Research Topics
Species | M B SteinSummaryAffiliation: University of California Country: USA Publications
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Publications
Implementation of the CALM intervention for anxiety disorders: a qualitative studyGeoffrey M Curran
Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Implement Sci 7:1-11. 2012..Key research questions were as follows: (1) What were the facilitators/barriers to implementing CALM? (2) What were the facilitators/barriers to sustaining CALM after the study was completed?..- Altered amygdala activation during face processing in Iraqi and Afghanistani war veteransAlan N Simmons
Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Biol Mood Anxiety Disord 1:6. 2011..abstract:.. 
Public health perspectives on generalized anxiety disorderMurray B Stein
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
J Clin Psychiatry 65:3-7. 2004..These observations lead to the conclusion that current public health efforts focused on identification and treatment of major depression should be extended to include GAD and other anxiety disorders...
Social anxiety disorderMurray B Stein
Department of Psychiatry, University of California San Diego 92093 0855, USA
Lancet 371:1115-25. 2008....- Efficacy of low and higher dose extended-release venlafaxine in generalized social anxiety disorder: a 6-month randomized controlled trialMurray B Stein
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
Psychopharmacology (Berl) 177:280-8. 2005..There is a need for new pharmacological treatments for generalized social anxiety disorder (GSAD), which is a common, often disabling condition... - Relationship of sexual assault history to somatic symptoms and health anxiety in womenMurray B Stein
Veterans Affairs San Diego Healthcare System and the University of California San Diego, La Jolla, CA, USA
Gen Hosp Psychiatry 26:178-83. 2004..Causal mechanisms cannot be inferred from these data. Studies in other cohorts are warranted... - Well-being and life satisfaction in generalized anxiety disorder: comparison to major depressive disorder in a community sampleMurray B Stein
Anxiety and Traumatic Stress Disorders Program Department of Psychiatry 0985, University of California San Diego, La Jolla, CA 92093 0985, USA
J Affect Disord 79:161-6. 2004..The demonstration of functional impairment attached to GAD, independent of that attributable to MDD, would support the importance of GAD as a separate diagnostic category... - Attending to anxiety disorders in primary careMurray B Stein
University of California, San Diego, La Jolla 92037, USA
J Clin Psychiatry 64:35-9. 2003..It is therefore important for primary care physicians to recognize and treat patients with anxiety disorders... - Advances in recognition and treatment of social anxiety disorder: a 10-year retrospectiveMurray B Stein
Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
Psychopharmacol Bull 37:97-107. 2003..The mechanism of action of paroxetine in the treatment of social anxiety disorder is at present unclear. A possible role for early treatment to prevent complications of social anxiety disorder should be explored... - In search of social phobia subtypes: similarity of feared social situationsMurray B Stein
Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0985, USA
Depress Anxiety 17:94-7. 2003..They should be considered separately in delineation of treatment response and may, if replicated in clinical samples, help identify meaningful subtypes of social phobia... - Patterns of incidence and psychiatric risk factors for traumatic eventsMurray B Stein
Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
Int J Methods Psychiatr Res 11:143-53. 2002..The mechanisms by which premorbid psychiatric disorders promote exposure to traumatic events are unknown. Better understanding of these pathways may lead to novel strategies for primary and secondary prevention of PTSD... - Increased amygdala activation to angry and contemptuous faces in generalized social phobiaMurray B Stein
Department of Psychiatry, University of California San Diego, CA 92093 0985, USA
Arch Gen Psychiatry 59:1027-34. 2002.... - Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled studyMurray B Stein
Anxiety and Traumatic Stress Disorders Program, Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA
Am J Psychiatry 159:1777-9. 2002..Posttraumatic stress disorder (PTSD), particularly in combat veterans with chronic illness, is often refractory to standard pharmacological interventions. There is a need to test adjunctive treatments to boost response... - Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin studyMurray B Stein
Anxiety and Traumatic Stress Disorders Program, Department of Psychiatry 0985, University of California San Diego, La Jolla, CA 92093 0985, USA
