D Steinberg

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy, part IV: the 1984 coronary primary prevention trial ends it--almost
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    J Lipid Res 47:1-14. 2006
  2. ncbi request reprint Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime
    Daniel Steinberg
    Department of Medicine University of California San Diego, La Jolla, California, USA
    Nat Med 8:1211-7. 2002
  3. ncbi request reprint Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part II: the early evidence linking hypercholesterolemia to coronary disease in humans
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    J Lipid Res 46:179-90. 2005
  4. ncbi request reprint Thematic review series: the pathogenesis of atherosclerosis: an interpretive history of the cholesterol controversy, part III: mechanistically defining the role of hyperlipidemia
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    J Lipid Res 46:2037-51. 2005
  5. ncbi request reprint Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy, part V: the discovery of the statins and the end of the controversy
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, CA
    J Lipid Res 47:1339-51. 2006
  6. doi request reprint The rationale for initiating treatment of hypercholesterolemia in young adulthood
    Daniel Steinberg
    Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093 0682, USA
    Curr Atheroscler Rep 15:296. 2013
  7. ncbi request reprint Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part I
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0682, USA
    J Lipid Res 45:1583-93. 2004
  8. ncbi request reprint Hypercholesterolemia and inflammation in atherogenesis: two sides of the same coin
    Daniel Steinberg
    University of California San Diego, La Jolla, CA 92093 0682, USA
    Mol Nutr Food Res 49:995-8. 2005
  9. doi request reprint Evidence mandating earlier and more aggressive treatment of hypercholesterolemia
    Daniel Steinberg
    Department of Medicine, BSB 1080, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0682, USA
    Circulation 118:672-7. 2008
  10. pmc The LDL modification hypothesis of atherogenesis: an update
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    J Lipid Res 50:S376-81. 2009

