C Sternini

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing
    Catia Sternini
    Division of Digestive Diseases and CURE Digestive Diseases Research Center, and Departments of Medicine, USA
    Curr Opin Endocrinol Diabetes Obes 15:73-8. 2008
  2. ncbi request reprint Somatostatin 2A receptor is expressed by enteric neurons, and by interstitial cells of Cajal and enterochromaffin-like cells of the gastrointestinal tract
    C Sternini
    Department of Medicine, CURE Digestive Diseases Research Center, University of California, Los Angeles 90073, USA
    J Comp Neurol 386:396-408. 1997
  3. ncbi request reprint Expression of cholecystokinin A receptors in neurons innervating the rat stomach and intestine
    C Sternini
    CURE Digestive Diseases Research Center, Division of Digestive Diseases, University of California, Los Angeles, California, USA
    Gastroenterology 117:1136-46. 1999
  4. ncbi request reprint Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors
    C Sternini
    CURE Digestive Diseases Research Center, Veterans Administration Greater Los Angeles Healthcare System, Digestive Diseases Division, Departments of Medicine and Neurobiology, Los Angeles, CA 90095, USA
    Neuroscience 98:233-41. 2000
  5. ncbi request reprint Role of galanin receptor 1 in peristaltic activity in the guinea pig ileum
    C Sternini
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Neuroscience 125:103-12. 2004
  6. ncbi request reprint Receptors and transmission in the brain-gut axis: potential for novel therapies. III. Mu-opioid receptors in the enteric nervous system
    C Sternini
    CURE Digestive Diseases Research Center, Department of Veterans Affairs Greater Los Angeles Healthcare System, Digestive Diseases Division, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Am J Physiol Gastrointest Liver Physiol 281:G8-15. 2001
  7. ncbi request reprint Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing
    Catia Sternini
    CURE Digestive Diseases Research Center, VAGLAHS, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 292:G457-61. 2007
  8. ncbi request reprint The opioid system in the gastrointestinal tract
    C Sternini
    CURE Digestive Diseases Research Center, Division of Digestive Diseases, Departments of Medicine and Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Neurogastroenterol Motil 16:3-16. 2004
  9. ncbi request reprint Identification of galanin receptor 1 on excitatory motor neurons in the guinea pig ileum
    L Anselmi
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Veterans Administration Greater Los Angeles Healthcare System, Bldg 115, Room 224, VAGLAHS, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 17:273-80. 2005
  10. ncbi request reprint Ligand-induced mu opioid receptor endocytosis and recycling in enteric neurons
    J G Minnis
    CURE Digestive Diseases Research Center, Building 115, Veterans Administration Greater Los Angeles Healthcare System, Digestive Diseases Division, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Neuroscience 119:33-42. 2003

Collaborators

Detail Information

Publications37

  1. pmc Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing
    Catia Sternini
    Division of Digestive Diseases and CURE Digestive Diseases Research Center, and Departments of Medicine, USA
    Curr Opin Endocrinol Diabetes Obes 15:73-8. 2008
    ....
  2. ncbi request reprint Somatostatin 2A receptor is expressed by enteric neurons, and by interstitial cells of Cajal and enterochromaffin-like cells of the gastrointestinal tract
    C Sternini
    Department of Medicine, CURE Digestive Diseases Research Center, University of California, Los Angeles 90073, USA
    J Comp Neurol 386:396-408. 1997
    ....
  3. ncbi request reprint Expression of cholecystokinin A receptors in neurons innervating the rat stomach and intestine
    C Sternini
    CURE Digestive Diseases Research Center, Division of Digestive Diseases, University of California, Los Angeles, California, USA
    Gastroenterology 117:1136-46. 1999
    ..Two distinct receptors, cholecystokinin (CCK)-A and CCK-B, mediate CCK effects in the digestive system. The aim of this study was to elucidate the cellular sites of expression of CCK-A receptor in the rat stomach and small intestine...
