TOM HALL STEVENS

Summary

Affiliation: University of Oregon
Country: USA

Publications

  1. ncbi request reprint Structure, function and regulation of the vacuolar (H+)-ATPase
    T H Stevens
    Institute of Molecular Biology, University of Oregon, Eugene 97403 1229, USA
    Annu Rev Cell Dev Biol 13:779-808. 1997

Collaborators

Detail Information

Publications1

  1. ncbi request reprint Structure, function and regulation of the vacuolar (H+)-ATPase
    T H Stevens
    Institute of Molecular Biology, University of Oregon, Eugene 97403 1229, USA
    Annu Rev Cell Dev Biol 13:779-808. 1997
    ..Recent information concerning targeting and regulation of V-ATPases has also been obtained...

Research Grants47

  1. SORTING AND TRANSPORT OF YEAST MEMBRANE PROTEINS
    TOM HALL STEVENS; Fiscal Year: 2010
    ..Understanding V-ATPase function will provide important insights into diseases of the kidney (renal tubular acidosis), bone diseases (osteopetrosis), and in tumor metastasis, and new drug targets should arise from our studies. ..
  2. CELL BIOLOGICAL STUDY OF EUKARYOTIC ORGANELLE ASSEMBLY
    Tom Stevens; Fiscal Year: 2002
    ..abstract_text> ..
  3. SORTING AND TRANSPORT OF YEAST MEMBRANE PROTEINS
    Tom Stevens; Fiscal Year: 2000
    ..Additional functions for the assembly factors will be investigated such as escorting the V- ATPase into ER derived vesicles and chaperoning the complex to the cis-Golgi. ..
  4. SORTING AND TRANSPORT OF MEMBRANE PROTEINS
    Tom Stevens; Fiscal Year: 1991
    ..These studies are likely to increase our basic understanding of diseases that result from missorting of lysosomal hydrolases such as Mucolipidosis II and III and other lysosomal storage diseases...
  5. LCQ Deca XP Ion Trap Mass Spectrometer
    Tom Stevens; Fiscal Year: 2003
    ..The sighting of this mass spectrometer at the University of Oregon will make this technology immediately accessible to our researchers, rather than having to rely on long distance collaborations. ..
  6. SORTING AND TRANSPORT OF YEAST MEMBRANE PROTEINS
    Tom Stevens; Fiscal Year: 2004
    ..The other two assembly factors, Vmal2p and Vma22p, will also be investigated for roles in assembly of the complex and for packaging of the V-ATPase into vesicles budding from the ER. ..
  7. SORTING AND TRANSPORT OF YEAST MEMBRANE PROTEINS
    Tom Stevens; Fiscal Year: 2009
    ..Understanding V-ATPase function will provide important insights into diseases of the kidney (renal tubular acidosis), bone diseases (osteopetrosis), and in tumor metastasis, and new drug targets should arise from our studies. ..
  8. CELL BIOLOGICAL STUDY OF EUKARYOTIC ORGANELLE ASSEMBLY
    Tom Stevens; Fiscal Year: 2007
    ..These basic mechanistic studies in yeast are providing important insights into our understanding of many lysosomal storage diseases in humans. ..
  9. GRADUATE TRAINING IN MOLECULAR BIOLOGY AND BIOPHYSICS
    Tom Stevens; Fiscal Year: 2007
    ..Major equipment is shared and housed in common space. The laboratories of most of the faculty are contiguous and in interconnected buildings. This arrangement fosters interactions and collaborations among faculty and students. ..
  10. SORTING AND TRANSPORT OF YEAST MEMBRANE PROTEINS
    Tom Stevens; Fiscal Year: 2007
    ..These basic studies in yeast are providing important insights into our understanding of many diseases in humans related to defects in organelle acidification. ..
  11. SORTING AND TRANSPORT OF YEAST MEMBRANE PROTEINS
    Tom Stevens; Fiscal Year: 1993
    ..The long-term objective of the studies with the vacuolar H+- ATPase is to develop a mechanistic understanding of the pathway of assembly for this very complex membrane protein...
  12. CELL BIOLOGICAL STUDY OF EUKARYOTIC ORGANELLE ASSEMBLY
    Tom Stevens; Fiscal Year: 1993
    ..Mutations will be constructed and their effects assessed in yeast cells by standard yeast genetic methodology. Antibodies to this protein will be used to test for its function in our cell-free Golgi to vacuole transport assay...
  13. CELL BIOLOGICAL STUDY OF EUKARYOTIC ORGANELLE ASSEMBLY
    Tom Stevens; Fiscal Year: 1990
    ..the work described in this proposal should increase our understanding of the specificity of the enzyme defective in Mucolipidosis II and III and thus help elucidate the process of targeting lysosomal proteins in general...