John W Steinke

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. doi request reprint T-cell biology in immunotherapy
    John W Steinke
    Asthma and Allergic Disease Center, Carter Immunology Center, University of Virginia Health Systems, Charlottesville, Virginia Electronic address
    Ann Allergy Asthma Immunol 112:195-9. 2014
  2. pmc Prominent role of IFN-γ in patients with aspirin-exacerbated respiratory disease
    John W Steinke
    Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, Va Carter Immunology Center, University of Virginia Health System, Charlottesville, VA Electronic address
    J Allergy Clin Immunol 132:856-65.e1-3. 2013
  3. ncbi request reprint 3. Cytokines and chemokines
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 117:S441-5. 2006
  4. ncbi request reprint Anti-interleukin-4 therapy
    John W Steinke
    Asthma and Allergic Diseases Center, Bierne Carter Center for Immunology, University of Virginia Health System, Lane Road, MR4 Building, Room 5031, Box 801355, Charlottesville, VA 22908 1355, USA
    Immunol Allergy Clin North Am 24:599-614, vi. 2004
  5. ncbi request reprint Functional analysis of -571 IL-10 promoter polymorphism reveals a repressor element controlled by sp1
    John W Steinke
    Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 173:3215-22. 2004
  6. ncbi request reprint The role of allergy in chronic rhinosinusitis
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Box 801355, Charlottesville, VA 22908 1355, USA
    Immunol Allergy Clin North Am 24:45-57. 2004
  7. pmc Differential interleukin-10 production stratified by -571 promoter polymorphism in purified human immune cells
    John W Steinke
    Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia, 409 Lane Road, Room 5031, P O Box 801355, Charlottesville, VA 22908 1355, USA
    Cell Immunol 249:101-7. 2007
  8. ncbi request reprint Characterization of interleukin-4-stimulated nasal polyp fibroblasts
    John W Steinke
    Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Respir Cell Mol Biol 30:212-9. 2004
  9. ncbi request reprint Leukotriene synthesis inhibitors versus antagonists: the pros and cons
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Curr Allergy Asthma Rep 7:126-33. 2007
  10. ncbi request reprint The relationship between rhinosinusitis and asthma sinusitis
    John W Steinke
    Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Curr Allergy Asthma Rep 6:495-501. 2006

Collaborators

Detail Information

Publications41

  1. doi request reprint T-cell biology in immunotherapy
    John W Steinke
    Asthma and Allergic Disease Center, Carter Immunology Center, University of Virginia Health Systems, Charlottesville, Virginia Electronic address
    Ann Allergy Asthma Immunol 112:195-9. 2014
    ..This review discusses the current state of immunotherapy and how the CD4 T-cell response is pivotal in altering the allergic response...
  2. pmc Prominent role of IFN-γ in patients with aspirin-exacerbated respiratory disease
    John W Steinke
    Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, Va Carter Immunology Center, University of Virginia Health System, Charlottesville, VA Electronic address
    J Allergy Clin Immunol 132:856-65.e1-3. 2013
    ....
  3. ncbi request reprint 3. Cytokines and chemokines
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 117:S441-5. 2006
    ..For this update, recent advances in our understanding of cytokines will be discussed, which includes the IL-10, IL-17, and IL-27 families...
  4. ncbi request reprint Anti-interleukin-4 therapy
    John W Steinke
    Asthma and Allergic Diseases Center, Bierne Carter Center for Immunology, University of Virginia Health System, Lane Road, MR4 Building, Room 5031, Box 801355, Charlottesville, VA 22908 1355, USA
    Immunol Allergy Clin North Am 24:599-614, vi. 2004
    ..Several approaches to IL-4 antagonism are or have been in clinical development. This article examines IL-4 and the antagonists that have been developed. Early trial results and the future of anti-IL-4 therapy are discussed...
  5. ncbi request reprint Functional analysis of -571 IL-10 promoter polymorphism reveals a repressor element controlled by sp1
    John W Steinke
    Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 173:3215-22. 2004
    ..Individuals carrying the A allele of the IL-10 promoter may display increased synthesis of IL-10, resulting in suppressed immune responses and a modulation of their susceptibility to autoimmune, infectious, neoplastic, or atopic disease...
