RICHARD ALAN STONE

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Scheie Eye Institute, D 603 Richards Building, Philadelphia, PA 19104 6075, USA Electronic address
    Exp Eye Res 114:35-47. 2013
  2. ncbi request reprint Associations between childhood refraction and parental smoking
    Richard A Stone
    Department of Ophthalmology, Scheie Eye Institute, Philadelphia, PA 19104 6075, USA
    Invest Ophthalmol Vis Sci 47:4277-87. 2006
  3. ncbi request reprint GABA, experimental myopia, and ocular growth in chick
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 44:3933-46. 2003
  4. ncbi request reprint Ocular shape and myopia
    R A Stone
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia, PA 19104 6075, USA
    Ann Acad Med Singapore 33:7-15. 2004
  5. ncbi request reprint Local patterns of image degradation differentially affect refraction and eye shape in chick
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania 19104 6075, USA
    Curr Eye Res 31:91-105. 2006
  6. ncbi request reprint Anterior segment growth and peripheral neural pathways in chick
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania 19104 6075, USA
    Curr Eye Res 31:511-7. 2006
  7. pmc Utility of digital stereo images for optic disc evaluation
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania, Scheie Eye Institute, Philadelphia, Pennsylvania 19104 3309, USA
    Invest Ophthalmol Vis Sci 51:5667-74. 2010
  8. pmc Image defocus and altered retinal gene expression in chick: clues to the pathogenesis of ametropia
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania 19104 6075, USA
    Invest Ophthalmol Vis Sci 52:5765-77. 2011
  9. ncbi request reprint Emmetropisation under continuous but non-constant light in chicks
    Ji Liu
    Department of Ophthalmology, School of Medicine, University of Pennsylvania, D 603 Richards Bldg, Philadelphia, PA 19104 6075, USA
    Exp Eye Res 79:719-28. 2004
  10. pmc Gene profiling in experimental models of eye growth: clues to myopia pathogenesis
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia, PA 19104 6075, USA
    Vision Res 50:2322-33. 2010

