O Steward

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Rapid activation of plasticity-associated gene transcription in hippocampal neurons provides a mechanism for encoding of one-trial experience
    Teiko Miyashita
    Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 29:898-906. 2009
  2. pmc A re-assessment of the effects of intracortical delivery of inosine on transmidline growth of corticospinal tract axons after unilateral lesions of the medullary pyramid
    Oswald Steward
    Reeve Irvine Research Center, University of California at Irvine School of Medicine, Irvine, CA 92697 4265, USA
    Exp Neurol 233:662-73. 2012
  3. ncbi request reprint Compartmentalized synthesis and degradation of proteins in neurons
    Oswald Steward
    Reeve Irvine Research Center and Department of Anatomy Neurobiology, College of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Neuron 40:347-59. 2003
  4. ncbi request reprint The successful aging of Carl Cotman: from proteins of the synapse, through sprouting, regeneration, and spinal cord injury to the mechanisms of brain aging
    Oswald Steward
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine College of Medicine, Irvine, California, USA
    Neurochem Res 28:1617-9. 2003
  5. ncbi request reprint The dorsolateral corticospinal tract in mice: an alternative route for corticospinal input to caudal segments following dorsal column lesions
    Oswald Steward
    Department of Anatomy, Reeve Irvine Research Center, University of California at Irvine College of Medicine, Irvine, California 92697 4292, USA
    J Comp Neurol 472:463-77. 2004
  6. ncbi request reprint Protein synthesis at synaptic sites on dendrites
    O Steward
    Reeve Irvine Research Center and Departments of Anatomy Neurobiology and Neurobiology and Behavior, College of Medicine, University of California at Irvine, Irvine, California 92697, USA
    Annu Rev Neurosci 24:299-325. 2001
  7. pmc Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice
    Oswald Steward
    Reeve Irvine Research Center and Departments of Anatomy and Neurobiology, and Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697 4292 USA
    J Neurosci 28:6836-47. 2008
  8. pmc A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice
    Oswald Steward
    Reeve Irvine Research Center, University of California at Irvine School of Medicine, Irvine, CA 92697 4265, USA
    Exp Neurol 209:446-68. 2008
  9. pmc A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction
    Oswald Steward
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA
    Learn Mem 14:433-45. 2007
  10. ncbi request reprint A re-assessment of the consequences of delayed transplantation of olfactory lamina propria following complete spinal cord transection in rats
    Oswald Steward
    Reeve Irvine Research Center, University of California at Irvine School of Medicine, Department of Anatomy and Neurobiology, 1105 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4292, USA
    Exp Neurol 198:483-99. 2006

Research Grants

  1. Axon Regeneration after Spinal Cord Injury in Mice
    Oswald Steward; Fiscal Year: 2009
  2. LOCALIZATION OF MRNAS AT SYNAPTIC SITES ON DENDRITES
    Oswald Steward; Fiscal Year: 2010
  3. LOCALIZATION OF MRNAS AT SYNAPTIC SITES ON DENDRITES
    Oswald Steward; Fiscal Year: 2001
  4. GENETIC APPROACH TO CNS REGENERATION RESEARCH
    Oswald Steward; Fiscal Year: 2001
  5. LOCALIZATION OF MRNAS AT SYNAPTIC SITES ON DENDRITES
    Oswald Steward; Fiscal Year: 2005
  6. Summer Training Program in Neuroscience
    Oswald Steward; Fiscal Year: 2006
  7. Axon Regeneration after Spinal Cord Injury in Mice
    Oswald Steward; Fiscal Year: 2007
  8. Postdoctoral Training Program in Neural Regeneration
    Oswald Steward; Fiscal Year: 2005
  9. LOCALIZATION OF MRNAS AT SYNAPTIC SITES ON DENDRITES
    Oswald Steward; Fiscal Year: 2011

Collaborators

Detail Information

Publications63

  1. pmc Rapid activation of plasticity-associated gene transcription in hippocampal neurons provides a mechanism for encoding of one-trial experience
    Teiko Miyashita
    Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 29:898-906. 2009
    ..These findings demonstrate for the first time that a single brief experience, equivalent to a single crossing of a firing field, can trigger IEG expression required for long-term plasticity in the hippocampus...
