Mario Stevenson

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction
    Natalia Sharova
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 4:e1000057. 2008
  2. ncbi request reprint Therapeutic potential of RNA interference
    Mario Stevenson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    N Engl J Med 351:1772-7. 2004
  3. ncbi request reprint HIV-1 pathogenesis
    Mario Stevenson
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech 2, Suite 319, Worcester, Massachusetts 01605, USA
    Nat Med 9:853-60. 2003
  4. pmc Synthesis and structure-activity relationship studies of HIV-1 virion infectivity factor (Vif) inhibitors that block viral replication
    Akbar Ali
    Chemical Biology Program, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    ChemMedChem 7:1217-29. 2012
  5. pmc Small-molecule inhibition of HIV-1 Vif
    Robin Nathans
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Biotechnol 26:1187-92. 2008
  6. ncbi request reprint The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity
    Jean Marc Jacque
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Suite 319, Worcester, Massachusetts 01605, USA
    Nature 441:641-5. 2006
  7. pmc Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5
    Yueh Hsin Ping
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Retrovirology 1:46. 2004
  8. pmc Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication
    Akbar Ali
    Chemical Biology Program, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 USA
    Chembiochem 10:2072-80. 2009
  9. pmc Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure
    Mark Sharkey
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 7:e1001303. 2011
  10. pmc Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS
    Simon Swingler
    University of Massachusetts Medical School, Program in Molecular Medicine, 373 Plantation Street, Worcester, MA 01605, USA
    Cell Host Microbe 4:63-76. 2008

Research Grants

  1. Activation of CD40 by HIV and Role in AIDS Dementia
    Mario Stevenson; Fiscal Year: 2010
  2. ANALYSIS OF COVERT VIRAL REPLICATION DURING HAART
    Mario Stevenson; Fiscal Year: 2001
  3. Cellular Co-Factors of HIV-1 Infection
    Mario Stevenson; Fiscal Year: 2007
  4. ROLE OF MONOCYTOTROPISM IN HIV/SIV PATHOGENICITY
    Mario Stevenson; Fiscal Year: 2000
  5. ROLE OF HIV-1 GAG MA IN VIRAL ENTRY
    Mario Stevenson; Fiscal Year: 2001
  6. Cellular Co-Factors of HIV-1 Infection
    Mario Stevenson; Fiscal Year: 2009
  7. ROLE OF HIV-1 GAG MA IN VIRAL ENTRY
    Mario Stevenson; Fiscal Year: 2004
  8. ROLE OF HIV-1 GAG MA IN VIRAL ENTRY
    Mario Stevenson; Fiscal Year: 2005
  9. ANALYSIS OF COVERT VIRAL REPLICATION DURING HAART
    Mario Stevenson; Fiscal Year: 2004
  10. ANALYSIS OF COVERT VIRAL REPLICATION DURING HAART
    Mario Stevenson; Fiscal Year: 2005

Detail Information

Publications40

  1. pmc Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction
    Natalia Sharova
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 4:e1000057. 2008
    ..Our results indicate that macrophage harbor a potent antiviral restriction and that primate lentiviruses have evolved Vpx to counteract this restriction...
  2. ncbi request reprint Therapeutic potential of RNA interference
    Mario Stevenson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    N Engl J Med 351:1772-7. 2004
  3. ncbi request reprint HIV-1 pathogenesis
    Mario Stevenson
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech 2, Suite 319, Worcester, Massachusetts 01605, USA
    Nat Med 9:853-60. 2003
    ..A deeper understanding of the interplay between HIV-1 and its host and why simian immunodeficiency virus (SIV) is nonpathogenic in some natural hosts may provide a few answers...
  4. pmc Synthesis and structure-activity relationship studies of HIV-1 virion infectivity factor (Vif) inhibitors that block viral replication
    Akbar Ali
    Chemical Biology Program, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    ChemMedChem 7:1217-29. 2012
    ....
  5. pmc Small-molecule inhibition of HIV-1 Vif
    Robin Nathans
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Biotechnol 26:1187-92. 2008
    ..These results demonstrate that the HIV-1 Vif-A3G axis is a valid target for developing small molecule-based new therapies for HIV infection or for enhancing innate immunity against viruses...
  6. ncbi request reprint The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity
    Jean Marc Jacque
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Suite 319, Worcester, Massachusetts 01605, USA
    Nature 441:641-5. 2006
    ..Therefore emerin, which bridges the interface between the inner nuclear envelope and chromatin, may be necessary for chromatin engagement by viral cDNA before integration...
