Research Topics
| J D SteketeeSummaryAffiliation: University of Tennessee Country: USA Publications
| Collaborators |
Detail Information
Publications
Cortical mechanisms of cocaine sensitizationJeffery D Steketee
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Crit Rev Neurobiol 17:69-86. 2005..A model will be presented that may serve to direct future studies on the involvement of the mPFC in the development of cocaine sensitization, which ultimately could lead to development of pharmacotherapies for cocaine addiction...
Pretreatment with corticosterone attenuates the nucleus accumbens dopamine response but not the stimulant response to cocaine in ratsJ D Steketee
Departments of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
Behav Pharmacol 13:593-601. 2002....
Repeated injections of sulpiride into the medial prefrontal cortex induces sensitization to cocaine in ratsJeffery D Steketee
Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue Room 115 Crowe, Memphis, TN 38163, USA
Psychopharmacology (Berl) 179:753-60. 2005..The present study was designed to further examine the involvement of mPFC dopamine D(2) receptors in cocaine sensitization...
Injections of baclofen into the ventral medial prefrontal cortex block the initiation, but not the expression, of cocaine sensitization in ratsJeffery D Steketee
Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue Room 115 Crowe, Memphis, TN 38163, USA
Psychopharmacology (Berl) 180:352-8. 2005..Increased excitatory output from the medial prefrontal cortex (mPFC) is thought to play a key role in the development of sensitization to cocaine. Gamma-aminobutyric acid (GABA) inhibits this excitatory output...
Dopamine depletion in the medial prefrontal cortex induces sensitized-like behavioral and neurochemical responses to cocaineC E Beyer
Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
Brain Res 833:133-41. 1999..Collectively, the present findings suggest that alterations in cortical DA transmission may be a neural substrate mediating the development of sensitization to cocaine, and thus, may contribute to the addictive properties of cocaine...
Repeated exposure to inhaled toluene induces behavioral and neurochemical cross-sensitization to cocaine in ratsC E Beyer
Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport 71130-3932, USA
Psychopharmacology (Berl) 154:198-204. 2001..CONCLUSIONS: Overall, these findings show that repeated toluene exposure enhances behavioral and neurochemical responses to subsequent cocaine administration...
Intra-medial prefrontal cortex injection of quinpirole, but not SKF 38393, blocks the acute motor-stimulant response to cocaine in the ratC E Beyer
Department of Pharmacology and Therapeutics and School of Graduate Studies, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
Psychopharmacology (Berl) 151:211-8. 2000..However, a role for cortical dopamine (DA) receptor subtypes in modulating these responses has yet to be elucidated...
Characterization of the role of medial prefrontal cortex dopamine receptors in cocaine-induced locomotor activityC E Beyer
Department of Pharmacology and Therapeutics, School of Graduate Studies, Louisiana State University Health Sciences Center, USA
Behav Neurosci 115:1093-100. 2001..These results suggest that D2 receptor mechanisms in the mPFC are at least partly responsible for mediating the acute motor-stimulant effects of cocaine...
Effects of cocaine-induced behavioural sensitization on GABA transmission within rat medial prefrontal cortexPrathiba Jayaram
Department of Pharmacology, University of Tennessee Health Sciences Center, 874 Union Avenue, Memphis, TN 38163, USA
Eur J Neurosci 21:2035-9. 2005..These data suggest that cocaine-induced sensitization is associated with a transient increase in mPFC GABA transmission...
Cocaine-induced increases in medial prefrontal cortical GABA transmission involves glutamatergic receptorsPrathiba Jayaram
Department of Pharmacology University of Tennessee Health Science Center 874 Union Avenue Room 115 Crowe Research Building Memphis, TN 38163, USA
Eur J Pharmacol 531:74-9. 2006..These data indicate that enhanced medial prefrontal cortex GABA transmission seen in cocaine-sensitized animals involves glutamatergic stimulation of AMPA receptors...
Upregulation of ionotropic glutamate receptor subunits within specific mesocorticolimbic regions during chronic nicotine self-administrationFan Wang
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Neuropsychopharmacology 32:103-9. 2007..These findings suggest that chronic nicotine SA selectively increased the levels of ionotropic glutamate receptor subunits in a brain region-specific manner...
Time-dependent effects of repeated cocaine administration on dopamine transmission in the medial prefrontal cortexJason M Williams
Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
Neuropharmacology 48:51-61. 2005..These data suggest that repeated cocaine produces temporally distinct behavioral effects associated with alterations in mPFC DA responsiveness to cocaine that may be involved in the development of behavioral sensitization...
Effects of repeated inhalation of toluene on ionotropic GABA A and glutamate receptor subunit levels in rat brainJason M Williams
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Neurochem Int 46:1-10. 2005..These studies show that toluene differentially alters the levels of specific GABAergic and glutamatergic receptor subunits in a regionally selective manner...
Effects of repeated cocaine on the release and clearance of dopamine within the rat medial prefrontal cortexJason M Williams
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Synapse 55:98-109. 2005..The relevance of these findings is discussed in relation to mPFC involvement in psychostimulant sensitization...
Cocaine increases medial prefrontal cortical glutamate overflow in cocaine-sensitized rats: a time course studyJason M Williams
Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
Eur J Neurosci 20:1639-46. 2004....
Effects of repeated cocaine on medial prefrontal cortical GABAB receptor modulation of neurotransmission in the mesocorticolimbic dopamine systemPrathiba Jayaram
Department of Pharmacology, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA
J Neurochem 90:839-47. 2004..The data suggest that alterations in GABAB receptor modulation of medial prefrontal cortical excitatory output may play an important role in the development of sensitization to cocaine...
Characterization of dopamine transport in crude synaptosomes prepared from rat medial prefrontal cortexJason M Williams
Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
J Neurosci Methods 137:161-5. 2004..The described assay conditions would be useful in examining DA uptake within specific brain regions obtained from a single animal...
Neurotransmitter systems of the medial prefrontal cortex: potential role in sensitization to psychostimulantsJeffery D Steketee
Department of Pharmacology, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
Brain Res Brain Res Rev 41:203-28. 2003..Finally a model of the mPFC that may be useful in directing future research efforts on the cortical mechanisms involved in the development of sensitization will be proposed...
Cocaine sensitization: modulation by dopamine D2 receptorsChad E Beyer
Department of Pharmacology and Therapeutics and School of Graduate Studies, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA
Cereb Cortex 12:526-35. 2002..Collectively, the results show that activation of D(2)-like receptors in the mPFC may alter the enduring changes responsible for the development of cocaine sensitization...
Repeated exposure to cocaine alters the modulation of mesocorticolimbic glutamate transmission by medial prefrontal cortex Group II metabotropic glutamate receptorsXiaohu Xie
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
J Neurochem 107:186-96. 2008....
