CRAIG ALLEN STOCKMEIER

Summary

Affiliation: University of Mississippi Medical Center
Country: USA

Publications

  1. pmc Glutamate signaling proteins and tyrosine hydroxylase in the locus coeruleus of alcoholics
    Beata Karolewicz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, USA
    J Psychiatr Res 42:348-55. 2008
  2. pmc Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression
    Xiaohong Si
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
    Neuropsychopharmacology 29:2088-96. 2004
  3. pmc Elevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depression
    Beata Karolewicz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Neuropsychopharmacology 30:1557-67. 2005
  4. pmc Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder
    Craig A Stockmeier
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216, USA
    J Psychiatr Res 43:887-94. 2009
  5. ncbi request reprint Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter
    Craig A Stockmeier
    Department of Psychiatry and Human Behavior Box 127, The University of Mississippi Medical Center, Jackson 39211, USA
    J Psychiatr Res 37:357-73. 2003
  6. pmc Cellular changes in the postmortem hippocampus in major depression
    Craig A Stockmeier
    Department of Psychiatry and Human Behavior Box 127, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Biol Psychiatry 56:640-50. 2004
  7. ncbi request reprint Serotonin transporter and MAO-B levels in monoamine nuclei of the human brainstem are normal in major depression
    Violetta Klimek
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA
    J Psychiatr Res 37:387-97. 2003
  8. pmc Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression
    Anteneh M Feyissa
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Prog Neuropsychopharmacol Biol Psychiatry 33:70-5. 2009
  9. pmc Comparative neuroprotective effects of rasagiline and aminoindan with selegiline on dexamethasone-induced brain cell apoptosis
    Shawna Tazik
    Division of Neurobiology and Behavioral Research, Department of Psychiatry and Human Behavior G 109, University of Mississippi Medical Center, 2500N State Street, Jackson, MS 39216, USA
    Neurotox Res 15:284-90. 2009
  10. pmc Effects of depression, cigarette smoking, and age on monoamine oxidase B in amygdaloid nuclei
    Beata Karolewicz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Brain Res 1043:57-64. 2005

Research Grants

  1. Postmortem Human Brain Collection (Supplement to MH67996)
    Craig Stockmeier; Fiscal Year: 2006
  2. Hippocampal atrophy in major depression
    Craig Stockmeier; Fiscal Year: 2007
  3. CORBE: CENTER FOR PSYCHIATRIC NEUROSCIENCE
    Craig Stockmeier; Fiscal Year: 2007
  4. CORBE: CENTER FOR PSYCHIATRIC NEUROSCIENCE
    Craig Stockmeier; Fiscal Year: 2009
  5. CORBE: CENTER FOR PSYCHIATRIC NEUROSCIENCE
    CRAIG ALLEN STOCKMEIER; Fiscal Year: 2010