Collaborators

Detail Information

Publications34

  1. ncbi request reprint The pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy, part IV: the 1984 coronary primary prevention trial ends it--almost
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    J Lipid Res 47:1-14. 2006
    ..The Institute initiated a national cooperative program to that end, the National Cholesterol Education Program. For the first time, preventing coronary heart disease became a national public health goal...
  2. ncbi request reprint Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime
    Daniel Steinberg
    Department of Medicine University of California San Diego, La Jolla, California, USA
    Nat Med 8:1211-7. 2002
  3. ncbi request reprint Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part II: the early evidence linking hypercholesterolemia to coronary disease in humans
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    J Lipid Res 46:179-90. 2005
    ..Some of the reasons the "cholesterol controversy" continued in the face of powerful evidence supporting intervention are discussed...
  4. ncbi request reprint Thematic review series: the pathogenesis of atherosclerosis: an interpretive history of the cholesterol controversy, part III: mechanistically defining the role of hyperlipidemia
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    J Lipid Res 46:2037-51. 2005
    ..The rapid advances in understanding of lipoprotein metabolism in the 1950s and 1960s and the application of modern cellular biology in the 1970s provided the context for a modern consensus on pathogenetic mechanisms of atherogenesis...
  5. ncbi request reprint Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy, part V: the discovery of the statins and the end of the controversy
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, CA
    J Lipid Res 47:1339-51. 2006
    ....
  6. doi request reprint The rationale for initiating treatment of hypercholesterolemia in young adulthood
    Daniel Steinberg
    Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093 0682, USA
    Curr Atheroscler Rep 15:296. 2013
    ..This report briefly reviews some of the emerging lines of evidence that are helping us reach a consensus on when and how we should intervene...
  7. ncbi request reprint Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part I
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0682, USA
    J Lipid Res 45:1583-93. 2004
    ..The history of this controversy is worth telling for its own sake and because remembering it may help us avoid similar mistakes in the future...
  8. ncbi request reprint Hypercholesterolemia and inflammation in atherogenesis: two sides of the same coin
    Daniel Steinberg
    University of California San Diego, La Jolla, CA 92093 0682, USA
    Mol Nutr Food Res 49:995-8. 2005
    ..There is no need to consider hypercholesterolemia and inflammation as alternative hypotheses. Both are very much involved. Optimal intervention and prevention will probably require attention to both...
  9. doi request reprint Evidence mandating earlier and more aggressive treatment of hypercholesterolemia
    Daniel Steinberg
    Department of Medicine, BSB 1080, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0682, USA
    Circulation 118:672-7. 2008
  10. pmc The LDL modification hypothesis of atherogenesis: an update
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    J Lipid Res 50:S376-81. 2009
    ..Yet many of the lines of evidence that support the hypothesis have been demonstrated to apply also in humans. In this review, we briefly summarize the lines of evidence on which the hypothesis rests, its strengths, and its weaknesses...
  11. doi request reprint Earlier intervention in the management of hypercholesterolemia: what are we waiting for?
    Daniel Steinberg
    Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Am Coll Cardiol 56:627-9. 2010
    ..Initiating treatment at, for example, age 30 years instead of age 60 years might very well prevent not just 30% of events, as in the 5-year statin trials, but perhaps as many as 60%...
  12. pmc Chance and serendipity in science: two examples from my own career
    Daniel Steinberg
    Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:37895-904. 2011
    ..Reflections" seems an appropriate space for the latter. I have chosen two scenarios from my own career in which happy accidents played important roles but, unhappily, received little recognition in my published papers...
  13. ncbi request reprint Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis?
    Daniel Steinberg
    Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of California San Diego, La Jolla, Calif 92093 0682, USA
    Circulation 105:2107-11. 2002
  14. ncbi request reprint Is there a potential therapeutic role for vitamin E or other antioxidants in atherosclerosis?
    D Steinberg
    University of California, San Diego, La Jolla, California 92093 0682, USA
    Curr Opin Lipidol 11:603-7. 2000
    ..The answer to the title query is 'Probably, but it is too soon to say'...
  15. ncbi request reprint Scavenger receptor class B type I as a receptor for oxidized low density lipoprotein
    K Gillotte-Taylor
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Lipid Res 42:1474-82. 2001
    ....
  16. pmc Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor
    H Yoshida
    University of California, San Diego, Department of Medicine, 0682, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Biochem J 334:9-13. 1998
    ..These results suggest that differentiation induces the expression of LOX-1 in macrophages, where it may play a role as a scavenger receptor and/or a receptor for oxidized LDL...
  17. ncbi request reprint Effect of the antioxidant N,N'-diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in apoE-deficient mice
    R K Tangirala
    Department of Medicine, University of California San Diego, La Jolla 92093 0682, USA
