M B Stein

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Implementation of the CALM intervention for anxiety disorders: a qualitative study
    Geoffrey M Curran
    Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Implement Sci 7:1-11. 2012
  2. pmc Altered amygdala activation during face processing in Iraqi and Afghanistani war veterans
    Alan N Simmons
    Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Biol Mood Anxiety Disord 1:6. 2011
  3. ncbi request reprint In search of social phobia subtypes: similarity of feared social situations
    Murray B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0985, USA
    Depress Anxiety 17:94-7. 2003
  4. ncbi request reprint Patterns of incidence and psychiatric risk factors for traumatic events
    Murray B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    Int J Methods Psychiatr Res 11:143-53. 2002
  5. doi request reprint Social anxiety disorder
    Murray B Stein
    Department of Psychiatry, University of California San Diego 92093 0855, USA
    Lancet 371:1115-25. 2008
  6. ncbi request reprint Increased amygdala activation to angry and contemptuous faces in generalized social phobia
    Murray B Stein
    Department of Psychiatry, University of California San Diego, CA 92093 0985, USA
    Arch Gen Psychiatry 59:1027-34. 2002
  7. ncbi request reprint Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled study
    Murray B Stein
    Anxiety and Traumatic Stress Disorders Program, Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA
    Am J Psychiatry 159:1777-9. 2002
  8. ncbi request reprint Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study
    Murray B Stein
    Anxiety and Traumatic Stress Disorders Program, Department of Psychiatry 0985, University of California San Diego, La Jolla, CA 92093 0985, USA
    Am J Psychiatry 159:1675-81. 2002
  9. ncbi request reprint A 46-year-old man with anxiety and nightmares after a motor vehicle collision
    Murray B Stein
    Department of Psychiatry, University of California, San Diego, 8950 Villa La Jolla Dr, Suite 2243, La Jolla, CA 92037, USA
    JAMA 288:1513-22. 2002
  10. doi request reprint Impairment associated with sleep problems in the community: relationship to physical and mental health comorbidity
    Murray B Stein
    Department of Psychiatry and Family, University of California, San Diego, La Jolla, CA 92093 0855, USA
    Psychosom Med 70:913-9. 2008

Detail Information

Publications123 found, 100 shown here

  1. pmc Implementation of the CALM intervention for anxiety disorders: a qualitative study
    Geoffrey M Curran
    Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Implement Sci 7:1-11. 2012
    ..Key research questions were as follows: (1) What were the facilitators/barriers to implementing CALM? (2) What were the facilitators/barriers to sustaining CALM after the study was completed?..
  2. pmc Altered amygdala activation during face processing in Iraqi and Afghanistani war veterans
    Alan N Simmons
    Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Biol Mood Anxiety Disord 1:6. 2011
    ..abstract:..
  3. ncbi request reprint In search of social phobia subtypes: similarity of feared social situations
    Murray B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0985, USA
    Depress Anxiety 17:94-7. 2003
    ..They should be considered separately in delineation of treatment response and may, if replicated in clinical samples, help identify meaningful subtypes of social phobia...
  4. ncbi request reprint Patterns of incidence and psychiatric risk factors for traumatic events
    Murray B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    Int J Methods Psychiatr Res 11:143-53. 2002
    ..The mechanisms by which premorbid psychiatric disorders promote exposure to traumatic events are unknown. Better understanding of these pathways may lead to novel strategies for primary and secondary prevention of PTSD...
  5. doi request reprint Social anxiety disorder
    Murray B Stein
    Department of Psychiatry, University of California San Diego 92093 0855, USA
    Lancet 371:1115-25. 2008
    ....
  6. ncbi request reprint Increased amygdala activation to angry and contemptuous faces in generalized social phobia
    Murray B Stein
    Department of Psychiatry, University of California San Diego, CA 92093 0985, USA
    Arch Gen Psychiatry 59:1027-34. 2002
    ....
  7. ncbi request reprint Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled study
    Murray B Stein
    Anxiety and Traumatic Stress Disorders Program, Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA
    Am J Psychiatry 159:1777-9. 2002
    ..Posttraumatic stress disorder (PTSD), particularly in combat veterans with chronic illness, is often refractory to standard pharmacological interventions. There is a need to test adjunctive treatments to boost response...
