Robert Stern

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Chain gangs: new aspects of hyaluronan metabolism
    Michael Erickson
    Department of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, 230 West 125th Street, New York, NY 10027, USA
    Biochem Res Int 2012:893947. 2012
  2. ncbi Complicated hyaluronan patterns in skin: enlightenment by UVB?
    Robert Stern
    Department of Pathology, School of Medicine, and UCSF Comprehensive Cancer Center, University of California, San Francisco, California 94143 0511, USA
    J Invest Dermatol 127:512-3. 2007
  3. doi Hyaluronan in skin: aspects of aging and its pharmacologic modulation
    Robert Stern
    Department of Pathology, School of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Clin Dermatol 26:106-22. 2008
  4. ncbi Association between cancer and "acid mucopolysaccharides": an old concept comes of age, finally
    Robert Stern
    Department of Pathology, Faculty of Medicine, Al Quds University, P O Box 20002, Abu Dies, Jerusalem
    Semin Cancer Biol 18:238-43. 2008
  5. ncbi Hyaluronidases in cancer biology
    Robert Stern
    Department of Pathology, Faculty of Medicine, Al Quds University, P O Box 20002, Abu Dies, Jerusalem
    Semin Cancer Biol 18:275-80. 2008
  6. ncbi Hyaluronidase reduces human breast cancer xenografts in SCID mice
    Svetlana Shuster
    Department of Pathology, School of Medicine, University of California San Francisco, San Francisco, CA 94143 0511, USA
    Int J Cancer 102:192-7. 2002
  7. ncbi CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion
    Lilly Y W Bourguignon
    Department of Medicine, University of California, Veterans Affairs Medical Center, San Francisco 94121, USA
    J Biol Chem 279:26991-7007. 2004
  8. ncbi Hyaluronan catabolism: a new metabolic pathway
    Robert Stern
    Department of Pathology, School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, S 564, San Francisco, CA 94143 0511, USA
    Eur J Cell Biol 83:317-25. 2004
  9. ncbi Hyaluronan fragments: an information-rich system
    Robert Stern
    Department of Pathology and UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, 513 Parnassus Avenue, S 564, San Francisco, CA 94143 0511, USA
    Eur J Cell Biol 85:699-715. 2006
  10. ncbi Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited
    Robert Stern
    Department of Pathology, School of Medicine, University of California, San Francisco, California 94143 0506, USA
    Exp Cell Res 276:24-31. 2002

