Kurt R Stenmark

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi request reprint Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure
    Kurt R Stenmark
    Univ of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1013-32. 2009
  2. pmc Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension
    Kurt R Stenmark
    Division of Critical Care Medicine, Department of Pediatrics, University of Colorado, Anschutz Medical Campus, Denver, Colorado Cardiovascular Pulmonary Research Laboratories, Department of Medicine, University of Colorado, Anschutz Medical Campus, Denver, Colorado and
    J Appl Physiol (1985) 119:1164-72. 2015
  3. pmc Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change
    Kurt R Stenmark
    Department of Pediatric Gastroenterology, Pediatric Critical Care Developmental Lung Biology Laboratory, University of Colorado, Aurora, Colorado, USA
    Pulm Circ 2:3-14. 2012
  4. pmc Progenitor cells in pulmonary vascular remodeling
    Michael E Yeager
    Department of Pediatrics and Critical Care, University of Colorado at Denver and Health Sciences Center, Colorado, USA
    Pulm Circ 1:3-16. 2011
  5. pmc The adventitia: Essential role in pulmonary vascular remodeling
    Kurt R Stenmark
    University of Colorado Denver Pediatric Critical Care, Aurora, Colorado, USA
    Compr Physiol 1:141-61. 2011
  6. pmc The adventitia: essential regulator of vascular wall structure and function
    Kurt R Stenmark
    Division of Pediatric Critical Care, University of Colorado Denver, Aurora, Colorado 80045, USA
    Annu Rev Physiol 75:23-47. 2013
  7. pmc Physiologic and molecular consequences of endothelial Bmpr2 mutation
    Susan Majka
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Respir Res 12:84. 2011
  8. doi request reprint Emerging therapies for the treatment of pulmonary hypertension
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, University of Colorado Denver, Aurora, CO, USA
    Pediatr Crit Care Med 11:S85-90. 2010
  9. pmc PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells
    Heather N Woodward
    Department of Pediatrics, 12700 E 19th Ave, University of Colorado Denver, Research Complex 2, Box B131, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L954-64. 2009
  10. pmc Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension
    Min Li
    Division of Critical Care Medicine, Department of Pediatrics, University of Colorado at Denver, Aurora, CO 80045, USA
    J Immunol 187:2711-22. 2011

Detail Information

Publications77

  1. doi request reprint Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure
    Kurt R Stenmark
    Univ of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1013-32. 2009
    ..This review highlights progress that has been made in animal modeling of this important human condition...
  2. pmc Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension
    Kurt R Stenmark
    Division of Critical Care Medicine, Department of Pediatrics, University of Colorado, Anschutz Medical Campus, Denver, Colorado Cardiovascular Pulmonary Research Laboratories, Department of Medicine, University of Colorado, Anschutz Medical Campus, Denver, Colorado and
    J Appl Physiol (1985) 119:1164-72. 2015
    ..This review discusses metabolic and inflammatory changes in fibroblasts and Mϕ in PH with the goal of raising ideas about new interventions to abrogate remodeling in hypoxic forms of PH...
  3. pmc Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change
    Kurt R Stenmark
    Department of Pediatric Gastroenterology, Pediatric Critical Care Developmental Lung Biology Laboratory, University of Colorado, Aurora, Colorado, USA
    Pulm Circ 2:3-14. 2012
    ..At present, therapies specifically targeting abnormalities of histone deacytelase (HDAC) activity in fibroblast-like cells appear to hold promise...
  4. pmc Progenitor cells in pulmonary vascular remodeling
    Michael E Yeager
    Department of Pediatrics and Critical Care, University of Colorado at Denver and Health Sciences Center, Colorado, USA
    Pulm Circ 1:3-16. 2011
    ....
  5. pmc The adventitia: Essential role in pulmonary vascular remodeling
    Kurt R Stenmark
    University of Colorado Denver Pediatric Critical Care, Aurora, Colorado, USA
    Compr Physiol 1:141-61. 2011
    ..This review presents the current evidence demonstrating that the adventitia acts as a key regulator of pulmonary vascular wall function and structure from the "outside in."..
  6. pmc The adventitia: essential regulator of vascular wall structure and function
    Kurt R Stenmark
    Division of Pediatric Critical Care, University of Colorado Denver, Aurora, Colorado 80045, USA
    Annu Rev Physiol 75:23-47. 2013
    ..This review presents the current evidence demonstrating that the adventitia acts as a key regulator of vascular wall function and structure from the outside in...