  6. ncbi request reprint The role of allergy in chronic rhinosinusitis
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Box 801355, Charlottesville, VA 22908 1355, USA
    Immunol Allergy Clin North Am 24:45-57. 2004
  7. pmc Differential interleukin-10 production stratified by -571 promoter polymorphism in purified human immune cells
    John W Steinke
    Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia, 409 Lane Road, Room 5031, P O Box 801355, Charlottesville, VA 22908 1355, USA
    Cell Immunol 249:101-7. 2007
    ..Changes in IL-10 protein production were paralleled by similar changes in IL-10 mRNA production. These results demonstrate that changes in IL-10 production observed due to the -571 genotype depend on both cell type and stimulus...
  8. ncbi request reprint Characterization of interleukin-4-stimulated nasal polyp fibroblasts
    John W Steinke
    Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Respir Cell Mol Biol 30:212-9. 2004
    ..The metabolic cascade involved in CysLT synthesis was not expressed in fibroblasts and could not be induced by IL-4 treatment...
  9. ncbi request reprint Leukotriene synthesis inhibitors versus antagonists: the pros and cons
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Curr Allergy Asthma Rep 7:126-33. 2007
    ..This review focuses on the role that leukotrienes play in various diseases, with the emphasis on allergic diseases, and considers the rationale for choosing either a leukotriene antagonist or synthesis inhibitor as a treatment option...
  10. ncbi request reprint The relationship between rhinosinusitis and asthma sinusitis
    John W Steinke
    Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Curr Allergy Asthma Rep 6:495-501. 2006
    ..In this article, the potential mechanisms linking these two diseases are examined...
  11. ncbi request reprint Current prospective of anti-IL-4, -IL-9, and -IL-13 therapies in allergic disease
    John W Steinke
    Asthma and Allergic Disease Center, Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA, USA
    Recent Pat Inflamm Allergy Drug Discov 4:222-30. 2010
    ..Inhibition of these cytokines may lead to true immunomodulation of disease and finally give us drugs that cure the disease rather than just treat symptoms...
  12. doi request reprint Corticosteroids as inhibitors of cysteinyl leukotriene metabolic and signaling pathways
    Julie Negri
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, Department of Medicine, University of Virginia Health System, Charlottesville, VA
    J Allergy Clin Immunol 121:1232-7. 2008
    ....
  13. pmc Concordant modulation of cysteinyl leukotriene receptor expression by IL-4 and IFN-gamma on peripheral immune cells
    S Brandon Early
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Respir Cell Mol Biol 36:715-20. 2007
    ..These results support the concept that cytokines increase expression of both receptors on lymphocytes and granulocytes, allowing these cells to be more responsive to secreted leukotrienes at sites of inflammation...
  14. pmc Microarray analysis of distinct gene transcription profiles in non-eosinophilic chronic sinusitis with nasal polyps
    Spencer C Payne
    Department of Otolaryngology Head and Neck Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Am J Rhinol 22:568-81. 2008
    ....
  15. ncbi request reprint Cysteinyl leukotriene expression in chronic hyperplastic sinusitis-nasal polyposis: importance to eosinophilia and asthma
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 111:342-9. 2003
    ..The frequent coexpression of these disorders and their shared pathophysiology suggests that these are similar disorders affecting the upper and lower airways...
  16. doi request reprint Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization
    John W Steinke
    Carter Immunology Center, Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA, USA
    J Allergy Clin Immunol 124:724-30.e4. 2009
    ..Through an unknown mechanism, aspirin desensitization is an effective treatment...
  17. pmc Evidence for distinct histologic profile of nasal polyps with and without eosinophilia
    Spencer C Payne
    Division of Rhinology and Sinus Surgery, Department of Otolaryngology Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Laryngoscope 121:2262-7. 2011
    ..To evaluate the histology, RNA, and protein signatures of nasal polyps (NPs) in order to demonstrate specific subtypes of disease and differentiate "idiopathic" NPs based on tissue eosinophilia...
