Irina Stepanov

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobacco
    Irina Stepanov
    Department of Industrial and Ecological Chemistry, Moldova State University, MD 2009 Chisinau, Moldova
    J Agric Food Chem 50:2793-7. 2002
  2. ncbi request reprint Monitoring Tobacco-Specific N-Nitrosamines and Nicotine in Novel Smokeless Tobacco Products: Findings From Round II of the New Product Watch
    Irina Stepanov
    Division of Environmental Health Sciences and Masonic Cancer Center, University of Minnesota, Minneapolis, MN
    Nicotine Tob Res 16:1070-8. 2014
  3. pmc Levels of (S)-N'-nitrosonornicotine in U.S. tobacco products
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 15:1305-10. 2013
  4. pmc Increased pouch sizes and resulting changes in the amounts of nicotine and tobacco-specific N-nitrosamines in single pouches of Camel Snus and Marlboro Snus
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE MMC 806, Minneapolis, MN 55455, USA
    Nicotine Tob Res 14:1241-5. 2012
  5. pmc Monitoring tobacco-specific N-nitrosamines and nicotine in novel Marlboro and Camel smokeless tobacco products: findings from Round 1 of the New Product Watch
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 14:274-81. 2012
  6. pmc New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 10:1773-82. 2008
  7. pmc Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:406-14. 2009
  8. pmc Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE Mayo Mail Code 806, Minneapolis, MN 55455, USA
    Nicotine Tob Res 11:99-105. 2009
  9. pmc Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products
    Irina Stepanov
    Masonic Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 69:8236-40. 2009
  10. pmc Analysis of 23 polycyclic aromatic hydrocarbons in smokeless tobacco by gas chromatography-mass spectrometry
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 23:66-73. 2010

Detail Information

Publications34

  1. ncbi request reprint Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobacco
    Irina Stepanov
    Department of Industrial and Ecological Chemistry, Moldova State University, MD 2009 Chisinau, Moldova
    J Agric Food Chem 50:2793-7. 2002
    ..The results of this study should be useful in heightening the awareness of the dangers of smoking in Moldova and can be envisioned as the initial step in the control of tobacco-related cancer in this republic...
  2. ncbi request reprint Monitoring Tobacco-Specific N-Nitrosamines and Nicotine in Novel Smokeless Tobacco Products: Findings From Round II of the New Product Watch
    Irina Stepanov
    Division of Environmental Health Sciences and Masonic Cancer Center, University of Minnesota, Minneapolis, MN
    Nicotine Tob Res 16:1070-8. 2014
    ..In this study, we analyzed snus and dissolvable tobacco products that were purchased in Round II of the NPW...
  3. pmc Levels of (S)-N'-nitrosonornicotine in U.S. tobacco products
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 15:1305-10. 2013
    ..Of its two enantiomers, (S)-NNN exhibits higher tumorigenic potency than (R)-NNN. There is no information available on the levels of (S)-NNN in various tobacco products currently marketed in the United States...
  4. pmc Increased pouch sizes and resulting changes in the amounts of nicotine and tobacco-specific N-nitrosamines in single pouches of Camel Snus and Marlboro Snus
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE MMC 806, Minneapolis, MN 55455, USA
    Nicotine Tob Res 14:1241-5. 2012
    ....
  5. pmc Monitoring tobacco-specific N-nitrosamines and nicotine in novel Marlboro and Camel smokeless tobacco products: findings from Round 1 of the New Product Watch
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 14:274-81. 2012
    ....
  6. pmc New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 10:1773-82. 2008
    ..The large variation in the levels of some toxicants and carcinogens analyzed here indicates that more effort is required from the U.S. tobacco industry to further reduce their amounts in new and traditional smokeless tobacco products...
  7. pmc Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:406-14. 2009
    ..The results support the hypothesis that preferential binding of tobacco carcinogens to mtDNA of the lung might be functionally important in the development of smoking-induced lung cancer...
