Martin Steinhoff

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea
    Mathias Sulk
    Department of Dermatology, University Hospital Munster, Munster, Germany
    J Invest Dermatol 132:1253-62. 2012
  2. ncbi request reprint New insights into rosacea pathophysiology: a review of recent findings
    Martin Steinhoff
    Department of Dermatology, University of California, San Francisco, California Electronic address
    J Am Acad Dermatol 69:S15-26. 2013
  3. pmc IL-33: a novel danger signal system in atopic dermatitis
    Ferda Cevikbas
    Department of Dermatology and Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Invest Dermatol 132:1326-9. 2012
  4. pmc Pruritus: management algorithms and experimental therapies
    Martin Steinhoff
    Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Semin Cutan Med Surg 30:127-37. 2011
  5. pmc Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins
    Benjamin E Padilla
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 179:981-97. 2007
  6. pmc Neurovascular and neuroimmune aspects in the pathophysiology of rosacea
    Verena D Schwab
    Department of Dermatology, University Hospital Munster, Munster, Germany
    J Investig Dermatol Symp Proc 15:53-62. 2011
  7. pmc Endothelin-converting enzyme-1 degrades internalized somatostatin-14
    Dirk Roosterman
    Department of Dermatology, Interdisziplinäres Zentrum für Klinische Forschung Münster, and Ludwig Bolzmann Institute for Cell and Immunobiology of the Skin, University Munster, D 48149 Munster, Germany
    Endocrinology 149:2200-7. 2008
  8. doi request reprint Role of matriptase and proteinase-activated receptor-2 in nonmelanoma skin cancer
    Georgeta Bocheva
    University of Munster, Munster, Germany
    J Invest Dermatol 129:1816-23. 2009
  9. pmc Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones
    Juan Carlos Pelayo
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 0660, USA
    J Physiol 589:5213-30. 2011
  10. pmc Proteinase-activated receptor-2 agonist activates anti-influenza mechanisms and modulates IFNγ-induced antiviral pathways in human neutrophils
    Micha Feld
    Department of Dermatology, Heinrich Heine University, 40225 Dusseldorf, Germany
    Biomed Res Int 2013:879080. 2013

Collaborators

Detail Information

Publications62

  1. pmc Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea
    Mathias Sulk
    Department of Dermatology, University Hospital Munster, Munster, Germany
    J Invest Dermatol 132:1253-62. 2012
    ..Thus, dysregulation of TRPV channels also expressed by non-neuronal cells may be critically involved in the initiation and/or development of rosacea. TRP ion channels may be targets for the treatment of rosacea...
  2. ncbi request reprint New insights into rosacea pathophysiology: a review of recent findings
    Martin Steinhoff
    Department of Dermatology, University of California, San Francisco, California Electronic address
    J Am Acad Dermatol 69:S15-26. 2013
    ..This review discusses some of the recent findings and aims to build unifying hypotheses for a modern understanding of rosacea pathophysiology. ..
  3. pmc IL-33: a novel danger signal system in atopic dermatitis
    Ferda Cevikbas
    Department of Dermatology and Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Invest Dermatol 132:1326-9. 2012
    ..On the other hand, several studies have reported on the inhibitory effects of sST2 in inflammatory and fibrotic diseases, suggesting that IL-33/ST2 is a unique cytokine with potential pro- and anti-inflammatory effects...
  4. pmc Pruritus: management algorithms and experimental therapies
    Martin Steinhoff
    Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Semin Cutan Med Surg 30:127-37. 2011
    ..Finally, we summarize current exciting developments of experimental strategies in itch research and in clinical development for itch therapy...
  5. pmc Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins
    Benjamin E Padilla
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 179:981-97. 2007
    ..We propose a mechanism by which endosomal ECE-1 degrades neuropeptides in endosomes to disrupt the peptide/receptor/beta-arrestin complex, freeing internalized receptors from beta-arrestins and promoting recycling and resensitization...
  6. pmc Neurovascular and neuroimmune aspects in the pathophysiology of rosacea
    Verena D Schwab
    Department of Dermatology, University Hospital Munster, Munster, Germany
    J Investig Dermatol Symp Proc 15:53-62. 2011
    ..Drugs that function on neurovascular and/or neuroimmune communication may be beneficial for the treatment of rosacea...