  2. pmc A re-assessment of the effects of intracortical delivery of inosine on transmidline growth of corticospinal tract axons after unilateral lesions of the medullary pyramid
    Oswald Steward
    Reeve Irvine Research Center, University of California at Irvine School of Medicine, Irvine, CA 92697 4265, USA
    Exp Neurol 233:662-73. 2012
    ..Our results revealed no evidence for enhanced growth of CST axons across the midline of the dorsal column in rats that received intracortical infusion of inosine. Possible reasons for the failure to replicate are discussed...
  3. ncbi request reprint Compartmentalized synthesis and degradation of proteins in neurons
    Oswald Steward
    Reeve Irvine Research Center and Department of Anatomy Neurobiology, College of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Neuron 40:347-59. 2003
    ..Here, we summarize what is known about local synthesis and degradation of protein in dendrites and axons, highlighting key unresolved questions...
  4. ncbi request reprint The successful aging of Carl Cotman: from proteins of the synapse, through sprouting, regeneration, and spinal cord injury to the mechanisms of brain aging
    Oswald Steward
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine College of Medicine, Irvine, California, USA
    Neurochem Res 28:1617-9. 2003
  5. ncbi request reprint The dorsolateral corticospinal tract in mice: an alternative route for corticospinal input to caudal segments following dorsal column lesions
    Oswald Steward
    Department of Anatomy, Reeve Irvine Research Center, University of California at Irvine College of Medicine, Irvine, California 92697 4292, USA
    J Comp Neurol 472:463-77. 2004
    ..Thus, the DLCST provides an alternate route for CST input to caudal segments, which is of particular relevance for studies of CST distribution and function following partial spinal cord injuries...
  6. ncbi request reprint Protein synthesis at synaptic sites on dendrites
    O Steward
    Reeve Irvine Research Center and Departments of Anatomy Neurobiology and Neurobiology and Behavior, College of Medicine, University of California at Irvine, Irvine, California 92697, USA
    Annu Rev Neurosci 24:299-325. 2001
    ....
  7. pmc Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice
    Oswald Steward
    Reeve Irvine Research Center and Departments of Anatomy and Neurobiology, and Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697 4292 USA
    J Neurosci 28:6836-47. 2008
    ....
  8. pmc A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice
    Oswald Steward
    Reeve Irvine Research Center, University of California at Irvine School of Medicine, Irvine, CA 92697 4265, USA
    Exp Neurol 209:446-68. 2008
    ..Enhanced functional recovery was not seen consistently with the different functional assessments, however...
  9. pmc A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction
    Oswald Steward
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA
    Learn Mem 14:433-45. 2007
    ..Moreover, these data demonstrate that different LTP induction paradigms do not have identical molecular consequences, which may account for certain discrepancies between previous studies...
  10. ncbi request reprint A re-assessment of the consequences of delayed transplantation of olfactory lamina propria following complete spinal cord transection in rats
    Oswald Steward
    Reeve Irvine Research Center, University of California at Irvine School of Medicine, Department of Anatomy and Neurobiology, 1105 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4292, USA
    Exp Neurol 198:483-99. 2006
    ..Our results indicate that, although OLP transplants may stimulate regeneration under some circumstances, the effect is not so robust as to reliably overcome the hostile setting created by a complete transection paradigm...
  11. ncbi request reprint False resurrections: distinguishing regenerated from spared axons in the injured central nervous system
    Oswald Steward
    Reeve Irvine Research Center, University of California at Irvine College of Medicine, Departments of Anatomy and Neurobiology and Neurobiology and Behavior, Irvine, California 92697 4292, USA
    J Comp Neurol 459:1-8. 2003
    ..Here, we illustrate the problem and propose criteria that may be used to identify regenerated vs. spared axons, focusing on the injured spinal cord...
  12. ncbi request reprint Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation
    O Steward
    Reeve Irvine Research Center and, Department of Anatomy and Neurobiology, College of Medicine, University of California at Irvine, Irvine, CA 92697, USA
    Neuron 30:227-40. 2001
    ..These results demonstrate that NMDA receptor activation is required for the targeting of Arc mRNA to active synapses...
  13. pmc A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites
    O Steward
    Reeve Irvine Research Center, and Department of Anatomy Neurobiology and Neurobiology, College of Medicine, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 98:7062-8. 2001
    ..The dynamics of trafficking of Arc mRNA reveal key features of the mechanism through which synaptic activity can both induce gene expression and target particular mRNA transcripts to the active synapses...