  8. ncbi request reprint Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study
    Murray B Stein
    Anxiety and Traumatic Stress Disorders Program, Department of Psychiatry 0985, University of California San Diego, La Jolla, CA 92093 0985, USA
    Am J Psychiatry 159:1675-81. 2002
    ..In this study the authors examined the heritability of trauma exposure and PTSD symptoms in male and female twin pairs of nonveteran volunteers...
  9. ncbi request reprint A 46-year-old man with anxiety and nightmares after a motor vehicle collision
    Murray B Stein
    Department of Psychiatry, University of California, San Diego, 8950 Villa La Jolla Dr, Suite 2243, La Jolla, CA 92037, USA
    JAMA 288:1513-22. 2002
  10. doi request reprint Impairment associated with sleep problems in the community: relationship to physical and mental health comorbidity
    Murray B Stein
    Department of Psychiatry and Family, University of California, San Diego, La Jolla, CA 92093 0855, USA
    Psychosom Med 70:913-9. 2008
    ..Little is known, however, about the extent to which associations between sleep problems and functional impairment are attributable to comorbid mental and physical health problems...
  11. pmc Genetic variation in 5HTTLPR is associated with emotional resilience
    Murray B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0855, USA
    Am J Med Genet B Neuropsychiatr Genet 150:900-6. 2009
    ..g., depressive symptoms). Replication is needed, in concert with identification of other genes that influence emotional resilience and related phenotypes...
  12. ncbi request reprint Quality of life in older adults receiving medications for anxiety, depression, or insomnia: findings from a community-based study
    Murray B Stein
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
    Am J Geriatr Psychiatry 10:568-74. 2002
    ..The authors examined the association between these conditions, as indicated by the use of antidepressant, anxiolytic, or hypnotic medications, and HRQoL parameters in older men and women...
  13. ncbi request reprint Neurobiology of generalized anxiety disorder
    Murray B Stein
    University of California at San Diego, 8939 Villa La Jolla Dr, Suite 200, La Jolla, CA 92037, USA
    J Clin Psychiatry 70:15-9. 2009
    ..Recent research into the genetics and neural circuitry of GAD may suggest solutions for the disorder's diagnostic controversies and point the way to productive future studies of etiology and pathophysiology...
  14. ncbi request reprint Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients
    Murray B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    J Trauma Stress 20:923-32. 2007
    ..Implications are discussed for future pharmacological prevention studies in survivors of acute traumatic injury...
  15. ncbi request reprint Advances in recognition and treatment of social anxiety disorder: a 10-year retrospective
    Murray B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    Psychopharmacol Bull 37:97-107. 2003
    ..The mechanism of action of paroxetine in the treatment of social anxiety disorder is at present unclear. A possible role for early treatment to prevent complications of social anxiety disorder should be explored...
  16. ncbi request reprint Attending to anxiety disorders in primary care
    Murray B Stein
    University of California, San Diego, La Jolla 92037, USA
    J Clin Psychiatry 64:35-9. 2003
    ..It is therefore important for primary care physicians to recognize and treat patients with anxiety disorders...
  17. ncbi request reprint Quality of care for primary care patients with anxiety disorders
    Murray B Stein
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0985, USA
    Am J Psychiatry 161:2230-7. 2004
    ..This study evaluated quality of care for primary care patients with anxiety disorders in university-affiliated outpatient clinics in Los Angeles, San Diego, and Seattle...
  18. ncbi request reprint Serotonin transporter gene promoter polymorphism predicts SSRI response in generalized social anxiety disorder
    Murray B Stein
    Department of Psychiatry, University of California, 9500 Gilman Drive 0985, La Jolla, San Diego, CA 92093 0985, USA
    Psychopharmacology (Berl) 187:68-72. 2006
    ..To determine whether variation in the serotonin transporter gene promoter (5HTTLPR) influences the efficacy of selective serotonin reuptake inhibitors (SSRIs) in generalized social anxiety disorder (GSAD)...