  7. pmc Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5
    Yueh Hsin Ping
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Retrovirology 1:46. 2004
    ....
  8. pmc Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication
    Akbar Ali
    Chemical Biology Program, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 USA
    Chembiochem 10:2072-80. 2009
    ..These compounds are valuable molecular probes for understanding P-TEFb-regulated cellular and HIV-1 gene transcription and provide potential anti-HIV-1 therapeutics...
  9. pmc Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure
    Mark Sharkey
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 7:e1001303. 2011
    ..Summarily, the results support the use of episomal HIV-1 as an additional or alternative approach to traditional assays to characterize virus that is maintained during long-term, suppressive ART...
  10. pmc Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS
    Simon Swingler
    University of Massachusetts Medical School, Program in Molecular Medicine, 373 Plantation Street, Worcester, MA 01605, USA
    Cell Host Microbe 4:63-76. 2008
    ..Collectively, these results indicate that the HIV-1 Nef protein carries a pathogenic determinant that governs B cell defects in HIV-1 infection...
  11. pmc Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1)
    Ya Lin Chiu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Virol 78:2517-29. 2004
    ....
  12. pmc Modest but reproducible inhibition of human immunodeficiency virus type 1 infection in macrophages following LEDGFp75 silencing
    Steven P Zielske
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    J Virol 80:7275-80. 2006
    ..Therefore, LEDGFp75 has a modest involvement in HIV-1 integration in macrophages...
  13. pmc A cellular restriction dictates the permissivity of nondividing monocytes/macrophages to lentivirus and gammaretrovirus infection
    Rajnish Kaushik
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Host Microbe 6:68-80. 2009
    ..Collectively, our results indicate that the relative ability of lentiviruses and gammaretroviruses to transduce nondividing myeloid cells is dependent upon their ability to neutralize a cellular restriction...
  14. ncbi request reprint HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection
    Simon Swingler
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 424:213-9. 2003
    ..Our results reveal a mechanism by which Nef expands the cellular reservoir of HIV-1 by permitting the infection of resting T lymphocytes...
  15. pmc Macrophages archive HIV-1 virions for dissemination in trans
    Natalia Sharova
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    EMBO J 24:2481-9. 2005
    ..The stable sequestration of infectious virions within cytoplasmic compartments of macrophages may represent an additional mechanism for viral persistence in HIV-1-infected individuals...
  16. pmc Apoptotic killing of HIV-1-infected macrophages is subverted by the viral envelope glycoprotein
    Simon Swingler
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Pathog 3:1281-90. 2007
    ..The anti-cancer agent Imatinib inhibited M-CSF receptor activation and restored the apoptotic sensitivity of HIV-1-infected macrophages, suggesting a novel strategy to curtail viral persistence in the macrophage reservoir...
  17. pmc Importin 7 may be dispensable for human immunodeficiency virus type 1 and simian immunodeficiency virus infection of primary macrophages
    Steven P Zielske
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    J Virol 79:11541-6. 2005
    ..The infection efficiency of HIV-1 was similarly unaltered. Therefore, in natural, nondividing targets of HIV-1, IPO7 may be dispensable for infection...
  18. ncbi request reprint HIV-1 replication increases HIV-specific CD4+ T cell frequencies but limits proliferative capacity in chronically infected children
    Zachary A Scott
    Graduate Program in Immunology Virology and Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 170:5786-92. 2003
    ....
  19. pmc Characterization of restrictions to human immunodeficiency virus type 1 infection of monocytes
    Karine Triques
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    J Virol 78:5523-7. 2004
    ..These results point to a restriction in monocytes that is independent of reverse transcription precursors and suggest that differentiation-dependent cellular cofactors of reverse transcription are rate limiting in monocytes...
  20. ncbi request reprint Dissecting HIV-1 through RNA interference
    Mario Stevenson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    Nat Rev Immunol 3:851-8. 2003
  21. ncbi request reprint Advances in basic science
    Mario Stevenson
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA
    Top HIV Med 18:28-34. 2010
    ....
  22. ncbi request reprint Developments in basic science research
    Mario Stevenson
    Center for AIDS Research, University of Massachusetts Medical School, Worcester, MA, USA
    Top HIV Med 14:4-7. 2006
    ....