  14. ncbi request reprint Translating axon guidance cues
    Oswald Steward
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, Department of Neurobiology and Behavior, University of California, Irvine Irvine, CA 92697, USA
    Cell 110:537-40. 2002
    ....
  15. ncbi request reprint Local synthesis of proteins at synaptic sites on dendrites: role in synaptic plasticity and memory consolidation?
    Oswald Steward
    Reeve Irvine Research Center, Department of Anatomy Neurobiology, College of Medicine, University of California at Irvine, 92697, USA
    Neurobiol Learn Mem 78:508-27. 2002
    ..We will review findings from other laboratories that both LTP and memory are disrupted when Arc induction is blocked, and we will discuss the possibility that Arc protein may play a key role in activity-dependent synaptic modification...
  16. ncbi request reprint Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendrites
    Fen Huang
    Department of Anatomy and Neurobiology, Reeve Irvine Research Center, Irvine, California 92697, USA
    J Neurosci 27:9054-67. 2007
    ..1 mRNA localization. Our results indicate that the reorganization of the actin cytoskeletal network in conjunction with MAP kinase activation is required for targeting newly synthesized Arc/Arg3.1 mRNA to activated synaptic sites...
  17. ncbi request reprint Spinal pathways involved in the control of forelimb motor function in rats
    Kim D Anderson
    Reeve Irvine Research Center, University of California at Irvine College of Medicine, Department of Anatomy, Irvine, CA 92697 4292, USA
    Exp Neurol 206:318-31. 2007
    ..These results suggest that different spinal circuits are involved in recovery of grip strength vs. recovery of skilled reaching...
  18. ncbi request reprint Quantitative assessment of forelimb motor function after cervical spinal cord injury in rats: relationship to the corticospinal tract
    Kim D Anderson
    Department of Anatomy and Neurobiology, Reeve Irvine Research Center, University of California at Irvine College of Medicine, 1105 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4292, USA
    Exp Neurol 194:161-74. 2005
    ..For the cases in which both histological and behavioral data were available, spared forelimb motor function was greatest in rats in which there was sparing of the dorsal CST...
  19. pmc A straight alley version of the BBB locomotor scale
    Jamie K Wong
    Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA 92697, USA
    Exp Neurol 217:417-20. 2009
    ..the open field (r(2) values of 0.90 and 0.74 for the straight alley and open field respectively), revealing that the straight alley yielded more reliable scores...
  20. ncbi request reprint Recovery of forepaw gripping ability and reorganization of cortical motor control following cervical spinal cord injuries in mice
    Jennifer E Blanco
    Department of Anatomy, University of California at Irvine School of Medicine, CA 92697 4292, USA
    Exp Neurol 203:333-48. 2007
    ..These results indicate a substantial reorganization of motor control of gripping function after cervical injuries in mice so that gripping ability by both forepaws becomes largely independent of cortical control...
  21. pmc A bilateral cervical contusion injury model in mice: assessment of gripping strength as a measure of forelimb motor function
    Roberto M Aguilar
    Reeve Irvine Research Center, University of California Irvine, Department of Anatomy and Neurobiology, 1105 Gillespie Neuroscience Research Facility, Irvine, CA 92607 4292, USA
    Exp Neurol 221:38-53. 2010
    ..Our results define conditions to produce graded bilateral cervical contusion injuries in mice and demonstrate the usefulness of the GSM for assessing forelimb motor function after cervical contusions...
  22. ncbi request reprint Visualizing changes in circuit activity resulting from denervation and reinnervation using immediate early gene expression
    Meredith D Temple
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA
    J Neurosci 23:2779-88. 2003
    ..These results document a novel approach for quantitatively assessing activity-regulated gene expression in polysynaptic circuits after trauma...
  23. pmc An investigation of the cortical control of forepaw gripping after cervical hemisection injuries in rats
    Melissa K Strong
    Reeve Irvine Research Center, University of California Irvine School of Medicine, Irvine, CA 92697 4292, USA
    Exp Neurol 217:96-107. 2009
    ..Thus, forelimb gripping ability as measured by the GSM is dependent on the contralateral sensorimotor cortex in rats even after a cervical hemisection...