  7. pmc Physiologic and molecular consequences of endothelial Bmpr2 mutation
    Susan Majka
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Respir Res 12:84. 2011
    ..Most hereditary PAH is associated with BMPR2 mutations. However, the physiologic and molecular consequences of expression of BMPR2 mutations in PMVEC are unknown...
  8. doi request reprint Emerging therapies for the treatment of pulmonary hypertension
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, University of Colorado Denver, Aurora, CO, USA
    Pediatr Crit Care Med 11:S85-90. 2010
    ....
  9. pmc PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells
    Heather N Woodward
    Department of Pediatrics, 12700 E 19th Ave, University of Colorado Denver, Research Complex 2, Box B131, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L954-64. 2009
    ..Taken together, our findings provide novel evidence for the signaling mechanisms that link hypoxia-induced increases in extracellular ATP and vasa vasorum expansion...
  10. pmc Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension
    Min Li
    Division of Critical Care Medicine, Department of Pediatrics, University of Colorado at Denver, Aurora, CO 80045, USA
    J Immunol 187:2711-22. 2011
    ....
  11. pmc Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells
    Evgenia V Gerasimovskaya
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, B131, 4200 East 9th Ave, Denver, CO 80262, USA
    Angiogenesis 11:169-82. 2008
    ..Collectively, our data support the idea that extracellular ATP participates in the expansion of the vasa vasorum that can be observed in hypoxic conditions...
  12. pmc Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage
    Maria G Frid
    Department of Pediatrics, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Pathol 168:659-69. 2006
    ..We conclude that circulating mesenchymal precursors of a monocyte/macrophage lineage, including fibrocytes, are essential contributors to hypoxia-induced pulmonary vascular remodeling...
  13. pmc Effects of pathological flow on pulmonary artery endothelial production of vasoactive mediators and growth factors
    Min Li
    Department of Pediatrics and CVP Research, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    J Vasc Res 46:561-71. 2009
    ..We therefore examined effects of pathologically low and high flow on endothelial production of factors capable of affecting pulmonary vascular tone and structure as well as on potential underlying mechanisms...
  14. pmc Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall
    Maria G Frid
    Department of Pediatrics, University of Colorado Denver, Aurora, 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1059-72. 2009
    ..These data suggest that the cellular mechanisms of dPA remodeling include the emergence of cells with phenotypic and functional characteristics markedly distinct from those of resident dPA cells...
  15. ncbi request reprint Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts
    Megan Short
    Department of Pediatrics, Developmental Lung Biology Research Laboratories, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 286:C416-25. 2004
    ....
  16. pmc Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment
    Danielle L Burke
    Department of Pediatrics and Medicine, University of Colorado Denver, USA
    Am J Physiol Lung Cell Mol Physiol 297:L238-50. 2009
    ....
  17. doi request reprint Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitia
    Mita Das
    Department of Pediatrics, B131, University of Colorado Denver, School of Medicine, 4200 E 9th Avenue, Denver, CO 80262, USA
    Cardiovasc Res 78:440-8. 2008
    ....
  18. pmc Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia
    Tanya Hartney
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 6:e27531. 2011
    ..We conclude that an oxidant/antioxidant imbalance arising from loss of EC-SOD in the PA with chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling...
  19. pmc Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension
    Adil Anwar
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 303:L1-L11. 2012
    ..Thus our data suggest OPN as an essential contributor to the activated (highly proliferative, migratory, and proinvasive) phenotype of pulmonary adventitial fibroblasts in hypoxic PH...
  20. pmc Pulmonary artery adventitial fibroblasts cooperate with vasa vasorum endothelial cells to regulate vasa vasorum neovascularization: a process mediated by hypoxia and endothelin-1
    Neil J Davie
    Department of Pediatric Cardiology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box C218, Denver, CO 80262, USA
    Am J Pathol 168:1793-807. 2006
    ....
  21. ncbi request reprint Role of the adventitia in pulmonary vascular remodeling
    Kurt R Stenmark
    Division of Pediatric Critical Care, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Physiology (Bethesda) 21:134-45. 2006
    ..The purpose of this review is to present the current evidence demonstrating that the adventitial fibroblast acts as a key regulator of pulmonary vascular function and structure from the "outside-in."..
  22. ncbi request reprint Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of rapamycin, and p70 S6 kinase signaling pathways
    Evgenia V Gerasimovskaya
    Developmental Lung Biology Laboratory, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 280:1838-48. 2005
    ....