Collaborators

Detail Information

Publications33

  1. pmc Chain gangs: new aspects of hyaluronan metabolism
    Michael Erickson
    Department of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, 230 West 125th Street, New York, NY 10027, USA
    Biochem Res Int 2012:893947. 2012
    ..It is also apparent that hyaluronan synthases and hyaluronidases are regulated at many more levels than previously realized, and that the several hyaluronidases have functions in addition to their enzymatic activities...
  2. ncbi Complicated hyaluronan patterns in skin: enlightenment by UVB?
    Robert Stern
    Department of Pathology, School of Medicine, and UCSF Comprehensive Cancer Center, University of California, San Francisco, California 94143 0511, USA
    J Invest Dermatol 127:512-3. 2007
    ..A systematic approach has been initiated in the studies by Averbeck et al...
  3. doi Hyaluronan in skin: aspects of aging and its pharmacologic modulation
    Robert Stern
    Department of Pathology, School of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Clin Dermatol 26:106-22. 2008
    ..High molecular size reflects intact tissues and antiangiogenic and immunosuppressive state, whereas smaller polymers are distress signals and potent inducers of inflammation and angiogenesis...
  4. ncbi Association between cancer and "acid mucopolysaccharides": an old concept comes of age, finally
    Robert Stern
    Department of Pathology, Faculty of Medicine, Al Quds University, P O Box 20002, Abu Dies, Jerusalem
    Semin Cancer Biol 18:238-43. 2008
    ..While hyaluronan does not give up its secrets easily, recent progress justifies a review of its role in malignancy...
  5. ncbi Hyaluronidases in cancer biology
    Robert Stern
    Department of Pathology, Faculty of Medicine, Al Quds University, P O Box 20002, Abu Dies, Jerusalem
    Semin Cancer Biol 18:275-80. 2008
    ..A complete understanding of the anabolic and catabolic systems for hyaluronan may provide new dimensions into our understanding of cancer progression, as well as new opportunities for therapeutic intervention...
  6. ncbi Hyaluronidase reduces human breast cancer xenografts in SCID mice
    Svetlana Shuster
    Department of Pathology, School of Medicine, University of California San Francisco, San Francisco, CA 94143 0511, USA
    Int J Cancer 102:192-7. 2002
    ..If confirmed, hyaluronidase may provide a new class of anti-cancer therapeutics and one without toxic side effects...
  7. ncbi CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion
    Lilly Y W Bourguignon
    Department of Medicine, University of California, Veterans Affairs Medical Center, San Francisco 94121, USA
    J Biol Chem 279:26991-7007. 2004
    ....
  8. ncbi Hyaluronan catabolism: a new metabolic pathway
    Robert Stern
    Department of Pathology, School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, S 564, San Francisco, CA 94143 0511, USA
    Eur J Cell Biol 83:317-25. 2004
    ..Some of the steps in this catabolic cascade can be commandeered by cancer cells in the process of growth, invasion, and metastatic spread...
  9. ncbi Hyaluronan fragments: an information-rich system
    Robert Stern
    Department of Pathology and UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, 513 Parnassus Avenue, S 564, San Francisco, CA 94143 0511, USA
    Eur J Cell Biol 85:699-715. 2006
    ..The vast range of activities of hyaluronan polymers is reviewed here, in order to determine if patterns can be detected that would provide insight into their production and regulation...
  10. ncbi Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited
    Robert Stern
    Department of Pathology, School of Medicine, University of California, San Francisco, California 94143 0506, USA
    Exp Cell Res 276:24-31. 2002
    ....
  11. ncbi Expression of hyaluronic acid and its receptors, CD44s and CD44v6, in normal, hyperplastic, and neoplastic endometrium
    Alaa M Afify
    Department of Pathology, University of California, Davis Health System, Sacramento, CA 95817, USA
    Ann Diagn Pathol 9:312-8. 2005
    ..Thus, HA and CD44 are both involved in the development and progression of endometrial cancer...
  12. ncbi Devising a pathway for hyaluronan catabolism: are we there yet?
    Robert Stern
    Department of Pathology, School of Medicine, 513 Parnassus Avenue, S 564, University of California San Francisco, San Francisco, CA 94143 0511, USA
    Glycobiology 13:105R-115R. 2003
    ..Most of these highly dynamic interactions remain to be determined. It is also proposed that malignant cells can commandeer some of these interactions for facilitating tumor growth and spread...
  13. ncbi Mystixin peptides reduce hyaluronan deposition and edema formation
    Susan Stair
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Eur J Pharmacol 450:291-6. 2002
    ..We propose that stimulation of hyaluronidase activity, with a decrease in net hyaluronan deposition and its associated water of hydration, is among the mechanisms of the anti-inflammatory effect of mystixin peptides...
  14. ncbi Hyaluronan metabolism: a major paradox in cancer biology
    Robert Stern
    Department of Pathology, UCSF Comprehensive Cancer Center, University of California San Francisco, CA 94143 0511, USA
    Pathol Biol (Paris) 53:372-82. 2005
    ..Such a systematic approach may reveal mechanisms used in the course of cancer progression, resolve some of the apparent disparities, render new prognostic markers, and provide new targets for therapeutic intervention...
  15. ncbi Hyaluronan (hyaluronic acid) and its regulation in human saliva by hyaluronidase and its inhibitors
    Michael Anthony Pogrel
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, San Francisco, CA 94143 0440, USA
    J Oral Sci 45:85-91. 2003
    ..The possible significance, interactions and function of hyaluronan, hyaluronidase and its regulation by hyaluronidase inhibitors in saliva is discussed, particularly in relation to intra-oral wound healing and periodontal disease...
  16. ncbi Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury
    Joseph George
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Clin Chim Acta 348:189-97. 2004
    ..We test the hypothesis that elevated levels of circulating hyaluronan and hyaluronidase could provide indicators of very early liver damage...
