Affiliation: University of California
- Hyaluronidases in cancer biologyRobert Stern
Department of Pathology, Faculty of Medicine, Al Quds University, P O Box 20002, Abu Dies, Jerusalem
Semin Cancer Biol 18:275-80. 2008..A complete understanding of the anabolic and catabolic systems for hyaluronan may provide new dimensions into our understanding of cancer progression, as well as new opportunities for therapeutic intervention...
- Complicated hyaluronan patterns in skin: enlightenment by UVB?Robert Stern
Department of Pathology, School of Medicine, and UCSF Comprehensive Cancer Center, University of California, San Francisco, California 94143 0511, USA
J Invest Dermatol 127:512-3. 2007..A systematic approach has been initiated in the studies by Averbeck et al...
- Association between cancer and "acid mucopolysaccharides": an old concept comes of age, finallyRobert Stern
Department of Pathology, Faculty of Medicine, Al Quds University, P O Box 20002, Abu Dies, Jerusalem
Semin Cancer Biol 18:238-43. 2008..While hyaluronan does not give up its secrets easily, recent progress justifies a review of its role in malignancy...
- Hyaluronan in skin: aspects of aging and its pharmacologic modulationRobert Stern
Department of Pathology, School of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
Clin Dermatol 26:106-22. 2008..High molecular size reflects intact tissues and antiangiogenic and immunosuppressive state, whereas smaller polymers are distress signals and potent inducers of inflammation and angiogenesis...
- Hyaluronidase reduces human breast cancer xenografts in SCID miceSvetlana Shuster
Department of Pathology, School of Medicine, University of California San Francisco, San Francisco, CA 94143-0511, USA
Int J Cancer 102:192-7. 2002..If confirmed, hyaluronidase may provide a new class of anti-cancer therapeutics and one without toxic side effects...
- CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasionLilly Y W Bourguignon
Department of Medicine, University of California, Veterans Affairs Medical Center, San Francisco 94121, USA
J Biol Chem 279:26991-7007. 2004....
- Hyaluronan fragments: an information-rich systemRobert Stern
Department of Pathology and UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, 513 Parnassus Avenue, S 564, San Francisco, CA 94143 0511, USA
Eur J Cell Biol 85:699-715. 2006..The vast range of activities of hyaluronan polymers is reviewed here, in order to determine if patterns can be detected that would provide insight into their production and regulation...
- Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisitedRobert Stern
Department of Pathology, School of Medicine, University of California, San Francisco, California 94143 0506, USA
Exp Cell Res 276:24-31. 2002....
- Hyaluronan catabolism: a new metabolic pathwayRobert Stern
Department of Pathology, School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, S 564, San Francisco, CA 94143 0511, USA
Eur J Cell Biol 83:317-25. 2004..Some of the steps in this catabolic cascade can be commandeered by cancer cells in the process of growth, invasion, and metastatic spread...
- Devising a pathway for hyaluronan catabolism: are we there yet?Robert Stern
Department of Pathology, School of Medicine, 513 Parnassus Avenue, S 564, University of California San Francisco, San Francisco, CA 94143 0511, USA
Glycobiology 13:105R-115R. 2003..Most of these highly dynamic interactions remain to be determined. It is also proposed that malignant cells can commandeer some of these interactions for facilitating tumor growth and spread...
- Mystixin peptides reduce hyaluronan deposition and edema formationSusan Stair
School of Public Health, University of California, Berkeley, CA 94720, USA
Eur J Pharmacol 450:291-6. 2002..We propose that stimulation of hyaluronidase activity, with a decrease in net hyaluronan deposition and its associated water of hydration, is among the mechanisms of the anti-inflammatory effect of mystixin peptides...
- Expression of hyaluronic acid and its receptors, CD44s and CD44v6, in normal, hyperplastic, and neoplastic endometriumAlaa M Afify
Department of Pathology, University of California, Davis Health System, Sacramento, CA 95817, USA
Ann Diagn Pathol 9:312-8. 2005..Thus, HA and CD44 are both involved in the development and progression of endometrial cancer...
- Hyaluronan (hyaluronic acid) and its regulation in human saliva by hyaluronidase and its inhibitorsMichael Anthony Pogrel
Department of Oral and Maxillofacial Surgery, University of California, San Francisco, San Francisco, CA 94143 0440, USA
J Oral Sci 45:85-91. 2003..The possible significance, interactions and function of hyaluronan, hyaluronidase and its regulation by hyaluronidase inhibitors in saliva is discussed, particularly in relation to intra-oral wound healing and periodontal disease...
- Hyaluronan metabolism: a major paradox in cancer biologyRobert Stern
Department of Pathology, UCSF Comprehensive Cancer Center, University of California San Francisco, CA 94143 0511, USA
Pathol Biol (Paris) 53:372-82. 2005..Such a systematic approach may reveal mechanisms used in the course of cancer progression, resolve some of the apparent disparities, render new prognostic markers, and provide new targets for therapeutic intervention...
- An assay for bacterial and eukaryotic chondroitinases using a chondroitin sulfate-binding proteinHans Georg Wisniewski
Department of Microbiology, School of Medicine, New York University, NY 10016, USA
Anal Biochem 347:42-8. 2005..Using the HA-binding domain of aggrecan for a comparison, we determined that the interaction between TSG-6 and chondroitin sulfate is uniquely suited for this CSase assay...