  24. ncbi request reprint Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury
    Hong Yang
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Neurosci 26:2157-66. 2006
    ..Thus, cell replacement is an extensive natural compensatory response to injury in the primate spinal cord that contributes to neural repair and is a potential target for therapeutic enhancement...
  25. ncbi request reprint Chronic nerve compression injury induces a phenotypic switch of neurons within the dorsal root ganglia
    Tom Chao
    Department of Orthopaedic Surgery, University of California, Irvine, Irvine, California 92697, USA
    J Comp Neurol 506:180-93. 2008
    ..Thus, CNC induces a phenotypic change in the DRG that appears to be temporally associated with increases in GDNF protein expression at and near the site of the compression injury in the nerve...
  26. ncbi request reprint Ascending sensory, but not other long-tract axons, regenerate into the connective tissue matrix that forms at the site of a spinal cord injury in mice
    Denise M Inman
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA
    J Comp Neurol 462:431-49. 2003
    ..These results indicate that the connective tissue matrix is permissive for regeneration of some classes of ascending sensory axons but not for other axonal systems...
  27. ncbi request reprint The mRNA for elongation factor 1alpha is localized in dendrites and translated in response to treatments that induce long-term depression
    Fen Huang
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California, Irvine, California 92697, USA
    J Neurosci 25:7199-209. 2005
    ..The findings suggest that local synthesis of EF1alpha protein may be important for the synaptic mechanisms that underlie protein synthesis-dependent LTD...
  28. ncbi request reprint Quantitative assessment of deficits and recovery of forelimb motor function after cervical spinal cord injury in mice
    Kim D Anderson
    Departments of Anatomy and Neurobiology, Neurobiology and Behavior, and Neurosurgery, Reeve Irvine Research Center, College of Medicine, University of California at Irvine, Irvine, CA 92697 4292, USA
    Exp Neurol 190:184-91. 2004
    ..Grip strength was minimally and transiently affected by hemisection at T1. The grip strength analysis provides a convenient, quantitative measure of the loss and recovery of forelimb function after cervical injury...
  29. pmc Deficits in bladder function following spinal cord injury vary depending on the level of the injury
    Brian T David
    Reeve Irvine Research Center, University of California at Irvine College of Medicine, Irvine, CA 92697 4265, USA
    Exp Neurol 226:128-35. 2010
    ..Thus, moderate contusion lesions at T1 spare a critical descending pathway able to mediate at least reflex voiding in rats...
  30. ncbi request reprint Septations in chronic spinal cord injury cavities contain axons
    Milan Radojicic
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, 2111 Gillespie Neuroscience Research Facility, College of Medicine, University of California Irvine, Irvine, CA 92697 4292, USA
    Exp Neurol 196:339-41. 2005
    ..Here, we show for the first time in a rodent model of chronic SCI that the septations spanning cavities contain axons...
  31. pmc Assessment of the role of MAP kinase in mediating activity-dependent transcriptional activation of the immediate early gene Arc/Arg3.1 in the dentate gyrus in vivo
    Jennifer K Chotiner
    Department of Anatomy and Neurobiology, Reeve Irvine Research Center, University of California at Irvine, Irvine, California 92697, USA
    Learn Mem 17:117-29. 2010
    ..1 transcription in dentate granule cells in vivo is mediated in part by MAP kinase activation, but other signaling pathways also contribute, especially in the case of Arc/Arg3.1 induction in response to experience...
  32. pmc Unexpected survival of neurons of origin of the pyramidal tract after spinal cord injury
    Jessica L Nielson
    Department of Anatomy and Neurobiology, Reeve Irvine Research Center, University of California, Irvine, California 92697, USA
    J Neurosci 30:11516-28. 2010
    ....
  33. pmc Bilateral cervical contusion spinal cord injury in rats
    Kim D Anderson
    Reeve Irvine Research Center, University of California, Irvine College of Medicine, Irvine, CA 92697 1385, USA
    Exp Neurol 220:9-22. 2009
    ....
  34. pmc Forelimb locomotor assessment scale (FLAS): novel assessment of forelimb dysfunction after cervical spinal cord injury
    Kim D Anderson
    Reeve Irvine Research Center, University of California at Irvine School of Medicine, Irvine, 1113 Hewitt Hall, Irvine, CA 92697 1385, USA
    Exp Neurol 220:23-33. 2009
    ..88-0.96 (p<0.0001), indicating a high inter-rater reliability. Thus, the FLAS is a simple, inexpensive, sensitive, and reliable measure of forelimb function during locomotion following cervical SCI...