  17. ncbi Differentiation of mesothelioma from adenocarcinoma in serous effusions: the role of hyaluronic acid and CD44 localization
    Alaa M Afify
    Department of Pathology, University of California, Davis, California, USA
    Diagn Cytopathol 32:145-50. 2005
    ..The CD44S staining pattern of cells of mesothelial origin is of diagnostic significance. CD44 may prove useful in conjunction with other stains in the differential diagnosis of mesothelioma and ADA...
  18. ncbi Hyaluronidases and CD44 undergo differential modulation during chondrogenesis
    Steven B Nicoll
    Joint Graduate Program in Bioengineering, University of California, Berkeley and San Francisco, California 94143 0775, USA
    Biochem Biophys Res Commun 292:819-25. 2002
    ..Differential expression of the somatic hyaluronidases and CD44-mediated hyaluronan turnover play a critical role in cartilage development from mesenchymal precursors...
  19. ncbi An assay for bacterial and eukaryotic chondroitinases using a chondroitin sulfate-binding protein
    Hans Georg Wisniewski
    Department of Microbiology, School of Medicine, New York University, NY 10016, USA
    Anal Biochem 347:42-8. 2005
    ..Using the HA-binding domain of aggrecan for a comparison, we determined that the interaction between TSG-6 and chondroitin sulfate is uniquely suited for this CSase assay...
  20. ncbi The many ways to cleave hyaluronan
    Robert Stern
    Department of Pathology, School of Medicine, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143 0511, USA
    Biotechnol Adv 25:537-57. 2007
    ..In this review, the vast arrays of reactions that cause scission of hyaluronan polymers is presented, including those on an enzymatic, free radical, and chemical basis...
  21. ncbi Scleromyxedema-like lesions of patients in renal failure contain hyaluronan: a possible pathophysiological mechanism
    Birgit A Neudecker
    Department of Pathology, School of Medicine, University of California, San Francisco, 94143, USA
    J Cutan Pathol 32:612-5. 2005
    ..These lesions are characterized grossly by extensive thickening of skin, brawny pigmentation, papules, and subcutaneous nodules. Mucinous deposits are observed histologically that resemble those in scleromyxedema...
  22. ncbi Contribution of oxidative-reductive reactions to high-molecular-weight hyaluronan catabolism
    Ladislav Soltes
    Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dubravska cesta 9, SK 84104 Bratislava
    Chem Biodivers 2:1242-5. 2005
    ..An alternative and plausible mechanism is that of oxidative-reductive degradation of HA chains by a combined action of oxygen and transition metal cations maintained in a reduced oxidation state by ascorbate...
  23. ncbi Lactate-sensitive response elements in genes involved in hyaluronan catabolism
    Bent Formby
    The Rasmus Institute for Medical Research, Santa Barbara, CA 93103, USA
    Biochem Biophys Res Commun 305:203-8. 2003
    ..We have thus identified lactate-activated genes important in the wound healing responses. Similar responses facilitating tumor progression, the Warburg effect, may share such mechanisms...
  24. ncbi Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments
    Kazuki N Sugahara
    Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:5861-8. 2006
    ..Such an autocrine/paracrine-like process may represent a novel activation mechanism that would facilitate and promote the malignant potential of tumor cells...
  25. ncbi Inhibitors of the hyaluronidases
    Kazuhiro Mio
    Lion Corporation, Life Science Research Center, Kanagawa 256 0811, Japan
    Matrix Biol 21:31-7. 2002
    ..A literature survey of other hyaluronidase inhibitors is also presented...
  26. ncbi Inhibition of hyaluronan degradation by dextran sulphate facilitates characterisation of hyaluronan synthesis: an in vitro and in vivo study
    Lishanthi Udabage
    Laboratory for Hyaluronan Research, Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria, 3800 Australia
    Glycoconj J 20:461-71. 2004
    ..These results suggest dynamic feedback signalling and complex mechanisms occur in the net deposition of HA in vivo...
  27. ncbi Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications
    Grigorij Kogan
    Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia
    Biotechnol Lett 29:17-25. 2007
    ..Herein we present an overview of the occurrence and physiological properties of HA, as well as of the recent advances in production biotechnology and preparation of the HA-based materials for medical application...
  28. doi Hyaluronan in cancer biology
    Robert Stern
    Semin Cancer Biol 18:237. 2008
  29. ncbi Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis
    Mark J Jedrzejas
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Proteins 61:227-38. 2005
    ..Each Hyal has a different C-terminal sequence and structure, the function of which is unknown. These unique C-termini may participate in the additional function(s) associated with these multifunctional enzymes...
  30. ncbi A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis
    Dianna C Martin
    Department of Biochemistry and Medical Genetics, University of Manitoba, 770 Bannatyne Avenue, Winnipeg, MB, Canada R3E 0W3
    Hum Mol Genet 17:1904-15. 2008
    ..Hyal3 expression was elevated in Hyal1 null mice, suggesting that Hyal3 may compensate in HA degradation in non-skeletal tissues. Overall, the murine MPS IX model displays the key features of the human disease...
  31. pmc Hyaluronidases: their genomics, structures, and mechanisms of action
    Robert Stern
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Chem Rev 106:818-39. 2006
  32. pmc A case of Churg-Strauss syndrome associated with antiphospholipid antibodies
    Katalin Ferenczi
    Department of Dermatology, Case University Hospitals of Cleveland, OH 44106 5028, USA
    J Am Acad Dermatol 56:701-4. 2007
    ....
  33. ncbi Magnetic resonance imaging visualization of hyaluronidase in ovarian carcinoma
    Liora Shiftan
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 65:10316-23. 2005
    ..c. ES-2 ovarian carcinoma tumors in nude mice. Thus, hyaluronan-GdDTPA-beads could allow noninvasive molecular imaging of hyaluronidase-mediated tilt of the peritumor angiogenic balance...