- Scleromyxedema-like lesions of patients in renal failure contain hyaluronan: a possible pathophysiological mechanismBirgit A Neudecker
Department of Pathology, School of Medicine, University of California, San Francisco, 94143, USA
J Cutan Pathol 32:612-5. 2005..The accumulation of such fragments in renal failure can account for HA deposition in the dermis and may be a mechanism for the nephrogenic fibrosing dermopathy that can accompany these lesions...
- The many ways to cleave hyaluronanRobert Stern
Department of Pathology, School of Medicine, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143 0511, USA
Biotechnol Adv 25:537-57. 2007..In this review, the vast arrays of reactions that cause scission of hyaluronan polymers is presented, including those on an enzymatic, free radical, and chemical basis...
- Hyaluronidases and CD44 undergo differential modulation during chondrogenesisSteven B Nicoll
Joint Graduate Program in Bioengineering, University of California, Berkeley and San Francisco, California 94143 0775, USA
Biochem Biophys Res Commun 292:819-25. 2002..Differential expression of the somatic hyaluronidases and CD44-mediated hyaluronan turnover play a critical role in cartilage development from mesenchymal precursors...
- Differentiation of mesothelioma from adenocarcinoma in serous effusions: the role of hyaluronic acid and CD44 localizationAlaa M Afify
Department of Pathology, University of California, Davis, California, USA
Diagn Cytopathol 32:145-50. 2005..The CD44S staining pattern of cells of mesothelial origin is of diagnostic significance. CD44 may prove useful in conjunction with other stains in the differential diagnosis of mesothelioma and ADA...
- Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragmentsKazuki N Sugahara
Laboratory of Immunodynamics, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
J Biol Chem 281:5861-8. 2006..Such an autocrine/paracrine-like process may represent a novel activation mechanism that would facilitate and promote the malignant potential of tumor cells...
- Inhibitors of the hyaluronidasesKazuhiro Mio
Lion Corporation, Life Science Research Center, Kanagawa 256-0811, Japan
Matrix Biol 21:31-7. 2002..A literature survey of other hyaluronidase inhibitors is also presented...
- Inhibition of hyaluronan degradation by dextran sulphate facilitates characterisation of hyaluronan synthesis: an in vitro and in vivo studyLishanthi Udabage
Laboratory for Hyaluronan Research, Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria, 3800 Australia
Glycoconj J 20:461-71. 2004..These results suggest dynamic feedback signalling and complex mechanisms occur in the net deposition of HA in vivo...
- Lactate-sensitive response elements in genes involved in hyaluronan catabolismBent Formby
The Rasmus Institute for Medical Research, Santa Barbara, CA 93103, USA
Biochem Biophys Res Commun 305:203-8. 2003..We have thus identified lactate-activated genes important in the wound healing responses. Similar responses facilitating tumor progression, the Warburg effect, may share such mechanisms...
- Contribution of oxidative-reductive reactions to high-molecular-weight hyaluronan catabolismLadislav Soltes
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dubravska cesta 9, SK 84104 Bratislava
Chem Biodivers 2:1242-5. 2005..An alternative and plausible mechanism is that of oxidative-reductive degradation of HA chains by a combined action of oxygen and transition metal cations maintained in a reduced oxidation state by ascorbate...
- A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritisDianna C Martin
Department of Biochemistry and Medical Genetics, University of Manitoba, 770 Bannatyne Avenue, Winnipeg, MB, Canada R3E 0W3
Hum Mol Genet 17:1904-15. 2008..Hyal3 expression was elevated in Hyal1 null mice, suggesting that Hyal3 may compensate in HA degradation in non-skeletal tissues. Overall, the murine MPS IX model displays the key features of the human disease...
- A case of Churg-Strauss syndrome associated with antiphospholipid antibodiesKatalin Ferenczi
Department of Dermatology, Case University Hospitals of Cleveland, OH 44106 5028, USA
J Am Acad Dermatol 56:701-4. 2007....
- Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applicationsGrigorij Kogan
Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia
Biotechnol Lett 29:17-25. 2007..Herein we present an overview of the occurrence and physiological properties of HA, as well as of the recent advances in production biotechnology and preparation of the HA-based materials for medical application...
- Hyaluronidases: their genomics, structures, and mechanisms of actionRobert Stern
Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA
Chem Rev 106:818-39. 2006
- Magnetic resonance imaging visualization of hyaluronidase in ovarian carcinomaLiora Shiftan
Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
Cancer Res 65:10316-23. 2005..c. ES-2 ovarian carcinoma tumors in nude mice. Thus, hyaluronan-GdDTPA-beads could allow noninvasive molecular imaging of hyaluronidase-mediated tilt of the peritumor angiogenic balance...
- Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysisMark J Jedrzejas
Children's Hospital Oakland Research Institute, Oakland, California 94609, USA
Proteins 61:227-38. 2005..Each Hyal has a different C-terminal sequence and structure, the function of which is unknown. These unique C-termini may participate in the additional function(s) associated with these multifunctional enzymes...
- Serum hyaluronan and hyaluronidase: very early markers of toxic liver injuryJoseph George
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
Clin Chim Acta 348:189-97. 2004..However, levels are increased only transiently, indicating that serial assays are necessary. CONCLUSIONS: Measures of circulating hyaluronidase activity may be used to assess liver damage...
- Hyaluronan in cancer biologyRobert Stern
Semin Cancer Biol 18:237. 2008