H Steiner

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi D3 dopamine receptor-deficient mouse: evidence for reduced anxiety
    H Steiner
    Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Physiol Behav 63:137-41. 1997
  2. ncbi Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior
    H Steiner
    Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis 38163, USA
    Exp Brain Res 123:60-76. 1998
  3. ncbi Cocaine effects on gene regulation in the striatum and behavior: increased sensitivity in D3 dopamine receptor-deficient mice
    A R Carta
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuroreport 11:2395-9. 2000
  4. ncbi Unilateral striatal dopamine depletion: time-dependent effects on cortical function and behavioural correlates
    H Steiner
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA
    Eur J Neurosci 14:1390-404. 2001
  5. pmc Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout mice
    H Steiner
    Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, 855 Monroe Avenue, Memphis, TN 38163, USA
    Proc Natl Acad Sci U S A 96:5786-90. 1999
  6. pmc A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice
    D Accili
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 93:1945-9. 1996
  7. ncbi Regulation of rat cortex function by D1 dopamine receptors in the striatum
    H Steiner
    Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis, Tennessee 38163, USA
    J Neurosci 20:5449-60. 2000
  8. ncbi Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin
    M Konig
    Unit on Developmental Biology, Laboratory of Cell Biology, Section on Neuroanatomy, Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Nature 383:535-8. 1996
  9. pmc Altered striatal function in a mutant mouse lacking D1A dopamine receptors
    J Drago
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 91:12564-8. 1994
  10. ncbi Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins
    H Steiner
    Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Adolf-Butenandt-Institute, Ludwig-Maximilians-University, 80036 Munich, Germany
    Neurobiol Dis 8:717-22. 2001

Collaborators

Detail Information

Publications13

  1. ncbi D3 dopamine receptor-deficient mouse: evidence for reduced anxiety
    H Steiner
    Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Physiol Behav 63:137-41. 1997
    ..We interpret these results as indicative of reduced anxiety in mice without D3 receptors. Our findings thus suggest that D3 dopamine receptors are involved in the regulation of anxiety...
  2. ncbi Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior
    H Steiner
    Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis 38163, USA
    Exp Brain Res 123:60-76. 1998
    ..Behavioral consequences of increased opioid peptide function in striatal output pathways may include behavioral sensitization (dynorphin) and recovery of motor function (enkephalin)...
  3. ncbi Cocaine effects on gene regulation in the striatum and behavior: increased sensitivity in D3 dopamine receptor-deficient mice
    A R Carta
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuroreport 11:2395-9. 2000
    ..The behavioral response to cocaine is also increased in these mice. These findings indicate that the D3 receptor plays an inhibitory role in the action of cocaine on behavior and gene regulation in the striatum...
  4. ncbi Unilateral striatal dopamine depletion: time-dependent effects on cortical function and behavioural correlates
    H Steiner
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA
    Eur J Neurosci 14:1390-404. 2001
    ..Moreover, the mechanisms mediating this cortical facilitation appear to be subject to substantial neuroplasticity after dopamine perturbation...
  5. pmc Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout mice
    H Steiner
    Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, 855 Monroe Avenue, Memphis, TN 38163, USA
    Proc Natl Acad Sci U S A 96:5786-90. 1999
    ..Our findings demonstrate that elimination of CB1 receptors results in behavioral abnormalities and functional reorganization of the basal ganglia...
  6. pmc A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice
    D Accili
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 93:1945-9. 1996
    ..Mice heterozygous for the D3 receptor mutation show similar, albeit less pronounced, behavioral alterations. Our findings indicate that D3 receptors play an inhibitory role in the control of certain behaviors...
  7. ncbi Regulation of rat cortex function by D1 dopamine receptors in the striatum
    H Steiner
    Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis, Tennessee 38163, USA
    J Neurosci 20:5449-60. 2000
    ..These results suggest that stimulation of D1 dopamine receptors in the striatum exerts a widespread facilitatory effect on cortical function...
  8. ncbi Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin
    M Konig
    Unit on Developmental Biology, Laboratory of Cell Biology, Section on Neuroanatomy, Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Nature 383:535-8. 1996
    ..Unexpectedly, enk-/- mice exhibit normal stress-induced analgesia. Our results show that enkephalins modulate responses to painful stimuli. Thus, genetic factors may contribute significantly to the experience of pain...
  9. pmc Altered striatal function in a mutant mouse lacking D1A dopamine receptors
    J Drago
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 91:12564-8. 1994
    ..These findings show that D1A-/- mice exhibit selective functional alterations in the striatal neurons giving rise to the direct striatal output pathway...
  10. ncbi Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins
    H Steiner
    Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Adolf-Butenandt-Institute, Ludwig-Maximilians-University, 80036 Munich, Germany
    Neurobiol Dis 8:717-22. 2001
    ..This finding indicates that gamma-secretase inhibitors, which are currently developed as therapeutic agents to lower the A beta burden in brains of AD patients, do not interfere with the UPR response...
  11. ncbi Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease
    H Steiner
    Adolf-Butenandt-Institute, Ludwig-Maximilians-University, Dept. of Biochemistry, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 249:266-70. 1999
    ..In the second part of this article recent results will be described, which demonstrate an unexpected biological and pathological function of an AD associated gene...
  12. ncbi A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling
    H Steiner
    Central Institute of Mental Health, Department of Molecular Biology, J5, 68159 Mannheim, Germany
    J Biol Chem 274:28669-73. 1999
    ..These data suggest that PS2 is functionally involved in Abeta production and Notch signaling by facilitating similar proteolytic cleavages...
  13. pmc Motor-skill learning in a novel running-wheel task is dependent on D1 dopamine receptors in the striatum
    I Willuhn
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Neuroscience 153:249-58. 2008
    ..Furthermore, our findings demonstrate that D1 receptors in the striatum are critical for consolidation of long-term skill memory...