  23. pmc In vivo evidence for instability of episomal human immunodeficiency virus type 1 cDNA
    Mark Sharkey
    Program in Molecular Medicine, University of Massachusetts, 373 Plantation St, Biotech 2, Suite 319, Worcester, MA 01605, USA
    J Virol 79:5203-10. 2005
    ..Therefore, evolution of episomal viral cDNAs is a valid surrogate of ongoing viral replication in HIV-1-infected individuals...
  24. pmc Evidence for a cytopathogenicity determinant in HIV-1 Vpr
    Mohan Somasundaran
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 99:9503-8. 2002
    ..This study suggests the presence of a determinant of in vivo cytopathogenicity within HIV-1 Vpr and further indicates that viral replication can be uncoupled from cytopathicity in vitro and in vivo...
  25. ncbi request reprint Developments in basic science research. Highlights of the 11th Conference on Retroviruses and Opportunistic Infections, February 8-11, 2004, San Francisco, California, USA
    Mario Stevenson
    University of Massachusetts Medical School, Worcester, MA, USA
    Top HIV Med 12:4-7. 2004
    ..How viruses move between cells was also the focus of several presentations at the meeting, and there were further surprises about the mechanism by which HIV-1 may establish latent infection...
  26. pmc A novel motif in HIV-1 Nef that regulates MIP-1beta chemokine release in macrophages
    Lue Dai
    University of Massachusetts Medical School, Program in Molecular Medicine, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    J Virol 84:8327-31. 2010
    ..This further underscores Nef as a modular protein with genetically separable activities that may contribute to its role in viral replication and pathogenicity...
  27. ncbi request reprint Developments in basic science research
    Mario Stevenson
    University of Massachusetts Medical School, Worcester, MA, USA
    Top HIV Med 13:4-8. 2005
    ..The crystal structure of an unliganded SIV envelope was presented and has broad significance in terms of understanding viral infection and generating better immunogens for vaccines...
  28. ncbi request reprint Basic science highlights
    Mario Stevenson
    Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA
    Top HIV Med 15:21-5. 2007
    ..Essential steps in the viral life cycle, uncovered through basic research, are now being targeted by new classes of antiviral agents. In addition, basic science is unveiling potential new targets of antiretroviral therapy...
  29. ncbi request reprint Basic science summary
    Mario Stevenson
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA
    Top HIV Med 17:30-4. 2009
    ..The identification of novel cellular restrictions and cellular cofactors of viral replication indicate the possibility of numerous opportunities for the development of novel therapeutic agents for the treatment of HIV and AIDS...
  30. ncbi request reprint Modulation of HIV-1 replication by RNA interference
    Jean Marc Jacque
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 418:435-8. 2002
    ....
  31. pmc A highly conserved residue in the C-terminal helix of HIV-1 matrix is required for envelope incorporation into virus particles
    Laura Brandano
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 86:2347-59. 2012
    ..Taken together, these results indicate that the C-terminal hydrophobic pocket of MA, which encompasses both residues 84 and 99, has a previously unsuspected and key role in HIV-1 Env incorporation...
  32. ncbi request reprint Developments in basic science research
    Mario Stevenson
    Center for AIDS Research, University of Massachusetts Medical School, Worcester, MA, USA
    Top HIV Med 11:70-5. 2003
  33. ncbi request reprint Highlights of the 15th Conference on Retroviruses and Opportunistic Infections. Basic science summary
    Mario Stevenson
    Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA
    Top HIV Med 16:1-5. 2008
    ..These research discoveries paint an optimistic picture regarding the development of new strategies to combat HIV and AIDS...
  34. ncbi request reprint HIV and cells of macrophage/dendritic lineage and other non-T cell reservoirs: new answers yield new questions
    Ronald G Collman
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Leukoc Biol 74:631-4. 2003
    ..This issue of JLB contains several reviews and original reports resulting from the workshop that address recent progress and highlight the current research questions regarding these cell types...
  35. ncbi request reprint Advances in macrophage and dendritic cell biology in HIV-1 infection stress key understudied areas in infection, pathogenesis, and analysis of viral reservoirs
    Luis J Montaner
    The Wistar Institute, Philadelphia, PA 19104 4268, USA
    J Leukoc Biol 80:961-4. 2006
    ....
  36. pmc Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1
    Oliver T Keppler
    Gladstone Institute of Virology and Immunology, School of Medicine, University of California at San Francisco, San Francisco, CA 94141, USA
    J Exp Med 195:719-36. 2002
    ..Transgenic rats also displayed a low-level plasma viremia early in infection. Thus, transgenic rats expressing the appropriate human receptor complex are promising candidates for a small animal model of HIV-1 infection...
