Richard G Stevens

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi Artificial lighting in the industrialized world: circadian disruption and breast cancer
    Richard G Stevens
    University of Connecticut Health Center, Farmington, CT 06030 6325, USA
    Cancer Causes Control 17:501-7. 2006
  2. ncbi Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer
    Richard G Stevens
    Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, CT, USA
    Cancer Lett 248:262-8. 2007
  3. pmc Electromagnetic fields and free radicals
    Richard G Stevens
    Environ Health Perspect 112:A726; author reply A726. 2004
  4. pmc Ovarian cancer immunotherapy: opportunities, progresses and challenges
    Bei Liu
    Department of Immunology, University of Connecticut School of Medicine, Farmington, USA
    J Hematol Oncol 3:7. 2010
  5. ncbi Light in the built environment: potential role of circadian disruption in endocrine disruption and breast cancer
    R G Stevens
    University of Connecticut Health Center, Department of Community Medicine, Farmington 06030 6325, USA
    Cancer Causes Control 12:279-87. 2001
  6. ncbi Alcohol consumption and serum hormone levels during pregnancy
    Richard G Stevens
    Department of Community Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    Alcohol 36:47-53. 2005
  7. ncbi Circadian disruption and breast cancer: from melatonin to clock genes
    Richard G Stevens
    Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 6325, USA
    Epidemiology 16:254-8. 2005
  8. pmc Epidemiology of colonic aberrant crypt foci: review and analysis of existing studies
    Richard G Stevens
    Colon Cancer Prevention Program CCPP, Neag Comprehensive Cancer Center, University of Connecticut Health Center UCHC, 263 Farmington Avenue, Farmington, CT 06030 6325, United States
    Cancer Lett 252:171-83. 2007
  9. ncbi Lighting during the day and night: possible impact on risk of breast cancer
    Richard G Stevens
    UCONN Health Center, University of Connecticut, Farmington, CT, USA
    Neuro Endocrinol Lett 23:57-60. 2002
  10. ncbi Oxidative damage in colon and mammary tissue of the HFE-knockout mouse
    Richard G Stevens
    Department of Community Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Free Radic Biol Med 34:1212-6. 2003