  8. pmc Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE Mayo Mail Code 806, Minneapolis, MN 55455, USA
    Nicotine Tob Res 11:99-105. 2009
    ..Nitrosation of nicotine or its metabolites in the human body could lead to formation of the 2 carcinogenic tobacco-specific nitrosamines-N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)...
  9. pmc Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products
    Irina Stepanov
    Masonic Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 69:8236-40. 2009
    ..Given the carcinogenicity of NNN and the frequent use of nicotine gum as a smoking cessation aid, further studies are needed so that preventive measures can be developed...
  10. pmc Analysis of 23 polycyclic aromatic hydrocarbons in smokeless tobacco by gas chromatography-mass spectrometry
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 23:66-73. 2010
    ..Urgent measures are required from the U.S. tobacco industry to modify manufacturing processes so that the levels of these toxicants and carcinogens in U.S. moist snuff are greatly reduced...
  11. pmc Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry
    Irina Stepanov
    Masonic Cancer Center and Tobacco Use Research Programs, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Tob Control 21:44-8. 2012
    ..There is no information available on current TSNA levels in tobacco of various cigarettes available in the US, particularly in the newer varieties introduced over the past decade...
  12. pmc Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 17:1764-73. 2008
    ....
  13. pmc Detection and quantitation of N'-nitrosonornicotine in human toenails by liquid chromatography-electrospray ionization-tandem mass spectrometry
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 17:945-8. 2008
    ..58; P = 0.05). The results of this study show the feasibility of quantifying NNN in human toenails, providing a potentially useful new biomarker of tobacco carcinogen exposure...
  14. ncbi request reprint Comparative analysis of tobacco-specific nitrosamines and total N-nitroso compounds in moldovan cigarette tobacco
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    J Agric Food Chem 53:8082-6. 2005
    ..66; P < 0.0001). These findings demonstrate that current technologies involved in the manufacture of some blended cigarettes create conditions that favor N-nitrosation of alkaloids and other tobacco constituents...
  15. ncbi request reprint Relationship of human toenail nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol to levels of these biomarkers in plasma and urine
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 16:1382-6. 2007
    ..53; P = 0.005). The results of this study provide essential validation data for the use of toenail biomarkers in investigations of the role of chronic tobacco smoke exposure in human cancer...
  16. ncbi request reprint Mass spectrometric quantitation of nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human toenails
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 15:2378-83. 2006
    ..These sensitive and quantitative methods should be useful in epidemiologic studies of the role of chronic tobacco smoke exposure, including environmental tobacco smoke exposure, in human cancer...
  17. pmc Urinary tobacco smoke-constituent biomarkers for assessing risk of lung cancer
    Jian Min Yuan
    Authors Affiliations Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
    Cancer Res 74:401-11. 2014
    ....
  18. pmc The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers
    Rachel I Vogel
    Masonic Cancer Center, University of Minnesota, Minneapolis, USA
    Biomarkers 16:491-7. 2011
    ..The total NNAL:total cotinine (×10(3)) ratio may provide an improved biomarker for evaluating the health effects of passive smoking...
  19. pmc Effect of oral snus and medicinal nicotine in smokers on toxicant exposure and withdrawal symptoms: a feasibility study
    Michael Kotlyar
    University of Minnesota Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer Epidemiol Biomarkers Prev 20:91-100. 2011
    ..Data are needed regarding how smokers interested in cessation would use these products, the levels of resultant toxicant exposure, and the feasibility of using these products as aids for tobacco cessation...
  20. pmc Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: remarkable coherence with rat tumor sites
    Irina Stepanov
    Division of Environmental Health Sciences, University of Minnesota, Minneapolis, MN Masonic Cancer Center, University of Minnesota, Minneapolis, MN
    Int J Cancer 134:2278-83. 2014
    ....
  21. ncbi request reprint Tobacco-specific nitrosamines in new tobacco products
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 8:309-13. 2006
    ..These results demonstrate that TSNA levels in new tobacco products range from relatively low to comparable with those found in some conventional brands...
