Kurt R Stenmark

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall
    Maria G Frid
    Department of Pediatrics, University of Colorado Denver, Aurora, 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1059-72. 2009
  2. ncbi request reprint Hypoxia, leukocytes, and the pulmonary circulation
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    J Appl Physiol (1985) 98:715-21. 2005
  3. ncbi request reprint Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
    Kurt R Stenmark
    Department of Pediatrics, Developmental Lung Biology Laboratory, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Circ Res 99:675-91. 2006
  4. ncbi request reprint Role of the adventitia in pulmonary vascular remodeling
    Kurt R Stenmark
    Division of Pediatric Critical Care, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Physiology (Bethesda) 21:134-45. 2006
  5. ncbi request reprint Hypoxic activation of adventitial fibroblasts: role in vascular remodeling
    Kurt R Stenmark
    Developmental Lung Biology Research Laboratory, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 122:326S-334S. 2002
  6. ncbi request reprint Lung vascular development: breathing new life into an old problem
    Kurt R Stenmark
    Department of Pediatrics, Developmental Lung Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Respir Cell Mol Biol 28:133-7. 2003
  7. ncbi request reprint Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado 80262, USA
    Annu Rev Physiol 67:623-61. 2005
  8. pmc PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells
    Heather N Woodward
    Department of Pediatrics, 12700 E 19th Ave, University of Colorado Denver, Research Complex 2, Box B131, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L954-64. 2009
  9. pmc Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage
    Maria G Frid
    Department of Pediatrics, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Pathol 168:659-69. 2006
  10. pmc Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells
    Evgenia V Gerasimovskaya
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, B131, 4200 East 9th Ave, Denver, CO 80262, USA
    Angiogenesis 11:169-82. 2008

Research Grants

Collaborators

Detail Information

Publications64

  1. pmc Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall
    Maria G Frid
    Department of Pediatrics, University of Colorado Denver, Aurora, 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1059-72. 2009
    ..These data suggest that the cellular mechanisms of dPA remodeling include the emergence of cells with phenotypic and functional characteristics markedly distinct from those of resident dPA cells...
  2. ncbi request reprint Hypoxia, leukocytes, and the pulmonary circulation
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    J Appl Physiol (1985) 98:715-21. 2005
    ....
  3. ncbi request reprint Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
    Kurt R Stenmark
    Department of Pediatrics, Developmental Lung Biology Laboratory, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Circ Res 99:675-91. 2006
    ..This review provides perspectives on each of the aforementioned areas...
  4. ncbi request reprint Role of the adventitia in pulmonary vascular remodeling
    Kurt R Stenmark
    Division of Pediatric Critical Care, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Physiology (Bethesda) 21:134-45. 2006
    ..The purpose of this review is to present the current evidence demonstrating that the adventitial fibroblast acts as a key regulator of pulmonary vascular function and structure from the "outside-in."..
  5. ncbi request reprint Hypoxic activation of adventitial fibroblasts: role in vascular remodeling
    Kurt R Stenmark
    Developmental Lung Biology Research Laboratory, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 122:326S-334S. 2002
    ....
  6. ncbi request reprint Lung vascular development: breathing new life into an old problem
    Kurt R Stenmark
    Department of Pediatrics, Developmental Lung Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Respir Cell Mol Biol 28:133-7. 2003
  7. ncbi request reprint Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado 80262, USA
    Annu Rev Physiol 67:623-61. 2005
    ..We speculate that understanding basic mechanisms that regulate and determine vascular growth will lead to new clinical strategies to improve the long-term outcome of premature babies with BPD...
  8. pmc PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells
    Heather N Woodward
    Department of Pediatrics, 12700 E 19th Ave, University of Colorado Denver, Research Complex 2, Box B131, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L954-64. 2009
    ..Taken together, our findings provide novel evidence for the signaling mechanisms that link hypoxia-induced increases in extracellular ATP and vasa vasorum expansion...
  9. pmc Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage
    Maria G Frid
    Department of Pediatrics, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Pathol 168:659-69. 2006
    ..We conclude that circulating mesenchymal precursors of a monocyte/macrophage lineage, including fibrocytes, are essential contributors to hypoxia-induced pulmonary vascular remodeling...
  10. pmc Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells
    Evgenia V Gerasimovskaya
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, B131, 4200 East 9th Ave, Denver, CO 80262, USA
    Angiogenesis 11:169-82. 2008
    ..Collectively, our data support the idea that extracellular ATP participates in the expansion of the vasa vasorum that can be observed in hypoxic conditions...