Am J Psychiatry 159:1675-81. 2002..In this study the authors examined the heritability of trauma exposure and PTSD symptoms in male and female twin pairs of nonveteran volunteers... - A 46-year-old man with anxiety and nightmares after a motor vehicle collisionMurray B Stein
Department of Psychiatry, University of California, San Diego, 8950 Villa La Jolla Dr, Suite 2243, La Jolla, CA 92037, USA
JAMA 288:1513-22. 2002 - Quality of care for primary care patients with anxiety disordersMurray B Stein
Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0985, USA
Am J Psychiatry 161:2230-7. 2004..This study evaluated quality of care for primary care patients with anxiety disorders in university-affiliated outpatient clinics in Los Angeles, San Diego, and Seattle... - COMT polymorphisms and anxiety-related personality traitsMurray B Stein
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0985, USA
Neuropsychopharmacology 30:2092-102. 2005..Other functional variants may exist that contribute to this relationship. Possible sex-specific effects remain to be further studied and explained... - Serotonin transporter gene promoter polymorphism predicts SSRI response in generalized social anxiety disorderMurray B Stein
Department of Psychiatry, University of California, 9500 Gilman Drive 0985, La Jolla, San Diego, CA 92093 0985, USA
Psychopharmacology (Berl) 187:68-72. 2006..To determine whether variation in the serotonin transporter gene promoter (5HTTLPR) influences the efficacy of selective serotonin reuptake inhibitors (SSRIs) in generalized social anxiety disorder (GSAD)... - Quality of and patient satisfaction with primary health care for anxiety disordersMurray B Stein
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0855, USA
J Clin Psychiatry 72:970-6. 2011..Most patients with anxiety disorders receive their care from primary care practitioners (PCPs). The purpose of this study was to evaluate quality of and patient satisfaction with primary health care for anxiety disorders... - A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traitsMurray B Stein
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0855, USA
Biol Psychiatry 69:825-31. 2011..We examined association of a susceptibility gene, contactin-associated protein-like 2 (CNTNAP2), for ASDs and specific language impairment with SM and social anxiety-related traits... - Levetiracetam in generalized social anxiety disorder: a double-blind, randomized controlled trialMurray B Stein
Anxiety and Traumatic Stress Disorders Research Program, University of California San Diego, 8939 Villa La Jolla Drive, Suite 200, La Jolla, CA 92037, USA
J Clin Psychiatry 71:627-31. 2010.... - Exploring the convergence of posttraumatic stress disorder and mild traumatic brain injuryMurray B Stein
University of California San Diego 0855, 9500 Gilman Dr, La Jolla, CA 92093 0855, USA
Am J Psychiatry 166:768-76. 2009..New studies are needed to improve our understanding of how emotional and biomechanical stressors can yield these adverse outcomes and how such outcomes can be prevented and treated... - Neurobiology of generalized anxiety disorderMurray B Stein
University of California at San Diego, 8939 Villa La Jolla Dr, Suite 200, La Jolla, CA 92037, USA
J Clin Psychiatry 70:15-9. 2009..Recent research into the genetics and neural circuitry of GAD may suggest solutions for the disorder's diagnostic controversies and point the way to productive future studies of etiology and pathophysiology... - Genetic variation in 5HTTLPR is associated with emotional resilienceMurray B Stein
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0855, USA
Am J Med Genet B Neuropsychiatr Genet 150:900-6. 2009..g., depressive symptoms). Replication is needed, in concert with identification of other genes that influence emotional resilience and related phenotypes... - Impairment associated with sleep problems in the community: relationship to physical and mental health comorbidityMurray B Stein
Department of Psychiatry and Family, University of California, San Diego, La Jolla, CA 92093 0855, USA
Psychosom Med 70:913-9. 2008..Little is known, however, about the extent to which associations between sleep problems and functional impairment are attributable to comorbid mental and physical health problems... - Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patientsMurray B Stein
Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
J Trauma Stress 20:923-32. 2007..Implications are discussed for future pharmacological prevention studies in survivors of acute traumatic injury... - Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disordersMurray B Stein
Anxiety and Traumatic Stress Disorders Program, Departments of Psychiatry and Family and Preventive Medicine, University of California San Diego, La Jolla, CA 92093 0855, USA
