James R Stone
Affiliation: University of Virginia
- Caspase-3-mediated cleavage of amyloid precursor protein and formation of amyloid Beta peptide in traumatic axonal injuryJames R Stone
Department of Neurosurgery, University of Virginia, Charlottesville, Virginia 22908 0212, USA
J Neurotrauma 19:601-14. 2002..These findings are of interest given recent epidemiological studies supporting an association between TBI and later risk for AD development...
- Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injuryJames R Stone
Department of Neurosurgery, University of Virginia, Charlottesville, VA 22908, USA
Exp Neurol 190:59-69. 2004..This finding underscores the need of multiple approaches to fully assess the axonal response to TBI...
- Illuminating protein interactions in tissue using confocal and two-photon excitation fluorescent resonance energy transfer microscopyJames D Mills
University of Virginia Health Sciences Center, Department of Neurosurgery, Charlottesville, Virginia 22908, USA
J Biomed Opt 8:347-56. 2003..Further, we report on a method to reliably detect protein interactions within aldehyde fixed tissue sections through conventional immunohistochemical approaches...
- Dose-response of cyclosporin A in attenuating traumatic axonal injury in ratDavid O Okonkwo
Departments of Neuroscience and Neurological Surgery, University of Virginia, PO Box 800212, Charlottesville, VA 22908, USA
Neuroreport 14:463-6. 2003..v. was toxic. Intravenous cyclosporin A administration achieves therapeutic levels in brain parenchyma and 10 mg/kg is the most effective dose in attenuating axonal damage after traumatic brain injury...
- Renal angioplasty and stent placement with distal protection: preliminary experience with the FilterWire EXKlaus D Hagspiel
Department of Radiology, University of Virginia Health System, PO Box 800170, 1215 Lee Street, Charlottesville, Virginia 22908, USA
J Vasc Interv Radiol 16:125-31. 2005..The FilterWire EX needs to be modified for the renal circulation to achieve the full theoretical advantages of these systems in this vascular bed...
- A comparison of adenosine A2A agonism and methylprednisolone in attenuating neuronal damage and improving functional outcome after experimental traumatic spinal cord injury in rabbitsDavid O Okonkwo
Department of Neurological Surgery, University of Virginia Health System, Charlottesville 22908 0212, USA
J Neurosurg Spine 4:64-70. 2006..The authors of this study evaluated ATL-146e and methylprednisolone for their ability to preserve neuronal viability and motor function in experimental SCI...
- Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementationDavid O Okonkwo
Department of Neuroscience, University of Virginia, P O Box 800212, Charlottesville, VA 22908 0212, USA
Neurosci Lett 352:97-100. 2003..Arterial blood gas parameters did not differ within groups. These results provide clear indication to study the utility of TSC in ameliorating hypoxic/ischemic insults in neurological disorders...
- Basic science of closed head injuries and spinal cord injuriesDavid O Okonkwo
Department of Neuroscience, University of Virginia, PO Box 800212, Charlottesville, VA 22908 0212, USA
Clin Sports Med 22:467-81. 2003..As no panacea exists, improvements in experimental models have empowered researchers in their search for novel therapeutic strategies...
- In vitro assessment of aortic stent-graft integrity following exposure to Onyx liquid embolic agentJames R Stone
Division of Interventional Radiology, Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
J Vasc Interv Radiol 20:107-12. 2009..Although DMSO is known to damage some angiographic catheters, little is known concerning whether this compound damages stent-graft material. The current study was undertaken to directly explore this issue...
- Traumatically induced axotomy adjacent to the soma does not result in acute neuronal deathRichard H Singleton
Departments of Anatomy and Anesthesiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Neurosci 22:791-802. 2002..Rather, some somata showed evidence of potential reorganization and repair. This study demonstrates a novel somatic response to TAI in the perisomatic domain and also provides insight into the multifaceted pathology associated with TBI...
- Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clustersAndrea Ventura
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 132:875-86. 2008..These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functions during B lymphopoiesis and lung development...
- Risk factors for atherosclerosis and the development of preatherosclerotic intimal hyperplasiaStephanie M Cizek
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cardiovasc Pathol 16:344-50. 2007..To gain insight into the etiology of preatherosclerotic intimal hyperplasia, we correlated traditional risk factors for atherosclerosis with the intimal hyperplasia in an atherosclerosis-resistant vessel, the internal thoracic artery...
- Case records of the Massachusetts General Hospital. Case 28-2007. A 68-year-old man with syncopeJames L Januzzi
Coronary Care Unit, Massachusetts General Hospital, USA
N Engl J Med 357:1137-45. 2007
- External iliac artery endofibrosis in an amateur runner: hemodynamic, angiographic, histopathological evaluation and percutaneous revascularizationAndrew O Maree
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Vasc Med 12:203-6. 2007..The diagnosis was made by a combination of hemodynamic, angiographic and histopathological assessment and percutaneous revascularization was performed using a balloon expandable stent...
- Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesisAlice T Shaw
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston 02114, USA
Genes Dev 21:694-707. 2007..These findings indicate that in the lung, Sprouty-2 plays a critical role in the regulation of oncogenic K-ras, and implicate counter-regulatory mechanisms in the pathogenesis of Ras-based disease...
- Case records of the Massachusetts General Hospital. Case 23-2006. A 36-year-old man with numbness in the left [corrected] hand and hypertensionOthon Iliopoulos
Cancer Center, Massachusetts General Hospital, USA
N Engl J Med 355:394-402. 2006
- Hydrogen peroxide: a signaling messengerJames R Stone
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Antioxid Redox Signal 8:243-70. 2006..Application of physiologic levels of H2O2 to mammalian cells has been shown to stimulate biological responses and to activate specific biochemical pathways in these cells...
- Rapid phosphorylation of heterogeneous nuclear ribonucleoprotein C1/C2 in response to physiologic levels of hydrogen peroxide in human endothelial cellsJames R Stone
Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:15621-8. 2002..The effects were observed with as little as 1 microm H(2)O(2) and were maximal with 5-8 microm H(2)O(2). The H(2)O(2)-stimulated phosphorylation was inhibited by catalase, but not by the transcriptional inhibitor actinomycin D...
- Coronary artery perforation by cutting balloon resulting in dissecting subepicardial hematoma and avulsion of the vasculatureVu H Quan
Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Catheter Cardiovasc Interv 64:163-8. 2005..This was complicated by a subepicardial hematoma leading to avulsion of the penetrating arteries and cardiogenic shock. Despite surgical evacuation and percutaneous left ventricular assist-device support, death ensued...
- Analysis of robust innate immune response after transplantation in the absence of adaptive immunityHongzhen He
Laboratory of Molecular Immunology, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Transplantation 73:853-61. 2002..CONCLUSIONS: Our study demonstrated a robust innate immune response that is independent of adaptive immunity and natural killer cell responses...
- Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II/NG-nitro-L-arginine methyl ester-induced myocardial injuryEveline M Oestreicher
Division of Endocrinology, Hypertension and Diabetes, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Ave, Boston, Mass 02115, USA
Circulation 108:2517-23. 2003....