Affiliation: University of Tennessee
- D3 dopamine receptor-deficient mouse: evidence for reduced anxietyH Steiner
Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, MD 20892, USA
Physiol Behav 63:137-41. 1997..We interpret these results as indicative of reduced anxiety in mice without D3 receptors. Our findings thus suggest that D3 dopamine receptors are involved in the regulation of anxiety...
- Role of dynorphin and enkephalin in the regulation of striatal output pathways and behaviorH Steiner
Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis 38163, USA
Exp Brain Res 123:60-76. 1998..Behavioral consequences of increased opioid peptide function in striatal output pathways may include behavioral sensitization (dynorphin) and recovery of motor function (enkephalin)...
- Cocaine effects on gene regulation in the striatum and behavior: increased sensitivity in D3 dopamine receptor-deficient miceA R Carta
Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
Neuroreport 11:2395-9. 2000..The behavioral response to cocaine is also increased in these mice. These findings indicate that the D3 receptor plays an inhibitory role in the action of cocaine on behavior and gene regulation in the striatum...
- Unilateral striatal dopamine depletion: time-dependent effects on cortical function and behavioural correlatesH Steiner
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA
Eur J Neurosci 14:1390-404. 2001..Moreover, the mechanisms mediating this cortical facilitation appear to be subject to substantial neuroplasticity after dopamine perturbation...
- Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout miceH Steiner
Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, 855 Monroe Avenue, Memphis, TN 38163, USA
Proc Natl Acad Sci U S A 96:5786-90. 1999..Our findings demonstrate that elimination of CB1 receptors results in behavioral abnormalities and functional reorganization of the basal ganglia...
- A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in miceD Accili
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 93:1945-9. 1996..Mice heterozygous for the D3 receptor mutation show similar, albeit less pronounced, behavioral alterations. Our findings indicate that D3 receptors play an inhibitory role in the control of certain behaviors...
- Regulation of rat cortex function by D1 dopamine receptors in the striatumH Steiner
Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis, Tennessee 38163, USA
J Neurosci 20:5449-60. 2000..These results suggest that stimulation of D1 dopamine receptors in the striatum exerts a widespread facilitatory effect on cortical function...
- Pain responses, anxiety and aggression in mice deficient in pre-proenkephalinM Konig
Unit on Developmental Biology, Laboratory of Cell Biology, Section on Neuroanatomy, Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Nature 383:535-8. 1996..Unexpectedly, enk-/- mice exhibit normal stress-induced analgesia. Our results show that enkephalins modulate responses to painful stimuli. Thus, genetic factors may contribute significantly to the experience of pain...
- Altered striatal function in a mutant mouse lacking D1A dopamine receptorsJ Drago
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 91:12564-8. 1994..These findings show that D1A-/- mice exhibit selective functional alterations in the striatal neurons giving rise to the direct striatal output pathway...
- Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilinsH Steiner
Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Adolf-Butenandt-Institute, Ludwig-Maximilians-University, 80036 Munich, Germany
Neurobiol Dis 8:717-22. 2001..This finding indicates that gamma-secretase inhibitors, which are currently developed as therapeutic agents to lower the A beta burden in brains of AD patients, do not interfere with the UPR response...
- Genes and mechanisms involved in beta-amyloid generation and Alzheimer's diseaseH Steiner
Adolf-Butenandt-Institute, Ludwig-Maximilians-University, Dept. of Biochemistry, Munich, Germany
Eur Arch Psychiatry Clin Neurosci 249:266-70. 1999..In the second part of this article recent results will be described, which demonstrate an unexpected biological and pathological function of an AD associated gene...
- A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signalingH Steiner
Central Institute of Mental Health, Department of Molecular Biology, J5, 68159 Mannheim, Germany
J Biol Chem 274:28669-73. 1999..These data suggest that PS2 is functionally involved in Abeta production and Notch signaling by facilitating similar proteolytic cleavages...
- Motor-skill learning in a novel running-wheel task is dependent on D1 dopamine receptors in the striatumI Willuhn
Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
Neuroscience 153:249-58. 2008..Furthermore, our findings demonstrate that D1 receptors in the striatum are critical for consolidation of long-term skill memory...