  23. ncbi request reprint Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation
    Evgenia V Gerasimovskaya
    Developmental Lung Biology Laboratory, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    J Appl Physiol (1985) 98:722-31. 2005
    ....
  24. pmc Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling
    Zachary Van Rheen
    Department of Pediatrics, University of Colorado, Aurora, CO 80045, USA
    Am J Respir Cell Mol Biol 44:500-8. 2011
    ....
  25. pmc High pulsatility flow induces adhesion molecule and cytokine mRNA expression in distal pulmonary artery endothelial cells
    Min Li
    Department of Pediatrics Cardiology, The Children s Hospital, University of Colorado at Denver, Aurora, CO 80045, USA
    Ann Biomed Eng 37:1082-92. 2009
    ..Thus, this study was designed to examine the responses of the microvascular pulmonary endothelium to changes in flow pulsatility...
  26. pmc Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression
    Megan D Short
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Mol Biol Cell 17:1995-2008. 2006
    ....
  27. pmc A microstructurally driven model for pulmonary artery tissue
    Philip H Kao
    Department of Mechanical Engineering, University of Colorado, Boulder, CO 80309, USA
    J Biomech Eng 133:051002. 2011
    ..These advancements result in a microstructural total crimped fiber model of pulmonary artery tissue mechanics, which demonstrates good quality of fit and flexibility for modeling varied mechanical behaviors encountered in disease states...
  28. pmc Linked opening angle and histological and mechanical aspects of the proximal pulmonary arteries of healthy and pulmonary hypertensive rats and calves
    Lian Tian
    Department of Mechanical Engineering, University of Colorado, Boulder, Colorado, USA
    Am J Physiol Heart Circ Physiol 301:H1810-8. 2011
    ..We conclude that the arterial remodeling in rat and calf proximal PAs is different and the change of opening angle can be linked to the change of the arterial histological structure and mechanics...
  29. pmc Impact of residual stretch and remodeling on collagen engagement in healthy and pulmonary hypertensive calf pulmonary arteries at physiological pressures
    Lian Tian
    Department of Mechanical Engineering, University of Colorado, Boulder, CO, USA
    Ann Biomed Eng 40:1419-33. 2012
    ..It is concluded that the residual stretch and arterial remodeling have strong impact on the in vivo stretch state and the collagen engagement and thus the mechanical behavior of the main pulmonary artery in calves...
  30. ncbi request reprint Extracellular adenosine triphosphate: a potential regulator of vasa vasorum neovascularization in hypoxia-induced pulmonary vascular remodeling
    Evgenia V Gerasimovskaya
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 128:608S-610S. 2005
  31. ncbi request reprint Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN
    Peter M Mourani
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Circulation 109:1299-306. 2004
    ..The aim of the present study was to evaluate the functional role of S6 ribosomal protein (S6RP) and upstream positive and negative regulators in the control of SMC serum-independent growth...
  32. ncbi request reprint Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling
    Joseph T Crossno
    Pulmonary and Critical Care Services, Veterans Affairs Medical Center, Denver, USA
    Am J Physiol Lung Cell Mol Physiol 292:L885-97. 2007
    ..However, this agent fails to block the development of PH, apparently because of its inability to repress sustained Rho kinase-mediated arterial vasoconstriction...
  33. ncbi request reprint Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
    Kurt R Stenmark
    Department of Pediatrics, Developmental Lung Biology Laboratory, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Circ Res 99:675-91. 2006
    ..This review provides perspectives on each of the aforementioned areas...
  34. ncbi request reprint Circulating mononuclear cells with a dual, macrophage-fibroblast phenotype contribute robustly to hypoxia-induced pulmonary adventitial remodeling
    Maria G Frid
    University of Colorado Health Sciences Center, Developmental Lung Biology Research Laboratory, Denver, CO 80262, USA
    Chest 128:583S-584S. 2005
  35. pmc In vivo measurement of proximal pulmonary artery elastic modulus in the neonatal calf model of pulmonary hypertension: development and ex vivo validation
    Kendall S Hunter
    Center for Bioengineering, University of Colorado at Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    J Appl Physiol (1985) 108:968-75. 2010
    ..Such measurements may be a valuable tool in the diagnosis and treatment of human PH...
  36. pmc Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves
    Steven R Lammers
    Mechanical Engineering, University of Colorado, Boulder, Colorado, USA
    Am J Physiol Heart Circ Physiol 295:H1451-9. 2008
    ..These results indicate that mechanobiological adaptations of the continuum and geometric properties of elastin, in response to PAH, significantly elevate the circumferential stiffness of proximal pulmonary arterial tissue...
