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Genomes and Genes | John W SteinkeSummaryAffiliation: University of Virginia Country: USA Publications
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Publications
The relationship between rhinosinusitis and asthma sinusitisJohn W Steinke
Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
Curr Allergy Asthma Rep 6:495-501. 2006..In this article, the potential mechanisms linking these two diseases are examined...- Leukotriene synthesis inhibitors versus antagonists: the pros and consJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
Curr Allergy Asthma Rep 7:126-33. 2007..This review focuses on the role that leukotrienes play in various diseases, with the emphasis on allergic diseases, and considers the rationale for choosing either a leukotriene antagonist or synthesis inhibitor as a treatment option... - 3. Cytokines and chemokinesJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA 22908, USA
J Allergy Clin Immunol 117:S441-5. 2006..For this update, recent advances in our understanding of cytokines will be discussed, which includes the IL-10, IL-17, and IL-27 families... 
Differential interleukin-10 production stratified by -571 promoter polymorphism in purified human immune cellsJohn W Steinke
Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia, 409 Lane Road, Room 5031, P O Box 801355, Charlottesville, VA 22908 1355, USA
Cell Immunol 249:101-7. 2007..Changes in IL-10 protein production were paralleled by similar changes in IL-10 mRNA production. These results demonstrate that changes in IL-10 production observed due to the -571 genotype depend on both cell type and stimulus...- Anti-interleukin-4 therapyJohn W Steinke
Asthma and Allergic Diseases Center, Bierne Carter Center for Immunology, University of Virginia Health System, Lane Road, MR4 Building, Room 5031, Box 801355, Charlottesville, VA 22908 1355, USA
Immunol Allergy Clin North Am 24:599-614, vi. 2004..Several approaches to IL-4 antagonism are or have been in clinical development. This article examines IL-4 and the antagonists that have been developed. Early trial results and the future of anti-IL-4 therapy are discussed... - Functional analysis of -571 IL-10 promoter polymorphism reveals a repressor element controlled by sp1John W Steinke
Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 173:3215-22. 2004..Individuals carrying the A allele of the IL-10 promoter may display increased synthesis of IL-10, resulting in suppressed immune responses and a modulation of their susceptibility to autoimmune, infectious, neoplastic, or atopic disease... - The role of allergy in chronic rhinosinusitisJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Box 801355, Charlottesville, VA 22908-1355, USA
Immunol Allergy Clin North Am 24:45-57. 2004 - Characterization of interleukin-4-stimulated nasal polyp fibroblastsJohn W Steinke
Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Respir Cell Mol Biol 30:212-9. 2004..The metabolic cascade involved in CysLT synthesis was not expressed in fibroblasts and could not be induced by IL-4 treatment... - Current prospective of anti-IL-4, -IL-9, and -IL-13 therapies in allergic diseaseJohn W Steinke
Asthma and Allergic Disease Center, Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA, USA
Recent Pat Inflamm Allergy Drug Discov 4:222-30. 2010..Inhibition of these cytokines may lead to true immunomodulation of disease and finally give us drugs that cure the disease rather than just treat symptoms... 