  35. pmc Role of early surgical decompression of the intradural space after cervical spinal cord injury in an animal model
    Jeremy S Smith
    Department of Orthopaedic Surgery, University of California, Irvine Medical Center, Orange, CA 92868, USA
    J Bone Joint Surg Am 92:1206-14. 2010
    ..We sought to determine the role of durotomy and duraplasty in the treatment of acute cervical spinal cord injury and its effects on inflammation, scar formation, and functional recovery...
  36. ncbi request reprint Chronic nerve compression induces local demyelination and remyelination in a rat model of carpal tunnel syndrome
    Ranjan Gupta
    Department of Orthopaedic Surgery, College of Medicine, University of California, Irvine, CA 92657, USA
    Exp Neurol 187:500-8. 2004
    ..These results confirm that an early consequence of chronic nerve compression (CNC) is local demyelination and remyelination, which may be the primary cause of alterations in nerve function during the early period post-compression...
  37. ncbi request reprint Chronic nerve compression induces concurrent apoptosis and proliferation of Schwann cells
    Ranjan Gupta
    Department of Orthopaedic Surgery, College of Medicine, University of California, Irvine, Irvine, California 92657, USA
    J Comp Neurol 461:174-86. 2003
    ..Our findings indicate that chronic nerve compression induces Schwann cell turnover with minimal axonal injury and support the idea that mechanical stimuli have a direct mitogenic effect on Schwann cells...
  38. pmc Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: the role of re-exposure duration
    Ann E Power
    Department of Anatomy and Neurobiology, Reeve Irvine Research Center, University of California Irvine, California 92697, USA
    Learn Mem 13:27-34. 2006
    ..The findings indicate that post-retrieval administration of anisomycin impairs subsequent retention performance only in the absence of extinction and that this impairment is temporary...
  39. ncbi request reprint Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury
    Hans S Keirstead
    Department of Anatomy and Neurobiology, Reeve Irvine Research Center, College of Medicine, University of California at Irvine, Irvine, California 92697 4292, USA
    J Neurosci 25:4694-705. 2005
    ..These studies document the feasibility of predifferentiating hESCs into functional OPCs and demonstrate their therapeutic potential at early time points after spinal cord injury...
  40. ncbi request reprint mRNA at synapses, synaptic plasticity, and memory consolidation
    Oswald Steward
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA 92697, USA
    Neuron 36:338-40. 2002
    ..3'UTR mutant mice exhibit decreases in alpha-CaMKII protein in postsynaptic densities, and deficits in late phase LTP and in memory consolidation...
  41. ncbi request reprint A noninvasive ultrasonographic method to evaluate bladder function recovery in spinal cord injured rats
    Hans S Keirstead
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, 2111 Gillespie Neuroscience Research Facility, College of Medicine, University of California Irvine, Irvine, CA 92697 4292, USA
    Exp Neurol 194:120-7. 2005
    ....
  42. pmc Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus
    Christa K McIntyre
    Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, 218 Bonney Research Laboratory, University of California, Irvine, CA 92697 3800, USA
    Proc Natl Acad Sci U S A 102:10718-23. 2005
    ....
  43. pmc Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death
    Patrick G Sullivan
    Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA 92697 4475, USA
    Ann Neurol 53:711-7. 2003
    ..This mechanism offers novel neuroprotective strategies for individuals, greater than 1% of the world's population, who are affected by seizures...
  44. ncbi request reprint Local down-regulation of myelin-associated glycoprotein permits axonal sprouting with chronic nerve compression injury
    Ranjan Gupta
    Department of Orthopaedic Surgery, University of California, Irvine, 92657, USA
    Exp Neurol 200:418-29. 2006
    ..These data demonstrate that CNC injury triggers axonal sprouting and suggests that a local down-regulation of MAG within the peripheral nerve secondary to CNC injury is the critical signal for the sprouting response...