Neuropsychopharmacology 33:312-9. 2008..These findings are consistent with the notion that 5-HTTLPR operates broadly to moderate emotional responsivity to stress... - Increased amygdala and insula activation during emotion processing in anxiety-prone subjectsMurray B Stein
Department of Psychiatry, University of California, San Diego, 8950 Villa La Jolla Dr, Suite B 218, La Jolla, CA 92037, USA
Am J Psychiatry 164:318-27. 2007..It is uncertain whether this heightened amygdala reactivity is specific to treatment-seeking patients with anxiety disorders or is a general feature of individuals with increased anxiety-related temperamental traits... - An epidemiologic perspective on social anxiety disorderMurray B Stein
Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
J Clin Psychiatry 67:3-8. 2006..SAD has an adverse impact on outcomes in patients with other comorbid mental conditions such as bipolar disorder, eating disorders, and personality disorders... - Antidepressant adherence and medical resource use among managed care patients with anxiety disordersMurray B Stein
Department of Psychiatry and family and preventive medicine at the University of California, La Jolla, California 92093 0985, USA
Psychiatr Serv 57:673-80. 2006.... - Does co-morbid depressive illness magnify the impact of chronic physical illness? A population-based perspectiveMurray B Stein
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0985, USA
Psychol Med 36:587-96. 2006..To examine the relative and combined impact of depressive and chronic physical conditions on functional status and health-care use in the general population... - Quality of life in older adults receiving medications for anxiety, depression, or insomnia: findings from a community-based studyMurray B Stein
Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
Am J Geriatr Psychiatry 10:568-74. 2002..The authors examined the association between these conditions, as indicated by the use of antidepressant, anxiolytic, or hypnotic medications, and HRQoL parameters in older men and women... - Familial aggregation of anxiety-related quantitative traits in generalized social phobia: clues to understanding "disorder" heritability?M B Stein
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
Am J Med Genet 105:79-83. 2001..More extensive efforts at phenotype refinement should be undertaken before such studies proceed... - Pindolol potentiation of paroxetine for generalized social phobia: a double-blind, placebo-controlled, crossover studyM B Stein
Department of Psychiatry, University of California San Diego, La Jolla, 92093 0985, USA
Am J Psychiatry 158:1725-7. 2001..The effectiveness of pindolol as an adjunctive treatment to boost response to selective serotonin reuptake inhibitors (SSRIs) in patients with generalized social phobia was tested... - Social anxiety disorder and the risk of depression: a prospective community study of adolescents and young adultsM B Stein
Department of Psychiatry, University of California San Diego, 8950 Villa La Jolla Dr, Suite 2243, La Jolla, CA 92037, USA
Arch Gen Psychiatry 58:251-6. 2001..This has led to interest in SAD as a possible modifier of the risk and/or course of mood disorders... - Gender differences in susceptibility to posttraumatic stress disorderM B Stein
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
Behav Res Ther 38:619-28. 2000..g. fire, witnessing injury to others). Understanding the basis of (and parameters for) this increased susceptibility to PTSD in women compared to men following trauma exposure should be a priority for future traumatic stress research... - Sexual assault and physical health: findings from a population-based study of older adultsM B Stein
Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093 0985, USA
Psychosom Med 62:838-43. 2000..The objective of this study was to determine whether there is an association between self-reported sexual assault history and objective parameters of physical health in a sample of older men and women... - Major depressive and post-traumatic stress disorder comorbidity in female victims of intimate partner violenceM B Stein
VA San Diego Healthcare System, San Diego, CA, USA
J Affect Disord 66:133-8. 2001.... - Heritability of anxiety sensitivity: a twin studyM B Stein
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
Am J Psychiatry 156:246-51. 1999..In this study, the authors examined the heritability of anxiety sensitivity through use of a twin group... - Development of a brief diagnostic screen for panic disorder in primary careM B Stein
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
Psychosom Med 61:359-64. 1999..The purpose of this study was to determine the utility of a brief screening tool for panic disorder in the primary care setting... - Post-traumatic stress disorder: a review of recent findingsS Seedat
