Mark D Sternlicht

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression
    Mark D Sternlicht
    Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, HSW 1301 San Francisco, CA 94143 0452, USA
    Cancer Epidemiol Biomarkers Prev 15:2107-14. 2006
  2. pmc Hormonal and local control of mammary branching morphogenesis
    Mark D Sternlicht
    Department of Anatomy and Program in Biomedical Sciences, University of California, San Francisco, CA 94143 0452, USA
    Differentiation 74:365-81. 2006
  3. pmc Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin
    Mark D Sternlicht
    Department of Anatomy, University of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Development 132:3923-33. 2005
  4. pmc Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression
    Laurie E Littlepage
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Cancer Res 70:2224-34. 2010
  5. pmc Comparative mechanisms of branching morphogenesis in diverse systems
    Pengfei Lu
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    J Mammary Gland Biol Neoplasia 11:213-28. 2006
  6. pmc GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland
    Hosein Kouros-Mehr
    Department of Anatomy and the Biomedical Sciences Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cell 127:1041-55. 2006
  7. pmc The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression
    Laurie E Littlepage
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Cancer Discov 2:638-51. 2012
  8. pmc Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis
    Mark D Sternlicht
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Breast Cancer Res 8:201. 2006
  9. pmc Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures
    Gregory J Tranah
    CPMC Research Institute, San Francisco, CA 94120, USA
    Calcif Tissue Int 83:155-66. 2008
  10. pmc Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis
    Bryony S Wiseman
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    J Cell Biol 162:1123-33. 2003

Collaborators

Detail Information

Publications13

  1. pmc Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression
    Mark D Sternlicht
    Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, HSW 1301 San Francisco, CA 94143 0452, USA
    Cancer Epidemiol Biomarkers Prev 15:2107-14. 2006
    ..Thus, local factors, such as CTGF and genomic amplification, seem to be more important than germ line genetic variation in influencing PAI1 expression and its untoward effects in breast cancer...
  2. pmc Hormonal and local control of mammary branching morphogenesis
    Mark D Sternlicht
    Department of Anatomy and Program in Biomedical Sciences, University of California, San Francisco, CA 94143 0452, USA
    Differentiation 74:365-81. 2006
    ..This review discusses our current sense and understanding of those mechanisms as they pertain to mammary branching, with the caveat that many more aspects are still waiting to be solved...
  3. pmc Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin
    Mark D Sternlicht
    Department of Anatomy, University of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Development 132:3923-33. 2005
    ..Thus, ADAM17 plays a crucial role in mammary morphogenesis by releasing AREG from mammary epithelial cells, thereby eliciting paracrine activation of stromal EGFR and reciprocal responses that regulate mammary epithelial development...
  4. pmc Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression
    Laurie E Littlepage
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Cancer Res 70:2224-34. 2010
    ..Together, these results suggest distinct contributions by MMPs to the progression of aggressive prostate tumor and to helping tumors cleverly find alternative routes to malignant progression...
  5. pmc Comparative mechanisms of branching morphogenesis in diverse systems
    Pengfei Lu
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    J Mammary Gland Biol Neoplasia 11:213-28. 2006
    ..Thus, in this review, we focus on the common themes that have emerged from such comparative analyses and discuss how they are implemented via a battery of signaling pathways to ensure proper branching morphogenesis in diverse systems...
  6. pmc GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland
    Hosein Kouros-Mehr
    Department of Anatomy and the Biomedical Sciences Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cell 127:1041-55. 2006
    ..This suggests that GATA-3 actively maintains luminal epithelial differentiation in the adult mammary gland, which raises important implications for the pathogenesis of breast cancer...
  7. pmc The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression
    Laurie E Littlepage
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Cancer Discov 2:638-51. 2012
    ..Because ZNF217 is amplified in numerous cancers, these results have implications for other cancers...
  8. pmc Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis
    Mark D Sternlicht
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Breast Cancer Res 8:201. 2006
    ..Thus a clearer understanding of the underlying endocrine and paracrine pathways that regulate mammary branching may shed light on how they contribute to cancer and how their ill effects might be overcome or entirely avoided...
  9. pmc Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures
    Gregory J Tranah
    CPMC Research Institute, San Francisco, CA 94120, USA
    Calcif Tissue Int 83:155-66. 2008
    ..In conclusion, polymorphisms in several candidate genes were associated with hip, vertebral, and nonhip/nonvertebral fractures but not with total hip BMD in this large population based cohort study...
  10. pmc Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis
    Bryony S Wiseman
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    J Cell Biol 162:1123-33. 2003
    ..Nevertheless, the mammary gland is able to develop lactational competence in MMP mutant mice. Thus, specific MMPs refine the mammary branching pattern by distinct mechanisms during mammary gland branching morphogenesis...
  11. pmc Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia
    Thorarinn Gudjonsson
    Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    J Mammary Gland Biol Neoplasia 10:261-72. 2005
    ..In this review we discuss data from our laboratories and from others regarding the cellular origin of human myoepithelial cells, their function in maintaining tissue polarity in the normal breast, and their role during neoplasia...
  12. pmc The ADAM17-amphiregulin-EGFR axis in mammary development and cancer
    Mark D Sternlicht
    FibroGen, Inc, 225 Gateway Boulevard, South San Francisco, CA 94080, USA
    J Mammary Gland Biol Neoplasia 13:181-94. 2008
    ....
  13. ncbi Epimorphin overexpression in the mouse mammary gland promotes alveolar hyperplasia and mammary adenocarcinoma
    Jamie L Bascom
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 65:8617-21. 2005
    ..This study reveals another pathway in which overexpression and alteration of a normal morphogenic process promote the development of cancer in the mammary gland...