C B Stephensen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Phylogenetic analysis of a highly conserved region of the polymerase gene from 11 coronaviruses and development of a consensus polymerase chain reaction assay
    C B Stephensen
    Department of International Health, School of Public Health, University of Alabama at Birmingham, 35294, USA
    Virus Res 60:181-9. 1999
  2. ncbi request reprint Immune activation and oxidative damage in HIV-positive and HIV-negative adolescents
    Charles B Stephensen
    United States Department of Agriculture Western Human Nutrition Research Center and Department of Nutrition, University of California at Davis, Davis, CA 95616, USA
    J Acquir Immune Defic Syndr 38:180-90. 2005
  3. ncbi request reprint Vitamin A deficiency increases the in vivo development of IL-10-positive Th2 cells and decreases development of Th1 cells in mice
    Charles B Stephensen
    U S Department of Agriculture, Western Human Nutrition Research Center at the University of California, Davis, and Nutrition Department, University of California, Davis, CA 95616, USA
    J Nutr 134:2660-6. 2004
  4. ncbi request reprint Commentary: A hypothesis concerning vitamin A supplementation, vaccines, and childhood mortality
    Charles B Stephensen
    USDA Western Human Nutrition Research Center, and Nutrition Department, University of California, Davis, CA 95616 8669, USA
    Int J Epidemiol 32:828-9. 2003
  5. ncbi request reprint Serum retinol, the acute phase response, and the apparent misclassification of vitamin A status in the third National Health and Nutrition Examination Survey
    C B Stephensen
    US Department of Agriculture, Western Human Nutrition Research Center, Davis, CA, USA
    Am J Clin Nutr 72:1170-8. 2000
  6. ncbi request reprint Vitamin A, infection, and immune function
    C B Stephensen
    USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, California 95616, USA
    Annu Rev Nutr 21:167-92. 2001
  7. ncbi request reprint Plasma cytokines and oxidative damage in HIV-positive and HIV-negative adolescents and young adults: a protective role for IL-10?
    Charles B Stephensen
    USDA ARS Western Human Nutrition Research Center at the University of California, Davis and Department of Nutrition, University of California, Davis, CA 95616, USA
    Free Radic Res 39:859-64. 2005
  8. ncbi request reprint Glutathione, glutathione peroxidase, and selenium status in HIV-positive and HIV-negative adolescents and young adults
    Charles B Stephensen
    US Department of Agriculture Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 85:173-81. 2007
  9. pmc Disruption of Rxra gene in thymocytes and T lymphocytes modestly alters lymphocyte frequencies, proliferation, survival and T helper type 1/type 2 balance
    Charles B Stephensen
    USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA 95616, USA
    Immunology 121:484-98. 2007
  10. ncbi request reprint Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway
    Charles B Stephensen
    U S Department of Agriculture Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA 95616, USA
    J Immunol 168:4495-503. 2002

Detail Information

Publications28

  1. ncbi request reprint Phylogenetic analysis of a highly conserved region of the polymerase gene from 11 coronaviruses and development of a consensus polymerase chain reaction assay
    C B Stephensen
    Department of International Health, School of Public Health, University of Alabama at Birmingham, 35294, USA
    Virus Res 60:181-9. 1999
    ..This consensus PCR assay for the genus Coronavirus may be useful in identifying as yet unknown coronaviruses...
  2. ncbi request reprint Immune activation and oxidative damage in HIV-positive and HIV-negative adolescents
    Charles B Stephensen
    United States Department of Agriculture Western Human Nutrition Research Center and Department of Nutrition, University of California at Davis, Davis, CA 95616, USA
    J Acquir Immune Defic Syndr 38:180-90. 2005
    ..Plasma ceruloplasmin was associated with decreased oxidative damage in HIV-positive subjects, although this association was not seen in those taking ART...
  3. ncbi request reprint Vitamin A deficiency increases the in vivo development of IL-10-positive Th2 cells and decreases development of Th1 cells in mice
    Charles B Stephensen
    U S Department of Agriculture, Western Human Nutrition Research Center at the University of California, Davis, and Nutrition Department, University of California, Davis, CA 95616, USA
    J Nutr 134:2660-6. 2004
    ..4 +/- 0.67 and 47.0 +/- 2.8%, respectively). Thus vitamin A deficiency, at the time of initial antigen exposure, enhances the development of IL-10-producing Th2 or T regulatory cells and diminishes the development of Th1 memory cells...