  11. ncbi request reprint Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts
    Megan Short
    Department of Pediatrics, Developmental Lung Biology Research Laboratories, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 286:C416-25. 2004
    ....
  12. pmc Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension
    Adil Anwar
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 303:L1-L11. 2012
    ..Thus our data suggest OPN as an essential contributor to the activated (highly proliferative, migratory, and proinvasive) phenotype of pulmonary adventitial fibroblasts in hypoxic PH...
  13. pmc Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia
    Tanya Hartney
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 6:e27531. 2011
    ..We conclude that an oxidant/antioxidant imbalance arising from loss of EC-SOD in the PA with chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling...
  14. doi request reprint Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitia
    Mita Das
    Department of Pediatrics, B131, University of Colorado Denver, School of Medicine, 4200 E 9th Avenue, Denver, CO 80262, USA
    Cardiovasc Res 78:440-8. 2008
    ....
  15. ncbi request reprint The adventitia: Essential role in pulmonary vascular remodeling
    Kurt R Stenmark
    University of Colorado Denver Pediatric Critical Care, Aurora, Colorado, USA
    Compr Physiol 1:141-61. 2011
    ..This review presents the current evidence demonstrating that the adventitia acts as a key regulator of pulmonary vascular wall function and structure from the "outside in."..
  16. pmc The adventitia: essential regulator of vascular wall structure and function
    Kurt R Stenmark
    Division of Pediatric Critical Care, University of Colorado Denver, Aurora, Colorado 80045, USA
    Annu Rev Physiol 75:23-47. 2013
    ..This review presents the current evidence demonstrating that the adventitia acts as a key regulator of vascular wall function and structure from the outside in...
  17. pmc Effects of pathological flow on pulmonary artery endothelial production of vasoactive mediators and growth factors
    Min Li
    Department of Pediatrics and CVP Research, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    J Vasc Res 46:561-71. 2009
    ..We therefore examined effects of pathologically low and high flow on endothelial production of factors capable of affecting pulmonary vascular tone and structure as well as on potential underlying mechanisms...
  18. pmc Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension
    Min Li
    Division of Critical Care Medicine, Department of Pediatrics, University of Colorado at Denver, Aurora, CO 80045, USA
    J Immunol 187:2711-22. 2011
    ....
  19. pmc Pulmonary artery adventitial fibroblasts cooperate with vasa vasorum endothelial cells to regulate vasa vasorum neovascularization: a process mediated by hypoxia and endothelin-1
    Neil J Davie
    Department of Pediatric Cardiology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box C218, Denver, CO 80262, USA
    Am J Pathol 168:1793-807. 2006
    ....
  20. ncbi request reprint Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation
    Evgenia V Gerasimovskaya
    Developmental Lung Biology Laboratory, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    J Appl Physiol (1985) 98:722-31. 2005
    ....
  21. ncbi request reprint Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of rapamycin, and p70 S6 kinase signaling pathways
    Evgenia V Gerasimovskaya
    Developmental Lung Biology Laboratory, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 280:1838-48. 2005
    ....
  22. pmc Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression
    Megan D Short
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Mol Biol Cell 17:1995-2008. 2006
    ....
  23. pmc Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling
    Zachary Van Rheen
    Department of Pediatrics, University of Colorado, Aurora, CO 80045, USA
    Am J Respir Cell Mol Biol 44:500-8. 2011
    ....
  24. ncbi request reprint Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells
    Neil J Davie
    Developmental Lung Biology Group, UCHSC, 4200 East 9 th Ave, Rm 3419, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 286:L668-78. 2004
    ..From these observations, we suggest that the vasa vasorum and circulating progenitor cells could be involved in vessel wall thickening in the setting of hypoxia-induced PH...
  25. ncbi request reprint Extracellular adenosine triphosphate: a potential regulator of vasa vasorum neovascularization in hypoxia-induced pulmonary vascular remodeling
    Evgenia V Gerasimovskaya
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 128:608S-610S. 2005
  26. ncbi request reprint Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts
    Mark F Banks
    Developmental Lung Biology Laboratory, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    J Appl Physiol (1985) 98:732-8. 2005
    ..We conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells...
