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Genomes and Genes | D SteinbergSummaryAffiliation: University of California Country: USA Publications
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Publications
The pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy, part IV: the 1984 coronary primary prevention trial ends it--almostDaniel Steinberg
Department of Medicine, University of California San Diego, La Jolla, CA, USA
J Lipid Res 47:1-14. 2006..The Institute initiated a national cooperative program to that end, the National Cholesterol Education Program. For the first time, preventing coronary heart disease became a national public health goal...- Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crimeDaniel Steinberg
Department of Medicine University of California San Diego, La Jolla, California, USA
Nat Med 8:1211-7. 2002 - Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part II: the early evidence linking hypercholesterolemia to coronary disease in humansDaniel Steinberg
Department of Medicine, University of California San Diego, La Jolla, CA, USA
J Lipid Res 46:179-90. 2005..Some of the reasons the "cholesterol controversy" continued in the face of powerful evidence supporting intervention are discussed... - Thematic review series: the pathogenesis of atherosclerosis: an interpretive history of the cholesterol controversy, part III: mechanistically defining the role of hyperlipidemiaDaniel Steinberg
Department of Medicine, University of California San Diego, La Jolla, CA, USA
J Lipid Res 46:2037-51. 2005..The rapid advances in understanding of lipoprotein metabolism in the 1950s and 1960s and the application of modern cellular biology in the 1970s provided the context for a modern consensus on pathogenetic mechanisms of atherogenesis... - Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy, part V: the discovery of the statins and the end of the controversyDaniel Steinberg
Department of Medicine, University of California-San Diego, La Jolla, CA
J Lipid Res 47:1339-51. 2006.... 
The rationale for initiating treatment of hypercholesterolemia in young adulthoodDaniel Steinberg
Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093 0682, USA
Curr Atheroscler Rep 15:296. 2013..This report briefly reviews some of the emerging lines of evidence that are helping us reach a consensus on when and how we should intervene...- Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part IDaniel Steinberg
Department of Medicine, University of California San Diego, La Jolla, CA 92093 0682, USA
J Lipid Res 45:1583-93. 2004..The history of this controversy is worth telling for its own sake and because remembering it may help us avoid similar mistakes in the future... - Hypercholesterolemia and inflammation in atherogenesis: two sides of the same coinDaniel Steinberg
University of California San Diego, La Jolla, CA 92093 0682, USA
Mol Nutr Food Res 49:995-8. 2005..There is no need to consider hypercholesterolemia and inflammation as alternative hypotheses. Both are very much involved. Optimal intervention and prevention will probably require attention to both... - Evidence mandating earlier and more aggressive treatment of hypercholesterolemiaDaniel Steinberg
Department of Medicine, BSB 1080, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093-0682, USA
Circulation 118:672-7. 2008 
The LDL modification hypothesis of atherogenesis: an updateDaniel Steinberg
Department of Medicine, University of California San Diego, La Jolla, CA, USA
J Lipid Res 50:S376-81. 2009..Yet many of the lines of evidence that support the hypothesis have been demonstrated to apply also in humans. In this review, we briefly summarize the lines of evidence on which the hypothesis rests, its strengths, and its weaknesses...- Earlier intervention in the management of hypercholesterolemia: what are we waiting for?Daniel Steinberg
Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
J Am Coll Cardiol 56:627-9. 2010..Initiating treatment at, for example, age 30 years instead of age 60 years might very well prevent not just 30% of events, as in the 5-year statin trials, but perhaps as many as 60%... - Chance and serendipity in science: two examples from my own careerDaniel Steinberg
Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California 92093, USA
J Biol Chem 286:37895-904. 2011..quot;Reflections" seems an appropriate space for the latter. I have chosen two scenarios from my own career in which happy accidents played important roles but, unhappily, received little recognition in my published papers... - Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis?Daniel Steinberg
Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of California San Diego, La Jolla, Calif 92093 0682, USA
Circulation 105:2107-11. 2002 - Is there a potential therapeutic role for vitamin E or other antioxidants in atherosclerosis?D Steinberg
University of California, San Diego, La Jolla, California 92093 0682, USA
Curr Opin Lipidol 11:603-7. 2000..The answer to the title query is 'Probably, but it is too soon to say'... - Scavenger receptor class B type I as a receptor for oxidized low density lipoproteinK Gillotte-Taylor
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
J Lipid Res 42:1474-82. 2001.... - Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptorH Yoshida
University of California, San Diego, Department of Medicine, 0682, 9500 Gilman Drive, La Jolla, CA 92093, USA
Biochem J 334:9-13. 1998..These results suggest that differentiation induces the expression of LOX-1 in macrophages, where it may play a role as a scavenger receptor and/or a receptor for oxidized LDL... - Effect of the antioxidant N,N'-diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in apoE-deficient miceR K Tangirala