Research Grants

  1. Light, Circadian Disruption, and Breast Cancer
    Richard Stevens; Fiscal Year: 2004

Detail Information

Publications42

  1. ncbi Artificial lighting in the industrialized world: circadian disruption and breast cancer
    Richard G Stevens
    University of Connecticut Health Center, Farmington, CT 06030 6325, USA
    Cancer Causes Control 17:501-7. 2006
    ..Exogenous melatonin may therefore contribute to circadian disruption rather than alleviate it...
  2. ncbi Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer
    Richard G Stevens
    Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, CT, USA
    Cancer Lett 248:262-8. 2007
    ..4; the mean was significantly higher in the patients with a positive family history of CRC (9.0, p<0.01; n=43) or a personal history of advanced adenoma (7.5, p<0.05; n=34)...
  3. pmc Electromagnetic fields and free radicals
    Richard G Stevens
    Environ Health Perspect 112:A726; author reply A726. 2004
  4. pmc Ovarian cancer immunotherapy: opportunities, progresses and challenges
    Bei Liu
    Department of Immunology, University of Connecticut School of Medicine, Farmington, USA
    J Hematol Oncol 3:7. 2010
    ..Finally, we will summarize our own experience on the use of patient-specific tumor-derived heat shock protein-peptide complex for the treatment of advanced ovarian cancer...
  5. ncbi Light in the built environment: potential role of circadian disruption in endocrine disruption and breast cancer
    R G Stevens
    University of Connecticut Health Center, Department of Community Medicine, Farmington 06030 6325, USA
    Cancer Causes Control 12:279-87. 2001
    ..In particular, if electric lighting as currently employed contributes to 'circadian disruption' it may be an important cause of 'endocrine disruption' and thereby contribute to a high risk of breast cancer in industrialized societies...
  6. ncbi Alcohol consumption and serum hormone levels during pregnancy
    Richard G Stevens
    Department of Community Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    Alcohol 36:47-53. 2005
    ..Light alcohol intake during pregnancy is associated with lower maternal testosterone. The health implications are uncertain, but may include an increased breast density in the daughters of drinking mothers...
  7. ncbi Circadian disruption and breast cancer: from melatonin to clock genes
    Richard G Stevens
    Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 6325, USA
    Epidemiology 16:254-8. 2005
    ..Epidemiologic studies should consider gene and environment interactions such as circadian gene variants and shift work requirements on the job...
  8. pmc Epidemiology of colonic aberrant crypt foci: review and analysis of existing studies
    Richard G Stevens
    Colon Cancer Prevention Program CCPP, Neag Comprehensive Cancer Center, University of Connecticut Health Center UCHC, 263 Farmington Avenue, Farmington, CT 06030 6325, United States
    Cancer Lett 252:171-83. 2007
    ..This information can then be used to improve the design of prospective studies, and of clinical intervention trials that use ACF as an intermediate endpoint...
  9. ncbi Lighting during the day and night: possible impact on risk of breast cancer
    Richard G Stevens
    UCONN Health Center, University of Connecticut, Farmington, CT, USA
    Neuro Endocrinol Lett 23:57-60. 2002
    ..Many candidate factors exist, each with a cadre of proponents. The sum of these may turn out to explain the bulk of the excess risk in modern societies. On the other hand, they may not, and worse, may fall woefully short...
  10. ncbi Oxidative damage in colon and mammary tissue of the HFE-knockout mouse
    Richard G Stevens
    Department of Community Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Free Radic Biol Med 34:1212-6. 2003
    ..226, p =.02) tissue among those mice on the standard iron diet compared to those on the low iron diet. These results suggest that dietary modification may affect the course of iron overload from HFE mutations...
  11. doi Adverse health effects of nighttime lighting: comments on American Medical Association policy statement
    Richard G Stevens
    University of Connecticut Health Center, Farmington, Connecticut 06030 6325, USA
    Am J Prev Med 45:343-6. 2013
    ..There are practical implications of the basic and epidemiologic science in the form of advancing lighting technologies that better accommodate human circadian rhythmicity. ..
  12. doi Considerations of circadian impact for defining 'shift work' in cancer studies: IARC Working Group Report
    Richard G Stevens
    University of Connecticut Health Center, Farmington, CT 06030, USA
    Occup Environ Med 68:154-62. 2011
    ..The group also recognised that for further domains to be identified, more research needs to be conducted on the impact of various shift schedules and routines on physiological and circadian rhythms of workers in real-world environments...
  13. ncbi Dietary iron promotes azoxymethane-induced colon tumors in mice
    Jillian N M Ilsley
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nutr Cancer 49:162-9. 2004
    ..Our results suggest that, following carcinogen exposure, elevated dietary iron promotes the growth of tumors with altered cellular homeostasis through a mechanism that is independent of oxidative stress...