  18. ncbi request reprint Hypoxia stimulates inflammatory and fibrotic responses from nasal-polyp derived fibroblasts
    S Brandon Early
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Laryngoscope 117:511-5. 2007
    ..The role of hypoxia in chronic sinusitis is unknown. We hypothesized that hypoxia induces production of mediators that recruit cells into the sinus tissue and are involved in remodeling of the nasal mucosa...
  19. ncbi request reprint Chronic hyperplastic eosinophilic sinusitis as a predictor of aspirin-exacerbated respiratory disease
    Kimberly Mascia
    Department of Medicine, University of Virginia Health Systems, Charlottesville, Virginia 22908 1355, USA
    Ann Allergy Asthma Immunol 94:652-7. 2005
    ..Aspirin-exacerbated respiratory disease (AERD) is a disease of intense eosinophilic inflammation that can produce fibrosis, hyperplasia, and remodeling...
  20. pmc Etiology of nasal polyps in cystic fibrosis: not a unimodal disease
    John W Steinke
    Asthma and Allergic Disease Center, Carter Immunology Center, Department of Medicine, University of Virginia Health Systems, Charlottesville, Virginia, USA
    Ann Otol Rhinol Laryngol 121:579-86. 2012
    ..The objective was to determine whether the polyp subtypes observed in cystic fibrosis (CF)-related sinusitis were similar to those observed in non-CF-related sinusitis...
  21. ncbi request reprint Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis
    Alessandro de Alarcon
    Department of Otolaryngology Head and Neck Surgery, University of Virginia Health Sciences System, Charlottesville, Virginia 22908, USA
    Am J Rhinol 20:545-9. 2006
    ..The role of these polymorphisms was investigated in patients with sinusitis and polyps. We performed a prospective study of patients undergoing endoscopic sinus surgery at a university hospital between 1996 and 2004...
  22. doi request reprint Immunologic messenger molecules: cytokines, interferons, and chemokines
    Scott P Commins
    University of Virginia Health System, Carter Center for Immunology Research, Asthma and Allergic Disease Center, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 125:S53-72. 2010
    ..A discussion of chemokine function and their role in cell trafficking and disease follows...
  23. doi request reprint Role of hypoxia in inflammatory upper airway disease
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Curr Opin Allergy Clin Immunol 8:16-20. 2008
    ..This hypoxia reflects occlusion of the sinus ostia and thereby failure of transepithelial oxygenation, nonvascularized exudates, and the tendency of inflammatory hyperplasia to exceed neovascularization...
  24. ncbi request reprint Leukotriene receptors in rhinitis and sinusitis
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, 22908 1355, USA
    Curr Allergy Asthma Rep 4:217-23. 2004
    ..Comprehensive inhibition of the proinflammatory activities of CysLTs might require either combination CysLT1 and CysLT2 receptor antagonists or inhibitors of the CysLT synthesis pathway...
  25. ncbi request reprint Dual action of TGF-beta1 on nasal-polyp derived fibroblasts
    Stewart C Little
    Department of Otolaryngology HNS, University of Virginia Health System, Charlottesville, VA 22908, USA
    Laryngoscope 118:320-4. 2008
    ..We wanted to determine the effect of stimulation with TGF-beta1 on nasal polyp-derived fibroblasts and assess the role this molecule would have in polyp formation and growth...
  26. ncbi request reprint Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells
    John W Steinke
    Allergy Division, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Mol Immunol 41:1145-53. 2004
    ..Together, these data provide the first analysis of regulatory modules necessary for GCET expression, a model for GC B cell-specific transcription...
  27. doi request reprint Genetics and phenotyping in chronic sinusitis
    Spencer C Payne
    Asthma and Allergic Disease Center, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22903, USA
    J Allergy Clin Immunol 128:710-20; quiz 721-2. 2011
    ....