  4. ncbi request reprint Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors
    C Sternini
    CURE Digestive Diseases Research Center, Veterans Administration Greater Los Angeles Healthcare System, Digestive Diseases Division, Departments of Medicine and Neurobiology, Los Angeles, CA 90095, USA
    Neuroscience 98:233-41. 2000
    ....
  5. ncbi request reprint Role of galanin receptor 1 in peristaltic activity in the guinea pig ileum
    C Sternini
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Neuroscience 125:103-12. 2004
    ..Endogenous galanin does not appear to affect neuronal pathways subserving peristalsis in physiologic conditions via GAL-R1...
  6. ncbi request reprint Receptors and transmission in the brain-gut axis: potential for novel therapies. III. Mu-opioid receptors in the enteric nervous system
    C Sternini
    CURE Digestive Diseases Research Center, Department of Veterans Affairs Greater Los Angeles Healthcare System, Digestive Diseases Division, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Am J Physiol Gastrointest Liver Physiol 281:G8-15. 2001
    ..Therefore, understanding these basic cellular mechanisms is important for developing appropriate therapeutic agents...
  7. ncbi request reprint Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing
    Catia Sternini
    CURE Digestive Diseases Research Center, VAGLAHS, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 292:G457-61. 2007
    ....
  8. ncbi request reprint The opioid system in the gastrointestinal tract
    C Sternini
    CURE Digestive Diseases Research Center, Division of Digestive Diseases, Departments of Medicine and Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Neurogastroenterol Motil 16:3-16. 2004
    ....
  9. ncbi request reprint Identification of galanin receptor 1 on excitatory motor neurons in the guinea pig ileum
    L Anselmi
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Veterans Administration Greater Los Angeles Healthcare System, Bldg 115, Room 224, VAGLAHS, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 17:273-80. 2005
    ..These findings indicate that GAL-R1s are present on motor neurons responsible for the ascending excitatory reflex, but not on ascending interneurons and intrinsic primary afferent neurons...
  10. ncbi request reprint Ligand-induced mu opioid receptor endocytosis and recycling in enteric neurons
    J G Minnis
    CURE Digestive Diseases Research Center, Building 115, Veterans Administration Greater Los Angeles Healthcare System, Digestive Diseases Division, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Neuroscience 119:33-42. 2003
    ..Following recycling, muOR is activated and internalized by DAMGO indicating that recycled receptors are functional...
  11. ncbi request reprint Role of galanin receptor 1 in gastric motility in rat
    S Guerrini
    CURE Digestive Diseases Research Center, Division of Digestive Diseases, VAGLAHS, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 16:429-38. 2004
    ..GAL-R1 intrinsic neurons do not appear to play a major role in the control of gastric motility...
  12. ncbi request reprint Monoclonal antibody to rat alpha-CGRP: production, characterization, and in vivo immunoneutralization activity
    H C Wong
    Center for Ulcer Research and Education, V A Wadsworth Medical Center, Los Angeles, CA
    Hybridoma 12:93-106. 1993
    ....
  13. ncbi request reprint Abdominal surgery induces mu opioid receptor endocytosis in enteric neurons of the guinea-pig ileum
    S Patierno
    CURE Digestive Diseases Research Center, Building 115, Room 224, Veterans Administration Greater Los Angeles Healthcare System, Digestive Diseases Division, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Neuroscience 123:101-9. 2004
    ..muOR internalization can serve as indirect evidence of opioid release and as a means to visualize neuronal pathways activated by opioids...
  14. ncbi request reprint Monoclonal antibody to rat galanin: production, characterization, and in vivo immunoneutralization activity
    H C Wong
    Center for Ulcer Research and Education, Department of Medicine, UCLA, Los Angeles, CA 90073, USA
    Hybridoma 20:109-15. 2001
    ..These results show that galanin antibody #G65G is useful for in vivo immunoneutralization of galanin effects and is a valuable tool for immunohistochemical localization of galanin in gastrointestinal tissues...
