Michael Stern

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart Study
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    BMC Genet 4:S52. 2003
  2. ncbi request reprint Impact of diabetes/metabolic syndrome in patients with established cardiovascular disease
    Michael P Stern
    Division of Clinical Epidemiology, Department of Medicine, Rm 5 616U, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Atheroscler Suppl 6:3-6. 2005
  3. ncbi request reprint Identification of individuals with insulin resistance using routine clinical measurements
    Steven E Stern
    School of Finance and Applied Statistics, Australian National University, Canberra, Australia
    Diabetes 54:333-9. 2005
  4. ncbi request reprint Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease?
    Michael P Stern
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes Care 27:2676-81. 2004
  5. ncbi request reprint Predicting future cardiovascular disease: do we need the oral glucose tolerance test?
    Michael P Stern
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Diabetes Care 25:1851-6. 2002
  6. ncbi request reprint The search for type 2 diabetes susceptibility genes using whole-genome scans: an epidemiologist's perspective
    Michael P Stern
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Diabetes Metab Res Rev 18:106-13. 2002
  7. ncbi request reprint Identification of persons at high risk for type 2 diabetes mellitus: do we need the oral glucose tolerance test?
    Michael P Stern
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900
    Ann Intern Med 136:575-81. 2002
  8. ncbi request reprint Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans
    M P Stern
    Department of Medicine, University of Texas Health Science Center, San Antonio 78284, USA
    Genome Res 6:724-34. 1996
  9. ncbi request reprint The effect of glycemic control on the incidence of macrovascular complications of type 2 diabetes
    M P Stern
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78284 7873, USA
    Arch Fam Med 7:155-62. 1998
  10. ncbi request reprint Do Mexican Americans really have low rates of cardiovascular disease?
    M P Stern
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78284 7871, USA
    Prev Med 29:S90-5. 1999

Research Grants

Detail Information

Publications71

  1. pmc Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart Study
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    BMC Genet 4:S52. 2003
    ..Subsequently, we performed bivariate multipoint linkage analysis to detect common loci influencing covariation between these two traits...
  2. ncbi request reprint Impact of diabetes/metabolic syndrome in patients with established cardiovascular disease
    Michael P Stern
    Division of Clinical Epidemiology, Department of Medicine, Rm 5 616U, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Atheroscler Suppl 6:3-6. 2005
    ..This excess prevalence of diabetes appears to account for the enhanced all-cause and CVD mortality in subjects with the MetS. However, these results will need to be confirmed in other populations...
  3. ncbi request reprint Identification of individuals with insulin resistance using routine clinical measurements
    Steven E Stern
    School of Finance and Applied Statistics, Australian National University, Canberra, Australia
    Diabetes 54:333-9. 2005
    ..1%), sensitivity (81.3%), and specificity (76.3%). Thus, insulin-resistant individuals can be identified using simple decision rules that can be tailored to specific needs...
  4. ncbi request reprint Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease?
    Michael P Stern
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes Care 27:2676-81. 2004
    ..We therefore sought to compare this syndrome, as defined by the National Cholesterol Education Program, to the Diabetes Predicting Model and the Framingham Risk Score as predictors of type 2 diabetes and CVD, respectively...
  5. ncbi request reprint Predicting future cardiovascular disease: do we need the oral glucose tolerance test?
    Michael P Stern
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Diabetes Care 25:1851-6. 2002
    ..Our objective was to compare the performance of oral glucose tolerance tests (OGTTs) and multivariate models incorporating commonly available clinical variables in their ability to predict future cardiovascular disease (CVD)...
  6. ncbi request reprint The search for type 2 diabetes susceptibility genes using whole-genome scans: an epidemiologist's perspective
    Michael P Stern
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Diabetes Metab Res Rev 18:106-13. 2002
    ..The linkages that have been replicated thus far provide good starting points to search for functional variants in type 2 diabetes susceptibility genes...