  37. ncbi request reprint Tat's seductive side
    Mario Stevenson
    Nat Med 9:163-4. 2003
  38. ncbi request reprint A plea for justice for jailed medical workers
    Sunil K Ahuja
    Science 314:924-5. 2006
  39. ncbi request reprint Public health. A sound rationale needed for phase III HIV-1 vaccine trials
    Dennis R Burton
    Scripps Research Institute, La Jolla, California, USA
    Science 303:316. 2004
  40. ncbi request reprint TRIMming HIV-1's mainsail
    Mario Stevenson
    Nat Immunol 5:355-6. 2004

Research Grants51

  1. Activation of CD40 by HIV and Role in AIDS Dementia
    Mario Stevenson; Fiscal Year: 2010
    ..These studies will provide fundamental insight into the molecular mechanisms underscoring viral persistence in macrophages and induction of neuronotoxicity by infected macrophages. ..
  2. ANALYSIS OF COVERT VIRAL REPLICATION DURING HAART
    Mario Stevenson; Fiscal Year: 2001
    ....
  3. Cellular Co-Factors of HIV-1 Infection
    Mario Stevenson; Fiscal Year: 2007
    ..Understanding the mechanism through which nuclear envelope proteins regulate HIV-1 infection may ultimately point to novel therapeutic strategies that truncate the viral replication cycle prior to establishment of the provirus. ..
  4. ROLE OF MONOCYTOTROPISM IN HIV/SIV PATHOGENICITY
    Mario Stevenson; Fiscal Year: 2000
    ..Examine in vivo and in vitro phenotype of SIV variants containing non-chemokine inducing Nef alleles and of HIV/SIV variants containing Nef/chemokine substitutions. ..
  5. ROLE OF HIV-1 GAG MA IN VIRAL ENTRY
    Mario Stevenson; Fiscal Year: 2001
    ..It is expected that these studies will more fully define how gag MA participates in early and late phases of the viral lifecycle. ..
  6. Cellular Co-Factors of HIV-1 Infection
    Mario Stevenson; Fiscal Year: 2009
    ..Understanding the mechanism through which nuclear envelope proteins regulate HIV-1 infection may ultimately point to novel therapeutic strategies that truncate the viral replication cycle prior to establishment of the provirus. ..
  7. ROLE OF HIV-1 GAG MA IN VIRAL ENTRY
    Mario Stevenson; Fiscal Year: 2004
    ..It is expected that these studies will more fully define how gag MA participates in early and late phases of the viral lifecycle. ..
  8. ROLE OF HIV-1 GAG MA IN VIRAL ENTRY
    Mario Stevenson; Fiscal Year: 2005
    ..It is expected that these studies will more fully define how gag MA participates in early and late phases of the viral lifecycle. ..
  9. ANALYSIS OF COVERT VIRAL REPLICATION DURING HAART
    Mario Stevenson; Fiscal Year: 2004
    ....
  10. ANALYSIS OF COVERT VIRAL REPLICATION DURING HAART
    Mario Stevenson; Fiscal Year: 2005
    ....
  11. Activation of CD40 by HIV and Role in AIDS Dementia
    Mario Stevenson; Fiscal Year: 2006
    ..These studies will provide fundamental insight into the molecular mechanisms underscoring viral persistence in macrophages and induction of neuronotoxicity by infected macrophages. ..
  12. FUNCTION FOR VPR AND VPX OF PRIMATE LENTIVIRUSES
    Mario Stevenson; Fiscal Year: 2007
    ..It is expected that these studies will more fully define the contribution of nuclear import activities of Vpr and i Vpx proteins to virus replication in vitro and in vivo. ..
  13. Activation of CD40 by HIV and Role in AIDS Dementia
    Mario Stevenson; Fiscal Year: 2009
    ..These studies will provide fundamental insight into the molecular mechanisms underscoring viral persistence in macrophages and induction of neuronotoxicity by infected macrophages. ..
  14. Cellular Co-Factors of HIV-1 Infection
    Mario Stevenson; Fiscal Year: 2010
    ..Understanding the mechanism through which nuclear envelope proteins regulate HIV-1 infection may ultimately point to novel therapeutic strategies that truncate the viral replication cycle prior to establishment of the provirus. ..
  15. ROLE OF MONOCYTOTROPISM IN HIV/SIV PATHOGENICITY
    Mario Stevenson; Fiscal Year: 2001
    ..Examine in vivo and in vitro phenotype of SIV variants containing non-chemokine inducing Nef alleles and of HIV/SIV variants containing Nef/chemokine substitutions. ..