  15. ncbi request reprint Neurochemically distinct classes of myenteric neurons express the mu-opioid receptor in the guinea pig ileum
    Anthony Ho
    Division of Digestive Diseases, CURE Digestive Diseases Research Center, Los Angeles, CA 90073, USA
    J Comp Neurol 458:404-11. 2003
    ....
  16. ncbi request reprint N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery
    Simona Patierno
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 90073, USA
    Gastroenterology 128:2009-19. 2005
    ..We tested the hypothesis that N-methyl-D-aspartate (NMDA) receptors mediate surgery-induced opioid release in enteric neurons...
  17. pmc Expression of galanin receptor messenger RNAs in different regions of the rat gastrointestinal tract
    Laura Anselmi
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Bldg 115, Room 224, VAGLAHS, 11301 Wilshire Blvd Los Angeles, CA 90073, USA
    Peptides 26:815-9. 2005
    ..The differential regional distribution of GalRs suggests that the complex effects of galanin in the gut are the result of activating multiple receptor subtypes, whose density, subtype and signaling vary along the gastrointestinal tract...
  18. pmc Galanin inhibition of voltage-dependent Ca(2+) influx in rat cultured myenteric neurons is mediated by galanin receptor 1
    Laura Anselmi
    CURE Digestive Diseases Research Center, Digestive Diseases Division, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Neurosci Res 87:1107-14. 2009
    ..This is consonant with the hypothesis that GalR1 mediates galanin inhibition of transmitter release from myenteric neurons...
  19. ncbi request reprint Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon
    Nora Rozengurt
    Department of Pathology, David Geffen School of Medicine, University of California Los Angeles, 900 Veteran Ave, Warren Hall Rm 11 115, Los Angeles, CA 90095 1786, USA
    Am J Physiol Gastrointest Liver Physiol 291:G792-802. 2006
    ....
  20. pmc Taste receptor signaling in the mammalian gut
    Enrique Rozengurt
    Division of Digestive Diseases and CURE, Digestive Diseases Research Center, David Geffen School of Medicine, University of California at Los Angeles, 900 Veteran Avenue, Los Angeles, CA 90095, USA
    Curr Opin Pharmacol 7:557-62. 2007
    ....
  21. ncbi request reprint Lentiviral vectors with CMV or MHCII promoters administered in vivo: immune reactivity versus persistence of expression
    Takahiro Kimura
    Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA
    Mol Ther 15:1390-9. 2007
    ..These studies reveal that APC transduction by LVs could lead to immune reactivity (LV-CMV) or persistence of transgene expression (LV-MHCII), providing a relevant paradigm for vaccination and gene replacement approaches...
  22. pmc Galanin receptors in the rat gastrointestinal tract
    Laura Anselmi
    CURE, Digestive Diseases Research Center, Digestive Diseases Division, VAGLAHS, Los Angeles, CA 90073, USA
    Neuropeptides 39:349-52. 2005
    ..Furthermore, this study confirms the presence of functional GalRs and suggests that galanin modulates transmitter release from myenteric neurons through inhibition of voltage-dependent calcium channels involving a G(i/o)-coupled GalR...
  23. ncbi request reprint Effect of N-methyl-d-aspartate receptor blockade on neuronal plasticity and gastrointestinal transit delay induced by ischemia/reperfusion in rats
    F Calcina
    CURE Digestive Diseases Research Center, Division of Digestive Diseases, Building 115, Room 224, Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Neuroscience 134:39-49. 2005
    ....
  24. pmc Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents
    Fiore Cattaruzza
    Center for Ulcer Research and Education, Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine University of California, Los Angeles, California, USA
    Am J Pathol 169:177-88. 2006
    ..PAR(2) might be a signaling system in the neuroimmune communication in intestinal ischemia/reperfusion...
  25. ncbi request reprint Distribution of galanin receptor 1 immunoreactivity in the rat stomach and small intestine
    Thomas Pham
    CURE Digestive Diseases Research Center, Division of Digestive Diseases, University of California, Los Angeles, California 90095, USA
    J Comp Neurol 450:292-302. 2002
    ....