  7. pmc Endothelin-converting enzyme-1 degrades internalized somatostatin-14
    Dirk Roosterman
    Department of Dermatology, Interdisziplinäres Zentrum für Klinische Forschung Münster, and Ludwig Bolzmann Institute for Cell and Immunobiology of the Skin, University Munster, D 48149 Munster, Germany
    Endocrinology 149:2200-7. 2008
    ..Moreover, further investigation of endopeptidase-regulated trafficking of neuropeptides may result in novel concepts of neuropeptide receptor inactivation in cancer diagnosis...
  8. doi request reprint Role of matriptase and proteinase-activated receptor-2 in nonmelanoma skin cancer
    Georgeta Bocheva
    University of Munster, Munster, Germany
    J Invest Dermatol 129:1816-23. 2009
    ..In conclusion, our results suggest that PAR(2) is a substrate for matriptase in human skin in vivo. Deregulation of these proteins delineates SCC progression...
  9. pmc Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones
    Juan Carlos Pelayo
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 0660, USA
    J Physiol 589:5213-30. 2011
    ....
  10. pmc Proteinase-activated receptor-2 agonist activates anti-influenza mechanisms and modulates IFNγ-induced antiviral pathways in human neutrophils
    Micha Feld
    Department of Dermatology, Heinrich Heine University, 40225 Dusseldorf, Germany
    Biomed Res Int 2013:879080. 2013
    ..Altogether, these findings emphasize two PAR2-controlled antiviral mechanisms that are independent of or modulated by IFNγ...
  11. ncbi request reprint Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells
    Corinna Moormann
    Department of Dermatology, IZKF Münster and Ludwig Boltzmann Institute for Cell and Immunbiology of the Skin, University of Munster, Munster, Germany
    J Invest Dermatol 126:746-55. 2006
    ..Thus, PAR2 may be an important regulator of skin mast cell function during cutaneous inflammation and hypersensitivity...
  12. pmc Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling
    Graeme S Cottrell
    Department of Surgery, University of California, San Francisco, CA 94143 0660, USA
    J Biol Chem 284:22411-25. 2009
    ..We propose that agonist availability in endosomes, here regulated by ECE-1, controls beta-arrestin-dependent signaling of endocytosed GPCRs...
  13. ncbi request reprint Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection
    Micha Feld
    Department of Dermatology and Ludwig Boltzmann Institute for Immunobiology of the Skin, University of Munster, Munster, Germany
    J Immunol 180:6903-10. 2008
    ..This effect could be associated with the ability of PAR(2) agonists to enhance IFN-gamma-induced protective effects on human monocytes...
  14. ncbi request reprint Proteinase-activated receptor-2 (PAR2): a tumor suppressor in skin carcinogenesis
    Anke Rattenholl
    Department of Dermatology and Interdisciplinary Center for Clinical Research IZKF Münster, University of Munster, Munster, Germany
    J Invest Dermatol 127:2245-52. 2007
    ..Thus, our results provide early experimental evidence for a tumor-protective role of PAR(2)...
  15. ncbi request reprint Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1
    Graeme S Cottrell
    Department of Surgery, University of California, San Francisco, California 94143 0660, USA
    J Biol Chem 282:12260-71. 2007
    ..After sustained stimulation, CLR and RAMP1 traffic from endosomes to lysosomes by ubiquitin-independent mechanisms, where they are degraded at different rates...
  16. ncbi request reprint Neuroimmune interactions in allergic skin diseases
    Ferda Cevikbas
    Department of Dermatology, IZKF Moenster and Boltzmann Institute for Cell and Immunobiology of the Skin, University of Munster, Germany
    Curr Opin Allergy Clin Immunol 7:365-73. 2007
    ..Moreover, structural cells and invading immune cells express neuronal receptors and release mediators which directly communicate with nerve endings in the skin...
  17. pmc Tumor immune escape by the loss of homeostatic chemokine expression
    Andor Pivarcsi
    Department of Dermatology, Heinrich Heine University, D 40255 Düsseldorf, Germany
    Proc Natl Acad Sci U S A 104:19055-60. 2007
    ..Collectively, our data identify a mechanism of skin tumors to evade host antitumor immune responses...
  18. pmc The TGR5 receptor mediates bile acid-induced itch and analgesia
    Farzad Alemi
    Department of Surgery, UCSF, San Francisco, California 94121, USA
    J Clin Invest 123:1513-30. 2013
    ..These mechanisms could contribute to pruritus and painless jaundice that occur during cholestatic liver diseases...