  37. ncbi request reprint Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts
    Mark F Banks
    Developmental Lung Biology Laboratory, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    J Appl Physiol (1985) 98:732-8. 2005
    ..We conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells...
  38. ncbi request reprint Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells
    Neil J Davie
    Developmental Lung Biology Group, UCHSC, 4200 East 9 th Ave, Rm 3419, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 286:L668-78. 2004
    ..From these observations, we suggest that the vasa vasorum and circulating progenitor cells could be involved in vessel wall thickening in the setting of hypoxia-induced PH...
  39. ncbi request reprint Hypoxic activation of adventitial fibroblasts: role in vascular remodeling
    Kurt R Stenmark
    Developmental Lung Biology Research Laboratory, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 122:326S-334S. 2002
    ....
  40. pmc MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension
    R Dale Brown
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Heart Circ Physiol 304:H269-81. 2013
    ..Therapies targeting MEKK2 may protect the myocardium from hypertrophy and pathological remodeling in human PH...
  41. pmc High proliferative potential endothelial colony-forming cells contribute to hypoxia-induced pulmonary artery vasa vasorum neovascularization
    Hala Nijmeh
    Univ of Colorado Denver, Pediatric Critical Care Medicine, Box B131, Research 2, Rm 6119, 12700 E 19th Ave, Aurora, CO 80045
    Am J Physiol Lung Cell Mol Physiol 306:L661-71. 2014
    ..These cells may serve as a potential target for regulating VVEC neovascularization. ..
  42. ncbi request reprint Bovine distal pulmonary arterial media is composed of a uniform population of well-differentiated smooth muscle cells with low proliferative capabilities
    Leopold Stiebellehner
    Developmental Lung Biology Research, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 285:L819-28. 2003
    ..We thus speculate that distinct SMC phenotypes present in distal vs. proximal PA may confer different response mechanisms during remodeling in conditions such as hypertension...
  43. pmc Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism
    Maria A Cavasin
    Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO, USA
    Circ Res 110:739-48. 2012
    ..The consequences of HDAC inhibition in the context of pulmonary hypertension with associated right ventricular cardiac remodeling are poorly understood...
  44. pmc Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    Eric T Clambey
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:E2784-93. 2012
    ..These studies demonstrate that hypoxia is an intrinsic molecular cue that promotes FoxP3 expression, in turn eliciting potent anti-inflammatory mechanisms to limit tissue damage in conditions of reduced oxygen availability...
  45. doi request reprint Mechanics and function of the pulmonary vasculature: implications for pulmonary vascular disease and right ventricular function
    Steven Lammers
    Department of Cardiovascular Pulmonary Research, University of Colorado Denver, Aurora, Colorado, USA
    Compr Physiol 2:295-319. 2012
    ..Here, we investigate systems-level changes associated with pulmonary hypertensive disease progression in an effort to better understand this coupled relationship...
  46. ncbi request reprint Hypoxia-induced alterations in protein kinase C zeta signaling result in augmented fibroblast proliferation
    Megan Short
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 128:582S. 2005
  47. ncbi request reprint Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development
    Janet M Wenzlau
    Department of Renal Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Circ Res 98:846-55. 2006
    ..These data suggest the EGAP NAT complex is an essential regulatory enzyme controlling the function of a subset of proteins required for embryonic growth control and vessel development...
  48. pmc Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling
    Eva Nozik-Grayck
    Department of Pediatrics, Univ of Colorado, Denver, 4200 E 9th Ave, B131, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 295:L422-30. 2008
    ..These data provide the first evidence that EC-SOD activity is disrupted in chronic hypoxia, and increased EC-SOD activity can attenuate chronic hypoxic PH by limiting the hypoxic upregulation of redox-sensitive genes...
  49. pmc Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administration
    Margaret B Clarke
    Pediatric Critical Care, Department of Pediatrics, University of Colorado at Denver, Aurora, CO 80045, USA
    Free Radic Biol Med 49:2032-9. 2010
    ..Further testing in models of chronic lung or pulmonary vascular diseases mediated by excess superoxide should consider the longer tissue half-life of SOD2/3 as well as its potential systemic vascular effects...
  50. pmc P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells
    Taras Lyubchenko
    Dept of Pediatrics, University of Colorado Denver, Research 2, Box B131, Aurora, CO 80045, USA
    Am J Physiol Cell Physiol 300:C266-75. 2011
    ....