  45. ncbi request reprint Differential susceptibility to striatal neurodegeneration induced by quinolinic acid and kainate in inbred, outbred and hybrid mouse strains
    Jessica Pilar McLin
    Department of Neurobiology and Behavior, Reeve Irvine Research Center, 1105 Gillespie Neuroscience Research Facility, University of California at Irvine, CA 92697 4292, USA
    Eur J Neurosci 24:3134-40. 2006
    ..These results are also of significance with regard to the issue of region-specific vulnerability in the context of different diseases in which genetic modifiers affect age of onset and/or disease progression...
  46. ncbi request reprint Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains
    Jessica Pilar McLin
    Reeve Irvine Research Center, 1105 Gillespie Neuroscience Research Facility, University of California at Irvine, Irvine, CA 92697 4292, USA
    Eur J Neurosci 24:2191-202. 2006
    ..Our results, using a large number of mouse strains, definitively demonstrate that a mouse strain's seizure phenotype is not related to its neurodegeneration phenotype...
  47. ncbi request reprint Assessment of factors regulating axon growth between the cortex and spinal cord in organotypic co-cultures: effects of age and neurotrophic factors
    Yosuke Oishi
    Reeve Irvine Research Center, Gillespie Neuroscience Research Facility, Department of Anatomy and Neurobiology, University of California at Irvine College of Medicine, Irvine, California 92697, USA
    J Neurotrauma 21:339-56. 2004
    ..These co-cultures provide a potentially useful assay for factors that affect axon growth that is intermediate between assays based on dissociated neurons and the intact tissue terrain...
  48. ncbi request reprint Zn(2+) induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria
    D Jiang
    Department of Neurology, University of California, 2101 Gillespie Neuroscience Facility, Irvine, CA 92697-4292, USA
    J Biol Chem 276:47524-9. 2001
    ....
  49. pmc Examination of axonal injury and regeneration in micropatterned neuronal culture using pulsed laser microbeam dissection
    Amy N Hellman
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Lab Chip 10:2083-92. 2010
    ..This integrated use of laser microbeam dissection within a micropatterned cell culture system to produce precise zones of neuronal injury shows potential for high-throughput screening of agents to promote neuronal regeneration...
  50. ncbi request reprint Dynamics of bidirectional transport of Arc mRNA in neuronal dendrites
    Joseph L Dynes
    Reeve Irvine Research Center, University of California, Irvine, Irvine, California 92697, USA
    J Comp Neurol 500:433-47. 2007
    ..These observations identify several phases of Arc mRNA movement that serve as potential points for regulating Arc mRNA localization...
  51. pmc Repulsive Wnt signaling inhibits axon regeneration after CNS injury
    Yaobo Liu
    Neurobiology Section, Biological Sciences Division, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 28:8376-82. 2008
    ..Therefore, repulsive Wnt signaling may be a cause of cortical spinal tract axon retraction and inhibits axon sprouting after injury...
  52. doi request reprint Impaired immune responses following spinal cord injury lead to reduced ability to control viral infection
    Katherine S Held
    Reeve Irvine Research Center and Department of Anatomy and Neurobiology, University of California, Irvine School of Medicine, 92697 4265, USA
    Exp Neurol 226:242-53. 2010
    ..Collectively, these data indicate that the inability to control viral replication following SCI is not level dependent and that increased susceptibility to infection is due to suppression of both innate and adaptive immune responses...
  53. ncbi request reprint Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid
    Jessica Pilar McLin
    Reeve Irvine Research Center, University of California, Irvine, Irvine, CA 92697, USA
    Neurobiol Dis 29:391-9. 2008
    ..These results suggest that gene(s) on distal chr18 are important determinants of vulnerability to KA-induced hippocampal neurodegeneration, but not QUIN-induced striatal neurodegeneration...
  54. ncbi request reprint Advances in the management of spinal cord injury
    Ranjan Gupta
    Department of Orthopaedic Surgery, University of California, Irvine, Irvine, CA, USA
    J Am Acad Orthop Surg 18:210-22. 2010
    ..It is unlikely that a single approach can uniformly address all of the issues associated with spinal cord injury. Thus, a multidisciplinary approach will be needed...
  55. ncbi request reprint Physical size does not determine the unique histopathological response seen in the injured mouse spinal cord
    Denise M Inman
    Department of Neurosurgery, University of Washington, Seattle, Washington, USA
    J Neurotrauma 20:33-42. 2003
    ..These results indicate that the physical size of the spinal cord does not determine the unique histopathological responses after spinal cord injury in mice...