Department of Psychiatry 0985, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA
Curr Psychiatry Rep 3:288-94. 2001.... - Fluvoxamine treatment of social phobia (social anxiety disorder): a double-blind, placebo-controlled studyM B Stein
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
Am J Psychiatry 156:756-60. 1999..The purpose of this study was to determine the efficacy of fluvoxamine for the treatment of social phobia (social anxiety disorder)... - Disability and quality of life in social phobia: epidemiologic findingsM B Stein
Department of Psychiatry, University of California at San Diego, La Jolla, 92093 0985, USA
Am J Psychiatry 157:1606-13. 2000..The authors examined relevant data from the Ontario Health Survey Mental Health Supplement... - Genetic linkage to the serotonin transporter protein and 5HT2A receptor genes excluded in generalized social phobiaM B Stein
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
Psychiatry Res 81:283-91. 1998..Other 5HT receptor subtypes or indirect modulatory effects of 5HT on other neurotransmitter systems may be involved... - Plasma neuropeptide Y in anxiety disorders: findings in panic disorder and social phobiaM B Stein
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
Psychiatry Res 59:183-8. 1996..These results are convergent with prior reports of normal sympathetic nerve activity in patients with anxiety disorders... - Full and partial posttraumatic stress disorder: findings from a community surveyM B Stein
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
Am J Psychiatry 154:1114-9. 1997..Full and partial posttraumatic stress disorder (PTSD) following trauma exposure were examined in a community sample in order to determine their prevalence and their relative importance and functional significance... - Obsessive-compulsive disorder in the community: an epidemiologic survey with clinical reappraisalM B Stein
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0603, USA
Am J Psychiatry 154:1120-6. 1997..To examine the prevalence of obsessive-compulsive symptoms and DSM-IV obsessive-compulsive disorder (OCD), the authors conducted a telephone survey of 2,261 adults in four regions of Canada... - Heritability of social anxiety-related concerns and personality characteristics: a twin studyMurray B Stein
Anxiety and Traumatic Stress Disorders Program, Department of Psychiatry 0985, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
J Nerv Ment Dis 190:219-24. 2002..Moreover, the same genes that influence negative evaluation fears appear to influence a cluster of anxiety-related personality characteristics. Implications and limitations of these findings are discussed... - A direct-interview family study of generalized social phobiaM B Stein
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
Am J Psychiatry 155:90-7. 1998..They also hypothesized that rates of avoidant personality disorder, a frequent comorbid condition, would be higher in relatives of probands with generalized social phobia... - Social phobia symptoms, subtypes, and severity: findings from a community surveyM B Stein
Department of Psychiatry, University of California San Diego, 8950 Villa La Jolla Dr, Suite 2243, La Jolla, CA 92037, USA
Arch Gen Psychiatry 57:1046-52. 2000.... - Medication treatments for panic disorder and social phobiaM B Stein
Department of Psychiatry 0985, University of California, San Diego, La Jolla 92093, USA
Depress Anxiety 7:134-8. 1998..Then, three panic disorder studies which used clonazepam, clomipramine or paroxetine, and citalopram are examined. These studies serve to strengthen the empirical research base regarding which treatments are useful in these disorders... - Paroxetine treatment of generalized social phobia (social anxiety disorder): a randomized controlled trialM B Stein
Department of Psychiatry, University of California at San Diego, La Jolla 92093 0985, USA
JAMA 280:708-13. 1998..Earlier research has shown monoamine oxidase inhibitors or benzodiazepines to be effective in treating this condition, but neither has achieved widespread use... - Bringing up bashful baby. Developmental pathways to social phobiaM B Stein
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
Psychiatr Clin North Am 24:661-75. 2001..If so, it should be possible to design early interventions to prevent the progression from phobia proneness (e.g., designated on the basis of family history) to phobic disorder... - Depression in a primary care clinic: the prevalence and impact of an unrecognized disorderJ R McQuaid
University of California, San Diego, USA
J Affect Disord 55:1-10. 1999..This study assesses depression among primary care patients, the relationship between depression and functioning, and how frequently depressed individuals receive mental health treatment... - Use of brief psychiatric screening measures in a primary care sampleJ R McQuaid
