Research Topics
| Irina StepanovSummaryAffiliation: University of Minnesota Country: USA Publications
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Detail Information
Publications
Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobaccoIrina Stepanov
Department of Industrial and Ecological Chemistry, Moldova State University, MD 2009 Chisinau, Moldova
J Agric Food Chem 50:2793-7. 2002..The results of this study should be useful in heightening the awareness of the dangers of smoking in Moldova and can be envisioned as the initial step in the control of tobacco-related cancer in this republic...
Increased pouch sizes and resulting changes in the amounts of nicotine and tobacco-specific N-nitrosamines in single pouches of Camel Snus and Marlboro SnusIrina Stepanov
Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE MMC 806, Minneapolis, MN 55455, USA
Nicotine Tob Res 14:1241-5. 2012....- Monitoring tobacco-specific N-nitrosamines and nicotine in novel Marlboro and Camel smokeless tobacco products: findings from Round 1 of the New Product WatchIrina Stepanov
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Nicotine Tob Res 14:274-81. 2012.... - New and traditional smokeless tobacco: comparison of toxicant and carcinogen levelsIrina Stepanov
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Nicotine Tob Res 10:1773-82. 2008..The large variation in the levels of some toxicants and carcinogens analyzed here indicates that more effort is required from the U.S. tobacco industry to further reduce their amounts in new and traditional smokeless tobacco products... - Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokersIrina Stepanov
The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Cancer Epidemiol Biomarkers Prev 17:1764-73. 2008.... - Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanolIrina Stepanov
Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 22:406-14. 2009..The results support the hypothesis that preferential binding of tobacco carcinogens to mtDNA of the lung might be functionally important in the development of smoking-induced lung cancer... - Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch usersIrina Stepanov
Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE Mayo Mail Code 806, Minneapolis, MN 55455, USA
Nicotine Tob Res 11:99-105. 2009..Nitrosation of nicotine or its metabolites in the human body could lead to formation of the 2 carcinogenic tobacco-specific nitrosamines-N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)... - Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy productsIrina Stepanov
Masonic Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Cancer Res 69:8236-40. 2009..Given the carcinogenicity of NNN and the frequent use of nicotine gum as a smoking cessation aid, further studies are needed so that preventive measures can be developed... - Analysis of 23 polycyclic aromatic hydrocarbons in smokeless tobacco by gas chromatography-mass spectrometryIrina Stepanov
Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 23:66-73. 2010..Urgent measures are required from the U.S. tobacco industry to modify manufacturing processes so that the levels of these toxicants and carcinogens in U.S. moist snuff are greatly reduced... - Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industryIrina Stepanov
Masonic Cancer Center and Tobacco Use Research Programs, University of Minnesota, Minneapolis, Minnesota 55455, USA
Tob Control 21:44-8. 2012..There is no information available on current TSNA levels in tobacco of various cigarettes available in the US, particularly in the newer varieties introduced over the past decade... 