  51. ncbi request reprint Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of phosphatidylinositol 3-kinase
    Shama Ahmad
    Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 28:179-87. 2003
    ..These results indicate that hypoxia-induced activation of PI3-K is an important event in the acquisition of resistance against subsequent hyperoxic toxicity...
  52. doi request reprint Validation of a pressure diameter method for determining modulus and strain of collagen engagement for long branches of bovine pulmonary arteries
    Mark Reusser
    Department of Bioengineering, University of Colorado, Denver, CO 80045, USA
    J Biomech Eng 134:054501. 2012
    ..The method allowed faster testing of tissues of multiple diameters, while removing the effect of end conditions. The PD method will be of further utility in continued study of tissue mechanics in pulmonary hypertension studies...
  53. ncbi request reprint Yin and Yang of an endothelial cell: from normal to the extreme in growth, secretion, and transdifferentiation capabilities
    Maria G Frid
    Pediatric Critical Care, University of Colorado Health Sciences Center, Box B131, 4200 E 9th Avenue, Denver, CO 80262, USA
    Paediatr Respir Rev 5:S253-7. 2004
  54. ncbi request reprint Hypoxia, leukocytes, and the pulmonary circulation
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, Univ of Colorado Health Sciences Center, 4200 E 9th Ave, Box B131, Denver, CO 80262, USA
    J Appl Physiol (1985) 98:715-21. 2005
    ....
  55. pmc Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury
    Todd C Carpenter
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, 80045, USA
    Am J Respir Cell Mol Biol 46:40-7. 2012
    ..This study demonstrates that the expression of EphA2 increases in the injured lung, and not only contributes to changes in permeability, but also plays a previously unrecognized role in promoting inflammatory responses...
  56. pmc Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner
    Derek Strassheim
    Pediatric Critical CareMedicine, University of Colorado Denver, Research Complex II, Room 6490, 12700 East 19th Avenue, Aurora, CO 80045, USA
    J Immunol 183:6981-8. 2009
    ..We conclude that PGI(2) exerts anti-inflammatory action by inhibiting STAT1-induced cytokine production, in part by targeting the transactivation domain-induced recruitment of the histone acetylase CBP/p300...
  57. pmc Varicella-zoster virus vasculopathy: immune characteristics of virus-infected arteries
    Maria A Nagel
    Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA
    Neurology 80:62-8. 2013
    ....
  58. ncbi request reprint Distensibility of the normal human lung circulation during exercise
    John T Reeves
    University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 288:L419-25. 2005
    ..We propose that the estimation of pulmonary vascular distensibility in humans may be a useful descriptor of pulmonary hemodynamics...
  59. ncbi request reprint Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor
    Evgenia V Gerasimovskaya
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:44638-50. 2002
    ..We conclude that hypoxia induces ATP release from endothelial cells and fibroblasts and that the activation of P2 purinoceptors is involved in the regulation of DNA synthesis by fibroblasts under hypoxic conditions...
  60. ncbi request reprint Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center and The Children s Hospital, Denver, Colorado 80262, USA
    Annu Rev Physiol 67:623-61. 2005
    ..We speculate that understanding basic mechanisms that regulate and determine vascular growth will lead to new clinical strategies to improve the long-term outcome of premature babies with BPD...
  61. pmc Relevant issues in the pathology and pathobiology of pulmonary hypertension
    Rubin M Tuder
    Program in Translational Lung Research, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado Electronic address
    J Am Coll Cardiol 62:D4-12. 2013
    ..Continued interest in the interface of the genetic basis of PH and cellular and molecular pathogenetic links should further expand our understanding of the disease. ..
  62. pmc Plasma proteomics of differential outcome to long-term therapy in children with idiopathic pulmonary arterial hypertension
    Michael E Yeager
    Department of Pediatric Critical Care, University of Colorado Denver, Denver, CO 80045, USA
    Proteomics Clin Appl 6:257-67. 2012
    ..The prognosis for children with IPAH unresponsive to therapy is poor. We investigated the plasma proteome for a molecular basis of good versus poor outcome to long-term vasodilator therapy...
  63. ncbi request reprint Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling
    Eva Nozik-Grayck
    Department of Pediatrics and Developmental Lung Biology Laboratory, University of Colorado at Denver and Health Science Center, Denver, Colorado, USA
    Adv Exp Med Biol 618:101-12. 2007
    ....