University of California, San Diego, USA
Depress Anxiety 12:21-9. 2000..The BAI was a relatively poor screening measure that added no significant information beyond the other measures... - Profiling posttraumatic functional impairmentSonya B Norman
Department of Psychiatry, University of California San Diego, and the VA San Diego Healthcare System, La Jolla, California 92093 0985, USA
J Nerv Ment Dis 195:48-53. 2007..The symptom profile can help identify traumatized individuals who may benefit from treatment but do not necessarily meet criteria for PTSD... - Functional impact and health utility of anxiety disorders in primary care outpatientsMurray B Stein
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093-0985, USA
Med Care 43:1164-70. 2005..Greater awareness of the deleterious impact of anxiety disorders in primary care is warranted... - Dose-dependent decrease of activation in bilateral amygdala and insula by lorazepam during emotion processingMartin P Paulus
Laboratory of Biological Dynamics and Theoretical Medicine and Department of Psychiatry, University of California, San Diego, USA
Arch Gen Psychiatry 62:282-8. 2005..This investigation may help to support the use of BOLD-fMRI with pharmacological probes to investigate the neural circuits underlying anxiety and the use of fMRI as a tool in the development of new anxiolytic agents... - Social phobia: prevalence and diagnostic thresholdA J Lang
Department of Psychiatry, University of California San Diego and VA San Diego Healthcare System, USA
J Clin Psychiatry 62:5-10. 2001..We discuss the diagnostic threshold of social phobia and potential difficulties in differentiating this disorder from other mental disorders... - Do selective serotonin re-uptake inhibitors enhance the efficacy of very brief cognitive behavioral therapy for panic disorder? A pilot studyM B Stein
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla CA 92093 0603, USA
Psychiatry Res 94:191-200. 2000..13%; P<0.017). These findings point to the need for additional studies to confirm the effectiveness of very brief forms of CBT, and to document the circumstances in which combined treatment with an SSRI would be warranted... - Associations between psychological trauma and physical illness in primary careSonya B Norman
Department of Psychiatry, University of California, San Diego, CA, USA
J Trauma Stress 19:461-70. 2006..Awareness of the presence of the physical illnesses examined here may help with the identification and treatment of primary care patients with trauma histories... - Direct and indirect links between childhood maltreatment, posttraumatic stress disorder, and women's healthAriel J Lang
The University of California San Diego UCSD, San Diego, CA 92108, USA
Behav Med 33:125-35. 2008..These findings should strengthen efforts directed at identifying and treating PTSD in female victims of childhood maltreatment with the aim of preventing or attenuating poor health outcomes... - Scrutinizing the relationship between shyness and social phobiaDenise A Chavira
Department of Psychiatry, University of California San Diego, La Jolla 92093-0985, USA
J Anxiety Disord 16:585-98. 2002..Findings suggest that shyness and social phobia (especially the generalized type) are related constructs but not completely synonymous; an individual can be extremely shy yet not have a social phobia diagnosis... - A polymorphism of the beta1-adrenergic receptor is associated with low extraversionMurray B Stein
Department of Psychiatry, University of California San Diego, San Diego, California, USA
Biol Psychiatry 56:217-24. 2004..We examined the possibility that allelic variation leading to alterations in beta(1)-adrenergic function might be present in persons with elevated social anxiety-related traits... - In search of mixed anxiety-depressive disorder: a primary care studyAdrienne J Means-Christensen
Department of Psychiatry, University of California, San Diego, California, USA
Depress Anxiety 23:183-9. 2006..These data dispute the need for a mixed anxiety-depression category (beyond mood and anxiety syndromes currently in DSM-IV) in future editions of the DSM... - Prevalence of dissociative experiences in a community sample: relationship to gender, ethnicity, and substance useSoraya Seedat
Department of Psychiatry, University of California San Diego, 8950 Villa La Jolla Drive, Suite 2243, La Jolla, California 92037, USA
J Nerv Ment Dis 191:115-20. 2003..Further assessment of the link between demographic factors and the severity and expression of dissociative phenomena in nonclinical samples is warranted... - Developmental antecedents of anxiety sensitivityChristine D Scher
