RICHARD ALAN STONE

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..To learn if peripheral nerve pathways are necessary for corneal expansion and anterior segment growth under a 12-hr light:dark cycle or for the inhibition of corneal expansion under constant light rearing...

..To evaluate visual blur as a mechanism for modulating eye shape...

..To learn if eye shape might be a useful parameter in refractive research...

..To learn whether gamma-aminobutyric acid (GABA) participates in retinal mechanisms that influence refractive development...

..To assess the suitability of digital stereo images for optic disc evaluations in glaucoma...

..Such studies also could provide mechanistic insights into whether and how daily rhythms in retinal dopamine metabolism, axial length or choroidal thickness modulate refractive development...

..Continued application of these methods offers promise to provide the much-needed mechanistic framework to develop therapies to normalize refractive development in children...

..The role of exposure to darkness in refractive development warrants additional study...

..Comparison of invasive and non-invasive measurement methods can document drug efficacy at intraocular target sites even if topical drug penetration is too slow to manifest convincing physiologic effects in intact eyes...

..In the present study, the retinal transcriptome was analyzed to identify alterations in gene expression and potential signaling pathways involved in form-deprivation myopia of the chick...

..We conclude that derivatives of the highly-selective A3AR agonist Cl-IB-MECA can reduce IOP upon reaching their intraocular target, and that nucleoside-based derivatives are promising A3 antagonists for study in multiple animal models...

..8 mmHg at 25-microM droplet concentration (n = 10, p < 0.005). CONCLUSIONS: MRS 1292 inhibits A3AR-mediated shrinkage of human NPE cells and reduces mouse IOP, consistent with its putative action as a cross-species A3 antagonist...

..That bumetanide can produce a previously unobserved lowering of IOP when the Na+/H+ antiport is also inhibited substantiates a dominant antiport mechanism...

..The purpose of this study was to detect and establish the cellular localizations of nicotinic acetylcholine receptor (nAChR) subunits in Rhesus monkey retina...

..To test the putative role of A(3) adenosine receptors (ARs) in modulating intraocular pressure (IOP)...

..Based on repeated measurements, these daily fluctuations may not appear regularly in all subjects, suggesting the possibility of physiologic influences that must be defined...

..To develop a noninvasive test for monitoring changes in aqueous humor turnover in the mouse eye...

..To examine the risk factors for variations in ocular biometry parameters in Singapore Chinese children, a population with a known high prevalence rate of myopia at an early age...

..To examine the association between the anthropometric measurements of height, weight, body mass index (BMI) and refraction and other ocular parameters in Singapore Chinese children...

..To explore the effect of dominance and laterality on refractive error and axial length...

..To determine the risk factors of incident myopia in a school-based cohort study in Singaporean children...

..CONCLUSIONS: Both axial length and IOP fluctuate during the day much of the time in most subjects. However, diurnal IOP fluctuations do not appear to cause diurnal axial length fluctuations...

..To evaluate the association between intelligence and myopia in children...

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..CONCLUSION: The partial coherence interferometry technique provides reproducible, extraordinarily precise eye length measurements in young children and should enable novel approaches to study eye growth and refractive development...

..To determine the relationship of nearwork and myopia in young elementary school-age children in Singapore...

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..The refined approach to stereo recovery will permit robust detection of optic disc stability or change, and it offers great promise for advancing optic nerve diagnosis in glaucoma. ..

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..The refined approach to stereo recovery will permit robust detection of optic disc stability or change, and it offers great promise for advancing optic nerve diagnosis in glaucoma. ..

..We believe this program will lead to improved understanding of the etiology of refractive errors and ultimately to effective approaches to arrest myopia in children. ..

..We hope that our studies will continue to lead to improved understanding of ocular growth and ultimately towards rational approaches to prevent refractive errors in children. ..

..We hope that these studies ultimately will lead to an improved understanding of human myopia and to a viable drug therapy to prevent its development...

..The PI hopes that these studies ultimately will lead to a sufficiently improved understanding of human refractive errors that rational approaches can be developed to prevent them. ..

..The refined approach to stereo recovery will permit robust detection of optic disc stability or change, and it offers great promise for advancing optic nerve diagnosis in glaucoma. ..