  4. ncbi request reprint Commentary: A hypothesis concerning vitamin A supplementation, vaccines, and childhood mortality
    Charles B Stephensen
    USDA Western Human Nutrition Research Center, and Nutrition Department, University of California, Davis, CA 95616 8669, USA
    Int J Epidemiol 32:828-9. 2003
  5. ncbi request reprint Serum retinol, the acute phase response, and the apparent misclassification of vitamin A status in the third National Health and Nutrition Examination Survey
    C B Stephensen
    US Department of Agriculture, Western Human Nutrition Research Center, Davis, CA, USA
    Am J Clin Nutr 72:1170-8. 2000
    ..Serum retinol decreases transiently during the acute phase response and can thus result in misclassification of vitamin A status...
  6. ncbi request reprint Vitamin A, infection, and immune function
    C B Stephensen
    USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, California 95616, USA
    Annu Rev Nutr 21:167-92. 2001
    ..These changes in mucosal epithelial regeneration and immune function presumably account for the increased mortality seen in vitamin A-deficient infants, young children, and pregnant women in many areas of the world today...
  7. ncbi request reprint Plasma cytokines and oxidative damage in HIV-positive and HIV-negative adolescents and young adults: a protective role for IL-10?
    Charles B Stephensen
    USDA ARS Western Human Nutrition Research Center at the University of California, Davis and Department of Nutrition, University of California, Davis, CA 95616, USA
    Free Radic Res 39:859-64. 2005
    ..This finding is consistent with a protective role for IL-10 in diminishing oxidative damage during immune activation...
  8. ncbi request reprint Glutathione, glutathione peroxidase, and selenium status in HIV-positive and HIV-negative adolescents and young adults
    Charles B Stephensen
    US Department of Agriculture Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 85:173-81. 2007
    ..Antioxidant nutrient deficiencies may hasten the progression of HIV disease by impairing antioxidant defenses...
  9. pmc Disruption of Rxra gene in thymocytes and T lymphocytes modestly alters lymphocyte frequencies, proliferation, survival and T helper type 1/type 2 balance
    Charles B Stephensen
    USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA 95616, USA
    Immunology 121:484-98. 2007
    ..These differences were modest in magnitude and their impact on disease resistance is yet to be examined...
  10. ncbi request reprint Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway
    Charles B Stephensen
    U S Department of Agriculture Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA 95616, USA
    J Immunol 168:4495-503. 2002
    ..These data show that stimulation of the RXR pathway enhances Th2 development, perhaps by affecting the relative expression of pertinent transcription factors, cytokines, and cytokine receptors...
  11. ncbi request reprint Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma
    Gertrud U Schuster
    Nutrition Department, U S Department of Agriculture Western Human Nutrition Research Center, University of California Davis, 430 West Health Science Drive, Davis, CA 95616, USA
    J Immunol 180:1834-42. 2008
    ..These data suggest that excessive intake of vitamin A may increase the risk or severity of asthma in industrialized countries whereas vitamin A deficiency continues to increase mortality from infectious diseases in developing countries...
  12. ncbi request reprint Diets rich in polyphenols and vitamin A inhibit the development of type I autoimmune diabetes in nonobese diabetic mice
    Susan J Zunino
    USDA, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    J Nutr 137:1216-21. 2007
    ..These data suggest that diets rich in polyphenols or vitamin A have protective effects against autoimmune inflammatory attack of the islet beta cells and have the potential to reduce the onset and pathogenesis of autoimmune diabetes...
  13. ncbi request reprint Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes
    Reuven Rasooly
    U S Department of Agriculture USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA, 95616, USA
    J Immunol 175:7916-29. 2005
    ..Thus, this effect on Bcl2a1 expression may account for the decreased apoptosis seen in naive T lymphocytes treated with RXR agonists...
  14. doi request reprint Vitamin A status is associated with T-cell responses in Bangladeshi men
    Shaikh M Ahmad
    Department of Nutrition, Program in International and Community Nutrition, University of California, Davis, CA, USA
    Br J Nutr 102:797-802. 2009
    ..These data show that increasing vitamin A stores above the level that maintains normal vision enhances some measures of T-cell-mediated immunity, suggesting a difference in requirements for maintaining vision and immune function...
  15. pmc Markers of innate immune function are associated with vitamin a stores in men
    Shaikh M Ahmad
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 139:377-85. 2009
    ..The negative association of stores with serum IL-6 and IL-17 suggests that not all protective responses are similarly enhanced by vitamin A...
  16. ncbi request reprint Assessment of vitamin A status with the relative-dose-response test in Peruvian children recovering from pneumonia
    Charles B Stephensen
    Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, USA
    Am J Clin Nutr 76:1351-7. 2002
    ..The relative-dose-response (RDR) test is used to identify subjects with marginal liver vitamin A stores, but its use has not been evaluated during episodes of infection...