  19. doi request reprint Intracellular degradation of somatostatin-14 following somatostatin-receptor3-mediated endocytosis in rat insulinoma cells
    Dirk Roosterman
    Department of Dermatology, IZKF Münster and Ludwig Boltzmann Institute for Cell and Immunobiology of the Skin, Germany
    FEBS J 275:4728-39. 2008
    ..Thus, the intracellular processing of internalized SST-14 and the regulation of SSTR3 markedly differ from the events mediated by the other SSTR subtypes...
  20. doi request reprint New tools for assessing the individual risk of metastasis in renal cell carcinoma
    Edwin Herrmann
    Department of Urology, University Hospital of Munster, Albert Schweitzer Campus 1, Munster, Germany
    Clin Exp Metastasis 30:215-24. 2013
    ..TEER-analysis has proven to be a useful functional assay giving highly relevant individual information on functional tumor cell characteristics that add to pathologic evaluation...
  21. pmc Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling
    Dirk Roosterman
    Department of Dermatology, Interdisziplinäres Zentrum für Klinische Forschung Münster, and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Von Esmarch Strasse 58, 48149 Munster, Germany
    Proc Natl Acad Sci U S A 104:11838-43. 2007
    ..Antagonism of these endosomal processes represents a strategy for inhibiting sustained signaling of receptors, and defects may explain the tachyphylaxis of drugs that are receptor agonists...
  22. pmc Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes
    Victoria M Shpacovitch
    Department of Dermatology, IZKF Münster, Boltzmann Institute for Immunobiology of the Skin, University of Munster, Germany
    Immunology 133:329-39. 2011
    ..Our findings suggest a potentially protective role of PAR(2) agonists in the anti-microbial defence established by human monocytes and neutrophils...
  23. ncbi request reprint Role of vasculature in atopic dermatitis
    Martin Steinhoff
    Department of Dermatology, University Hospital Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    J Allergy Clin Immunol 118:190-7. 2006
    ..Endothelial cells play a pivotal role in the pathophysiology of AD and represent future targets for the treatment of AD...
  24. ncbi request reprint Ubiquitin-dependent down-regulation of the neurokinin-1 receptor
    Graeme S Cottrell
    Departments of Surgery and Physiology, University of California, San Francisco, 94143 0660, USA
    J Biol Chem 281:27773-83. 2006
    ..Thus, chronic stimulation with SP induces ubiquitination of the NK(1)R, which mediates its degradation and down-regulation...
  25. ncbi request reprint Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B
    Jörg Buddenkotte
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    J Invest Dermatol 124:38-45. 2005
    ..Thus, PAR2 may play an important regulatory role of human KTC during inflammation and immune response...
  26. pmc Clinical, cellular, and molecular aspects in the pathophysiology of rosacea
    Martin Steinhoff
    Departments of Dermatology and Surgery, University of California, San Francisco, San Francisco, California, USA
    J Investig Dermatol Symp Proc 15:2-11. 2011
    ..This review highlights recent molecular (gene array) and cellular findings and aims to integrate the different body defense mechanisms into a modern concept of rosacea pathophysiology...
  27. pmc Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor
    Jane E Murphy
    Department of Surgery, University of California, San Francisco, 94143 0660, USA
    Am J Physiol Cell Physiol 301:C780-91. 2011
    ..PP2A interaction with NK(1)R requires β-arrestin1. ECE-1 promotes this process by releasing β-arrestin1 from NK(1)R in endosomes. These findings represent a novel mechanism of PP2A- and ECE-1-dependent resensitization of GPCRs...
  28. doi request reprint Proteinase-activated receptor-2 in the skin: receptor expression, activation and function during health and disease
    Anke Rattenholl
    Department of Dermatology, Interdisziplinares Zentrum fur Klinische Forschung IZKF, Ludwig Bolzmann Institute for Cell and Immunobiology of the Skin, University of Munster, Munster, Germany
    Drug News Perspect 21:369-81. 2008
    ..Activation of the receptor leads to the production of various cytokines and chemokines which modulate skin homeostasis, immune and inflammatory responses as well as tumor surveillance...