  28. ncbi request reprint Lysophosphatidic acid stimulates inflammatory cascade in airway epithelial cells
    Elizabeth Barekzi
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Prostaglandins Leukot Essent Fatty Acids 74:357-63. 2006
    ..Our results suggest epithelial cells undergo rapid proliferation in response to LPA resulting in a transient decrease in inflammatory cytokines followed by an upregulation of these cytokines that could lead to increased inflammation...
  29. ncbi request reprint Fungi in chronic hyperplastic eosinophilic sinusitis: reasonable doubt
    Larry Borish
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA, USA
    Clin Rev Allergy Immunol 30:195-204. 2006
    ....
  30. doi request reprint The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29
    Scott Commins
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 121:1108-11. 2008
    ..However, its members mediate diverse activities, including immune suppression, enhanced antibacterial and antiviral immunity, antitumor activity, and promotion of self-tolerance in autoimmune diseases...
  31. ncbi request reprint Genetics of allergic disease
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA 22908 1355, USA
    Med Clin North Am 90:1-15. 2006
    ..The end result will be the ability to tailor a specific treatment regime for each patient and reduce the overall cost of health care related to allergies and asthma...
  32. ncbi request reprint 2. Cytokines and chemokines
    Larry C Borish
    Beirne Carter Center for Immunology, Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 111:S460-75. 2003
    ..The biology of chemokines are then reviewed, grouped by family...
  33. ncbi request reprint 5. Genetics of hypersensitivity
    John W Steinke
    University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 111:S495-501. 2003
    ..It is to be hoped that they will also define new targets for the next generation of asthma and allergy therapeutic agents...
  34. doi request reprint 5. Genetics of allergic disease
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, PO Box 801355, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 121:S384-7; quiz S416. 2008
    ..This review will discuss the techniques used for genetic analysis of complex diseases, some of the important genes that have been replicated in multiple asthma studies, and the future of genetic studies in asthma...
  35. pmc Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcεRI
    Tanya M Laidlaw
    Department of Medicine, Harvard Medical School, Boston, Mass, USA
    J Allergy Clin Immunol 127:815-22.e1-5. 2011
    ..Studies of human mast cells (MCs) are constrained by the paucity of functional cell lines, the expense of maintaining MCs in culture, and technical complexities...
  36. pmc Interleukin-33 in asthma: how big of a role does it play?
    Larry Borish
    Asthma and Allergic Disease Center, Box 801355, University of Virginia Health Systems, Charlottesville, VA 22908 1355, USA
    Curr Allergy Asthma Rep 11:7-11. 2011
    ..As such, IL-33 is an attractive candidate for therapeutic intervention with the goal of ameliorating disease. This review focuses on the role of IL-33 in promoting and maintaining the asthma phenotype...
  37. doi request reprint Lack of a role for cross-reacting anti-thyroid antibodies in chronic idiopathic urticaria
    Jonathan D Mozena
    Asthma and Allergic Disease Center, Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, USA
    J Invest Dermatol 130:1860-5. 2010
    ..Epitopic cross-reactivity does not explain the increased prevalence of HT found in CIU patients. The frequent concurrence of HT and CIU likely reflects a genetic tendency toward autoimmune diseases...
  38. pmc Interleukin-4 in the Generation of the AERD Phenotype: Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter B Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Allergy (Cairo) 2012:182090. 2012
    ..This review will examine the evidence supporting this hypothesis and describe a model of how aspirin desensitization provides therapeutic benefit for AERD patients...
  39. ncbi request reprint Opposing actions of (R,R)-isomers and (S,S)-isomers of formoterol on T-cell function
    John W Steinke
    J Allergy Clin Immunol 118:963-5. 2006
  40. ncbi request reprint Proinflammatory effects of IL-4 antagonism
    John W Steinke
    J Allergy Clin Immunol 118:756-8. 2006
  41. ncbi request reprint Initiation site binding protein and the initiator-like promoter element of mouse mammary tumor virus
    Brian E Fee
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    Virology 302:185-94. 2002
    ..Partially purified ISBP did, however, bind with high affinity to sequences near the initiation sites of the SV40 major late and adenovirus 2 E1B promoters...