Research Grants

Collaborators

Detail Information

Publications30

  1. pmc Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Scheie Eye Institute, D 603 Richards Building, Philadelphia, PA 19104 6075, USA Electronic address
    Exp Eye Res 114:35-47. 2013
    ..While much future research is needed, this hypothesis could unify many of the disparate clinical and laboratory observations addressing the pathogenesis of refractive errors. ..
  2. ncbi request reprint Associations between childhood refraction and parental smoking
    Richard A Stone
    Department of Ophthalmology, Scheie Eye Institute, Philadelphia, PA 19104 6075, USA
    Invest Ophthalmol Vis Sci 47:4277-87. 2006
    ....
  3. ncbi request reprint GABA, experimental myopia, and ocular growth in chick
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 44:3933-46. 2003
    ..To learn whether gamma-aminobutyric acid (GABA) participates in retinal mechanisms that influence refractive development...
  4. ncbi request reprint Ocular shape and myopia
    R A Stone
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia, PA 19104 6075, USA
    Ann Acad Med Singapore 33:7-15. 2004
    ..To learn if eye shape might be a useful parameter in refractive research...
  5. ncbi request reprint Local patterns of image degradation differentially affect refraction and eye shape in chick
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania 19104 6075, USA
    Curr Eye Res 31:91-105. 2006
    ..To evaluate visual blur as a mechanism for modulating eye shape...
  6. ncbi request reprint Anterior segment growth and peripheral neural pathways in chick
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania 19104 6075, USA
    Curr Eye Res 31:511-7. 2006
    ..To learn if peripheral nerve pathways are necessary for corneal expansion and anterior segment growth under a 12-hr light:dark cycle or for the inhibition of corneal expansion under constant light rearing...
  7. pmc Utility of digital stereo images for optic disc evaluation
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania, Scheie Eye Institute, Philadelphia, Pennsylvania 19104 3309, USA
    Invest Ophthalmol Vis Sci 51:5667-74. 2010
    ..To assess the suitability of digital stereo images for optic disc evaluations in glaucoma...
  8. pmc Image defocus and altered retinal gene expression in chick: clues to the pathogenesis of ametropia
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania 19104 6075, USA
    Invest Ophthalmol Vis Sci 52:5765-77. 2011
    ....
  9. ncbi request reprint Emmetropisation under continuous but non-constant light in chicks
    Ji Liu
    Department of Ophthalmology, School of Medicine, University of Pennsylvania, D 603 Richards Bldg, Philadelphia, PA 19104 6075, USA
    Exp Eye Res 79:719-28. 2004
    ..Such studies also could provide mechanistic insights into whether and how daily rhythms in retinal dopamine metabolism, axial length or choroidal thickness modulate refractive development...
  10. pmc Gene profiling in experimental models of eye growth: clues to myopia pathogenesis
    Richard A Stone
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia, PA 19104 6075, USA
    Vision Res 50:2322-33. 2010
    ..Continued application of these methods offers promise to provide the much-needed mechanistic framework to develop therapies to normalize refractive development in children...
  11. ncbi request reprint Darkness and near work: myopia and its progression in third-year law students
    Jane Loman
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ophthalmology 109:1032-8. 2002
    ..To evaluate myopia prevalence, myopia progression, and various potential myopia risk factors in third-year law students...
  12. pmc Barrier qualities of the mouse eye to topically applied drugs
    Zhao Wang
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
    Exp Eye Res 85:105-12. 2007
    ..Comparison of invasive and non-invasive measurement methods can document drug efficacy at intraocular target sites even if topical drug penetration is too slow to manifest convincing physiologic effects in intact eyes...
  13. pmc Form-deprivation myopia in chick induces limited changes in retinal gene expression
    Alice M McGlinn
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6075, USA
    Invest Ophthalmol Vis Sci 48:3430-6. 2007
    ..In the present study, the retinal transcriptome was analyzed to identify alterations in gene expression and potential signaling pathways involved in form-deprivation myopia of the chick...
  14. pmc Nucleoside-derived antagonists to A3 adenosine receptors lower mouse intraocular pressure and act across species
    Zhao Wang
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
    Exp Eye Res 90:146-54. 2010
    ..We conclude that derivatives of the highly-selective A3AR agonist Cl-IB-MECA can reduce IOP upon reaching their intraocular target, and that nucleoside-based derivatives are promising A3 antagonists for study in multiple animal models...
  15. pmc The cross-species A3 adenosine-receptor antagonist MRS 1292 inhibits adenosine-triggered human nonpigmented ciliary epithelial cell fluid release and reduces mouse intraocular pressure
    Hui Yang
    Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6085, USA
    Curr Eye Res 30:747-54. 2005
    ..We tested whether the specific A3AR antagonist MRS 1292, designed to cross species, mimicks the effects of other A3AR antagonists on cultured human nonpigmented ciliary epithelial (NPE) cells and mouse IOP...
  16. ncbi request reprint Noninvasive assessment of aqueous humor turnover in the mouse eye
    Marcel Y Avila
    Department of Physiology, Ophthalmology, and Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 44:722-7. 2003
    ..To develop a noninvasive test for monitoring changes in aqueous humor turnover in the mouse eye...
  17. ncbi request reprint Inhibitors of NHE-1 Na+/H+ exchange reduce mouse intraocular pressure
    Marcel Y Avila
    Department of Physiology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 6085, USA
    Invest Ophthalmol Vis Sci 43:1897-902. 2002
    ..To test whether blocking the Na+/H+ antiport reduces intraocular pressure (IOP) in the mouse...
  18. ncbi request reprint Knockout of A3 adenosine receptors reduces mouse intraocular pressure
    Marcel Y Avila
    Department of Physiology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 43:3021-6. 2002
    ..To test the putative role of A(3) adenosine receptors (ARs) in modulating intraocular pressure (IOP)...
  19. ncbi request reprint Diurnal axial length fluctuations in human eyes
    Richard A Stone
    Division of Pediatric Ophthalmology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 45:63-70. 2004
    ..This study sought diurnal variations of eye length in human subjects, analogous to those reported in laboratory animals...
  20. pmc Nicotinic acetylcholine receptor subunits in rhesus monkey retina
    Ji Liu
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6075, USA
    Invest Ophthalmol Vis Sci 50:1408-15. 2009
    ..The purpose of this study was to detect and establish the cellular localizations of nicotinic acetylcholine receptor (nAChR) subunits in Rhesus monkey retina...
  21. ncbi request reprint Height and its relationship to refraction and biometry parameters in Singapore Chinese children
    Seang Mei Saw
    Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive, Singapore 117597, Republic of Singapore
    Invest Ophthalmol Vis Sci 43:1408-13. 2002
    ..To examine the association between the anthropometric measurements of height, weight, body mass index (BMI) and refraction and other ocular parameters in Singapore Chinese children...
  22. ncbi request reprint Component dependent risk factors for ocular parameters in Singapore Chinese children
    Seang Mei Saw
    Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Republic of Singapore Singapore Eye Research Institute, Singapore, Republic of Singapore
    Ophthalmology 109:2065-71. 2002
    ..To examine the risk factors for variations in ocular biometry parameters in Singapore Chinese children, a population with a known high prevalence rate of myopia at an early age...
  23. ncbi request reprint Ocular dominance, laterality, and refraction in Singaporean children
    Audrey Chia
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 48:3533-6. 2007
    ..To explore the effect of dominance and laterality on refractive error and axial length...
  24. ncbi request reprint Association between breastfeeding and likelihood of myopia in children
    Yap Seng Chong
    JAMA 293:3001-2. 2005
  25. ncbi request reprint Highly precise eye length measurements in children aged 3 through 12 years
    Graham E Quinn
    Division of Pediatric Ophthalmology, The Children s Hospital of Philadelphia, One Children s Center, PA 19104, USA
    Arch Ophthalmol 121:985-90. 2003
    ..To determine the feasibility, reliability, and validity of using partial coherence interferometry, a noncontact method that detects interference patterns from various layers of the eye, to measure axial length in young children...
  26. ncbi request reprint Myopia and natural lighting extremes: risk factors in Finnish army conscripts
    Antti E Vannas
    Central Military Hospital, Helsinki, Finland
    Acta Ophthalmol Scand 81:588-95. 2003
    ..To establish whether features of environmental lighting in far northern latitudes might be associated with prevalence of myopia...
  27. ncbi request reprint A cohort study of incident myopia in Singaporean children
    Seang Mei Saw
    Department of Community, Occupational, and Family Medicine, National University of Singapore, Singapore
    Invest Ophthalmol Vis Sci 47:1839-44. 2006
    ..To determine the risk factors of incident myopia in a school-based cohort study in Singaporean children...
  28. ncbi request reprint The relation of axial length and intraocular pressure fluctuations in human eyes
    Lorri B Wilson
    Division of Pediatric Ophthalmology, The Children s Hospital of Philadelphia, PA 19104, USA
    Invest Ophthalmol Vis Sci 47:1778-84. 2006
    ....
  29. ncbi request reprint IQ and the association with myopia in children
    Seang Mei Saw
    Department of Community, Occupational and Family Medicine, National University of Singapore
    Invest Ophthalmol Vis Sci 45:2943-8. 2004
    ..To evaluate the association between intelligence and myopia in children...
  30. ncbi request reprint Nearwork in early-onset myopia
    Seang Mei Saw
    Department of Community, Occupational and Family Medicine, National University of Singapore, Republic of Singapore
    Invest Ophthalmol Vis Sci 43:332-9. 2002
    ..To determine the relationship of nearwork and myopia in young elementary school-age children in Singapore...