  26. pmc Amino acid sensing by enteroendocrine STC-1 cells: role of the Na+-coupled neutral amino acid transporter 2
    Steven H Young
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1786, USA
    Am J Physiol Cell Physiol 298:C1401-13. 2010
    ....
  27. ncbi request reprint Expression of the human insulin gene in the gastric G cells of transgenic mice
    E Zhukova
    CURE Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Transgenic Res 10:329-41. 2001
    ..We conclude that gastrin promoter can be used for targeting expression of human insulin to antral G cells and that antral G cells can express human insulin. Further refining of the chimeric gene design is required to enhance expression...
  28. pmc Neurokinin 1 receptor expression in the rat retina
    G Casini
    Department of Neurobiology, Brain Research Institute, CURE Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Comp Neurol 389:496-507. 1997
    ..Overall, the present findings suggest that SP acts directly upon several cell populations, including GABA-containing amacrine cells and ganglion cells, to influence visual information processing in the inner retina...
  29. ncbi request reprint Release of transgenic human insulin from gastric g cells: a novel approach for the amelioration of diabetes
    Yu Chun Lu
    Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at University of California, Los Angeles, California 90095 1786, USA
    Endocrinology 146:2610-9. 2005
    ..We suggest that an efficient G cells-based insulin gene therapy can relieve diabetic patients from daily insulin injections and protect them from complications of insulin insufficiency while avoiding episodes of toxic hypoglycemia...
  30. ncbi request reprint The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats
    Sylvie Bradesi
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Gastroenterology 130:1729-42. 2006
    ..Here we examined the participation of NK(1)Rs in sustained visceral hyperalgesia observed in rats exposed to chronic psychological stress...
  31. ncbi request reprint Ligand-induced 5-HT3 receptor internalization in enteric neurons in rat ileum
    Samara L Freeman
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, 95616, USA
    Gastroenterology 131:97-107. 2006
    ..The aims of the study were to determine the following: (1) if 5-HT(3)R undergoes ligand-induced internalization in myenteric neurons, and (2) the effect of long-term increase of mucosal 5-HT on 5-HT(3)Rs...
  32. ncbi request reprint Expression of 5-HT3 receptors in the rat gastrointestinal tract
    Jorg Glatzle
    Department of Anatomy, Physiology, and Cell Biology, University of California Davis School of Veterinary Medicine, Davis, California 95616, USA
    Gastroenterology 123:217-26. 2002
    ..The aim of the present study was to elucidate the cellular sites of 5-HT3R expression in the rat GI tract using immunohistochemistry...
  33. ncbi request reprint Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands
    Shuzhen Hao
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Physiol Regul Integr Comp Physiol 294:R33-8. 2008
    ..T2Rs may regulate GI function via release of regulatory peptides and activation of the vagal reflex pathway...
  34. ncbi request reprint 5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum
    Marcello Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
    Gastroenterology 129:1557-66. 2005
    ..In this study, we evaluated the expression of 5-HT7 receptors in the guinea pig ileum and their role in peristalsis and accommodation of the circular muscle...
  35. ncbi request reprint Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat
    Graeme S Cottrell
    Department of Surgery, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0660, USA
    J Comp Neurol 490:239-55. 2005
    ....
  36. ncbi request reprint Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying
    Helen E Raybould
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, 1321 Haring Hall, Davis, CA 95616, USA
    Am J Physiol Gastrointest Liver Physiol 284:G367-72. 2003
    ..The primary glucose sensors of the intestine may be mucosal enterochromaffin cells...
  37. ncbi request reprint Neurology and neuropathology of the pancreatic innervation
    Beatrice Salvioli
    JOP 3:26-33. 2002

Research Grants25

  1. OPIOID RECEPTOR FUNCTION IN THE ENTERIC NERVOUS SYSTEM
    Catia Sternini; Fiscal Year: 2001
    ..Information on sequestration and cellular handling of the MOR will provide insight into mechanisms for receptor desensitization and eventual down-regulation. ..
