Mariana C Stern

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Room 5421A, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 16:2363-72. 2007
  2. pmc Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 18:3057-61. 2009
  3. pmc Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA
    Cancer Res 69:6857-64. 2009
  4. ncbi request reprint XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk
    Mariana C Stern
    University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Room 5421A, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 15:2384-90. 2006
  5. pmc Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA
    J Nutrigenet Nutrigenomics 2:273-9. 2009
  6. pmc Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat
    Asgeir Brevik
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 19:3167-73. 2010
  7. pmc Red meat and poultry, cooking practices, genetic susceptibility and risk of prostate cancer: results from a multiethnic case-control study
    Amit D Joshi
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center Los Angeles, CA 90033, USA
    Carcinogenesis 33:2108-18. 2012
  8. pmc Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk
    Jun Wang
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, CA, USA
    Int J Cancer 130:1898-907. 2012
  9. pmc Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai
    Roman Corral
    Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA
    Int J Cancer 135:335-47. 2014
  10. doi request reprint Genetic variation in insulin pathway genes and distal colorectal adenoma risk
    A Joan Levine
    Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
    Int J Colorectal Dis 27:1587-95. 2012

Detail Information

Publications30

  1. ncbi request reprint DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Room 5421A, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 16:2363-72. 2007
    ..8; 95% CI, 1.0-8.1). Our results support a role for reactive oxygen species as relevant genotoxins that may account for the effects of both smoking and alcohol on colorectal cancer risk...
  2. pmc Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 18:3057-61. 2009
    ..045). Our results suggest that a TP63 gene variant may increase susceptibility for the development of urinary bladder tumors with low risk of progression...
  3. pmc Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA
    Cancer Res 69:6857-64. 2009
    ..002) and was strongest for the highest levels of smoking dose and smoking duration. Overall, our study provides the strongest evidence to date for a role of common variants in DNA repair genes in bladder carcinogenesis...
  4. ncbi request reprint XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk
    Mariana C Stern
    University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Room 5421A, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 15:2384-90. 2006
    ..04). Our data suggest that the effects of smoking and alcohol may vary depending on the genetic background of proteins that participate in the base excision repair and nucleotide excision repair pathways...
  5. pmc Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA
    J Nutrigenet Nutrigenomics 2:273-9. 2009
    ..003). Our results suggest a positive association between high intake of marine n-3 PUFA and rectal cancer risk among carriers of at least one PARP codon 762 Ala allele (odds ratio=1.7, 95% confidence interval=1.1-2.7)...
  6. pmc Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat
    Asgeir Brevik
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 19:3167-73. 2010
    ..Carcinogens generated during meat cooking have been implicated as causal agents and can induce oxidative DNA damage, which elicits repair by the base excision repair (BER) pathway...
  7. pmc Red meat and poultry, cooking practices, genetic susceptibility and risk of prostate cancer: results from a multiethnic case-control study
    Amit D Joshi
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center Los Angeles, CA 90033, USA
    Carcinogenesis 33:2108-18. 2012
    ..008). Our results support a role for carcinogens that accumulate in meats cooked at high temperatures as potential PCA risk factors, and may support a role for heterocyclic amines (HCAs) in PCA etiology...
  8. pmc Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk
    Jun Wang
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, CA, USA
    Int J Cancer 130:1898-907. 2012
    ..Our findings also suggest a possible role for diets high in poultry cooked at high temperatures in CRC risk...
  9. pmc Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai
    Roman Corral
    Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA
    Int J Cancer 135:335-47. 2014
    ..A SNP that tags both the XRCC6 and SREBF2 genes strongly modifies the association between bladder cancer risk and smoking. ..
  10. doi request reprint Genetic variation in insulin pathway genes and distal colorectal adenoma risk
    A Joan Levine
    Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
    Int J Colorectal Dis 27:1587-95. 2012
    ....
  11. pmc Hypertension, diuretics and antihypertensives in relation to bladder cancer
    Xuejuan Jiang
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Carcinogenesis 31:1964-71. 2010
    ..7 pg/g Hb) compared with individuals without hypertension (79.8 pg/g Hb) (P = 0.009). In conclusion, untreated hypertension was associated with a reduced risk of bladder cancer...
  12. pmc Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk
    Roman Corral
    Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e71211. 2013
    ..Our findings strengthen the role of oxidative damage induced by key lifestyle and dietary risk factors in colorectal adenoma formation. ..
  13. pmc Polymorphisms in carcinogen metabolism enzymes, fish intake, and risk of prostate cancer
    Chelsea Catsburg
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Carcinogenesis 33:1352-9. 2012
    ..However, the gene-diet interactions should be interpreted with caution given the limited sample size. Thus, our findings require further validation with additional studies...
  14. pmc Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study
    Victoria K Cortessis
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, MC 9175, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 19:3150-6. 2010
    ..Recent genome-wide association studies of urinary bladder cancer report risk to be associated with the T allele of rs9642880 on 8q24 among individuals of European descent...
  15. pmc Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study
    Manuela Gago-Dominguez
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9175, USA
    Carcinogenesis 32:197-202. 2011
    ..26; 95% CI, 1.04-1.54; P = 0.017). Our results support 5p15 and 15q25 as susceptibility regions for bladder cancer risk...
  16. doi request reprint Dietary sources of N-nitroso compounds and bladder cancer risk: findings from the Los Angeles bladder cancer study
