Daniel B Stetson

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Trex1 prevents cell-intrinsic initiation of autoimmunity
    Daniel B Stetson
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 134:587-98. 2008
  2. pmc Connections between antiviral defense and autoimmunity
    Daniel B Stetson
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    Curr Opin Immunol 21:244-50. 2009
  3. pmc Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
    Alevtina Gall
    Department of Immunology, University of Washington School of Medicine, Seattle, 98195, USA
    Immunity 36:120-31. 2012
  4. pmc Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
    Rebecca L Brunette
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 209:1969-83. 2012
  5. ncbi request reprint Type I interferons in host defense
    Daniel B Stetson
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:373-81. 2006
  6. doi request reprint Endogenous retroelements and autoimmune disease
    Daniel B Stetson
    Department of Immunology, University of Washington, School of Medicine, Seattle, WA 98195, USA
    Curr Opin Immunol 24:692-7. 2012
  7. pmc Antiviral defense: interferons and beyond
    Daniel B Stetson
    Howard Hughes Medical Institute, Yale University School of Medicine, CT 06520, USA
    J Exp Med 203:1837-41. 2006
  8. ncbi request reprint Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    Daniel B Stetson
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 24:93-103. 2006
  9. ncbi request reprint T helper 17 cells get the NOD
    Daniel B Stetson
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:546-8. 2007

Research Grants

  1. Intracellular nucleic acid detection in autoimmunity
    Daniel B Stetson; Fiscal Year: 2010

Collaborators

  • Janet M Young
  • Rebecca L Brunette
  • Alevtina Gall
  • Keith B Elkon
  • Deborah G Whitley
  • Igor E Brodsky
  • Glen N Barber
  • Harmit S Malik
  • Yueh Ming Loo
  • Michael Gale
  • Piper Treuting

Detail Information

Publications9

  1. pmc Trex1 prevents cell-intrinsic initiation of autoimmunity
    Daniel B Stetson
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 134:587-98. 2008
    ..These findings reveal a cell-intrinsic mechanism for initiation of autoimmunity, implicate the ISD pathway as the cause of AGS, and suggest an unanticipated contribution of endogenous retroelements to autoimmunity...
  2. pmc Connections between antiviral defense and autoimmunity
    Daniel B Stetson
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    Curr Opin Immunol 21:244-50. 2009
    ....
  3. pmc Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
    Alevtina Gall
    Department of Immunology, University of Washington School of Medicine, Seattle, 98195, USA
    Immunity 36:120-31. 2012
    ..These findings reveal a stepwise progression of autoimmune disease in Trex1-deficient mice, with implications for the treatment of AGS and related disorders...
  4. pmc Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
    Rebecca L Brunette
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 209:1969-83. 2012
    ..These findings validate ALRs as key activators of the antiviral response and provide an evolutionary and functional framework for understanding their roles in innate immunity...
  5. ncbi request reprint Type I interferons in host defense
    Daniel B Stetson
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:373-81. 2006
    ..These advances highlight the context-specific actions of type I IFNs and clarify the multiple points at which they are integrated into both innate and adaptive immunity...
  6. doi request reprint Endogenous retroelements and autoimmune disease
    Daniel B Stetson
    Department of Immunology, University of Washington, School of Medicine, Seattle, WA 98195, USA
    Curr Opin Immunol 24:692-7. 2012
    ..Understanding this potentially pathologic role for retroelements and the precise mechanisms by which their genomes are sensed and metabolized has important implications for the diagnosis and treatment of numerous autoimmune disorders...
  7. pmc Antiviral defense: interferons and beyond
    Daniel B Stetson
    Howard Hughes Medical Institute, Yale University School of Medicine, CT 06520, USA
    J Exp Med 203:1837-41. 2006
    ....
  8. ncbi request reprint Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    Daniel B Stetson
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 24:93-103. 2006
    ..These findings define an innate immune response to DNA linked to type I interferon production...
  9. ncbi request reprint T helper 17 cells get the NOD
    Daniel B Stetson
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:546-8. 2007
    ..In this issue of Immunity, van Beelen et al. (2007) reveal a pathway that elicits potent IL-17 production from memory T cells through activation of the intracellular receptor NOD2...

Research Grants2

  1. Intracellular nucleic acid detection in autoimmunity
    Daniel B Stetson; Fiscal Year: 2010
    ..We will develop new tools to explore the interconnections between nucleic acid detection, antiviral responses, and autoimmunity, with the hope of identifying new treatments for AGS and related diseases. ..