Research Topics
| Richard G StevensSummaryAffiliation: University of Connecticut Health Center Country: USA Publications
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Publications
Electric light causes cancer? Surely you're joking, Mr. StevensRichard G Stevens
Department of Community Medicine and Health Care, University of Connecticut Health Center, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030 6325, USA
Mutat Res 682:1-6. 2009..Although it may seem logical now, the journey on the path from electric light to breast cancer has been a tortuous one, at least for me...
Working against our endogenous circadian clock: Breast cancer and electric lighting in the modern worldRichard G Stevens
University of Connecticut Health Center, Farmington, CT 06032, United States
Mutat Res 680:106-8. 2009..g., shift work) can induce deleterious epigenetic changes in these genes...- Invited commentary: validity of case-control studies of sleep duration and breast cancerRichard G Stevens
University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6325, USA
Am J Epidemiol 177:328-30. 2013..Girschik et al. (Am J Epidemiol. 2013;177(4):316-327) have tested the latter in a case-control study. Although the case-control design is useful for many questions, it is probably not useful for studies of sleep duration and health... - Body iron stores and breast cancer risk in female atomic bomb survivorsRichard G Stevens
Department of Community Medicine, UCONN Health Center, Farmington, Connecticut, USA
Cancer Sci 102:2236-40. 2011..The results support the hypothesis that elevated body iron stores increase the risk of breast cancer. However, the study was inconclusive regarding the question of whether body iron alters radiation-induced breast cancer risk... - Does electric light stimulate cancer development in children?Richard G Stevens
Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
Cancer Epidemiol Biomarkers Prev 21:701-4. 2012..There are practical implications and interventions that accrue from this idea should it later be confirmed to be true... 
Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathwaysAaron E Hoffman
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
BMC Cancer 10:110. 2010..As such, aberrant expression of CRY2 may influence carcinogenic processes and thereby impact cancer susceptibility...- Considerations of circadian impact for defining 'shift work' in cancer studies: IARC Working Group ReportRichard G Stevens
University of Connecticut Health Center, Farmington, CT 06030, USA
Occup Environ Med 68:154-62. 2011..The group also recognised that for further domains to be identified, more research needs to be conducted on the impact of various shift schedules and routines on physiological and circadian rhythms of workers in real-world environments... - Light-at-night, circadian disruption and breast cancer: assessment of existing evidenceRichard G Stevens
Department of Community Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6325, USA
Int J Epidemiol 38:963-70. 2009..The possibility that a portion of the breast cancer burden might be explained by the introduction and increasing use of electricity to light the night was suggested >20 years ago... - Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseasesRichard G Stevens
Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 6325, USA
Environ Health Perspect 115:1357-62. 2007..Third are effects of light-induced physiologic disruption on disease occurrence and prognosis, and how prevention and treatment could be improved by application of this knowledge... - HFE mutation and dietary iron content interact to increase ischemia/reperfusion injury of the heart in miceTibor Turoczi
Department of Surgery, University of Connecticut School of Medicine, Farmington, Conn 06030 1110, USA
Circ Res 92:1240-6. 2003..The results suggest that increased amount of ROS and reduced antioxidant reserve secondary to iron overloading may be instrumental for the susceptibility of the HFE gene knockout mice to cardiac injury... - Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humansDaniel W Rosenberg
Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, and Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Cancer Res 67:3551-4. 2007.... - Shift work, light at night, and breast cancer on Long Island, New YorkErin S O'Leary
Department of Preventive Medicine, School of Medicine, Stony Brook University, Stony Brook, NY 11794 8036, USA
Am J Epidemiol 164:358-66. 2006..Furthermore, overall and evening shift work were not significant factors, and analyses of overnight shift workers yielded reduced risk estimates. The study thus provides mixed evidence for the light-at-night hypothesis... - Artificial lighting in the industrialized world: circadian disruption and breast cancerRichard G Stevens
University of Connecticut Health Center, Farmington, CT 06030 6325, USA
Cancer Causes Control 17:501-7. 2006..Exogenous melatonin may therefore contribute to circadian disruption rather than alleviate it... - Dietary iron promotes azoxymethane-induced colon tumors in miceJillian N M Ilsley
Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Nutr Cancer 49:162-9. 2004..Our results suggest that, following carcinogen exposure, elevated dietary iron promotes the growth of tumors with altered cellular homeostasis through a mechanism that is independent of oxidative stress... - Epidemiology of colonic aberrant crypt foci: review and analysis of existing studiesRichard G Stevens
Colon Cancer Prevention Program CCPP, Neag Comprehensive Cancer Center, University of Connecticut Health Center UCHC, 263 Farmington Avenue, Farmington, CT 06030 6325, United States
Cancer Lett 252:171-83. 2007..This information can then be used to improve the design of prospective studies, and of clinical intervention trials that use ACF as an intermediate endpoint... - Circadian disruption and breast cancer: from melatonin to clock genesRichard G Stevens
Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 6325, USA
Epidemiology 16:254-8. 2005..Epidemiologic studies should consider gene and environment interactions such as circadian gene variants and shift work requirements on the job... - Alcohol consumption and serum hormone levels during pregnancyRichard G Stevens
Department of Community Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
Alcohol 36:47-53. 2005..Light alcohol intake during pregnancy is associated with lower maternal testosterone. The health implications are uncertain, but may include an increased breast density in the daughters of drinking mothers... - Number of aberrant crypt foci associated with adiposity and IGF1 bioavailabilityHelen Swede
Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6325, USA
Cancer Causes Control 20:653-61. 2009..Evidence has been derived from studies of cancer and polyps. Supporting data about aberrant crypt foci (ACF), putative pre-polyp changes, have been generated only from animal studies to date... - Prevalence and prognostic role of triple-negative breast cancer by race: a surveillance studyHelen Swede
Department of Community Medicine and Health Care, University of Connecticut School of Medicine, Farmington, CT 06030, USA
Clin Breast Cancer 11:332-41. 2011..No reports however have been generated from a statewide cancer registry... - Lighting during the day and night: possible impact on risk of breast cancerRichard G Stevens
UCONN Health Center, University of Connecticut, Farmington, CT, USA
Neuro Endocrinol Lett 23:57-60. 2002..Many candidate factors exist, each with a cadre of proponents. The sum of these may turn out to explain the bulk of the excess risk in modern societies. On the other hand, they may not, and worse, may fall woefully short... - Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancerRichard G Stevens
Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, CT, USA
Cancer Lett 248:262-8. 2007..4; the mean was significantly higher in the patients with a positive family history of CRC (9.0, p<0.01; n=43) or a personal history of advanced adenoma (7.5, p<0.05; n=34)... - Epigenetic impact of long-term shiftwork: pilot evidence from circadian genes and whole-genome methylation analysisYong Zhu
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
Chronobiol Int 28:852-61. 2011..Considering there are millions of shiftworkers worldwide, understanding the effects of this exposure may lead to novel strategies for cancer prevention and new policies regulating shiftwork... - Oxidative damage in colon and mammary tissue of the HFE-knockout mouseRichard G Stevens
Department of Community Medicine, University of Connecticut Health Center, Farmington 06030, USA
Free Radic Biol Med 34:1212-6. 2003..226, p =.02) tissue among those mice on the standard iron diet compared to those on the low iron diet. These results suggest that dietary modification may affect the course of iron overload from HFE mutations...