    Chelsea E Catsburg
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA
    Int J Cancer 134:125-35. 2014
    ..In addition, any effect of consuming these meats may be greater when accompanied by high nitrate intake. ..
  17. pmc Cigarette smoking and subtypes of bladder cancer
    Xuejuan Jiang
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Int J Cancer 130:896-901. 2012
    ..Our results indicate that cigarette smoking was more strongly associated with increased risk of invasive bladder cancer than with low-grade superficial bladder cancer...
  18. pmc Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk
    Amit D Joshi
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, CA 90089, USA
    Carcinogenesis 30:472-9. 2009
    ..These findings highlight the possible contribution of diets high in red meat to the formation of lesions that elicit the NER pathway, such as carcinogen-induced bulky adducts...
  19. ncbi request reprint XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 14:609-15. 2005
    ....
  20. ncbi request reprint DNA repair gene polymorphisms and probability of p53 mutation in bladder cancer
    Mariana C Stern
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, USA
    Mol Carcinog 45:715-9. 2006
    ..7; 95% CI = 1.1-13). Our data provide some limited support for the hypothesis that mutations in the p53 gene in bladder cancer may differ according to the presence or absence of certain DNA repair gene variants...
  21. doi request reprint Genetic admixture and risk of hypertensive disorders of pregnancy among Latinas in Los Angeles County
    Ahva Shahabi
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Epidemiology 24:285-94. 2013
    ..This study examines the role of genetic ancestry and environmental risk factors in the risk of hypertensive disorder of pregnancy among Latinas in Los Angeles County...
  22. doi request reprint Fish intake, cooking practices, and risk of prostate cancer: results from a multi-ethnic case-control study
    Amit D Joshi
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
    Cancer Causes Control 23:405-20. 2012
    ..In this study, we investigated the association between fish intake and localized and advanced PCA taking into account fish types (lean vs. fatty) and cooking practices...
  23. pmc Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study
    A Joan Levine
    Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Cancer Causes Control 22:541-52. 2011
    ..Folate-associated one-carbon metabolism (FOCM) is an important pathway in colorectal neoplasia risk but data on genetic variation in this pathway are largely limited to studies of single SNPs in selected genes...
  24. pmc Lower risk in parous women suggests that hormonal factors are important in bladder cancer etiology
    Carol A Davis-Dao
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 20:1156-70. 2011
    ..Our objective was to determine whether hormonal and reproductive factors are involved in female bladder cancer...
  25. pmc Genetic ancestry and risk of mortality among U.S. Latinas with breast cancer
    Laura Fejerman
    Authors Affiliations Department of Medicine, Division of General Internal Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, Center for Aging in Diverse Communities, and Medical Effectiveness Research Center for Diverse Populations, University of California San Francisco, San Francisco Cancer Prevention Institute of California, Fremont Division of Epidemiology, Department of Health Research and Policy, and Stanford Cancer Institute, Stanford University School of Medicine, Stanford and Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, California
    Cancer Res 73:7243-53. 2013
    ..003). Overall, results suggest that genetic factors and/or unmeasured differences in treatment or access to care should be further explored to understand and reduce ethnic disparities in breast cancer outcomes...
  26. doi request reprint A review of cancer in U.S. Hispanic populations
    Robert W Haile
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Prev Res (Phila) 5:150-63. 2012
    ..We review the literature and discuss study design options and features that should be considered in future studies...
  27. ncbi request reprint Genetic variants in interleukin genes are associated with breast cancer risk and survival in a genetically admixed population: the Breast Cancer Health Disparities Study
    Martha L Slattery
    Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, UT 84108, USA, Instituto Nacional de Salud Publica, Centro de Investigacion en Salud Poblacional, Av Universidad No 655, Col Sta Ma Ahuacatitlan, Cuernavaca Morelos CP 62100, Mexico, Cancer Prevention Institute of California, Fremont, CA 84108, USA, Division of Epidemiology, Department of Health Research and Policy and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 62508, USA, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA, Department of Biology, University of Colorado at Colorado Springs, 1420 Austin Bluffs Parkway, Colorado Springs, CO 80918, USA, Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA 90089, USA and Department of Epidemiology and Population Health, School of Public Health and Information Sciences, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 90089 9031, USA
    Carcinogenesis 35:1750-9. 2014
    ..We confirmed associations with several functional polymorphisms previously associated with breast cancer risk and provide support that their combined effect influences the carcinogenic process. ..
  28. ncbi request reprint Differences in base excision repair capacity may modulate the effect of dietary antioxidant intake on prostate cancer risk: an example of polymorphisms in the XRCC1 gene
    Carla H van Gils
    Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Epidemiol Biomarkers Prev 11:1279-84. 2002
    ..The data give some support for our hypothesis but should be regarded as preliminary, because it is limited by small sample size. We discuss what kind of data and what kind of studies are needed for future evaluation of this hypothesis...
  29. ncbi request reprint XPD codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk
    Mariana C Stern
    Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis and the National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, 27709, USA
    Cancer Epidemiol Biomarkers Prev 11:1004-11. 2002
    ..52). We found little evidence for a gene-gene-exposure, three-way interaction among the XPD codon 751 genotype, smoking, and the NAT1/NAT2 genotype...
  30. ncbi request reprint DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk
    Mariana C Stern
    Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Epidemiol Biomarkers Prev 11:939-43. 2002
    ..In this study, we found some evidence for a gene-gene interaction between the XRCC1 codon 194 and XRCC3 codon 241 polymorphisms (P = 0.09) and some support for a possible gene-gene-smoking three-way interaction (P = 0.08)...