  7. ncbi request reprint Identification of persons at high risk for type 2 diabetes mellitus: do we need the oral glucose tolerance test?
    Michael P Stern
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900
    Ann Intern Med 136:575-81. 2002
    ..Because clinical trials have indicated that diabetes is preventable by using behavioral or pharmacologic interventions, less expensive methods of identifying high-risk persons are needed...
  8. ncbi request reprint Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans
    M P Stern
    Department of Medicine, University of Texas Health Science Center, San Antonio 78284, USA
    Genome Res 6:724-34. 1996
    ..Results were similar whether all diabetics were included in the analyses or only those who were not under treatment with oral antidiabetic agents or insulin...
  9. ncbi request reprint The effect of glycemic control on the incidence of macrovascular complications of type 2 diabetes
    M P Stern
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78284 7873, USA
    Arch Fam Med 7:155-62. 1998
    ..Definitive clinical trials on the benefits and risks of insulin therapy related to macrovascular complications are lacking and urgently needed...
  10. ncbi request reprint Do Mexican Americans really have low rates of cardiovascular disease?
    M P Stern
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78284 7871, USA
    Prev Med 29:S90-5. 1999
    ..This excess risk was confined to U.S.-born Mexican Americans, since immigrants from Mexico had very low mortality despite low socioeconomic status. We attribute this latter finding to a "healthy migrant effect."..
  11. ncbi request reprint Birth weight and the metabolic syndrome: thrifty phenotype or thrifty genotype?
    M P Stern
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes Metab Res Rev 16:88-93. 2000
    ..These correlations are thought to reflect primarily nutritional inadequacies during fetal and early life. We explored familial influences on these correlations...
  12. ncbi request reprint What is the best predictor of future type 2 diabetes?
    Muhammad A Abdul-Ghani
    Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Diabetes Care 30:1544-8. 2007
    ..We sought to assess insulin secretion/insulin resistance index in predicting the risk for future type 2 diabetes..
  13. ncbi request reprint Factors of insulin resistance syndrome--related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic mexican-americans
    Rector Arya
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Diabetes 51:841-7. 2002
    ..2). In conclusion, we found substantial evidence for susceptibility loci on chromosomes 6 and 7 that appear to influence the factors representing the IRS-related phenotypes in Mexican-Americans...
  14. ncbi request reprint Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Diabetes Care 25:1177-84. 2002
    ....
  15. ncbi request reprint Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Sciences Center, San Antonio 78229, USA
    Diabetes 52:463-9. 2003
    ..This index may reflect other aspects of diabetes pathogenesis in addition to IR, which might explain its strong predictive abilities despite its moderate correlation with direct measures of IR...
  16. ncbi request reprint The metabolic syndrome as predictor of type 2 diabetes: the San Antonio heart study
    Carlos Lorenzo
    Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, Texas 78284 7873, USA
    Diabetes Care 26:3153-9. 2003
    ....
  17. ncbi request reprint Risk of progression to type 2 diabetes based on relationship between postload plasma glucose and fasting plasma glucose
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Dr, MS 7886, San Antonio, 78229, USA
    Diabetes Care 29:1613-8. 2006
    ....
  18. ncbi request reprint Secular trends in obesity in Mexico City and in San Antonio
    Ken Williams
    University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Clinical Epidemiology, San Antonio, TX, USA
    Nutr Rev 62:S158-62. 2004
    ....
  19. ncbi request reprint Bivariate linkage analysis of the insulin resistance syndrome phenotypes on chromosome 7q
    Donna M Lehman
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Hum Biol 77:231-46. 2005
    ..23, 103-109 cM; a maximum bivariate LOD of 4.51 was found for the trait pair HDLC and LSPI (the LODeq score is 3.94)]. We observed evidence of pleiotropic effects in this region on obesity and insulin-related trait pairs...