  17. ncbi request reprint Vitamin A, beta-carotene, and mother-to-child transmission of HIV
    Charles B Stephensen
    USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA 95616, USA
    Nutr Rev 61:280-4. 2003
    ..Overall, there is no reduction in either mortality or HIV transmission in two recent studies. Contrary to expectations, one study reported an increased risk of transmission using vitamin A plus beta-carotene supplements...
  18. pmc Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells
    Craig L Maynard
    Department of Pathology, University of Alabama at Birmingham, AL 35294, USA
    J Exp Med 206:343-57. 2009
    ....
  19. ncbi request reprint Vitamins C and E in adolescents and young adults with HIV infection
    Charles B Stephensen
    US Department of Agriculture Agricultural Research Service, Western Human Nutrition Research Center at the University of California Davis, Davis, CA 95616, USA
    Am J Clin Nutr 83:870-9. 2006
    ..Oxidative stress during HIV infection may impair immune function, cause more rapid disease progression, and increase requirements for dietary antioxidants such as vitamins C and E...
  20. pmc Men with low vitamin A stores respond adequately to primary yellow fever and secondary tetanus toxoid vaccination
    Shaikh M Ahmad
    Program in International and Community Nutrition, Department of Nutrition, University of California Davis, CA 95616, USA
    J Nutr 138:2276-83. 2008
    ..084 micromol/g. Such increases may enhance vaccine protection but raise the question of whether immune-mediated chronic diseases may by exacerbated by high-level dietary vitamin A...
  21. ncbi request reprint A randomized, 4-month mango and fat supplementation trial improved vitamin A status among young Gambian children
    Bakary S Drammeh
    Department of Epidemiology and International Health, University of Alabama at Birmingham, USA
    J Nutr 132:3693-9. 2002
    ....
  22. ncbi request reprint Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakes
    Robert A Jacob
    U S Department of Agriculture ARS Western Human Nutrition Research Center, University of California at Davis, 95616 8683, USA
    J Nutr 133:740-3. 2003
    ..In healthy young men, the endogenous antioxidant defense system and a modest intake of dietary antioxidants are adequate to minimize levels of in vivo oxidant damage such that they cannot be differentiated by current methods...
  23. ncbi request reprint Fish oil and inflammatory disease: is asthma the next target for n-3 fatty acid supplements?
    Charles B Stephensen
    US Department of Agriculture Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, California, USA
    Nutr Rev 62:486-9. 2004
    ..Such supplements also provide symptomatic relief for rheumatoid arthritis patients. Recent research suggests that asthma, another highly prevalent, chronic inflammatory disease, may also respond to fish oil supplements...
  24. ncbi request reprint Vitamin D status in adolescents and young adults with HIV infection
    Charles B Stephensen
    US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center at the University of California, Davis, CA 95616, USA
    Am J Clin Nutr 83:1135-41. 2006
    ..Vitamin D status affects immune function and thus may affect the progress of HIV infection...
  25. ncbi request reprint Zinc supplementation of pregnant rats with adequate zinc nutriture suppresses immune functions in their offspring
    Rubhana Raqib
    International Centre for Diarrhoeal Diseases Research, Bangladesh, Dhaka 1212, Bangladesh
    J Nutr 137:1037-42. 2007
    ..Zn supplementation of ZC dams induced immunosuppressive effects in utero that may also be mediated through milk and persist in the offspring after weaning...
  26. ncbi request reprint US youths in the early stages of HIV disease have low intakes of some micronutrients important for optimal immune function
    Laurie A Kruzich
    Department of Food Science and Human Nutrition, Iowa State University, Ames, USA
    J Am Diet Assoc 104:1095-101. 2004
    ..We examined the association between micronutrient intakes and human immunodeficiency virus (HIV) infection in youths who were at increased nutritional risk because of the demands of growth and disease as well as poor dietary habits...
  27. ncbi request reprint HIV-infected US youth are at high risk of obesity and poor diet quality: a challenge for improving short- and long-term health outcomes
    Laurie A Kruzich
    Department of Food Science and Human Nutrition, Iowa State University, Ames 50011, USA
    J Am Diet Assoc 104:1554-60. 2004
    ..To examine the relationships among dietary quality, weight status, and human immunodeficiency virus (HIV) infection in US adolescents and young adults...
  28. ncbi request reprint Urinary retinol excretion in children with acute watery diarrhoea
    Amal K Mitra
    University of Southern Mississippi, Center for Community Health, Hattiesburg 39406 5122, USA
    J Health Popul Nutr 20:12-7. 2002
    ..Kidney tubular dysfunctions of increased RBP excretion significantly predicted urinary retinol excretion in children with watery diarrhoea...