Corticosteroids as inhibitors of cysteinyl leukotriene metabolic and signaling pathwaysJulie Negri
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, Department of Medicine, University of Virginia Health System, Charlottesville, VA
J Allergy Clin Immunol 121:1232-7. 2008....- Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitizationJohn W Steinke
Carter Immunology Center, Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA, USA
J Allergy Clin Immunol 124:724-30.e4. 2009..Through an unknown mechanism, aspirin desensitization is an effective treatment... - Cysteinyl leukotriene expression in chronic hyperplastic sinusitis-nasal polyposis: importance to eosinophilia and asthmaJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, University of Virginia Health System, Charlottesville, VA 22908, USA
J Allergy Clin Immunol 111:342-9. 2003..The frequent coexpression of these disorders and their shared pathophysiology suggests that these are similar disorders affecting the upper and lower airways... - Evidence for distinct histologic profile of nasal polyps with and without eosinophiliaSpencer C Payne
Division of Rhinology and Sinus Surgery, Department of Otolaryngology Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Laryngoscope 121:2262-7. 2011..To evaluate the histology, RNA, and protein signatures of nasal polyps (NPs) in order to demonstrate specific subtypes of disease and differentiate "idiopathic" NPs based on tissue eosinophilia... - Microarray analysis of distinct gene transcription profiles in non-eosinophilic chronic sinusitis with nasal polypsSpencer C Payne
Department of Otolaryngology Head and Neck Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Am J Rhinol 22:568-81. 2008.... - Concordant modulation of cysteinyl leukotriene receptor expression by IL-4 and IFN-gamma on peripheral immune cellsS Brandon Early
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Respir Cell Mol Biol 36:715-20. 2007..These results support the concept that cytokines increase expression of both receptors on lymphocytes and granulocytes, allowing these cells to be more responsive to secreted leukotrienes at sites of inflammation... - Hypoxia stimulates inflammatory and fibrotic responses from nasal-polyp derived fibroblastsS Brandon Early
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Laryngoscope 117:511-5. 2007..The role of hypoxia in chronic sinusitis is unknown. We hypothesized that hypoxia induces production of mediators that recruit cells into the sinus tissue and are involved in remodeling of the nasal mucosa... - Etiology of nasal polyps in cystic fibrosis: not a unimodal diseaseJohn W Steinke
Asthma and Allergic Disease Center, Carter Immunology Center, Department of Medicine, University of Virginia Health Systems, Charlottesville, Virginia, USA
Ann Otol Rhinol Laryngol 121:579-86. 2012..The objective was to determine whether the polyp subtypes observed in cystic fibrosis (CF)-related sinusitis were similar to those observed in non-CF-related sinusitis... - Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitisAlessandro de Alarcon
Department of Otolaryngology Head and Neck Surgery, University of Virginia Health Sciences System, Charlottesville, Virginia 22908, USA
Am J Rhinol 20:545-9. 2006..The role of these polymorphisms was investigated in patients with sinusitis and polyps. We performed a prospective study of patients undergoing endoscopic sinus surgery at a university hospital between 1996 and 2004... - Immunologic messenger molecules: cytokines, interferons, and chemokinesScott P Commins
University of Virginia Health System, Carter Center for Immunology Research, Asthma and Allergic Disease Center, Charlottesville, VA 22908 1355, USA
J Allergy Clin Immunol 125:S53-72. 2010..A discussion of chemokine function and their role in cell trafficking and disease follows... - Role of hypoxia in inflammatory upper airway diseaseJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Curr Opin Allergy Clin Immunol 8:16-20. 2008..This hypoxia reflects occlusion of the sinus ostia and thereby failure of transepithelial oxygenation, nonvascularized exudates, and the tendency of inflammatory hyperplasia to exceed neovascularization... - Chronic hyperplastic eosinophilic sinusitis as a predictor of aspirin-exacerbated respiratory diseaseKimberly Mascia
Department of Medicine, University of Virginia Health Systems, Charlottesville, Virginia 22908-1355, USA
Ann Allergy Asthma Immunol 94:652-7. 2005..CONCLUSIONS: AERD can be distinguished from ATA by the extent of hyperplasia on CT scan and the presence of nasal polyps. We hypothesize that AERD represents a remodeling process that affects both the upper and lower airways... - Leukotriene receptors in rhinitis and sinusitisJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, 22908-1355, USA
Curr Allergy Asthma Rep 4:217-23. 2004..Comprehensive inhibition of the proinflammatory activities of CysLTs might require either combination CysLT1 and CysLT2 receptor antagonists or inhibitors of the CysLT synthesis pathway... - Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cellsJohn W Steinke
Allergy Division, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