  29. pmc Proteinase-activated receptors 1 and 2 regulate invasive behavior of human melanoma cells via activation of protein kinase D1
    Cordula Kempkes
    Department of Dermatology and IZKF Münster, University of Munster, Munster, Germany
    J Invest Dermatol 132:375-84. 2012
    ..Inactivation of the PKD1 pathway may be beneficial for the inhibition of PAR-induced melanoma proliferation and for maintenance of the inflammatory tumor environment...
  30. doi request reprint α-1-Antitrypsin and IFN-γ reduce the severity of IC-mediated vasculitis by regulation of leukocyte recruitment in vivo
    Micha Feld
    Department of Dermatology and Boltzmann Institute for Immunobiology of Skin, University of Munster, Munster, Germany
    J Invest Dermatol 132:2286-95. 2012
    ..We also revealed that the recruitment of neutrophils during RPA was a prerequisite for full KC expression. Thus, therapeutic administration of α1AT and IFN-γ might be beneficial for limiting the duration and severity of ICV...
  31. ncbi request reprint Neurophysiology of pruritus: cutaneous elicitation of itch
    Sonja Ständer
    Department of Dermatology, University of Munster, Munster, Germany
    Arch Dermatol 139:1463-70. 2003
    ..This review focuses on the peripheral generation of itch, including neurotransmitters, neuropeptides, and inflammatory mediators...
  32. ncbi request reprint Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils
    Victoria M Shpacovitch
    Department of Dermatology, IZKF Münster, and Boltzmann Institute for Immunobiology of the Skin, University of Munster, Germany
    Exp Dermatol 16:799-806. 2007
    ....
  33. doi request reprint A TR(I)P to pruritus research: role of TRPV3 in inflammation and itch
    Martin Steinhoff
    Department of Dermatology, IZKF Münster, Ludwig Boltzmann Institute for Immunobiology of the Skin, University Hospital Munster, Munster, Germany
    J Invest Dermatol 129:531-5. 2009
    ..New evidence indicates that the vanilloid type 3 (TRPV3) channel is crucially involved in pruritic dermatitis, making it a good candidate for future therapy in skin inflammation and pruritus...
  34. ncbi request reprint Microfluidic reveals generation of platelet-strings on tumor-activated endothelium
    Tobias Goerge
    University of Munster, Department of Dermatology, Munster, Germany
    Thromb Haemost 98:283-6. 2007
    ..Immunofluorescence imaging showed that TU-SN rapidly induces platelet-string formation via secreted VWF. We demonstrated that tumor-derived supernatant is a potent agonist inducing platelet adhesion under flow conditions...
  35. ncbi request reprint Cutaneous allergic contact dermatitis responses are diminished in mice deficient in neurokinin 1 receptors and augmented by neurokinin 2 receptor blockage
    Thomas E Scholzen
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarch Strasse 58, 48149 Munster, Germany
    FASEB J 18:1007-9. 2004
    ..Thus, SP, NKA, NK-1R, and NK-2R have important but differential roles in the regulation of cutaneous inflammatory responses...
  36. pmc A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1
    Ferda Cevikbas
    Departments of Dermatology and Surgery, University of California, San Francisco, San Francisco, Calif Department of Dermatology, University Hospital Dusseldorf, Dusseldorf, Germany
    J Allergy Clin Immunol 133:448-60. 2014
    ..Although the cytokine IL-31 has been implicated in inflammatory and lymphoma-associated itch, the cellular basis for its pruritic action is yet unclear...
  37. pmc Rosacea: The cytokine and chemokine network
    Peter Arne Gerber
    Department of Dermatology, University Hospital Dusseldorf, Dusseldorf, Germany
    J Investig Dermatol Symp Proc 15:40-7. 2011
    ..Here we summarize the current knowledge of the cytokine and chemokine network in rosacea and propose pathways that may be of therapeutic interest...
  38. ncbi request reprint Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures
    Sonja Ständer
    Department of Dermatology, University of Munster, Muenster, Germany
    Exp Dermatol 13:129-39. 2004
    ..After cessation of capsaicin therapy, neuropeptides re-accumulated in skin nerves. In conclusion, VR1 is widely distributed in the skin, suggesting a major role for this receptor, e.g. in nociception and neurogenic inflammation...