    Arterioscler Thromb Vasc Biol 15:1625-30. 1995
    ..02). These results are consistent with the hypothesis that lipoprotein oxidation contributes to atherogenesis in apoE-deficient mice. However, further studies with other antioxidants are needed to validate this hypothesis...
  18. ncbi request reprint The oxidative modification hypothesis of atherosclerosis: does it hold for humans?
    J L Witztum
    Department of Medicine, Division of Endocrinology and Metabolism, Specialized Center of Research in Molecular Medicine and Atherosclerosis, University of California, San Diego School of Medicine, La Jolla, California, USA
    Trends Cardiovasc Med 11:93-102. 2001
    ..The oxidation hypothesis is still viable, but a great deal needs to be learned in order to design the appropriate clinical trials to properly test the importance of oxidation in the pathogenesis of atherosclerosis in humans...
  19. pmc Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions
    S Yla-Herttuala
    Department of Medicine, University of California San Diego, La Jolla 92093
    Proc Natl Acad Sci U S A 87:6959-63. 1990
    ..These data suggest that therapy targeted to block macrophage lipoxygenase activity might decrease the rate of development of atherosclerotic lesions...
  20. ncbi request reprint Scavenger receptors, oxidized LDL, and atherosclerosis
    A Boullier
    Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    Ann N Y Acad Sci 947:214-22; discussion 222-3. 2001
    ..This has important implications in biology generally and specifically in atherogenesis, because apoptosis is a prominent feature of late lesions...
  21. pmc Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein
    M P Ramprasad
    Department of Medicine, University of California at San Diego, La Jolla 92093 0682, USA
    Proc Natl Acad Sci U S A 93:14833-8. 1996
    ....
  22. ncbi request reprint Intensive combination drug therapy of familial hypercholesterolemia with lovastatin, probucol, and colestipol hydrochloride
    J L Witztum
    Department of Medicine, University of California, San Diego, La Jolla 92093 0613
    Circulation 79:16-28. 1989
    ..The addition of probucol as a third hypolipidemic agent adds little to the therapeutic regimen as measured by lowering of LDL levels...
  23. ncbi request reprint A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome
    Karsten Hartvigsen
    Department of Medicine, 0682, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0682, USA
    Arterioscler Thromb Vasc Biol 27:878-85. 2007
    ..Our aim was to design a diet inducing atherosclerosis through moderate hypercholesterolemia without associated parameters of the metabolic syndrome...
  24. ncbi request reprint Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes
    K Murao
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0682, USA
    J Biol Chem 272:17551-7. 1997
    ..An additional role in recognition of damaged cells is suggested by these studies...
  25. doi request reprint The statins in preventive cardiology
    Daniel Steinberg
    Division of Endocrinology and Metabolism, University of California, San Diego, School of Medicine, La Jolla, USA
    N Engl J Med 359:1426-7. 2008
  26. ncbi request reprint Surface expression and rapid internalization of macrosialin (mouse CD68) on elicited mouse peritoneal macrophages
    H Kurushima
    Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Leukoc Biol 67:104-8. 2000
    ..Exchange with intracellular pools occurs at an extremely high rate. The results are compatible with a surface function, including internalization of bound ligands or adhesion to surfaces...
  27. ncbi request reprint ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum
    W Palinski
    Department of Medicine, University of California San Diego, La Jolla 92093
    Arterioscler Thromb 14:605-16. 1994
    ....
  28. ncbi request reprint Cloning and expression in Xenopus oocytes of a mouse homologue of the human acylcoenzyme A: cholesterol acyltransferase and its potential role in metabolism of oxidized LDL
    S Green
    Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    Biochem Biophys Res Commun 218:924-9. 1996
    ..Injection of ACAT mRNA into oocytes induced specific binding of OxLDL. ACAT is expressed in mouse macrophages as a approximately 3.6 kB transcript and the expression is upregulated in human THP-1 cells treated with PMA...
  29. ncbi request reprint Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation
    Peter Friedman
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093 0601, USA
    J Biol Chem 277:7010-20. 2002
    ..Synthetic imine adducts of oxidized phospholipids of this type are capable of blocking the uptake of OxLDL...
  30. ncbi request reprint Expression of hormone-sensitive lipase mRNA in macrophages
    J C Khoo
    Department of Medicine, University of California, San Diego, La Jolla 92039 0682
    J Lipid Res 34:1969-74. 1993
    ..The development of a PCR assay for HSL mRNA may allow further study of the regulation of neutral cholesteryl ester hydrolase expression in macrophages and foam cells, and its potential role in atherogenesis...
  31. ncbi request reprint Phosphocholine as a pattern recognition ligand for CD36
    Agnes Boullier
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0682, USA
    J Lipid Res 46:969-76. 2005
    ..In conclusion, our data demonstrate that the PC headgroup of OxPL alone is sufficient for binding to CD36, but only if presented in the correct conformation as in OxPL of OxLDL or as in POVPC-peptide adducts...
  32. doi request reprint Statin treatment does not cause cancer
    Daniel Steinberg
    J Am Coll Cardiol 52:1148-9. 2008
  33. doi request reprint Simvastatin with or without ezetimibe in familial hypercholesterolemia
    Daniel Steinberg
    N Engl J Med 359:529; author reply 532. 2008
  34. ncbi request reprint Antioxidant vitamin supplements and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 110:637-41. 2004