Collaborators

Detail Information

Publications29

  1. pmc Glutamate signaling proteins and tyrosine hydroxylase in the locus coeruleus of alcoholics
    Beata Karolewicz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, USA
    J Psychiatr Res 42:348-55. 2008
    ..Lower levels of NR1 subunit of the NMDA receptor in the LC implicates altered glutamate-norepinephrine interactions in alcoholism...
  2. pmc Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression
    Xiaohong Si
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
    Neuropsychopharmacology 29:2088-96. 2004
    ..These findings indicate that a decrease in levels of GFAP may contribute to the pathophysiology of MDD, particularly in subjects of relatively young age...
  3. pmc Elevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depression
    Beata Karolewicz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Neuropsychopharmacology 30:1557-67. 2005
    ..003) in the LC and modestly, but not significantly, elevated in the cerebellum (+ 35%) of depressives as compared to matched controls. Higher levels of NR2C subunit implicate altered glutamatergic input to the LC in depressive disorders...
  4. pmc Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder
    Craig A Stockmeier
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216, USA
    J Psychiatr Res 43:887-94. 2009
    ..Decreased antagonist binding to serotonin-1A receptors in outer layers of orbitofrontal cortex suggests diminished receptor signaling and may be linked to corresponding neuronal changes detected previously in these depressed subjects...
  5. ncbi request reprint Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter
    Craig A Stockmeier
    Department of Psychiatry and Human Behavior Box 127, The University of Mississippi Medical Center, Jackson 39211, USA
    J Psychiatr Res 37:357-73. 2003
    ..Carefully controlled studies in postmortem tissues will ensure a greater likelihood of reaching a consensus on the involvement of monoamine measures in the etiology of depression...
  6. pmc Cellular changes in the postmortem hippocampus in major depression
    Craig A Stockmeier
    Department of Psychiatry and Human Behavior Box 127, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Biol Psychiatry 56:640-50. 2004
    ..Imaging studies report that hippocampal volume is decreased in major depressive disorder (MDD). A cellular basis for reduced hippocampal volume in MDD has not been identified...
  7. ncbi request reprint Serotonin transporter and MAO-B levels in monoamine nuclei of the human brainstem are normal in major depression
    Violetta Klimek
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA
    J Psychiatr Res 37:387-97. 2003
    ..These findings imply that serotonergic innervation of the LC is intact in major depression...
  8. pmc Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression
    Anteneh M Feyissa
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Prog Neuropsychopharmacol Biol Psychiatry 33:70-5. 2009
    ..This study provides additional evidence that NMDA receptor complex is a target for discovery of novel antidepressants...
  9. pmc Comparative neuroprotective effects of rasagiline and aminoindan with selegiline on dexamethasone-induced brain cell apoptosis
    Shawna Tazik
    Division of Neurobiology and Behavioral Research, Department of Psychiatry and Human Behavior G 109, University of Mississippi Medical Center, 2500N State Street, Jackson, MS 39216, USA
    Neurotox Res 15:284-90. 2009
    ..In summary, the greater neuroprotective effect of rasagiline may be associated with the combination of the parent drug and its metabolite 1-R-aminoindan...
  10. pmc Effects of depression, cigarette smoking, and age on monoamine oxidase B in amygdaloid nuclei
    Beata Karolewicz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Brain Res 1043:57-64. 2005
    ..The amount of MAO-B binding positively correlated with the age of subjects in all nuclei investigated. A decreased amount of MAO-B in smokers further validates the pharmacological effect of tobacco smoke on this enzyme...
  11. pmc Normal [3H]flunitrazepam binding to GABAA receptors in the locus coeruleus in major depression and suicide
    He Zhu
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Brain Res 1125:138-46. 2006
    ..These results demonstrate that GABA(A) receptor binding in the LC measured with [(3)H]flunitrazepam is not altered in subjects with depressive illnesses...
  12. ncbi request reprint Dopaminergic abnormalities in amygdaloid nuclei in major depression: a postmortem study
    Violetta Klimek
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA
    Biol Psychiatry 52:740-8. 2002
    ..Here we show amounts of dopaminergic proteins in the amygdala, a key brain structure involved in the integration of emotions and stress, in subjects with major depression and in psychiatrically normal control subjects...
  13. ncbi request reprint Neurokinin-1 receptors are decreased in major depressive disorder
    Craig A Stockmeier
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson 39216, USA
    Neuroreport 13:1223-7. 2002
    ..024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex...
  14. pmc Reduced density of calbindin immunoreactive GABAergic neurons in the occipital cortex in major depression: relevance to neuroimaging studies
    Dorota Maciag
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Biol Psychiatry 67:465-70. 2010
    ..The goal of this study was to test whether the changes in CB-IR neurons can also be detected in the occipital cortex, where neuroimaging studies report a prominent GABA decrease...
  15. pmc A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage
    Xiao Ming Ou
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Biol Psychiatry 67:855-63. 2010
    ..Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and monoamine oxidase B (MAO B) reportedly play a role in cellular dysfunction under stressful conditions and might contribute to EtOH-induced cell damage...
  16. pmc Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression
