NHEJ...

Research Grants3

  1. P28-DRA IN THE STRESS RESPONSE OF MAMMALIAN CELLS
    Michael Story; Fiscal Year: 2001
    ..Understanding how p28dra functions will provide new insights into overcoming resistance to cancer therapy and possibly lead to new clinical strategies in cancer management. ..