  20. pmc A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans
    Sobha Puppala
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Hum Genet 78:377-92. 2006
    ..In conclusion, we found significant evidence of major genetic determinants of symptomatic GBD on chromosome 1p in Mexican Americans...
  21. pmc Validation of prediction of diabetes by the Archimedes model and comparison with other predicting models
    Michael Stern
    Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes Care 31:1670-1. 2008
    ..To validate the ability of the Archimedes model to accurately predict the risk of developing diabetes in individuals...
  22. pmc Minimal contribution of fasting hyperglycemia to the incidence of type 2 diabetes in subjects with normal 2-h plasma glucose
    Muhammad A Abdul-Ghani
    Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Diabetes Care 33:557-61. 2010
    ..After controlling for 1-h plasma glucose concentration, the increase in FPG concentration is not associated with an increase in the incidence of type 2 diabetes...
  23. doi request reprint Fueling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain
    Sharon P Fowler
    Department of Medicine, Division of Clinical Epidemiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Obesity (Silver Spring) 16:1894-900. 2008
    ..069), were significant in all 13 remaining strata. These findings raise the question whether AS use might be fueling--rather than fighting--our escalating obesity epidemic...
  24. doi request reprint Pulse pressure, prehypertension, and mortality: the San Antonio heart study
    Carlos Lorenzo
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Am J Hypertens 22:1219-26. 2009
    ..Nevertheless, the impact of pulse pressure on the relationship between prehypertension and mortality is not known in individuals who are free of diabetes and cardiovascular disease...
  25. ncbi request reprint Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: the San Antonio Family Diabetes/Gallbladder Study
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 54:2655-62. 2005
    ..87 and 3.76, respectively. In summary, we report evidence for linkage to diabetes on chromosome 3p in a region previously identified in at least three independent populations...
  26. ncbi request reprint Joint linkage and association analysis of the hepatic lipase promoter polymorphism and lipoprotein size phenotypes
    Laura Almasy
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0549, USA
    Hum Biol 77:17-25. 2005
    ....
  27. pmc Height, ethnicity, and the incidence of diabetes: the San Antonio Heart Study
    Carlos Lorenzo
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284 7873, USA
    Metabolism 58:1530-5. 2009
    ....
  28. ncbi request reprint A novel missense mutation in ADRB3 increases risk for type 2 diabetes in a Mexican American family
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes Metab Res Rev 22:331-6. 2006
    ..The aim of this study was to investigate the association of this mutation in the SAFDGS with risk for diabetes...
  29. ncbi request reprint A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies
    Rector Arya
    Division of Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, 78229 3900, USA
    Hum Mol Genet 15:1569-79. 2006
    ..3 to 2.7. Thus, we have found strong evidence for a major gene on chromosome 6q that influences variation in birth weight in both Mexican- and European-Americans...
  30. ncbi request reprint Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes 56:389-93. 2007
    ..02, RR 1.64). These data provide evidence that variation in the TCF7L2 genomic region may affect risk for type 2 diabetes in Mexican Americans, but the attributable risk may be lower than in Caucasian populations...
  31. ncbi request reprint P2 promoter variants of the hepatocyte nuclear factor 4alpha gene are associated with type 2 diabetes in Mexican Americans
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes 56:513-7. 2007
    ....
  32. pmc Evaluation of gremlin 1 (GREM1) as a candidate susceptibility gene for albuminuria-related traits in Mexican Americans with type 2 diabetes mellitus
    Farook Thameem
    Division of Nephrology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Metabolism 58:1496-502. 2009
    ..In conclusion, the variants examined at GREM1 are not significant contributors to variation in ACR in Mexican Americans, although they appear to minimally influence risk factors related to ACR...
  33. doi request reprint Association of genetic variation in ENPP1 with obesity-related phenotypes
    Christopher P Jenkinson
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Obesity (Silver Spring) 16:1708-13. 2008
    ..However, these results indicate that ENPP1 is a genetic determinant of these traits in this population, and are consistent with multiple positive association findings in independent studies in diverse human populations...