San Diego State University, San Diego, CA, USA
J Anxiety Disord 17:253-69. 2003.... - Double-blind, placebo-controlled assessment of combined clonazepam with paroxetine compared with paroxetine monotherapy for generalized social anxiety disorderSoraya Seedat
Anxiety and Traumatic Stress Disorders Program, Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA
J Clin Psychiatry 65:244-8. 2004..Monotherapy with the benzodiazepine clonazepam is also efficacious for GSAD, but the adjunctive use of clonazepam with an SSRI to potentially improve outcomes has not been studied to date... - Plasma cortisol and neuropeptide Y in female victims of intimate partner violenceS Seedat
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA
Psychoneuroendocrinology 28:796-808. 2003.... - Abbreviated brief symptom inventory for use as an anxiety and depression screening instrument in primary careAriel J Lang
Department of Psychiatry, University of California San Diego, CA, USA
Depress Anxiety 26:537-43. 2009..The feasibility of such screening, however, depends on the availability of quick, easily interpretable screening tools... - Refining the classification of children with selective mutism: a latent profile analysisSharon L Cohan
Department of Psychiatry, University of California, San Diego, CA, USA
J Clin Child Adolesc Psychol 37:770-84. 2008..These results suggest that, although social anxiety is typically a prominent feature of SM, children with the disorder are also likely to present with communication delays and/or mild behavior problems... - Comorbidity of generalized social anxiety disorder and depression in a pediatric primary care sampleDenise A Chavira
Department of Psychiatry, University of California San Diego, 8950 Villa La Jolla Drive, Suite 2243, La Jolla, CA 92037, USA
J Affect Disord 80:163-71. 2004..Screening and treatment approaches that consider both social anxiety and depressive symptoms are necessary. Early intervention to treat social anxiety disorder may prevent later depressive disorders... - Predictors of willingness to consider medication and psychosocial treatment for panic disorder in primary care patientsHolly Hazlett-Stevens
University of California, Los Angeles, CA, USA
Gen Hosp Psychiatry 24:316-21. 2002.... - Sexual trauma and pregnancy: a conceptual frameworkCarie S Rodgers
VA San Diego Healthcare System, San Diego, California 92108, USA
J Womens Health (Larchmt) 12:961-70. 2003..We suggest future directions for this area of research and discuss the clinical implications of this association, including the development of prenatal intervention and prevention programs... - Recent developments in child and adolescent social phobiaD A Chavira
Department of Psychiatry, University of California at San Diego, Box 0985, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
Curr Psychiatry Rep 2:347-52. 2000..Initial data regarding the use of SSRIs suggest that they may be a promising treatment option... - Sexual dysfunction in combat veterans with post-traumatic stress disorderDaniel J Cosgrove
Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103-8897, USA
Urology 60:881-4. 2002..The IIEF may be useful in evaluating the response to treatment of erectile dysfunction. Clinicians should proactively address the sexual concerns of combat veterans with PTSD... - Assessment of beliefs about psychotropic medication and psychotherapy: development of a measure for patients with anxiety disordersAlexander Bystritsky
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
Gen Hosp Psychiatry 27:313-8. 2005..Its brevity may make it particularly useful in primary health care settings... - Brief measures to screen for social phobia in primary care pediatricsKelly A Bailey
San Diego State University, La Jolla, California, USA
J Pediatr Psychol 31:512-21. 2006..CONCLUSION: The use of valid, brief screening instruments can significantly improve the feasibility of detecting social phobia among youth in primary care pediatric settings... - Combined psychoeducation and treatment with selective serotonin reuptake inhibitors for youth with generalized social anxiety disorderDenise A Chavira
Department of Psychiatry, University of California San Diego, La Jolla 92037, USA
J Child Adolesc Psychopharmacol 12:47-54. 2002..Findings support the need for double-blind, placebo-controlled studies of combined treatments for youth with generalized social anxiety disorder... - Relationships among childhood maltreatment, PTSD, and health in female veterans in primary careAriel J Lang
VA San Diego Healthcare System, 8810 Rio San Diego Drive (MC116A4Z, San Diego, CA 92108, USA
