Karen Stephens

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Genetics of neurofibromatosis 1-associated peripheral nerve sheath tumors
    Karen Stephens
    Departments of Medicine and Laboratory Medicine, University of Washington, 1959 NE Pacific St, Rm I 204, Box 357720, Seattle, WA 98195 7720, USA
    Cancer Invest 21:897-914. 2003
  2. ncbi Interstitial uniparental isodisomy at clustered breakpoint intervals is a frequent mechanism of NF1 inactivation in myeloid malignancies
    Karen Stephens
    Department of Medicine, University of Washington, Medical Genetics 357720, Seattle, WA 98195, USA
    Blood 108:1684-9. 2006
  3. ncbi Genomic context of paralogous recombination hotspots mediating recurrent NF1 region microdeletion
    Stephen H Forbes
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Genes Chromosomes Cancer 41:12-25. 2004
  4. ncbi The ichq mutant mouse, a model for the human skin disorder harlequin ichthyosis: mapping, keratinocyte culture, and consideration of candidate genes involved in epidermal growth regulation
    Martine Dunnwald
    Department of Oral Biology, University of Washington, Seattle, WA, USA
    Exp Dermatol 12:245-54. 2003
  5. ncbi Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse
    Dieter E Jenne
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Genes Chromosomes Cancer 37:111-20. 2003
  6. ncbi Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion
    Thomas De Raedt
    Department of Human Genetics, Catholic University Leuven, Leuven, Belgium
    Nat Genet 38:1419-23. 2006
  7. ncbi Plexiform-like neurofibromas develop in the mouse by intraneural xenograft of an NF1 tumor-derived Schwann cell line
    George Q Perrin
    Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610 0244, USA
    J Neurosci Res 85:1347-57. 2007

Collaborators

Detail Information

Publications7

  1. ncbi Genetics of neurofibromatosis 1-associated peripheral nerve sheath tumors
    Karen Stephens
    Departments of Medicine and Laboratory Medicine, University of Washington, 1959 NE Pacific St, Rm I 204, Box 357720, Seattle, WA 98195 7720, USA
    Cancer Invest 21:897-914. 2003
    ..These studies have provided insight into the genetic basis of both the variable expression of the disorder and of benign and malignant peripheral nerve sheath tumorigenesis...
  2. ncbi Interstitial uniparental isodisomy at clustered breakpoint intervals is a frequent mechanism of NF1 inactivation in myeloid malignancies
    Karen Stephens
    Department of Medicine, University of Washington, Medical Genetics 357720, Seattle, WA 98195, USA
    Blood 108:1684-9. 2006
    ....
  3. ncbi Genomic context of paralogous recombination hotspots mediating recurrent NF1 region microdeletion
    Stephen H Forbes
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Genes Chromosomes Cancer 41:12-25. 2004
    ....
  4. ncbi The ichq mutant mouse, a model for the human skin disorder harlequin ichthyosis: mapping, keratinocyte culture, and consideration of candidate genes involved in epidermal growth regulation
    Martine Dunnwald
    Department of Oral Biology, University of Washington, Seattle, WA, USA
    Exp Dermatol 12:245-54. 2003
    ..Sequence of RELA in five unrelated human HI cases was normal. The results provide compelling evidence that none of these genes are the primary defect in the ichq mouse and that CAPN1 and RELA are not mutated in the human disorder...
  5. ncbi Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse
    Dieter E Jenne
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Genes Chromosomes Cancer 37:111-20. 2003
    ....
  6. ncbi Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion
    Thomas De Raedt
    Department of Human Genetics, Catholic University Leuven, Leuven, Belgium
    Nat Genet 38:1419-23. 2006
    ..This apparent conservation of patterns of recombination hotspots in moderately diverged paralogous regions contrasts with recent evidence that these patterns are not conserved in less-diverged orthologous regions of chimpanzees...
  7. ncbi Plexiform-like neurofibromas develop in the mouse by intraneural xenograft of an NF1 tumor-derived Schwann cell line
    George Q Perrin
    Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610 0244, USA
    J Neurosci Res 85:1347-57. 2007
    ..This model facilitates testing of potential therapeutic interventions, including angiogenesis inhibitors, in a relevant cellular environment...