James R Stone
Affiliation: University of Virginia
- Caspase-3-mediated cleavage of amyloid precursor protein and formation of amyloid Beta peptide in traumatic axonal injuryJames R Stone
Department of Neurosurgery, University of Virginia, Charlottesville, Virginia 22908 0212, USA
J Neurotrauma 19:601-14. 2002..These findings are of interest given recent epidemiological studies supporting an association between TBI and later risk for AD development...
- Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injuryJames R Stone
Department of Neurosurgery, University of Virginia, Charlottesville, VA 22908, USA
Exp Neurol 190:59-69. 2004..This finding underscores the need of multiple approaches to fully assess the axonal response to TBI...
- Illuminating protein interactions in tissue using confocal and two-photon excitation fluorescent resonance energy transfer microscopyJames D Mills
University of Virginia Health Sciences Center, Department of Neurosurgery, Charlottesville, Virginia 22908, USA
J Biomed Opt 8:347-56. 2003..Further, we report on a method to reliably detect protein interactions within aldehyde fixed tissue sections through conventional immunohistochemical approaches...
- Dose-response of cyclosporin A in attenuating traumatic axonal injury in ratDavid O Okonkwo
Departments of Neuroscience and Neurological Surgery, University of Virginia, PO Box 800212, Charlottesville, VA 22908, USA
Neuroreport 14:463-6. 2003..v. was toxic. Intravenous cyclosporin A administration achieves therapeutic levels in brain parenchyma and 10 mg/kg is the most effective dose in attenuating axonal damage after traumatic brain injury...
- Renal angioplasty and stent placement with distal protection: preliminary experience with the FilterWire EXKlaus D Hagspiel
Department of Radiology, University of Virginia Health System, PO Box 800170, 1215 Lee Street, Charlottesville, Virginia 22908, USA
J Vasc Interv Radiol 16:125-31. 2005..The FilterWire EX needs to be modified for the renal circulation to achieve the full theoretical advantages of these systems in this vascular bed...
- A comparison of adenosine A2A agonism and methylprednisolone in attenuating neuronal damage and improving functional outcome after experimental traumatic spinal cord injury in rabbitsDavid O Okonkwo
Department of Neurological Surgery, University of Virginia Health System, Charlottesville 22908 0212, USA
J Neurosurg Spine 4:64-70. 2006..The authors of this study evaluated ATL-146e and methylprednisolone for their ability to preserve neuronal viability and motor function in experimental SCI...
- Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementationDavid O Okonkwo
Department of Neuroscience, University of Virginia, P O Box 800212, Charlottesville, VA 22908 0212, USA
Neurosci Lett 352:97-100. 2003..Arterial blood gas parameters did not differ within groups. These results provide clear indication to study the utility of TSC in ameliorating hypoxic/ischemic insults in neurological disorders...
- Basic science of closed head injuries and spinal cord injuriesDavid O Okonkwo
Department of Neuroscience, University of Virginia, PO Box 800212, Charlottesville, VA 22908 0212, USA
Clin Sports Med 22:467-81. 2003..As no panacea exists, improvements in experimental models have empowered researchers in their search for novel therapeutic strategies...
- In vitro assessment of aortic stent-graft integrity following exposure to Onyx liquid embolic agentJames R Stone
Division of Interventional Radiology, Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
J Vasc Interv Radiol 20:107-12. 2009..Although DMSO is known to damage some angiographic catheters, little is known concerning whether this compound damages stent-graft material. The current study was undertaken to directly explore this issue...
- Traumatically induced axotomy adjacent to the soma does not result in acute neuronal deathRichard H Singleton
Departments of Anatomy and Anesthesiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Neurosci 22:791-802. 2002..Rather, some somata showed evidence of potential reorganization and repair. This study demonstrates a novel somatic response to TAI in the perisomatic domain and also provides insight into the multifaceted pathology associated with TBI...
- Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clustersAndrea Ventura
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 132:875-86. 2008..These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functions during B lymphopoiesis and lung development...
- Risk factors for atherosclerosis and the development of preatherosclerotic intimal hyperplasiaStephanie M Cizek
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cardiovasc Pathol 16:344-50. 2007..To gain insight into the etiology of preatherosclerotic intimal hyperplasia, we correlated traditional risk factors for atherosclerosis with the intimal hyperplasia in an atherosclerosis-resistant vessel, the internal thoracic artery...
- Case records of the Massachusetts General Hospital. Case 28-2007. A 68-year-old man with syncopeJames L Januzzi
Coronary Care Unit, Massachusetts General Hospital, USA
N Engl J Med 357:1137-45. 2007
- External iliac artery endofibrosis in an amateur runner: hemodynamic, angiographic, histopathological evaluation and percutaneous revascularizationAndrew O Maree
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Vasc Med 12:203-6. 2007..The diagnosis was made by a combination of hemodynamic, angiographic and histopathological assessment and percutaneous revascularization was performed using a balloon expandable stent...
- Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesisAlice T Shaw
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston 02114, USA
Genes Dev 21:694-707. 2007..These findings indicate that in the lung, Sprouty-2 plays a critical role in the regulation of oncogenic K-ras, and implicate counter-regulatory mechanisms in the pathogenesis of Ras-based disease...
- Case records of the Massachusetts General Hospital. Case 23-2006. A 36-year-old man with numbness in the left [corrected] hand and hypertensionOthon Iliopoulos
Cancer Center, Massachusetts General Hospital, USA
N Engl J Med 355:394-402. 2006
- Hydrogen peroxide: a signaling messengerJames R Stone
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Antioxid Redox Signal 8:243-70. 2006..Application of physiologic levels of H2O2 to mammalian cells has been shown to stimulate biological responses and to activate specific biochemical pathways in these cells...
- Rapid phosphorylation of heterogeneous nuclear ribonucleoprotein C1/C2 in response to physiologic levels of hydrogen peroxide in human endothelial cellsJames R Stone
Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:15621-8. 2002..The effects were observed with as little as 1 microm H(2)O(2) and were maximal with 5-8 microm H(2)O(2). The H(2)O(2)-stimulated phosphorylation was inhibited by catalase, but not by the transcriptional inhibitor actinomycin D...
- Coronary artery perforation by cutting balloon resulting in dissecting subepicardial hematoma and avulsion of the vasculatureVu H Quan
Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Catheter Cardiovasc Interv 64:163-8. 2005..This was complicated by a subepicardial hematoma leading to avulsion of the penetrating arteries and cardiogenic shock. Despite surgical evacuation and percutaneous left ventricular assist-device support, death ensued...
- Analysis of robust innate immune response after transplantation in the absence of adaptive immunityHongzhen He
Laboratory of Molecular Immunology, Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Transplantation 73:853-61. 2002..During transplantation, innate immunity may be stimulated by multiple factors, including ischemia, reperfusion, sterile injury, systemic stress, and cell death...
- Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II/NG-nitro-L-arginine methyl ester-induced myocardial injuryEveline M Oestreicher
Division of Endocrinology, Hypertension and Diabetes, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Ave, Boston, Mass 02115, USA
Circulation 108:2517-23. 2003....