Child Abuse Negl 30:1281-92. 2006..Given that several empirically supported interventions are available for PTSD, there may be physical health benefits in early identification and treatment of psychopathology related to CM... - Anterior cingulate activation in high trait anxious subjects is related to altered error processing during decision makingMartin P Paulus
Department of Psychiatry, University of California Sand Diego, La Jolla 92093-9116, USA
Biol Psychiatry 55:1179-87. 2004..e., the low-error-rate condition). The extent to which this altered activation within the anterior cingulate contributes to anxiety-proneness remains to be determined... - Anxiety disorders. How to recognize and treat the medical symptoms of emotional illnessA J Lang
Department of Psychiatry, University of California, San Diego, USA
Geriatrics 56:24-7, 31-4. 2001..Older patients may benefit from cognitive-behavioral therapy and relaxation training. Antidepresants, particularly selective serotonin reuptake inhibitors, are the preferred medical treatment... - Perceived threat to life predicts posttraumatic stress disorder after major trauma: risk factors and functional outcomeT L Holbrook
Department of Family and Preventive Medicine, University of California, San Diego, California, USA
J Trauma 51:287-92; discussion 292-3. 2001..0001). CONCLUSION: These results provide new and provocative evidence that perceived threat to life and mechanism predict PTSD after major traumatic injury. PTSD had a prolonged and profound impact on short- and long-term outcome and QoL... - An open-label, 12-week clinical and sleep EEG study of nefazodone in chronic combat-related posttraumatic stress disorderJ C Gillin
University of California and VA San Diego Healthcare System, 92161, USA
J Clin Psychiatry 62:789-96. 2001..To our knowledge, this is the first polysomnographic study of treatment in patients with PTSD... - An insular view of anxietyMartin P Paulus
Department of Psychiatry, University of California, San Diego, La Jolla, California 92037, USA
Biol Psychiatry 60:383-7. 2006.... - Validation of a brief measure of anxiety-related severity and impairment: the Overall Anxiety Severity and Impairment Scale (OASIS)Laura Campbell-Sills
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0603, USA
J Affect Disord 112:92-101. 2009..A prior investigation with a nonclinical sample supported the reliability and validity of the OASIS; however, to date it has not been validated for use in clinical samples... - From sensory processes to conscious perceptionJustin S Feinstein
Laboratory of Biological Dynamics and Theoretical Medicine, University of California, San Diego, USA
Conscious Cogn 13:323-35. 2004..These results are discussed in light of a neural framework for conscious processing... - Correlates of alcohol use among anxious and depressed primary care patientsJoanna J Arch
Department of Psychology, University of California, Los Angeles, 90095 1563, USA
Gen Hosp Psychiatry 28:37-42. 2006..The purpose of this study is to determine the patterns of alcohol use for primary care patients with anxiety disorders and/or major depression in three urban university-affiliated outpatient clinics... - Adult psychopathology and intimate partner violence among survivors of childhood maltreatmentAriel J Lang
VA San Diego Healthcare System, CA, USA
J Interpers Violence 19:1102-18. 2004..This work underscores the importance of assessing multiple types of childhood maltreatment and of considering the cumulative effects of such experiences... - Anxiety sensitivity and PTSD among female victims of intimate partner violenceAriel J Lang
San Diego VA Healthcare System, San Diego, California, USA
Depress Anxiety 16:77-83. 2002..Nonetheless, AS may be an important factor to consider in treatment of individuals with PTSD... - Anticipation of emotionally aversive visual stimuli activates right insulaAlan Simmons
Laboratory of Biological Dynamics and Theoretical Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
Neuroreport 15:2261-5. 2004..These findings indicate that common neural circuitry is involved in the anticipation of (and, perhaps, the subjective experience of anticipating) aversive affective and noxious physical stimuli... - Issues in the assessment of social phobia: a reviewAndrea M Letamendi
Department ofPsychology, San Diego State University, San Diego, California 82037 0855, USA
Isr J Psychiatry Relat Sci 46:13-24. 2009..This review evaluates each method by highlighting the assessment features recommended in social phobia literature, including method of administration, item content, coverage, length of scale, type of scores generated, and time frame... - Escitalopram attenuates posterior cingulate activity during self-evaluation in healthy volunteersScott C Matthews
Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
Psychiatry Res 182:81-7. 2010..These results show that SSRIs change medial cortical activity and may alter self-evaluation... - Habituation of attentional networks during emotion processingJustin S Feinstein