  34. ncbi request reprint Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans
    Dawn K Coletta
    Division of Diabetes MC 7886, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Obesity (Silver Spring) 15:809-15. 2007
    ..98). These preliminary results provide evidence for association of SNPs in the NPY5R gene with dyslipidemia (elevated triglyceride concentrations and reduced high-density lipoprotein levels) in our Mexican American population...
  35. ncbi request reprint Which obesity index best explains prevalence differences in type 2 diabetes mellitus?
    Carlos Lorenzo
    Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 7873, USA
    Obesity (Silver Spring) 15:1294-301. 2007
    ..Obesity drives the diabetes epidemic. However, it is not known which obesity index best explains variations in type 2 diabetes mellitus prevalence across populations...
  36. pmc Endothelial nitric oxide synthase (eNOS) gene polymorphisms and their association with type 2 diabetes-related traits in Mexican Americans
    Farook Thameem
    Division of Nephrology, Department of Medicine, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    Diab Vasc Dis Res 5:109-13. 2008
    ..In conclusion, of the genetic polymorphisms examined at the eNOS locus, only 27bp-VNTR appears to be a minor contributor to the variation in T2DM-related traits in Mexican Americans...
  37. ncbi request reprint Elevated carotid artery intima-media thickness levels in individuals who subsequently develop type 2 diabetes
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 78229, USA
    Arterioscler Thromb Vasc Biol 23:1845-50. 2003
    ..We examined whether B-mode ultrasound-detected carotid artery intima-media thickness (IMT) was elevated before the onset of clinical diabetes...
  38. ncbi request reprint All-cause and cardiovascular mortality among Mexican-American and non-Hispanic White older participants in the San Antonio Heart Study- evidence against the "Hispanic paradox"
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Am J Epidemiol 158:1048-57. 2003
    ..Contrary to the prediction of the "Hispanic paradox," in the San Antonio Heart Study, Mexican Americans were at greater risk of all-cause, cardiovascular, and coronary heart disease mortality than were non-Hispanic Whites...
  39. ncbi request reprint Association between carotid atherosclerosis and markers of inflammation in rheumatoid arthritis patients and healthy subjects
    INMACULADA DEL RINCON
    University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Arthritis Rheum 48:1833-40. 2003
    ..To examine the relationship between markers of systemic inflammation and carotid atherosclerosis in patients with rheumatoid arthritis (RA) and healthy controls...
  40. pmc Evidence of a novel quantitative-trait locus for obesity on chromosome 4p in Mexican Americans
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Am J Hum Genet 74:272-82. 2004
    ..In conclusion, we identified a major genetic locus influencing BMI on chromosome 4p in Mexican Americans...
  41. ncbi request reprint The genetics of obesity in Mexican Americans: the evidence from genome scanning efforts in the San Antonio family heart study
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Hum Biol 75:635-46. 2003
    ..Here, we summarize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study...
  42. ncbi request reprint Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart Study
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Stroke 33:2775-80. 2002
    ..In contrast to the commonly used quantitative marker of subclinical atherosclerosis, namely intima-media thickness, we investigated the extent to which the presence or absence of carotid artery plaque (CAP) was under genetic control...
  43. ncbi request reprint Linkage of high-density lipoprotein-cholesterol concentrations to a locus on chromosome 9p in Mexican Americans
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Nat Genet 30:102-5. 2002
    ..A replication study in an independent set of Mexican American families confirmed the existence of a QTL on chromosome 9p...
  44. ncbi request reprint National Cholesterol Education Program versus World Health Organization metabolic syndrome in relation to all-cause and cardiovascular mortality in the San Antonio Heart Study
    Kelly J Hunt
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Circulation 110:1251-7. 2004
    ....
  45. ncbi request reprint A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, Texas 78229, USA
    Diabetes 54:1214-21. 2005
    ..The variance attributed to this SNP accounted for approximately 25% of the logarithm of odds. These results suggest that this variant within the MGEA5 gene may increase diabetes risk in Mexican Americans...
