Cheryl A Stoddart

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus
    Mary E Keir
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 168:325-31. 2002
  2. ncbi Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus
    Mary E Keir
    Biomedical Sciences Graduate Program, University of California, San Francisco 94143, USA
    J Immunol 169:2788-96. 2002
  3. ncbi Efficacy of broadly neutralizing monoclonal antibody PG16 in HIV-infected humanized mice
    Cheryl A Stoddart
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, Box 1234, San Francisco, San Francisco, CA 94143, USA Electronic address
    Virology 462:115-25. 2014
  4. pmc Impaired infectivity of ritonavir-resistant HIV is rescued by heat shock protein 90AB1
    Pheroze Joshi
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 286:24581-92. 2011
  5. pmc Preexposure prophylaxis with albumin-conjugated C34 peptide HIV-1 fusion inhibitor in SCID-hu Thy/Liv mice
    Cheryl A Stoddart
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    Antimicrob Agents Chemother 56:2162-5. 2012
  6. pmc Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rγ(-/-) (NSG) BLT mice
    Cheryl A Stoddart
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
    Virology 417:154-60. 2011
  7. pmc IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo
    Cheryl A Stoddart
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    PLoS Pathog 6:e1000766. 2010
  8. pmc Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice
    Cheryl A Stoddart
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California 94110, USA
    J Biol Chem 283:34045-52. 2008
  9. pmc Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice
    Cheryl A Stoddart
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e1251. 2007
  10. pmc Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals
    Cheryl A Stoddart
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e655. 2007