  27. ncbi request reprint Circulating mononuclear cells with a dual, macrophage-fibroblast phenotype contribute robustly to hypoxia-induced pulmonary adventitial remodeling
    Maria G Frid
    University of Colorado Health Sciences Center, Developmental Lung Biology Research Laboratory, Denver, CO 80262, USA
    Chest 128:583S-584S. 2005
  28. pmc Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves
    Steven R Lammers
    Mechanical Engineering, University of Colorado, Boulder, Colorado, USA
    Am J Physiol Heart Circ Physiol 295:H1451-9. 2008
    ..These results indicate that mechanobiological adaptations of the continuum and geometric properties of elastin, in response to PAH, significantly elevate the circumferential stiffness of proximal pulmonary arterial tissue...
  29. ncbi request reprint Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN
    Peter M Mourani
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Circulation 109:1299-306. 2004
    ..The aim of the present study was to evaluate the functional role of S6 ribosomal protein (S6RP) and upstream positive and negative regulators in the control of SMC serum-independent growth...
  30. ncbi request reprint Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling
    Joseph T Crossno
    Pulmonary and Critical Care Services, Veterans Affairs Medical Center, Denver, USA
    Am J Physiol Lung Cell Mol Physiol 292:L885-97. 2007
    ..However, this agent fails to block the development of PH, apparently because of its inability to repress sustained Rho kinase-mediated arterial vasoconstriction...
  31. ncbi request reprint Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor
    Evgenia V Gerasimovskaya
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:44638-50. 2002
    ..We conclude that hypoxia induces ATP release from endothelial cells and fibroblasts and that the activation of P2 purinoceptors is involved in the regulation of DNA synthesis by fibroblasts under hypoxic conditions...
  32. ncbi request reprint Bovine distal pulmonary arterial media is composed of a uniform population of well-differentiated smooth muscle cells with low proliferative capabilities
    Leopold Stiebellehner
    Developmental Lung Biology Research, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 285:L819-28. 2003
    ..We thus speculate that distinct SMC phenotypes present in distal vs. proximal PA may confer different response mechanisms during remodeling in conditions such as hypertension...
  33. pmc MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension
    R Dale Brown
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Heart Circ Physiol 304:H269-81. 2013
    ..Therapies targeting MEKK2 may protect the myocardium from hypertrophy and pathological remodeling in human PH...
  34. doi request reprint Validation of a pressure diameter method for determining modulus and strain of collagen engagement for long branches of bovine pulmonary arteries
    Mark Reusser
    Department of Bioengineering, University of Colorado, Denver, CO 80045, USA
    J Biomech Eng 134:054501. 2012
    ..The method allowed faster testing of tissues of multiple diameters, while removing the effect of end conditions. The PD method will be of further utility in continued study of tissue mechanics in pulmonary hypertension studies...
  35. pmc Linked opening angle and histological and mechanical aspects of the proximal pulmonary arteries of healthy and pulmonary hypertensive rats and calves
    Lian Tian
    Department of Mechanical Engineering, University of Colorado, Boulder, Colorado, USA
    Am J Physiol Heart Circ Physiol 301:H1810-8. 2011
    ..We conclude that the arterial remodeling in rat and calf proximal PAs is different and the change of opening angle can be linked to the change of the arterial histological structure and mechanics...
  36. pmc Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling
    Eva Nozik-Grayck
    Department of Pediatrics, Univ of Colorado, Denver, 4200 E 9th Ave, B131, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 295:L422-30. 2008
    ..These data provide the first evidence that EC-SOD activity is disrupted in chronic hypoxia, and increased EC-SOD activity can attenuate chronic hypoxic PH by limiting the hypoxic upregulation of redox-sensitive genes...
  37. pmc Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administration
    Margaret B Clarke
    Pediatric Critical Care, Department of Pediatrics, University of Colorado at Denver, Aurora, CO 80045, USA
    Free Radic Biol Med 49:2032-9. 2010
    ..Further testing in models of chronic lung or pulmonary vascular diseases mediated by excess superoxide should consider the longer tissue half-life of SOD2/3 as well as its potential systemic vascular effects...
  38. ncbi request reprint Hypoxia-induced alterations in protein kinase C zeta signaling result in augmented fibroblast proliferation
    Megan Short
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 128:582S. 2005
  39. pmc P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells
    Taras Lyubchenko
    Dept of Pediatrics, University of Colorado Denver, Research 2, Box B131, Aurora, CO 80045, USA
    Am J Physiol Cell Physiol 300:C266-75. 2011
    ....