  46. ncbi request reprint Lower hypertension risk in Mexico City than in San Antonio
    Carlos Lorenzo
    Department of Medicine, The University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78220, USA
    Am J Hypertens 18:385-91. 2005
    ..We examined the effects of blood pressure (BP), weight, and weight gain on hypertension risk in two similar ethnic origin populations, subjects in Mexico City and Mexican Americans in San Antonio...
  47. ncbi request reprint All-cause and cardiovascular mortality among diabetic participants in the San Antonio Heart Study: evidence against the "Hispanic Paradox"
    Kelly J Hunt
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Diabetes Care 25:1557-63. 2002
    ..We examined the relationship between ethnicity and all-cause and cardiovascular mortality in Mexican Americans (MAs) and non-Hispanic whites (NHWs) with diabetes...
  48. ncbi request reprint Prevalence of hypertension in Hispanic and non-Hispanic white populations
    Carlos Lorenzo
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 78284 7873, USA
    Hypertension 39:203-8. 2002
    ..Although we cannot conclude definitively that these differences are genetically driven, our results suggest no relationship between Spanish genetic admixture and the deficit in hypertension prevalence in Mexican-origin populations...
  49. ncbi request reprint Central adiposity determines prevalence differences of the metabolic syndrome
    Carlos Lorenzo
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78284 7873, USA
    Obes Res 11:1480-7. 2003
    ..To compare the expression of the metabolic syndrome in Spain and San Antonio, TX, two populations with major differences regarding their cardiovascular risk profile...
  50. ncbi request reprint Heritability and linkage analysis of hand, foot, and eye preference in Mexican Americans
    Diane M Warren
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227 5301, USA
    Laterality 11:508-24. 2006
    ..No obvious candidate genes occur in these regions. Our results indicate that genes are an important component of side preferences, and suggest chromosomal regions for further investigation...
  51. ncbi request reprint Further evidence for a type 2 diabetes susceptibility locus on chromosome 11q
    Ravindranath Duggirala
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas
    Genet Epidemiol 24:240-2. 2003
  52. ncbi request reprint Genotype by diabetes interaction effects on the detection of linkage of glomerular filtration rate to a region on chromosome 2q in Mexican Americans
    Sobha Puppala
    Southwest Foundation for Biomedical Research, Department of Genetics, P O Box 760549, San Antonio, TX 78254, USA
    Diabetes 56:2818-28. 2007
    ..We also examined the effect of genotype by diabetes interaction (G x DM) on the detection of linkage to address whether genetic effects on GFR differ in diabetic and nondiabetic subjects...
  53. ncbi request reprint Familial aggregation of nutrient intake and physical activity: results from the San Antonio Family Heart Study
    Braxton D Mitchell
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Ann Epidemiol 13:128-35. 2003
    ..To evaluate the extent to which levels of physical activity and nutrient intake aggregate in families, and secondarily, to assess the repeatability of these behavioral measures over a 5-year period...
  54. ncbi request reprint A population perspective on diabetes prevention: whom should we target for preventing weight gain?
    James P Burke
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Diabetes Care 26:1999-2004. 2003
    ..To examine the influence of obesity and prevention of weight gain on the incidence of type 2 diabetes...
  55. ncbi request reprint The Cys(311)Ser polymorphism of paraoxonase 2 (PON2) is associated with albumin-to-creatinine ratio (ACR) in Mexican Americans
    Farook Thameem
    Nephrol Dial Transplant 23:416-7. 2008
  56. ncbi request reprint Genetic polymorphisms in the renin-angiotensin system (RAS) genes and their association analysis with type 2 diabetes and related traits in Mexican Americans
    Farook Thameem
    Diabetes Res Clin Pract 79:e14-6. 2008
  57. ncbi request reprint Meta-analysis of genome-wide linkage studies in BMI and obesity
    Catherine L Saunders
    King s College London, Guy s, King s and St Thomas School of Medicine, London, United Kingdom
    Obesity (Silver Spring) 15:2263-75. 2007
    ..The objective was to provide an overall assessment of genetic linkage data of BMI and BMI-defined obesity using a nonparametric genome scan meta-analysis...