Collaborators

Detail Information

Publications24

  1. ncbi IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus
    Mary E Keir
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 168:325-31. 2002
    ..Furthermore, thymic preDC2 are permissive for HIV-1 infection and positive for intracellular p24. These data demonstrate the ability of IFN-alpha secreted by preDC2 to induce MHC I up-regulation in the HIV-1-infected human thymus...
  2. ncbi Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus
    Mary E Keir
    Biomedical Sciences Graduate Program, University of California, San Francisco 94143, USA
    J Immunol 169:2788-96. 2002
    ..We suggest that this HIV-1-initiated selection process may contribute to the generation of dysfunctional CD8(+) T cells in HIV-1-infected patients...
  3. ncbi Efficacy of broadly neutralizing monoclonal antibody PG16 in HIV-infected humanized mice
    Cheryl A Stoddart
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, Box 1234, San Francisco, San Francisco, CA 94143, USA Electronic address
    Virology 462:115-25. 2014
    ..These results provide evidence of tissue penetration of the antibodies, which could aid in their ability to prevent infection if virus crosses the mucosal barrier. ..
  4. pmc Impaired infectivity of ritonavir-resistant HIV is rescued by heat shock protein 90AB1
    Pheroze Joshi
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 286:24581-92. 2011
    ..These results suggest a possible role for HSP90AB1 in postentry HIV replication and may provide an attractive target for therapeutic intervention...
  5. pmc Preexposure prophylaxis with albumin-conjugated C34 peptide HIV-1 fusion inhibitor in SCID-hu Thy/Liv mice
    Cheryl A Stoddart
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    Antimicrob Agents Chemother 56:2162-5. 2012
    ..3 log₁₀ and protected T cells from virus-mediated depletion. In contrast, a single preexposure dose of Truvada reduced viral RNA by only 0.8 log₁₀ and was substantially less effective in preventing T cell depletion...
  6. pmc Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rγ(-/-) (NSG) BLT mice
    Cheryl A Stoddart
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
    Virology 417:154-60. 2011
    ..These results should speed efforts to obtain preclinical animal efficacy data for new HIV drugs and microbicides...
  7. pmc IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo
    Cheryl A Stoddart
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    PLoS Pathog 6:e1000766. 2010
    ..These observations suggest a mechanism by which IFN-alpha production may paradoxically expand the tropism of R5 HIV and, in so doing, accelerate disease progression...
  8. pmc Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice
    Cheryl A Stoddart
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California 94110, USA
    J Biol Chem 283:34045-52. 2008
    ....
  9. pmc Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice
    Cheryl A Stoddart
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e1251. 2007
    ..Bevirimat has a novel mechanism of action, specifically inhibiting cleavage of spacer peptide 1 (SP1) from the C-terminus of capsid which results in defective core condensation...
  10. pmc Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals
    Cheryl A Stoddart
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e655. 2007
    ..We performed this study to validate the model with representatives of all four classes of licensed antiretrovirals...
  11. pmc Coxsackievirus B4 infection of human fetal thymus cells
    Fabienne Brilot
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    J Virol 78:9854-61. 2004
    ..Thus, CVB4 E2 can infect human fetal thymocytes, which subsequently results in quantitative and qualitative abnormalities of these cells...
  12. pmc Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7
    Johan K Sandberg
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94103, USA
    Proc Natl Acad Sci U S A 101:7058-63. 2004
    ..Furthermore, data suggest an intrathymic pathway of CD4+ Valpha24 NK T cell development that is regulated by IL-7...
  13. ncbi Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141, USA
    J Immunol 171:645-54. 2003
    ..Given the growing interest in the use of IL-7 for the treatment of human immunodeficiency, these findings support additional investigation into its in vivo effects on thymopoiesis and HIV infection...
  14. pmc Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans
    Jeff E Mold
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94143 1234, USA
    Science 330:1695-9. 2010
    ..These observations offer a mechanistic explanation for the tolerogenic properties of the developing fetus and for variable degrees of immune responsiveness at birth...
  15. pmc Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis
    Cheryl A Stoddart
    Gladstone Institute of Virology and Immunology Departments of Medicine Microbiology and Immunology, University of California, San Francisco, California 94141, USA
    J Virol 77:2124-33. 2003
    ..Nef-mediated CD4 downregulation merits consideration as a new target for the development of small-molecule inhibitors...
  16. pmc Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores
    Pheroze Joshi
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94110, USA
    Virology 436:162-72. 2013
    ..In sum, the transdominant effect of HSP90AB1 on CA-mutant HIV infectivity suggests a potential role for this class of cellular chaperones in HIV core stability and uncoating...
  17. pmc Impaired surfactant production by alveolar epithelial cells in a SCID-hu lung mouse model of congenital human cytomegalovirus infection
    Ekaterina Maidji
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    J Virol 86:12795-805. 2012
    ..Additionally, this model would greatly facilitate the development and testing of new antiviral therapies for HCMV along with select human pulmonary pathogens...
  18. pmc HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells
    David Favre
    Division of Experimental Medicine, University of California at San Francisco, San Francisco, CA, USA
    Blood 117:2189-99. 2011
    ..This study is registered at www.clinicaltrials.gov as NCT00187512...
  19. pmc Alpha interferon and HIV infection cause activation of human T cells in NSG-BLT mice
    Brian R Long
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    J Virol 86:3327-36. 2012
    ..These results are consistent with studies linking T-cell activation to progressive disease in humans and lend support for the use of NSG-BLT mice in studies of HIV pathogenesis...
  20. doi Derivation of non-infectious envelope proteins from virions isolated from plasma negative for HIV antibodies
    Girish N Vyas
    Department of Laboratory Medicine, University of California, School of Medicine, UCSF Box 0134, 185 Berry Street, Suite 2010 07, San Francisco, CA 94143, USA
    Biologicals 40:15-20. 2012
    ..These data should help development of mHIVenv as a virally safe immunogen and enable preparation of polyclonal hyper-immune globulins for immunoprophylaxis against HIV-1 infection...
  21. pmc Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase
    Paul D Baum
    Division of Experimental Medicine, Department of Medicine bVeterans Affairs Medical Center, University of California San Francisco, San Francisco, California 94143 1234, USA
    AIDS 25:2243-8. 2011
    ..To provide a molecular mechanism that explains the association of the antiretroviral guanosine analogue, abacavir, with an increased risk of myocardial infarction...
  22. pmc Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation
    Kristy Red-Horse
    Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, California, USA
    J Clin Invest 116:2643-52. 2006
    ....
  23. ncbi Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells
    Udayan Chatterji
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 280:40293-300. 2005
    ..This study demonstrates that specific capsid substitutions can release HIV-1 from both CypA dependence in human cells and TRIM-Cyp restriction in monkey cells...
  24. ncbi Dysoxylins A-D, tetranortriterpenoids with potent anti-RSV activity from Dysoxylum gaudichaudianum
    Jian Lu Chen
    Shaman Pharmaceuticals, South San Francisco, California 94080, USA
    J Nat Prod 70:312-5. 2007
    ..These structures were determined by NMR spectroscopy and mass spectrometry and were shown to have anti-RSV EC50 activities in the range 1.0-4.0 microg/mL in cytopathic effect inhibition and plaque reduction assays...