Department of Medicine, University of California San Diego, La Jolla 92093 0682, USA
Arterioscler Thromb Vasc Biol 15:1625-30. 1995..02). These results are consistent with the hypothesis that lipoprotein oxidation contributes to atherogenesis in apoE-deficient mice. However, further studies with other antioxidants are needed to validate this hypothesis... - The oxidative modification hypothesis of atherosclerosis: does it hold for humans?J L Witztum
Department of Medicine, Division of Endocrinology and Metabolism, Specialized Center of Research in Molecular Medicine and Atherosclerosis, University of California, San Diego School of Medicine, La Jolla, California, USA
Trends Cardiovasc Med 11:93-102. 2001..The oxidation hypothesis is still viable, but a great deal needs to be learned in order to design the appropriate clinical trials to properly test the importance of oxidation in the pathogenesis of atherosclerosis in humans... - Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesionsS Yla-Herttuala
Department of Medicine, University of California San Diego, La Jolla 92093
Proc Natl Acad Sci U S A 87:6959-63. 1990..These data suggest that therapy targeted to block macrophage lipoxygenase activity might decrease the rate of development of atherosclerotic lesions... - Scavenger receptors, oxidized LDL, and atherosclerosisA Boullier
Department of Medicine, University of California, San Diego, La Jolla 92093, USA
Ann N Y Acad Sci 947:214-22; discussion 222-3. 2001..This has important implications in biology generally and specifically in atherogenesis, because apoptosis is a prominent feature of late lesions... - Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoproteinM P Ramprasad
Department of Medicine, University of California at San Diego, La Jolla 92093 0682, USA
Proc Natl Acad Sci U S A 93:14833-8. 1996.... - Intensive combination drug therapy of familial hypercholesterolemia with lovastatin, probucol, and colestipol hydrochlorideJ L Witztum
Department of Medicine, University of California, San Diego, La Jolla 92093 0613
Circulation 79:16-28. 1989..The addition of probucol as a third hypolipidemic agent adds little to the therapeutic regimen as measured by lowering of LDL levels... - A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndromeKarsten Hartvigsen
Department of Medicine, 0682, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0682, USA
Arterioscler Thromb Vasc Biol 27:878-85. 2007..Our aim was to design a diet inducing atherosclerosis through moderate hypercholesterolemia without associated parameters of the metabolic syndrome... - Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytesK Murao
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0682, USA
J Biol Chem 272:17551-7. 1997..An additional role in recognition of damaged cells is suggested by these studies... - The statins in preventive cardiologyDaniel Steinberg
Division of Endocrinology and Metabolism, University of California, San Diego, School of Medicine, La Jolla, USA
N Engl J Med 359:1426-7. 2008 - Surface expression and rapid internalization of macrosialin (mouse CD68) on elicited mouse peritoneal macrophagesH Kurushima
Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
J Leukoc Biol 67:104-8. 2000..Exchange with intracellular pools occurs at an extremely high rate. The results are compatible with a surface function, including internalization of bound ligands or adhesion to surfaces... - ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serumW Palinski
Department of Medicine, University of California San Diego, La Jolla 92093
Arterioscler Thromb 14:605-16. 1994.... - Cloning and expression in Xenopus oocytes of a mouse homologue of the human acylcoenzyme A: cholesterol acyltransferase and its potential role in metabolism of oxidized LDLS Green
Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
Biochem Biophys Res Commun 218:924-9. 1996..Injection of ACAT mRNA into oocytes induced specific binding of OxLDL. ACAT is expressed in mouse macrophages as a approximately 3.6 kB transcript and the expression is upregulated in human THP-1 cells treated with PMA... - Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensationPeter Friedman
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0601, USA
J Biol Chem 277:7010-20. 2002..Synthetic imine adducts of oxidized phospholipids of this type are capable of blocking the uptake of OxLDL... - Expression of hormone-sensitive lipase mRNA in macrophagesJ C Khoo
Department of Medicine, University of California, San Diego, La Jolla 92039 0682
J Lipid Res 34:1969-74. 1993..The development of a PCR assay for HSL mRNA may allow further study of the regulation of neutral cholesteryl ester hydrolase expression in macrophages and foam cells, and its potential role in atherogenesis... - Phosphocholine as a pattern recognition ligand for CD36Agnes Boullier
Department of Medicine, University of California San Diego, La Jolla, CA 92093 0682, USA
J Lipid Res 46:969-76. 2005..In conclusion, our data demonstrate that the PC headgroup of OxPL alone is sufficient for binding to CD36, but only if presented in the correct conformation as in OxPL of OxLDL or as in POVPC-peptide adducts... - Statin treatment does not cause cancerDaniel Steinberg
J Am Coll Cardiol 52:1148-9. 2008 - Simvastatin with or without ezetimibe in familial hypercholesterolemiaDaniel Steinberg
N Engl J Med 359:529; author reply 532. 2008 - Antioxidant vitamin supplements and cardiovascular diseasePenny M Kris-Etherton
Circulation 110:637-41. 2004