  58. pmc Risk of progression to hypertension in a low-income Mexican population with prehypertension and normal blood pressure
    Aida Jimenez-Corona
    Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    Am J Hypertens 20:929-36. 2007
    ..We estimated the incidence rates of hypertension in a low-income Mexican population according to several subcategories of baseline BP within normal and prehypertensive categories...
  59. pmc The metabolic syndrome and the impact of diabetes on coronary heart disease mortality in women and men: the San Antonio Heart Study
    Kelly J Hunt
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Ann Epidemiol 17:870-7. 2007
    ..In the San Antonio Heart Study we examined the relationship between gender, the metabolic syndrome defined by the National Cholesterol Education Program (NCEP-MetS) and diabetes and their ability to predict CHD mortality...
  60. ncbi request reprint Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study
    Monica Nannipieri
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126 Pisa, Italy
    Diabetes Care 28:1757-62. 2005
    ..To test the hypothesis that enzymes conventionally associated with liver dysfunction (aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase [GGT], and alkaline phosphatase) may predict diabetes...
  61. ncbi request reprint Family history of type 2 diabetes is associated with increased carotid artery intimal-medial thickness in Mexican Americans
    W H Linda Kao
    Department of Epidemiology, Bloomberg School of Public Health, John s Hopkins University, Baltimore, Maryland, USA
    Diabetes Care 28:1882-9. 2005
    ..To evaluate whether the joint risk of diabetes and atherosclerosis tracked within families, we assessed the correlation between a family history of diabetes and intimal-medial thickness (IMT) of the common carotid artery (CCA)...
  62. ncbi request reprint Using metabolic syndrome traits for efficient detection of impaired glucose tolerance
    James B Meigs
    General Internal Medicine Unit, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA 02114, USA
    Diabetes Care 27:1417-26. 2004
    ..Efficient detection of impaired glucose tolerance (IGT) is needed to implement type 2 diabetes prevention interventions...
  63. ncbi request reprint Genetics of insulin resistance syndrome
    Michael P Stern
    Endocr Pract 9:35-8. 2003
  64. ncbi request reprint Polymorphism of the 3'-untranslated region of the leptin receptor gene, but not the adiponectin SNP45 polymorphism, predicts type 2 diabetes: a population-based study
    Monica Nannipieri
    Internal Medicine, Institute of Clinical Psychology, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Diabetes Care 29:2509-11. 2006
  65. ncbi request reprint Do we need the oral glucose tolerance test to identify future cases of type 2 diabetes?
    Michael P Stern
    Diabetes Care 26:940-1. 2003
  66. ncbi request reprint Mode of onset of type 2 diabetes from normal or impaired glucose tolerance
    Ele Ferrannini
    Metabolism Unit, Department of Internal Medicine and C N R Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Diabetes 53:160-5. 2004
    ..We conclude that, within a 3-year time frame, the onset of diabetes is very often rapid rather than gradual and is in part explained by a fall in glucose-stimulated insulin response...
  67. ncbi request reprint SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse
    Mark O Goodarzi
    Cedars Sinai Medical Center, Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Blvd, Becker B 131, Los Angeles, CA 90048, USA
    Diabetes 56:1922-9. 2007
    ..Thus, we sought to determine whether variation in the human SORCS1 gene was associated with diabetes-related traits...
  68. ncbi request reprint Gene by smoking interaction: evidence for effects on low-density lipoprotein size and plasma levels of triglyceride and high-density lipoprotein cholesterol
    Stefan A Czerwinski
    Lifespan Health Research Center, Department of Community Health, Wright State University School of Medicine, 3171 Research Blvd, Kettering, OH 45420 4014, USA
    Hum Biol 76:863-76. 2004
    ....