Detection and quantitation of N'-nitrosonornicotine in human toenails by liquid chromatography-electrospray ionization-tandem mass spectrometryIrina Stepanov
The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Cancer Epidemiol Biomarkers Prev 17:945-8. 2008..58; P = 0.05). The results of this study show the feasibility of quantifying NNN in human toenails, providing a potentially useful new biomarker of tobacco carcinogen exposure...- Comparative analysis of tobacco-specific nitrosamines and total N-nitroso compounds in moldovan cigarette tobaccoIrina Stepanov
The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
J Agric Food Chem 53:8082-6. 2005..66; P < 0.0001). These findings demonstrate that current technologies involved in the manufacture of some blended cigarettes create conditions that favor N-nitrosation of alkaloids and other tobacco constituents... - Relationship of human toenail nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol to levels of these biomarkers in plasma and urineIrina Stepanov
The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Cancer Epidemiol Biomarkers Prev 16:1382-6. 2007..53; P = 0.005). The results of this study provide essential validation data for the use of toenail biomarkers in investigations of the role of chronic tobacco smoke exposure in human cancer... - Mass spectrometric quantitation of nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human toenailsIrina Stepanov
The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
Cancer Epidemiol Biomarkers Prev 15:2378-83. 2006..These sensitive and quantitative methods should be useful in epidemiologic studies of the role of chronic tobacco smoke exposure, including environmental tobacco smoke exposure, in human cancer... - The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokersRachel I Vogel
Masonic Cancer Center, University of Minnesota, Minneapolis, USA
Biomarkers 16:491-7. 2011..The total NNAL:total cotinine (×10(3)) ratio may provide an improved biomarker for evaluating the health effects of passive smoking... - Effect of oral snus and medicinal nicotine in smokers on toxicant exposure and withdrawal symptoms: a feasibility studyMichael Kotlyar
University of Minnesota Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota, USA
Cancer Epidemiol Biomarkers Prev 20:91-100. 2011..Data are needed regarding how smokers interested in cessation would use these products, the levels of resultant toxicant exposure, and the feasibility of using these products as aids for tobacco cessation... - Tobacco-specific nitrosamines in new tobacco productsIrina Stepanov
The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Nicotine Tob Res 8:309-13. 2006..These results demonstrate that TSNA levels in new tobacco products range from relatively low to comparable with those found in some conventional brands... - Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Moldovan childrenIrina Stepanov
The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
Cancer Epidemiol Biomarkers Prev 15:7-11. 2006..These results should be useful in heightening the awareness of the dangers of smoking and ETS exposure in this eastern European country... - Changing smokeless tobacco products new tobacco-delivery systemsDorothy K Hatsukami
Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55414, USA
Am J Prev Med 33:S368-78. 2007.... - Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessationDorothy K Hatsukami
University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA
Addiction 105:343-55. 2010..To examine the effects of reduced nicotine cigarettes on smoking behavior, toxicant exposure, dependence and abstinence... - Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokersJian Min Yuan
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Carcinogenesis 32:1366-71. 2011..These findings along with results of previous studies in laboratory animals support a significant and unique role of NNN in esophageal carcinogenesis in humans... - Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco usersIrina Stepanov
The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
Cancer Epidemiol Biomarkers Prev 14:885-91. 2005.... - Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco usersStephen S Hecht
The Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Cancer Epidemiol Biomarkers Prev 17:732-5. 2008..The results of this study also indicate that metabolic activation of NNK to intermediates that can react with DNA is its major pathway of metabolism in smokeless tobacco users... - Tobacco-specific nitrosamines in smokeless tobacco products marketed in IndiaIrina Stepanov
The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Int J Cancer 116:16-9. 2005..The results of our study demonstrate that exposure to substantial amounts of carcinogenic tobacco-specific nitrosamines through use of smokeless tobacco products remains a major problem in India... - Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humansAleksandar Knezevich
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Nicotine Tob Res 15:591-5. 2013..Although the acidic environment of the stomach creates the most favorable conditions for nitrosation, this reaction could also occur in the oral cavity in the presence of bacteria that catalyze nitrosation at neutral pH... - Delivery of nicotine in an extract of a smokeless tobacco product reduces its reinforcement-attenuating and discriminative stimulus effects in ratsAndrew C Harris
Minneapolis Medical Research Foundation, 914 South 8th St, S 3 Labs, 860, Minneapolis, MN 55404, USA
Psychopharmacology (Berl) 220:565-76. 2012..Models using tobacco extracts derived from tobacco products and containing a range of tobacco constituents might more accurately simulate tobacco exposure in humans... - Endogenous formation of N'-nitrosonornicotine in F344 rats in the presence of some antioxidants and grape seed extractDiana Porubin
Department of Industrial and Ecological Chemistry, Moldova State University, 60 A Mateevici Street, Chisinau, Moldova
J Agric Food Chem 55:7199-204. 2007..This is the first study that demonstrates endogenous NNN formation in rats treated with nornicotine and sodium nitrite and effective inhibition of this process by ascorbic acid, dixydroxyfumaric acid, and catechin...