  16. ANALYSIS OF COVERT VIRAL REPLICATION DURING HAART
    Mario Stevenson; Fiscal Year: 2002
    ....
  17. Preclinical Development of HIV-1 Vif Antagonists
    Mario Stevenson; Fiscal Year: 2007
    ..abstract_text> ..
  18. ROLE OF MONOCYTOTROPISM IN HIV/SIV PATHOGENICITY
    Mario Stevenson; Fiscal Year: 2007
    ..These studies will define how macrophages contribute to primate lentiviral replication and pathogenicity and identify strategies through which to interrupt viral replication in this reservoir. ..
  19. ROLE OF MONOCYTOTROPISM IN HIV/SIV PATHOGENICITY
    Mario Stevenson; Fiscal Year: 1999
    ..Examine in vivo and in vitro phenotype of SIV variants containing non-chemokine inducing Nef alleles and of HIV/SIV variants containing Nef/chemokine substitutions. ..
  20. Activation of CD40 by HIV and Role in AIDS Dementia
    Mario Stevenson; Fiscal Year: 2007
    ..These studies will provide fundamental insight into the molecular mechanisms underscoring viral persistence in macrophages and induction of neuronotoxicity by infected macrophages. ..
  21. Biology and Pathogenesis of Primate Lentiviruses
    Mario Stevenson; Fiscal Year: 2002
    ..However, the small size of the Keystone Conference allows the intimacy in which scientific ideas can be exchanged, and such an intimacy is not provided by the National AIDS meeting. ..
  22. ANALYSIS OF COVERT VIRAL REPLICATION DURING HAART
    Mario Stevenson; Fiscal Year: 2003
    ....
  23. ROLE OF MONOCYTOTROPISM IN HIV/SIV PATHOGENICITY
    Mario Stevenson; Fiscal Year: 2005
    ..These studies will define how macrophages contribute to primate lentiviral replication and pathogenicity and identify strategies through which to interrupt viral replication in this reservoir. ..
  24. ROLE OF MONOCYTOTROPISM IN HIV/SIV PATHOGENICITY
    Mario Stevenson; Fiscal Year: 2004
    ..These studies will define how macrophages contribute to primate lentiviral replication and pathogenicity and identify strategies through which to interrupt viral replication in this reservoir. ..
  25. ROLE OF MONOCYTOTROPISM IN HIV/SIV PATHOGENICITY
    Mario Stevenson; Fiscal Year: 2003
    ..Examine in vivo and in vitro phenotype of SIV variants containing non-chemokine inducing Nef alleles and of HIV/SIV variants containing Nef/chemokine substitutions. ..
  26. ROLE OF HIV-1 GAG MA IN VIRAL ENTRY
    Mario Stevenson; Fiscal Year: 2003
    ..It is expected that these studies will more fully define how gag MA participates in early and late phases of the viral lifecycle. ..
  27. NUCLEAR IMPORT FUNCTIONS OF PRIMATE LENTIVIRUSES
    Mario Stevenson; Fiscal Year: 1999
    ..4. Examine pathogenic potential of SIVagm gag MA nuclear import mutants in pig-tailed macaques. ..
  28. ROLE OF MONOCYTOTROPISM IN HIV/SIV PATHOGENICITY
    Mario Stevenson; Fiscal Year: 2002
    ..Examine in vivo and in vitro phenotype of SIV variants containing non-chemokine inducing Nef alleles and of HIV/SIV variants containing Nef/chemokine substitutions. ..
  29. ROLE OF HIV-1 GAG MA IN VIRAL ENTRY
    Mario Stevenson; Fiscal Year: 2002
    ..It is expected that these studies will more fully define how gag MA participates in early and late phases of the viral lifecycle. ..
  30. ROLE OF MONOCYTOTROPISM IN HIV/SIV PATHOGENICITY
    Mario Stevenson; Fiscal Year: 2006
    ..These studies will define how macrophages contribute to primate lentiviral replication and pathogenicity and identify strategies through which to interrupt viral replication in this reservoir. ..
  31. ROLE OF MONOCYTOTROPISM IN HIV/SIV PATHOGENICITY
    Mario Stevenson; Fiscal Year: 2000
    ..Examine in vivo and in vitro phenotype of SIV variants containing non-chemokine inducing Nef alleles and of HIV/SIV variants containing Nef/chemokine substitutions. ..