Mol Immunol 41:1145-53. 2004..Together, these data provide the first analysis of regulatory modules necessary for GCET expression, a model for GC B cell-specific transcription... - Dual action of TGF-beta1 on nasal-polyp derived fibroblastsStewart C Little
Department of Otolaryngology HNS, University of Virginia Health System, Charlottesville, VA 22908, USA
Laryngoscope 118:320-4. 2008..We wanted to determine the effect of stimulation with TGF-beta1 on nasal polyp-derived fibroblasts and assess the role this molecule would have in polyp formation and growth... - Genetics and phenotyping in chronic sinusitisSpencer C Payne
Asthma and Allergic Disease Center, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22903, USA
J Allergy Clin Immunol 128:710-20; quiz 721-2. 2011.... - Lysophosphatidic acid stimulates inflammatory cascade in airway epithelial cellsElizabeth Barekzi
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
Prostaglandins Leukot Essent Fatty Acids 74:357-63. 2006..Our results suggest epithelial cells undergo rapid proliferation in response to LPA resulting in a transient decrease in inflammatory cytokines followed by an upregulation of these cytokines that could lead to increased inflammation... - Fungi in chronic hyperplastic eosinophilic sinusitis: reasonable doubtLarry Borish
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA, USA
Clin Rev Allergy Immunol 30:195-204. 2006.... - The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29Scott Commins
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908, USA
J Allergy Clin Immunol 121:1108-11. 2008..However, its members mediate diverse activities, including immune suppression, enhanced antibacterial and antiviral immunity, antitumor activity, and promotion of self-tolerance in autoimmune diseases... - 2. Cytokines and chemokinesLarry C Borish
Beirne Carter Center for Immunology, Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA 22908-1355, USA
J Allergy Clin Immunol 111:S460-75. 2003..The biology of chemokines are then reviewed, grouped by family... - Genetics of allergic diseaseJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA 22908-1355, USA
Med Clin North Am 90:1-15. 2006..The end result will be the ability to tailor a specific treatment regime for each patient and reduce the overall cost of health care related to allergies and asthma... - 5. Genetics of hypersensitivityJohn W Steinke
University of Virginia Health System, Charlottesville, VA 22908-1355, USA
J Allergy Clin Immunol 111:S495-501. 2003..It is to be hoped that they will also define new targets for the next generation of asthma and allergy therapeutic agents... - Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcεRITanya M Laidlaw
Department of Medicine, Harvard Medical School, Boston, Mass, USA
J Allergy Clin Immunol 127:815-22.e1-5. 2011..Studies of human mast cells (MCs) are constrained by the paucity of functional cell lines, the expense of maintaining MCs in culture, and technical complexities... - Interleukin-33 in asthma: how big of a role does it play?Larry Borish
Asthma and Allergic Disease Center, Box 801355, University of Virginia Health Systems, Charlottesville, VA 22908 1355, USA
Curr Allergy Asthma Rep 11:7-11. 2011..As such, IL-33 is an attractive candidate for therapeutic intervention with the goal of ameliorating disease. This review focuses on the role of IL-33 in promoting and maintaining the asthma phenotype... - Lack of a role for cross-reacting anti-thyroid antibodies in chronic idiopathic urticariaJonathan D Mozena
Asthma and Allergic Disease Center, Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, USA
J Invest Dermatol 130:1860-5. 2010..Epitopic cross-reactivity does not explain the increased prevalence of HT found in CIU patients. The frequent concurrence of HT and CIU likely reflects a genetic tendency toward autoimmune diseases... - 5. Genetics of allergic diseaseJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, PO Box 801355, Charlottesville, VA 22908 1355, USA
J Allergy Clin Immunol 121:S384-7; quiz S416. 2008..This review will discuss the techniques used for genetic analysis of complex diseases, some of the important genes that have been replicated in multiple asthma studies, and the future of genetic studies in asthma... - Interleukin-4 in the Generation of the AERD Phenotype: Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin DesensitizationJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter B Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908, USA
J Allergy (Cairo) 2012:182090. 2012..This review will examine the evidence supporting this hypothesis and describe a model of how aspirin desensitization provides therapeutic benefit for AERD patients... - Opposing actions of (R,R)-isomers and (S,S)-isomers of formoterol on T-cell functionJohn W Steinke
J Allergy Clin Immunol 118:963-5. 2006 - Proinflammatory effects of IL-4 antagonismJohn W Steinke
J Allergy Clin Immunol 118:756-8. 2006 - Initiation site binding protein and the initiator-like promoter element of mouse mammary tumor virusBrian E Fee
Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843-2128, USA
Virology 302:185-94. 2002..Partially purified ISBP did, however, bind with high affinity to sequences near the initiation sites of the SV40 major late and adenovirus 2 E1B promoters...