  39. pmc Anatomy and neurophysiology of pruritus
    Akihiko Ikoma
    Department of Dermatology and Surgery, University of California, San Francisco, San Francisco, CA, USA
    Semin Cutan Med Surg 30:64-70. 2011
    ..Itch sensitization must also be considered in discussions of itch. This review highlights anatomical and functional properties of itch pathways and their relation to understanding itch perception and pruritic diseases...
  40. ncbi request reprint Agonist-induced endocytosis of rat somatostatin receptor 1
    Dirk Roosterman
    Department of Dermatology, and Ludwig Boltzmann Institute for Cell and Immunobiology of the Skin, Von Esmarch Strasse 58, D 48148 Münster, Germany
    Endocrinology 148:1050-8. 2007
    ..Our results show for the first time that sst1 mediates a dynamic process of endocytosis, recycling, and re-endocytosis of its cognate ligand...
  41. pmc Mouse model of touch-evoked itch (alloknesis)
    Tasuku Akiyama
    Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, California, USA
    J Invest Dermatol 132:1886-91. 2012
    ..In mice with experimental dry skin, there was a time-dependent increase in spontaneous and touch-evoked scratching. This animal model appears to be useful to investigate neural mechanisms of itch and alloknesis...
  42. ncbi request reprint Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation
    Tobias Goerge
    Department of Dermatology, Institute of Physiology II, Interdisziplinäres Zentrum für Klinische Forschung Münster, Von Esmarch Strasse 58, 48149 Munster, Germany
    Cancer Res 66:7766-74. 2006
    ..Inhibition of this cross-talk may be a powerful means to prevent tumor-induced ECA and thus thrombotic and inflammatory cell adhesion...
  43. ncbi request reprint Neuronal control of skin function: the skin as a neuroimmunoendocrine organ
    Dirk Roosterman
    Department of Dermatology, IZKF Münster, Germany
    Physiol Rev 86:1309-79. 2006
    ..A deeper understanding of cutaneous neuroimmunoendocrinology may help to develop new strategies for the treatment of several skin diseases...
  44. ncbi request reprint Modern aspects of cutaneous neurogenic inflammation
    Martin Steinhoff
    Department of Dermatology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Arch Dermatol 139:1479-88. 2003
    ..Understanding the mechanisms and the factors controlling neuromediators and their receptors and degrading enzymes will lead to the identification of novel therapeutic targets for the treatment of cutaneous diseases...
  45. ncbi request reprint Cytokines and chemokines orchestrate atopic skin inflammation
    Bernhard Homey
    Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, Dusseldorf 40225, Germany
    J Allergy Clin Immunol 118:178-89. 2006
    ..In this review we summarize advances in our understanding of the complex interdependent network of members of the rapidly growing protein superfamilies of cytokines and chemokines that lead to the development of AD...
  46. ncbi request reprint IL-31: a new link between T cells and pruritus in atopic skin inflammation
    Eniko Sonkoly
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    J Allergy Clin Immunol 117:411-7. 2006
    ..IL-31 is a novel T-cell-derived cytokine that induces severe pruritus and dermatitis in transgenic mice, and signals through a heterodimeric receptor composed of IL-31 receptor A and oncostatin M receptor...
  47. ncbi request reprint Histamine and antihistamines in atopic dermatitis
    Jörg Buddenkotte
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University Hospital Munster, Germany
    Adv Exp Med Biol 709:73-80. 2010
    ..This book chapter will therefore summarize and assess the role of histamine in AD and the efficacy of antihistamines in its treatment based on results of basic research and clinical studies...
  48. doi request reprint Role of spinal neurotransmitter receptors in itch: new insights into therapies and drug development
    Ferda Cevikbas
    Department of Dermatology, University of California, San Francisco, CA 94143 0660, USA
    CNS Neurosci Ther 17:742-9. 2011
    ..Thus, the identification of itch-specific receptors and understanding itch-related circuits in the spinal cord may be innovative strategies for the development of novel antipruritic drugs...
  49. ncbi request reprint Calcineurin inhibitors for the treatment of atopic dermatitis
    Jan Ehrchen
    University Hospital Munster, Boltzmann Institute for Cell and Immunobiology of the Skin, Department of Dermatology, Munster, Germany
    Expert Opin Pharmacother 9:3009-23. 2008
    ..Therapeutic objectives for AD should be to quickly reduce disease symptoms by targeting pathophysiological pathways, and to provide long-term management by reducing recurrences...