  56. ncbi request reprint Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis
    Enrico Tongiorgi
    BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, 34127 Trieste, Italy
    J Neurosci 24:6842-52. 2004
    ..Together, these results suggest that dendritic accumulation of BDNF mRNA and protein plays a critical role in the cellular changes leading to epilepsy...
  57. ncbi request reprint Lack of enhanced spinal regeneration in Nogo-deficient mice
    Binhai Zheng
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Neuron 38:213-24. 2003
    ....
  58. ncbi request reprint Nitrogen disruption of synaptoneurosomes: an alternative method to isolate brain mitochondria
    Maile R Brown
    Ph D Program in Gerontology, Lexington, KY 40536, USA
    J Neurosci Methods 137:299-303. 2004
    ..This nitrogen decompression technique will allow for further characterization of synaptic pools of mitochondria, which are almost exclusively neuronal in origin...
  59. ncbi request reprint Response to: Kim et al., "axon regeneration in young adult mice lacking Nogo-A/B." Neuron 38, 187-199
    Oswald Steward
    Neuron 54:191-5. 2007
  60. ncbi request reprint Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice
    Denise Inman
    Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22904, USA
    J Comp Neurol 451:225-35. 2002
    ....
  61. pmc Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo
    Binhai Zheng
    Department of Biological Sciences, Program in Neurosciences, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:1205-10. 2005
    ..Our results thus fail to support a central role for NgR in axonal growth inhibition in vitro or in corticospinal tract regeneration block in vivo...
  62. ncbi request reprint Synaptic regulation of translation of dendritic mRNAs
    Erin M Schuman
    Division of Biology, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 26:7143-6. 2006
    ..It is useful to begin by considering constraints imposed by the nature of the protein synthetic machinery at synapses...
  63. ncbi request reprint Spatial learning and memory is preserved in rats after early development in a microgravity environment
    Meredith D Temple
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 9525, USA
    Neurobiol Learn Mem 78:199-216. 2002
    ..Any differences due to development in microgravity are quickly reversed after return to earth normal gravity...

Research Grants25

  1. Axon Regeneration after Spinal Cord Injury in Mice
    Oswald Steward; Fiscal Year: 2009
    ..Together, these studies will provide a critical data base regarding the growth capacity of cortico-spinal tract axons in mice, which will be essential for future studies involving genetically modified mice. ..
  2. LOCALIZATION OF MRNAS AT SYNAPTIC SITES ON DENDRITES
    Oswald Steward; Fiscal Year: 2010
    ..These studies will provide novel insights into the basic mechanisms underlying information storage in the brain and neurological disorders that disrupt this fundamental mechanism, including Fragile-X Mental Retardation Syndrome. ..
  3. LOCALIZATION OF MRNAS AT SYNAPTIC SITES ON DENDRITES
    Oswald Steward; Fiscal Year: 2001
    ....
  4. GENETIC APPROACH TO CNS REGENERATION RESEARCH
    Oswald Steward; Fiscal Year: 2001
    ....
  5. LOCALIZATION OF MRNAS AT SYNAPTIC SITES ON DENDRITES
    Oswald Steward; Fiscal Year: 2005
    ..These studies will allow us to further define how local translation of mRNAs at synapses regulates synapse function, especially as synapses are being modified in an activity-dependent fashion. ..
  6. Summer Training Program in Neuroscience
    Oswald Steward; Fiscal Year: 2006
    ..Such appointments may be consecutive or during "off-quarter" periods. Where appropriate, trainees will be encouraged to present their results at national meetings, and support will be provided for students to attend such meetings. ..
  7. Axon Regeneration after Spinal Cord Injury in Mice
    Oswald Steward; Fiscal Year: 2007
    ..Together, these studies will provide a critical data base regarding the growth capacity of cortico-spinal tract axons in mice, which will be essential for future studies involving genetically modified mice. ..
  8. Postdoctoral Training Program in Neural Regeneration
    Oswald Steward; Fiscal Year: 2005
    ....
  9. LOCALIZATION OF MRNAS AT SYNAPTIC SITES ON DENDRITES
    Oswald Steward; Fiscal Year: 2011
    ..These studies will provide novel insights into the basic mechanisms underlying information storage in the brain and neurological disorders that disrupt this fundamental mechanism, including Fragile-X Mental Retardation Syndrome. ..