  69. ncbi request reprint Carotid intima-media thickness in confirmed prehypertensive subjects: predictors and progression
    Romana Femia
    Department of Internal Medicine and Metabolism Unit of the C N R Institute of Clinical Physiology
    Arterioscler Thromb Vasc Biol 27:2244-9. 2007
    ....
  70. pmc Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium
    Weihua Guan
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Hum Hered 66:35-49. 2008
    ..The International Type 2 Diabetes Linkage Analysis Consortium was formed to localize type 2 diabetes predisposing variants based on 23 autosomal linkage scans...
  71. ncbi request reprint Genetic basis of diabetic nephropathy
    Hernan Rincon-Choles
    Department of Research, The South Texas Veterans Health Care System, USA
    Am J Ther 12:555-61. 2005
    ..New knowledge in identifying and understanding the role of susceptibility gene(s) will provide valuable information that could help develop new preventive and therapeutic strategies...

Research Grants19

  1. NIDDM SUSCEPTIBILITY GENES IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 2004
    ..They will also employ a novel statistical functional genomics approach to localizing functional variants and polymorphisms exhibiting the highest disequilibria with the putative susceptibility loci. ..
  2. NIDDM SUSCEPTIBILITY GENES IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 2003
    ..They will also employ a novel statistical functional genomics approach to localizing functional variants and polymorphisms exhibiting the highest disequilibria with the putative susceptibility loci. ..
  3. INCIDENCE OF DIABETES AND CVD IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 2002
    ..The investigators note that this will aid in the interpretation of data relating to possible ethnic differences in cause-specific mortality based on death certificate coding. ..
  4. NIDDM SUSCEPTIBILITY GENES IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 2002
    ..They will also employ a novel statistical functional genomics approach to localizing functional variants and polymorphisms exhibiting the highest disequilibria with the putative susceptibility loci. ..
  5. NIDDM SUSCEPTIBILITY GENES IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 2001
    ..They will also employ a novel statistical functional genomics approach to localizing functional variants and polymorphisms exhibiting the highest disequilibria with the putative susceptibility loci. ..
  6. INCIDENCE OF DIABETES AND CVD IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 2001
    ..The investigators note that this will aid in the interpretation of data relating to possible ethnic differences in cause-specific mortality based on death certificate coding. ..
  7. NIDDM SUSCEPTIBILITY GENES IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 2001
    ..They will also employ a novel statistical functional genomics approach to localizing functional variants and polymorphisms exhibiting the highest disequilibria with the putative susceptibility loci. ..
  8. NIDDM SUSCEPTIBILITY GENES IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 2000
    ..They will also employ a novel statistical functional genomics approach to localizing functional variants and polymorphisms exhibiting the highest disequilibria with the putative susceptibility loci. ..
  9. INCIDENCE OF DIABETES AND CVD IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 2000
    ..The investigators note that this will aid in the interpretation of data relating to possible ethnic differences in cause-specific mortality based on death certificate coding. ..
  10. INCIDENCE OF DIABETES AND CVD IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 1999
    ..The investigators note that this will aid in the interpretation of data relating to possible ethnic differences in cause-specific mortality based on death certificate coding. ..
  11. NIDDM SUSCEPTIBILITY GENES IN MEXICAN-AMERICANS
    Michael Stern; Fiscal Year: 1993
    ..The phenotypes to be considered in these analyses are NIDDM, the quantitative traits, glucose, insulin, and C-peptide levels, and a risk score derived from a predictive model for NIDDM...
  12. NIDDM SUSCEPTIBILITY GENES IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 2006
    ..5 LOD support interval. Furthermore, the utilization of a novel statistical functional genomic analysis (Bayesian quantitative trait nucleotide analysis) should enhance the final stage of identifying the specific variants involved. ..