  50. pmc Psychoneuroimmunology of psychological stress and atopic dermatitis: pathophysiologic and therapeutic updates
    Andrea L Suarez
    Department of Dermatology, University of Colorado Denver, School of Medicine, Aurora, USA
    Acta Derm Venereol 92:7-15. 2012
    ....
  51. pmc Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice
    Fiore Cattaruzza
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Physiol Gastrointest Liver Physiol 304:G1002-12. 2013
    ..We have demonstrated, using novel and objective pain measurements, that TRPA1 mediates inflammation and visceral hypersensitivity in CP and could be a therapeutic target for the treatment of sustained inflammatory abdominal pain...
  52. ncbi request reprint Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo
    Stephan Seeliger
    Department of Pediatrics, University of Munster, Munster, Germany
    FASEB J 17:1871-85. 2003
    ..Thus, PAR-2 may be a beneficial therapeutic target for the treatment of inflammatory skin diseases...
  53. pmc Pruritus in elderly patients--eruptions of senescence
    Timothy G Berger
    Department of Dermatology, University of California San Francisco, San Francisco, CA 94143, USA
    Semin Cutan Med Surg 30:113-7. 2011
    ....
  54. ncbi request reprint Innovative management of pruritus
    Jamison D Feramisco
    Department of Dermatology, University of California at San Francisco, 1701 Divisadero Street, 3rd Floor, San Francisco, CA 94115, USA
    Dermatol Clin 28:467-78. 2010
    ..They also addresses mechanisms and management modalities of itch in common systemic diseases, including cholestasis, uremia, and neuropathic dysfunction...
  55. ncbi request reprint Recycling and resensitization of the neurokinin 1 receptor. Influence of agonist concentration and Rab GTPases
    Dirk Roosterman
    Departments of Surgery and Physiology, University of California San Francisco, San Francisco, California 94143 0660, USA
    J Biol Chem 279:30670-9. 2004
    ....
  56. pmc Management of itch in atopic dermatitis
    Judith Hong
    Department of Dermatology, University of California San Francisco, San Francisco, CA 94143, USA
    Semin Cutan Med Surg 30:71-86. 2011
    ..This review highlights various topical, systemic, and complementary and alternative therapies, as well as provide a therapeutic ladder for optimized long-term control of itch in atopic dermatitis...
  57. pmc Pruritus and renal failure
    Timothy G Berger
    Department of Dermatology, University of California San Francisco, San Francisco, CA 94143, USA
    Semin Cutan Med Surg 30:99-100. 2011
    ..Gabapentin has been recently discovered as an effective agent for the patient with ESRD pruritus. Kappa opiate agonists are promising new therapeutic options...
  58. ncbi request reprint Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus
    Martin Steinhoff
    Department of Dermatology, IZKF Münster, Ludwig Boltzmann Institute for Immunobiology of the Skin, University Hospital Muenster, Muenster, Germany
    J Invest Dermatol 126:1705-18. 2006
    ..A deeper understanding of these circuits is required for the development of novel antipruritic strategies...
  59. ncbi request reprint Localization of mu-opioid receptor 1A on sensory nerve fibers in human skin
    Sonja Ständer
    Department of Dermatology, University of Munster, Munster, Germany
    Regul Pept 110:75-83. 2002
    ..Together, our findings contribute to the understanding of the high antipruritic potency of opioid receptor antagonists in various skin and systemic diseases...
  60. ncbi request reprint Successful treatment of generalized eruptive histiocytoma with PUVA
    H Lan Ma
    Department of Dermatology, University Hospital of Munster, Munster, Germany
    J Dtsch Dermatol Ges 5:131-4. 2007
    ..The lesions resolved completely after 20 PUVA treatments. No relapses occurred. Systemic PUVA therapy represents a promising option for the treatment of GEH...
  61. pmc "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 128:1067-70. 2008
    ..This cycle comprises an "outside-inside-outside" model of AD pathogenesis (Elias et al., in press)...
  62. ncbi request reprint Pathway management in ambulatory wound care: defining local standards for quality improvement and interprofessional care
    Peter Hensen
    Department of Dermatology, University of Muenster, Von Esmarch Strasse 58, D 48149 Muenster, Germany
    Int Wound J 2:104-11. 2005
    ..Variances must be merely written down in detail. After 1 year in clinical practice, we state that the use of a clinical pathway for chronic wound management is an effective method of improving clinical processes and patient outcomes...