  2. ROLE OF GALANIN RECEPTORS IN GASTROINTESTINAL MOTILITY
    Catia Sternini; Fiscal Year: 2004
    ..abstract_text> ..
  3. Opiod Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2005
    ..These studies will further our understanding of uOR function in the gastrointestinal tract. ..
  4. ROLE OF GALANIN RECEPTORS IN GASTROINTESTINAL MOTILITY
    Catia Sternini; Fiscal Year: 2006
    ..abstract_text> ..
  5. mu Opioid Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2008
    ....
  6. Opiod Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2007
    ..These studies will further our understanding of uOR function in the gastrointestinaltract. ..
  7. mu Opioid Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2007
    ..abstract_text> ..
  8. mu Opioid Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2009
    ....
  9. Chemosensing in the Gastrointestinal Tract
    Catia Sternini; Fiscal Year: 2009
    ....
  10. mu Opioid Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2010
    ....
  11. Chemosensing in the Gastrointestinal Tract
    Catia Sternini; Fiscal Year: 2010
    ....
  12. Opiod Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2004
    ..These studies will further our understanding of uOR function in the gastrointestinal tract. ..
  13. Opiod Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2003
    ..These studies will further our understanding of uOR function in the gastrointestinal tract. ..
  14. ROLE OF GALANIN RECEPTORS IN GASTROINTESTINAL MOTILITY
    Catia Sternini; Fiscal Year: 2003
    ..abstract_text> ..
  15. OPIOID RECEPTOR FUNCTION IN THE ENTERIC NERVOUS SYSTEM
    Catia Sternini; Fiscal Year: 1999
    ..Information on sequestration and cellular handling of the MOR will provide insight into mechanisms for receptor desensitization and eventual down-regulation. ..
  16. OPIOID RECEPTOR FUNCTION IN THE ENTERIC NERVOUS SYSTEM
    Catia Sternini; Fiscal Year: 2000
    ..Information on sequestration and cellular handling of the MOR will provide insight into mechanisms for receptor desensitization and eventual down-regulation. ..
  17. GASTRIC NEUROPEPTIDASES/PEPTIDE RECEPTOR INTERACTIONS
    Catia Sternini; Fiscal Year: 2000
    ..We also plan to characterize GRP receptor recycling and resensitization in cells that normally express GRP receptors: gastric G cells, Swiss 3T3 cells, and small cell lung carcinoma line NCI-H345 cells. ..
  18. ROLE OF GALANIN RECEPTORS IN GASTROINTESTINAL MOTILITY
    Catia Sternini; Fiscal Year: 2000
    ..abstract_text> ..
  19. GASTRIC NEUROPEPTIDASES/PEPTIDE RECEPTOR INTERACTIONS
    Catia Sternini; Fiscal Year: 2001
    ..We also plan to characterize GRP receptor recycling and resensitization in cells that normally express GRP receptors: gastric G cells, Swiss 3T3 cells, and small cell lung carcinoma line NCI-H345 cells. ..
  20. ROLE OF GALANIN RECEPTORS IN GASTROINTESTINAL MOTILITY
    Catia Sternini; Fiscal Year: 2001
    ..abstract_text> ..
  21. ROLE OF GALANIN RECEPTORS IN GASTROINTESTINAL MOTILITY
    Catia Sternini; Fiscal Year: 2002
    ..abstract_text> ..
  22. GASTRIC NEUROPEPTIDASES/PEPTIDE RECEPTOR INTERACTIONS
    Catia Sternini; Fiscal Year: 2002
    ..We also plan to characterize GRP receptor recycling and resensitization in cells that normally express GRP receptors: gastric G cells, Swiss 3T3 cells, and small cell lung carcinoma line NCI-H345 cells. ..
  23. Opiod Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2002
    ..These studies will further our understanding of uOR function in the gastrointestinal tract. ..
  24. mu Opioid Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2010
    ....