  40. ncbi request reprint Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development
    Janet M Wenzlau
    Department of Renal Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Circ Res 98:846-55. 2006
    ..These data suggest the EGAP NAT complex is an essential regulatory enzyme controlling the function of a subset of proteins required for embryonic growth control and vessel development...
  41. ncbi request reprint Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of phosphatidylinositol 3-kinase
    Shama Ahmad
    Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 28:179-87. 2003
    ..These results indicate that hypoxia-induced activation of PI3-K is an important event in the acquisition of resistance against subsequent hyperoxic toxicity...
  42. ncbi request reprint Mechanics and function of the pulmonary vasculature: implications for pulmonary vascular disease and right ventricular function
    Steven Lammers
    Department of Cardiovascular Pulmonary Research, University of Colorado Denver, Aurora, Colorado, USA
    Compr Physiol 2:295-319. 2012
    ..Here, we investigate systems-level changes associated with pulmonary hypertensive disease progression in an effort to better understand this coupled relationship...
  43. pmc Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury
    Todd C Carpenter
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, 80045, USA
    Am J Respir Cell Mol Biol 46:40-7. 2012
    ..This study demonstrates that the expression of EphA2 increases in the injured lung, and not only contributes to changes in permeability, but also plays a previously unrecognized role in promoting inflammatory responses...
  44. ncbi request reprint Yin and Yang of an endothelial cell: from normal to the extreme in growth, secretion, and transdifferentiation capabilities
    Maria G Frid
    Pediatric Critical Care, University of Colorado Health Sciences Center, Box B131, 4200 E 9th Avenue, Denver, CO 80262, USA
    Paediatr Respir Rev 5:S253-7. 2004
  45. pmc Plasma proteomics of differential outcome to long-term therapy in children with idiopathic pulmonary arterial hypertension
    Michael E Yeager
    Department of Pediatric Critical Care, University of Colorado Denver, Denver, CO 80045, USA
    Proteomics Clin Appl 6:257-67. 2012
    ..The prognosis for children with IPAH unresponsive to therapy is poor. We investigated the plasma proteome for a molecular basis of good versus poor outcome to long-term vasodilator therapy...
  46. ncbi request reprint Induction of SM-alpha-actin expression by mechanical strain in adult vascular smooth muscle cells is mediated through activation of JNK and p38 MAP kinase
    Jenny Tock
    Department of Pediatrics, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Box C 281, 4200 E Ninth Ave, Denver, CO 80262, USA
    Biochem Biophys Res Commun 301:1116-21. 2003
    ..These studies indicate that in adult VSMC, mechanical strain leads to increased expression of smooth muscle markers, resulting in a more contractile phenotype...
  47. ncbi request reprint Distensibility of the normal human lung circulation during exercise
    John T Reeves
    University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 288:L419-25. 2005
    ..We propose that the estimation of pulmonary vascular distensibility in humans may be a useful descriptor of pulmonary hemodynamics...
  48. pmc Activation of the unfolded protein response is associated with pulmonary hypertension
    Michael E Yeager
    Department of Pediatrics, Division of Pulmonary and Critical Care Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Pulm Circ 2:229-40. 2012
    ..As such, understanding the functional contributions of the UPR in the setting of PH may have important therapeutic implications...
  49. pmc Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change
    Kurt R Stenmark
    Department of Pediatric Gastroenterology, Pediatric Critical Care Developmental Lung Biology Laboratory, University of Colorado, Aurora, Colorado, USA
    Pulm Circ 2:3-14. 2012
    ..At present, therapies specifically targeting abnormalities of histone deacytelase (HDAC) activity in fibroblast-like cells appear to hold promise...
  50. doi request reprint Emerging therapies for the treatment of pulmonary hypertension
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, University of Colorado Denver, Aurora, CO, USA
    Pediatr Crit Care Med 11:S85-90. 2010
    ....
  51. ncbi request reprint Predisposition of infants with chronic lung disease to respiratory syncytial virus-induced respiratory failure: a vascular hypothesis
    Todd C Carpenter
    Developmental Lung Biology Laboratory, University of Colorado Health Sciences Center, Denver, 80602, USA
    Pediatr Infect Dis J 23:S33-40. 2004
    ..e. impaired alveolar and pulmonary vascular development). This article describes potential mechanisms by which RSV infection causes respiratory failure in the infant with BPD...
  52. ncbi request reprint Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis
    Maria G Frid
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Circ Res 90:1189-96. 2002
    ....