  14. pmc Light-at-night, circadian disruption and breast cancer: assessment of existing evidence
    Richard G Stevens
    Department of Community Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6325, USA
    Int J Epidemiol 38:963-70. 2009
    ..The possibility that a portion of the breast cancer burden might be explained by the introduction and increasing use of electricity to light the night was suggested >20 years ago...
  15. pmc Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways
    Aaron E Hoffman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Cancer 10:110. 2010
    ..As such, aberrant expression of CRY2 may influence carcinogenic processes and thereby impact cancer susceptibility...
  16. ncbi Working against our endogenous circadian clock: Breast cancer and electric lighting in the modern world
    Richard G Stevens
    University of Connecticut Health Center, Farmington, CT 06032, United States
    Mutat Res 680:106-8. 2009
    ..g., shift work) can induce deleterious epigenetic changes in these genes...
  17. ncbi Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans
    Daniel W Rosenberg
    Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, and Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Cancer Res 67:3551-4. 2007
    ....
  18. ncbi HFE mutation and dietary iron content interact to increase ischemia/reperfusion injury of the heart in mice
    Tibor Turoczi
    Department of Surgery, University of Connecticut School of Medicine, Farmington, Conn 06030 1110, USA
    Circ Res 92:1240-6. 2003
    ..The results suggest that increased amount of ROS and reduced antioxidant reserve secondary to iron overloading may be instrumental for the susceptibility of the HFE gene knockout mice to cardiac injury...
  19. doi Electric light causes cancer? Surely you're joking, Mr. Stevens
    Richard G Stevens
    Department of Community Medicine and Health Care, University of Connecticut Health Center, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030 6325, USA
    Mutat Res 682:1-6. 2009
    ..Although it may seem logical now, the journey on the path from electric light to breast cancer has been a tortuous one, at least for me...
  20. pmc Breast cancer and circadian disruption from electric lighting in the modern world
    Richard G Stevens
    Professor, Department of Community Medicine, University of Connecticut Health Center, Farmington, CT
    CA Cancer J Clin 64:207-18. 2014
    ....
  21. doi Does electric light stimulate cancer development in children?
    Richard G Stevens
    Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Cancer Epidemiol Biomarkers Prev 21:701-4. 2012
    ..There are practical implications and interventions that accrue from this idea should it later be confirmed to be true...
  22. ncbi Baseline serum C-reactive protein and death from colorectal cancer in the NHANES III cohort
    Helen Swede
    Department of Community Medicine and Health Care, University of Connecticut Health Center, Farmington, CT
    Int J Cancer 134:1862-70. 2014
    ..Future research is recommended to confirm emerging data that elevated serologic CRP might reflect underlying colonic inflammation. ..
  23. doi Body iron stores and breast cancer risk in female atomic bomb survivors
    Richard G Stevens
    Department of Community Medicine, UCONN Health Center, Farmington, Connecticut, USA
    Cancer Sci 102:2236-40. 2011
    ..The results support the hypothesis that elevated body iron stores increase the risk of breast cancer. However, the study was inconclusive regarding the question of whether body iron alters radiation-induced breast cancer risk...
  24. pmc Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseases
    Richard G Stevens
    Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 6325, USA
    Environ Health Perspect 115:1357-62. 2007
    ..Third are effects of light-induced physiologic disruption on disease occurrence and prognosis, and how prevention and treatment could be improved by application of this knowledge...
  25. pmc Number of aberrant crypt foci associated with adiposity and IGF1 bioavailability
    Helen Swede
    Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6325, USA
    Cancer Causes Control 20:653-61. 2009
    ..Evidence has been derived from studies of cancer and polyps. Supporting data about aberrant crypt foci (ACF), putative pre-polyp changes, have been generated only from animal studies to date...
  26. doi Response to Ijaz S, et al. "Night-shift work and breast cancer - a systematic review and meta-analysis"
    Richard G Stevens
    University of Connecticut Health Center, Farmington, CT, USA
    Scand J Work Environ Health 39:631-2. 2013
    ....
  27. doi Invited commentary: validity of case-control studies of sleep duration and breast cancer
    Richard G Stevens
    University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6325, USA
    Am J Epidemiol 177:328-30. 2013
    ..Girschik et al. (Am J Epidemiol. 2013;177(4):316-327) have tested the latter in a case-control study. Although the case-control design is useful for many questions, it is probably not useful for studies of sleep duration and health...
  28. doi Prevalence and prognostic role of triple-negative breast cancer by race: a surveillance study