Laboratory of Biological Dynamics and Theoretical Medicine, University of California, San Diego, CA 92093, USA
Neuroreport 13:1255-8. 2002.... - Mutation screen of the GAD2 gene and association study of alcoholism in three populationsJaakko Lappalainen
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Am J Med Genet B Neuropsychiatr Genet 144:183-92. 2007..The functional promoter GAD2 -243 A > G variant may influence risk for AD in some populations, or its role may be limited to susceptibility to severe AD... - Pain in the aftermath of trauma is a risk factor for post-traumatic stress disorderS B Norman
Department of Psychiatry, University of California, San Diego, CA 92103, USA
Psychol Med 38:533-42. 2008..This study assessed pain shortly after traumatic injury (i.e. peritraumatic pain) as a risk factor for PTSD... - Exposure to traumatic events and experiences: aetiological relationships with personality functionKerry L Jang
Division of Behavioural Science, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
Psychiatry Res 120:61-9. 2003..These findings suggest that heritable personality characteristics explain part of the variance in the likelihood of exposure to some classes of traumatic events... - Anxiety disorders and comorbid medical illnessPeter P Roy-Byrne
University of Washington School of Medicine, Seattle, WA 98195, USA
Gen Hosp Psychiatry 30:208-25. 2008..To provide an overview of the role of anxiety disorders in medical illness... - Beliefs about psychotropic medication and psychotherapy among primary care patients with anxiety disordersAmy W Wagner
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine at Harborview Medical Center, Seattle, Washington 98104 2499, USA
Depress Anxiety 21:99-105. 2005..Treatment adherence may therefore be increased by addressing these beliefs directly... - Posttraumatic stress disorder symptoms influence health status of deployed peacekeepers and nondeployed military personnelGordon J G Asmundson
Faculty of Kinesiology and Health Studies, University of Regina, 3737 Wascana Parkway, Regina, Saskatchewan, Canada S4S 0A2
J Nerv Ment Dis 190:807-15. 2002..Increased alcohol use did not contribute to poorer health beyond the contribution of PTSD symptoms alone. Future research directions are discussed... - Considering comorbidity in social phobiaMariette J Chartier
Dept of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Soc Psychiatry Psychiatr Epidemiol 38:728-34. 2003..We also considered whether social fears, reported by respondents with social phobia, had an earlier or later age of onset than other disorders...
Research Grants
- Neural Substrates of Anticipation and Interoception in Anxiety DisordersMurray Stein; Fiscal Year: 2007....
- CALM: IMPROVING PRIMARY CARE ANXIETY OUTCOMESMurray Stein; Fiscal Year: 2007..g. instrumental variables) to examine the effects of appropriate treatment, independent of intervention assignment, on functioning and other clinical outcomes; and (2) to estimate health care costs and cost effectiveness of CALM. ..
- Improving Outcomes in Pharmacotherapy of Social PhobiaMurray Stein; Fiscal Year: 2007..It thus directly addresses a critical public health issue that adversely affects a substantial proportion of the population. ..
- Improving Outcomes and Understanding Response Heterogeneity in Anxiety DisordersMurray Stein; Fiscal Year: 2007....
- Neural Substrates of Anticipation and Interoception in Anxiety DisordersMurray Stein; Fiscal Year: 2009....
- Improving Outcomes in Pharmacotherapy of Social PhobiaMurray Stein; Fiscal Year: 2009..It thus directly addresses a critical public health issue that adversely affects a substantial proportion of the population. ..
- Pharmacological fMRI to Identify New Anxiolytics: A Human BioassayMurray Stein; Fiscal Year: 2007..Enhancing the development of new treatments for anxiety is a public health priority. The projects proposed in this application have the potential to achieve this important aim. ..
- IMPROVING CARE FOR PANIC DISORDER IN PRIMARY CAREMurray Stein; Fiscal Year: 2002..abstract_text> ..
- Preventing Psychiatric Sequelae of Traumatic InjuryMurray Stein; Fiscal Year: 2003..Findings will provide justification for and information about optimal parameters (e.g., subject selection; sample size; dose and duration) for a future randomized controlled trial (RCT). ..
- Neural Substrates of Decision-making in AnxietyMurray Stein; Fiscal Year: 2006..In addition, identifying dysfunctional neurocognitive processes and underlying neural substrates will enable us to better specify anxiety-based intermediate phenotypes. ..
- Neural Substrates of Anticipation and Interoception in Anxiety DisordersMurray B Stein; Fiscal Year: 2010....