  22. ncbi request reprint Elevated levels of 1-hydroxypyrene and N'-nitrosonornicotine in smokers with head and neck cancer: A matched control study
    Samir S Khariwala
    Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Head Neck 35:1096-100. 2013
    ..Still, most smokers do not develop HNSCC. The mechanisms of varying susceptibility to HNSCC are poorly studied to date. Tobacco metabolite research provides insight regarding the innate metabolism and excretion of carcinogens...
  23. ncbi request reprint Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Moldovan children
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 15:7-11. 2006
    ..These results should be useful in heightening the awareness of the dangers of smoking and ETS exposure in this eastern European country...
  24. pmc Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humans
    Aleksandar Knezevich
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 15:591-5. 2013
    ..Although the acidic environment of the stomach creates the most favorable conditions for nitrosation, this reaction could also occur in the oral cavity in the presence of bacteria that catalyze nitrosation at neutral pH...
  25. ncbi request reprint Changing smokeless tobacco products new tobacco-delivery systems
    Dorothy K Hatsukami
    Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55414, USA
    Am J Prev Med 33:S368-78. 2007
    ....
  26. doi request reprint Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation
    Dorothy K Hatsukami
    University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA
    Addiction 105:343-55. 2010
    ..To examine the effects of reduced nicotine cigarettes on smoking behavior, toxicant exposure, dependence and abstinence...
  27. pmc Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers
    Jian Min Yuan
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 32:1366-71. 2011
    ..These findings along with results of previous studies in laboratory animals support a significant and unique role of NNN in esophageal carcinogenesis in humans...
  28. ncbi request reprint Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 14:885-91. 2005
    ....
  29. doi request reprint Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users
    Stephen S Hecht
    The Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 17:732-5. 2008
    ..The results of this study also indicate that metabolic activation of NNK to intermediates that can react with DNA is its major pathway of metabolism in smokeless tobacco users...
  30. pmc (S)-N'-Nitrosonornicotine, a constituent of smokeless tobacco, is a powerful oral cavity carcinogen in rats
    Silvia Balbo
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 34:2178-83. 2013
    ....
  31. pmc Analysis of 4-Hydroxy-1-(3-pyridyl)-1-butanone (HPB)-Releasing DNA Adducts in Human Exfoliated Oral Mucosa Cells by Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry
    Irina Stepanov
    Masonic Cancer Center and Division of Environmental Health Sciences, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, United States
    Chem Res Toxicol 26:37-45. 2013
    ..73, p < 0.0001). Potentially, the method can be applied in studies of individual susceptibility to tobacco-induced cancers in humans. ..
  32. ncbi request reprint Tobacco-specific nitrosamines in smokeless tobacco products marketed in India
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Cancer 116:16-9. 2005
    ..The results of our study demonstrate that exposure to substantial amounts of carcinogenic tobacco-specific nitrosamines through use of smokeless tobacco products remains a major problem in India...
  33. pmc Delivery of nicotine in an extract of a smokeless tobacco product reduces its reinforcement-attenuating and discriminative stimulus effects in rats
    Andrew C Harris
    Minneapolis Medical Research Foundation, 914 South 8th St, S 3 Labs, 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 220:565-76. 2012
    ..Models using tobacco extracts derived from tobacco products and containing a range of tobacco constituents might more accurately simulate tobacco exposure in humans...
  34. ncbi request reprint Endogenous formation of N'-nitrosonornicotine in F344 rats in the presence of some antioxidants and grape seed extract
    Diana Porubin
    Department of Industrial and Ecological Chemistry, Moldova State University, 60 A Mateevici Street, Chisinau, Moldova
    J Agric Food Chem 55:7199-204. 2007
    ..This is the first study that demonstrates endogenous NNN formation in rats treated with nornicotine and sodium nitrite and effective inhibition of this process by ascorbic acid, dixydroxyfumaric acid, and catechin...