    Helen Swede
    Department of Community Medicine and Health Care, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Clin Breast Cancer 11:332-41. 2011
    ..No reports however have been generated from a statewide cancer registry...
  29. pmc Shiftwork and prostate-specific antigen in the National Health and Nutrition Examination Survey
    Erin E Flynn-Evans
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Natl Cancer Inst 105:1292-7. 2013
    ..Our aim was to investigate the relationship between shiftwork and prostate-specific antigen (PSA) test obtained as part of the National Health and Nutrition Examination Survey (NHANES) study...
  30. ncbi Light at night and breast cancer: an editorial correction
    Richard G Stevens
    Epidemiology 13:116. 2002
  31. ncbi Residential magnetic fields and the risk of breast cancer
    Scott Davis
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North MP 474, Seattle, WA 98109 1024, USA
    Am J Epidemiol 155:446-54. 2002
    ..These data do not support the hypothesis that exposure to residential magnetic fields is associated with an increased risk of developing breast cancer...
  32. ncbi Shift work, light at night, and breast cancer on Long Island, New York
    Erin S O'Leary
    Department of Preventive Medicine, School of Medicine, Stony Brook University, Stony Brook, NY 11794 8036, USA
    Am J Epidemiol 164:358-66. 2006
    ..Furthermore, overall and evening shift work were not significant factors, and analyses of overnight shift workers yielded reduced risk estimates. The study thus provides mixed evidence for the light-at-night hypothesis...
  33. ncbi Epidemiology of urinary melatonin in women and its relation to other hormones and night work
    Richard G Stevens
    Cancer Epidemiol Biomarkers Prev 14:551; author reply 551. 2005
  34. ncbi Cancer and rhythm
    Maximilian Moser
    Cancer Causes Control 17:483-7. 2006
  35. pmc Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Cancer 120:432-5. 2007
    ....
  36. ncbi Does incidence of breast cancer and prostate cancer decrease with increasing degree of visual impairment
    Eero Pukkala
    Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Liisankatu 21B, Helsinki, FIN 00170, Finland
    Cancer Causes Control 17:573-6. 2006
    ..The major hypotheses are that melatonin may decrease risk of hormone-related cancers, particularly breast cancer, or even act as a potent antioxidant and thus have a protective effect against cancer development in general...
  37. pmc Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, LEPH Room 702, New Haven, CT 06520, USA
    Breast Cancer Res Treat 107:421-5. 2008
    ..46-0.81, P = 0.001). This is the first evidence demonstrating a role of the circadian gene NPAS2 in human breast cancer, suggesting that genetic variations in circadian genes might be a novel panel of biomarkers for breast cancer risk...
  38. doi Light at night co-distributes with incident breast but not lung cancer in the female population of Israel
    Itai Kloog
    Department of Natural Resources and Environmental Management, University of Haifa, Haifa, Israel
    Chronobiol Int 25:65-81. 2008
    ..The analysis yielded an estimated 73% higher breast cancer incidence in the highest LAN exposed communities compared to the lowest LAN exposed communities...
  39. pmc Does "clock" matter in prostate cancer?
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer Epidemiol Biomarkers Prev 15:3-5. 2006
    ..Confirmation of this hypothesis will add to our understanding of the role of the circadian clock in prostate tumorigenesis and further facilitate the development of novel risk and prognostic biomarkers for prostate cancer...
  40. ncbi Sleep duration and breast cancer: a prospective cohort study
    Pia K Verkasalo
    Department of Environmental Health, National Public Health Institute, Kuopio
    Cancer Res 65:9595-600. 2005
    ..10 (CI, 0.59-2.05), 1.0, and 0.28 (CI, 0.09-0.88), with a decreasing trend (P = 0.03). This study provides some support for a decreased risk of breast cancer in long sleepers...
  41. ncbi Exploring lag and duration effect of sunshine in triggering suicide
    Fotios C Papadopoulos
    Department of Hygiene and Epidemiology, Athens University Medical School, 75 M Asias str, Goudi, P O Box 11527, Athens, Greece
    J Affect Disord 88:287-97. 2005
    ..Sunshine is considered to have a beneficial impact on mood. Interestingly, it has been consistently found that the incidence of suicide reaches a peak during early summer...
  42. ncbi Period3 structural variation: a circadian biomarker associated with breast cancer in young women
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer Epidemiol Biomarkers Prev 14:268-70. 2005
    ..7; 95% confidence interval, 1.0-3.0). Our finding suggests that the circadian genes might be a novel panel of potential biomarkers for breast cancer and worth further investigation...

Research Grants1

  1. Light, Circadian Disruption, and Breast Cancer
    Richard Stevens; Fiscal Year: 2004
    ..oupjoumals.org/cgi/content/full/92/9/686. It represents the investigators' initial efforts at crossdiscipline collaboration on the emerging topic of lighting, circadian disruption, and breast cancer. ..