  64. pmc The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes
    Steven C Pugliese
    Developmental Lung Biology, Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics Critical Care, Departments of Medicine and Pediatrics, University of Colorado, Anschutz Medical Campus, Aurora, Colorado
    Am J Physiol Lung Cell Mol Physiol 308:L229-52. 2015
    ..A better understanding of these signaling pathways may lead to the development of specific therapeutic targets, as none are currently available for WHO group III disease. ..
  65. pmc Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension
    Karim C El Kasmi
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, University of Colorado Denver, Aurora, CO 80045
    J Immunol 193:597-609. 2014
    ....
  66. pmc Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes
    Sarah M Williams
    Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO, USA
    J Mol Cell Cardiol 67:112-25. 2014
    ....
  67. pmc Activation of the unfolded protein response is associated with pulmonary hypertension
    Michael E Yeager
    Department of Pediatrics, Division of Pulmonary and Critical Care Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Pulm Circ 2:229-40. 2012
    ..As such, understanding the functional contributions of the UPR in the setting of PH may have important therapeutic implications...
  68. pmc Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction
    Danielle R Bruns
    Department of Medicine, Cardiology, University of Colorado Denver, Aurora, Colorado and
    Am J Physiol Lung Cell Mol Physiol 308:L158-67. 2015
    ....
  69. pmc Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension
    Lori A Walker
    Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    Am J Physiol Heart Circ Physiol 301:H832-40. 2011
    ..No changes in total force or cooperativity were seen. Taken together, these results suggest that RV failure is mechanistically unique from left ventricular failure...
  70. ncbi request reprint Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia
    Todd C Carpenter
    Developmental Lung Biology Laboratory, Box B 131, University of Colorado School of Medicine, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1075-82. 2005
    ..These findings suggest that ET-driven increases in lung VEGF content can contribute to the formation of pulmonary edema...
  71. pmc Circulating myeloid-derived suppressor cells are increased and activated in pulmonary hypertension
    Michael E Yeager
    Department of Pediatrics, Division of Pulmonary and Critical Care Medicine, University of Colorado, Denver, Aurora, CO 80045, USA
    Chest 141:944-52. 2012
    ..Immature myeloid cells are found in the lungs of humans and animals with PH, and we hypothesized that they would be increased in the blood of patients with PH compared with control subjects...
  72. pmc Complementary effects of extracellular nucleotides and platelet-derived extracts on angiogenesis of vasa vasorum endothelial cells in vitro and subcutaneous Matrigel plugs in vivo
    Mark Roedersheimer
    Department of Pediatrics, University of Colorado Denver, 12700 East 19th Ave, Aurora, CO 80045, USA
    Vasc Cell 3:4. 2011
    ..abstract:..
  73. pmc Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension
    Eva Nozik-Grayck
    Department of Pediatrics, University of Colorado, Aurora, Colorado Department of Cardiovascular Pulmonary Research, University of Colorado, Aurora, Colorado
    Am J Physiol Lung Cell Mol Physiol 307:L868-76. 2014
    ..We conclude that the localized loss of PA EC-SOD augments chronic hypoxic PH. In addition to oxidative inactivation of NO, deletion of EC-SOD seems to reduce eNOS activity, further compromising pulmonary vascular function. ..
  74. pmc Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration
    David C Irwin
    Cardiovascular Pulmonary Research Group, Division of Cardiology, School of Medicine, University of Colorado at Denver, Anschutz Medical Campus, Aurora, CO 80045, USA Electronic address
    Free Radic Biol Med 82:50-62. 2015
    ..By preventing Hb-mediated pathology, Hp infusions: (1) demonstrate a critical role for Hb in vascular remodeling associated with hypoxia and (2) suggest a novel therapy for chronic hemolysis-associated PH...
  75. pmc Stiffening-induced high pulsatility flow activates endothelial inflammation via a TLR2/NF-κB pathway
    Yan Tan
    Department of Mechanical Engineering, University of Colorado at Boulder, Boulder, Colorado, United States of America Department of Pediatrics, University of Colorado at Denver, Aurora, Colorado, United States of America
    PLoS ONE 9:e102195. 2014
    ....
  76. pmc Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, MD, USA
    Am J Physiol Lung Cell Mol Physiol 303:L312-26. 2012
    ..Tempol demonstrated a modest effect on the attenuation of Hb-induced pulmonary vascular disease. NO bioavailability was found to be of minimal importance in this model...
  77. ncbi request reprint Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis
    Maria G Frid
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Circ Res 90:1189-96. 2002
    ....