Research Grants19

  1. Molecular Characterization of Chick Retina during Refractive Development
    RICHARD ALAN STONE; Fiscal Year: 2010
    ....
  2. Computer analysis of optic disc images in glaucoma
    Richard Stone; Fiscal Year: 2009
    ..The refined approach to stereo recovery will permit robust detection of optic disc stability or change, and it offers great promise for advancing optic nerve diagnosis in glaucoma. ..
  3. Molecular Characterization of Chick Retina during Refractive Development
    Richard Stone; Fiscal Year: 2009
    ....
  4. Computer analysis of optic disc images in glaucoma
    Richard Stone; Fiscal Year: 2007
    ..The refined approach to stereo recovery will permit robust detection of optic disc stability or change, and it offers great promise for advancing optic nerve diagnosis in glaucoma. ..
  5. mRNA expression by RPE cells in myopia
    Richard Stone; Fiscal Year: 2006
    ..We believe this program will lead to improved understanding of the etiology of refractive errors and ultimately to effective approaches to arrest myopia in children. ..
  6. MYOPIA AND OCULAR GROWTH--NEURAL MECHANISMS
    Richard Stone; Fiscal Year: 2004
    ..We hope that our studies will continue to lead to improved understanding of ocular growth and ultimately towards rational approaches to prevent refractive errors in children. ..
  7. MYOPIA & OCULAR GROWTH--NEURAL MECHANISMS
    Richard Stone; Fiscal Year: 1992
    ..We hope that these studies ultimately will lead to an improved understanding of human myopia and to a viable drug therapy to prevent its development...
  8. MYOPIA AND OCULAR GROWTH--NEURAL MECHANISMS
    Richard Stone; Fiscal Year: 1999
    ..The PI hopes that these studies ultimately will lead to a sufficiently improved understanding of human refractive errors that rational approaches can be developed to prevent them. ..
  9. Computer analysis of optic disc images in glaucoma
    RICHARD ALAN STONE; Fiscal Year: 2010
    ..The refined approach to stereo recovery will permit robust detection of optic disc stability or change, and it offers great promise for advancing optic nerve diagnosis in glaucoma. ..