  53. ncbi request reprint Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling
    Eva Nozik-Grayck
    Department of Pediatrics and Developmental Lung Biology Laboratory, University of Colorado at Denver and Health Science Center, Denver, Colorado, USA
    Adv Exp Med Biol 618:101-12. 2007
    ....
  54. ncbi request reprint Connective tissue growth factor expression is increased in biliary epithelial cells in biliary atresia
    Michael R Narkewicz
    Department of Pediatrics, The Pediatric Liver Center, The Children s Hospital, University of Colorado School of Medicine, Denver, CO 80218, USA
    J Pediatr Surg 40:1721-5. 2005
    ..The objective of this study was to evaluate hepatic CTGF messenger RNA (mRNA) expression and its relationship to hepatic histology in children with BA...
  55. ncbi request reprint Hypoxia reversibly inhibits epithelial sodium transport but does not inhibit lung ENaC or Na-K-ATPase expression
    Todd C Carpenter
    Department of Pediatrics and Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 284:L77-83. 2003
    ....
  56. ncbi request reprint Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia
    Todd C Carpenter
    Developmental Lung Biology Laboratory, Box B 131, University of Colorado School of Medicine, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1075-82. 2005
    ..These findings suggest that ET-driven increases in lung VEGF content can contribute to the formation of pulmonary edema...
  57. pmc Complementary effects of extracellular nucleotides and platelet-derived extracts on angiogenesis of vasa vasorum endothelial cells in vitro and subcutaneous Matrigel plugs in vivo
    Mark Roedersheimer
    Department of Pediatrics, University of Colorado Denver, 12700 East 19th Ave, Aurora, CO 80045, USA
    Vasc Cell 3:4. 2011
    ..abstract:..
  58. pmc Circulating myeloid-derived suppressor cells are increased and activated in pulmonary hypertension
    Michael E Yeager
    Department of Pediatrics, Division of Pulmonary and Critical Care Medicine, University of Colorado, Denver, Aurora, CO 80045, USA
    Chest 141:944-52. 2012
    ..Immature myeloid cells are found in the lungs of humans and animals with PH, and we hypothesized that they would be increased in the blood of patients with PH compared with control subjects...
  59. pmc Progenitor cells in pulmonary vascular remodeling
    Michael E Yeager
    Department of Pediatrics and Critical Care, University of Colorado at Denver and Health Sciences Center, Colorado, USA
    Pulm Circ 1:3-16. 2011
    ....
  60. pmc Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling
    Heather A Walker
    Department of Pediatrics, Renal Division, University of Colorado Health Sciences Center, Denver 80262, USA
    Mol Biol Cell 14:1941-52. 2003
    ..FRNK, in turn, may control SMC growth by downregulating FAK-dependent signaling events...
  61. ncbi request reprint Cellular and molecular pathobiology of pulmonary arterial hypertension
    Marc Humbert
    Service de Pneumologie et Reanimation Respiratoire, Centre des Maladies Vasculaires Pulmonaires, UPRES EA2705, Hopital Antoine Beclere, Universite Paris Sud, Clamart, France
    J Am Coll Cardiol 43:13S-24S. 2004
    ..Disordered proteolysis of the extracellular matrix is also evident in PAH. Future studies are required to find which if any of these abnormalities initiates PAH and which ones are best targeted to cure the disease...
  62. ncbi request reprint Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal?
    Kurt R Stenmark
    Circ Res 97:95-8. 2005
  63. ncbi request reprint Angiogenic therapy for bronchopulmonary dysplasia: rationale and promise
    Kurt R Stenmark
    Circulation 112:2383-5. 2005
  64. ncbi request reprint Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension
    Enrique Arciniegas
    Laboratorio de Microscopía Electrónica, Servicio Autónomo Instituto de Biomedicina, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela
    Am J Physiol Lung Cell Mol Physiol 293:L1-8. 2007
    ..Thus insights into the mechanisms controlling endothelial-mesenchymal transition are relevant to vascular remodeling and are important as we consider new therapies aimed at reversing pulmonary vascular remodeling...

Research Grants5

  1. Lung Vascular Disease in Infants and Children: Mechanisms and Treatment
    Kurt Stenmark; Fiscal Year: 2007
    ..End of Abstract) ..
  2. RESPIRATION AND CIRCULATION DURING HYPOXIA
    Kurt Stenmark; Fiscal Year: 2007
    ..The program director, with the advice and consent of the senior program faculty is responsible for the administration and coordination of the program. ..