    Beata Karolewicz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Int J Neuropsychopharmacol 12:143-53. 2009
    ..Amounts of NR1, nNOS, glutamine synthetase, and GAD-67 were unchanged. Increased levels of NR2A and PSD-95 suggest that glutamate signalling at the NMDA receptor in the amygdala is disrupted in depression...
  17. pmc Transcriptional expression of serotonergic regulators in laser-captured microdissected dorsal raphe neurons of subjects with major depressive disorder: sex-specific differences
    Dharmendra B Goswami
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, USA
    J Neurochem 112:397-409. 2010
    ..This study reveals sex-specific alterations in gene expression of the pre-synaptic 5-HT1D autoreceptors and 5-HT-related transcription factors, NUDR and REST, in DR neurons of women with MDD...
  18. pmc Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression
    Beata Karolewicz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Int J Neuropsychopharmacol 13:411-20. 2010
    ..Moreover, our data support previous neuroimaging observations that antidepressant medication normalizes GABA deficits in depression...
  19. pmc Glia pathology in the prefrontal cortex in alcohol dependence with and without depressive symptoms
    Jose Javier Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Biol Psychiatry 52:1121-33. 2002
    ..In alcohol dependence, often comorbid with depression, it is unclear whether there are changes in the density and size of glial cells in the dlPFC...
  20. pmc Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients
    Grazyna Rajkowska
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Biol Psychiatry 58:297-306. 2005
    ..Elderly depressed patients have more vascular hyperintensities in frontal white matter and basal ganglia than elderly control subjects. Cell pathology that might be related to increased vascular hyperintensities has not been examined...
  21. pmc GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression
    Grazyna Rajkowska
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Neuropsychopharmacology 32:471-82. 2007
    ..These cellular changes are consistent with recent neuroimaging studies revealing a reduction in the cortical levels of GABA in depression...
  22. pmc Reduced glial and neuronal packing density in the orbitofrontal cortex in alcohol dependence and its relationship with suicide and duration of alcohol dependence
    Jose J Miguel-Hidalgo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Alcohol Clin Exp Res 30:1845-55. 2006
    ....
  23. pmc Reductions in neuronal density in elderly depressed are region specific
    Eric Van Otterloo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Int J Geriatr Psychiatry 24:856-64. 2009
    ..Prominent reductions in pyramidal neuron density have been recently reported in the ORB of older depressed subjects. However, the cellular pathology of the dlPFC has not yet been examined in these subjects...
  24. pmc Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder
    Bernadeta Szewczyk
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Int J Neuropsychopharmacol 12:155-68. 2009
    ..In addition, the gender-specific alterations in cortical NUDR and 5-HT1A receptor proteins could represent an underlying biological mechanism associated with the higher incidence of depression in women...
  25. pmc Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression
    Anteneh M Feyissa
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:279-83. 2010
    ..This observation is consistent with reports showing that mGluR2/3 antagonists exhibit antidepressant-like activity in animal models and demonstrates that these receptors are promising targets for the discovery of novel antidepressants...
  26. ncbi request reprint Elevated agonist binding to alpha2-adrenoceptors in the locus coeruleus in major depression
    Gregory A Ordway
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Biol Psychiatry 53:315-23. 2003
    ..Here we describe a study of alpha2-adrenoceptors in the LC and raphe nuclei of subjects with MD compared with psychiatrically normal control subjects...
  27. pmc Gene expression profiling in postmortem prefrontal cortex of major depressive disorder
    Hyo Jung Kang
    Department Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    J Neurosci 27:13329-40. 2007
    ..These findings identify abnormal gene expression in a discrete region of MDD subjects and contribute to further elucidation of the molecular alterations of this complex mood disorder...
  28. pmc Dopamine receptor gene expression in human amygdaloid nuclei: elevated D4 receptor mRNA in major depression
    Lianbin Xiang
    Department of Pharmacology, East Tennessee State University, Johnson City, TN 37614, USA
    Brain Res 1207:214-24. 2008
    ..Elevated DA receptor gene expression in depressive subjects further implicates altered dopaminergic transmission in the amygdala in depression...
  29. ncbi request reprint A monoclonal antibody to tryptophan hydroxylase: applications and identification of the epitope
    John W Haycock
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, LSUHSC BIOCHEM, 1100 Florida Avenue, New Orleans, LA 70119, USA
    J Neurosci Methods 114:205-12. 2002
    ....

Research Grants9

  1. Postmortem Human Brain Collection (Supplement to MH67996)
    Craig Stockmeier; Fiscal Year: 2006
    ..C. Stockmeier, G. Ordway, G. Rajkowska, R. Duman, B. Karolewicz and M. Austin depends solely on this Supplement for brain tissue to better understanding of the cellular and molecular pathophysiology of the major mental illnesses. ..
  2. Hippocampal atrophy in major depression
    Craig Stockmeier; Fiscal Year: 2007
    ..Cellular changes detected in MDD postmortem may underlie hippocampal atrophy detected by some in living subjects with MDD. ..
  3. CORBE: CENTER FOR PSYCHIATRIC NEUROSCIENCE
    Craig Stockmeier; Fiscal Year: 2007
    ....
  4. CORBE: CENTER FOR PSYCHIATRIC NEUROSCIENCE
    Craig Stockmeier; Fiscal Year: 2009
    ....
  5. CORBE: CENTER FOR PSYCHIATRIC NEUROSCIENCE
    CRAIG ALLEN STOCKMEIER; Fiscal Year: 2010
    ....