  19. ncbi request reprint Public health perspectives on generalized anxiety disorder
    Murray B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    J Clin Psychiatry 65:3-7. 2004
    ..These observations lead to the conclusion that current public health efforts focused on identification and treatment of major depression should be extended to include GAD and other anxiety disorders...
  20. ncbi request reprint Does co-morbid depressive illness magnify the impact of chronic physical illness? A population-based perspective
    Murray B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0985, USA
    Psychol Med 36:587-96. 2006
    ..To examine the relative and combined impact of depressive and chronic physical conditions on functional status and health-care use in the general population...
  21. ncbi request reprint Antidepressant adherence and medical resource use among managed care patients with anxiety disorders
    Murray B Stein
    Department of Psychiatry and family and preventive medicine at the University of California, La Jolla, California 92093 0985, USA
    Psychiatr Serv 57:673-80. 2006
    ....
  22. ncbi request reprint COMT polymorphisms and anxiety-related personality traits
    Murray B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0985, USA
    Neuropsychopharmacology 30:2092-102. 2005
    ..Other functional variants may exist that contribute to this relationship. Possible sex-specific effects remain to be further studied and explained...
  23. ncbi request reprint Efficacy of low and higher dose extended-release venlafaxine in generalized social anxiety disorder: a 6-month randomized controlled trial
    Murray B Stein
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
    Psychopharmacology (Berl) 177:280-8. 2005
    ..There is a need for new pharmacological treatments for generalized social anxiety disorder (GSAD), which is a common, often disabling condition...
  24. ncbi request reprint An epidemiologic perspective on social anxiety disorder
    Murray B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    J Clin Psychiatry 67:3-8. 2006
    ..SAD has an adverse impact on outcomes in patients with other comorbid mental conditions such as bipolar disorder, eating disorders, and personality disorders...
  25. ncbi request reprint Relationship of sexual assault history to somatic symptoms and health anxiety in women
    Murray B Stein
    Veterans Affairs San Diego Healthcare System and the University of California San Diego, La Jolla, CA, USA
    Gen Hosp Psychiatry 26:178-83. 2004
    ..Causal mechanisms cannot be inferred from these data. Studies in other cohorts are warranted...
  26. ncbi request reprint Well-being and life satisfaction in generalized anxiety disorder: comparison to major depressive disorder in a community sample
    Murray B Stein
    Anxiety and Traumatic Stress Disorders Program Department of Psychiatry 0985, University of California San Diego, La Jolla, CA 92093 0985, USA
    J Affect Disord 79:161-6. 2004
    ..The demonstration of functional impairment attached to GAD, independent of that attributable to MDD, would support the importance of GAD as a separate diagnostic category...
  27. ncbi request reprint Increased amygdala and insula activation during emotion processing in anxiety-prone subjects
    Murray B Stein
    Department of Psychiatry, University of California, San Diego, 8950 Villa La Jolla Dr, Suite B 218, La Jolla, CA 92037, USA
    Am J Psychiatry 164:318-27. 2007
    ..It is uncertain whether this heightened amygdala reactivity is specific to treatment-seeking patients with anxiety disorders or is a general feature of individuals with increased anxiety-related temperamental traits...
  28. ncbi request reprint Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders
    Murray B Stein
    Anxiety and Traumatic Stress Disorders Program, Departments of Psychiatry and Family and Preventive Medicine, University of California San Diego, La Jolla, CA 92093 0855, USA
    Neuropsychopharmacology 33:312-9. 2008
    ..These findings are consistent with the notion that 5-HTTLPR operates broadly to moderate emotional responsivity to stress...
  29. doi request reprint Exploring the convergence of posttraumatic stress disorder and mild traumatic brain injury
    Murray B Stein
    University of California San Diego 0855, 9500 Gilman Dr, La Jolla, CA 92093 0855, USA
    Am J Psychiatry 166:768-76. 2009
    ..New studies are needed to improve our understanding of how emotional and biomechanical stressors can yield these adverse outcomes and how such outcomes can be prevented and treated...
  30. ncbi request reprint Heritability of social anxiety-related concerns and personality characteristics: a twin study
    Murray B Stein
    Anxiety and Traumatic Stress Disorders Program, Department of Psychiatry 0985, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
    J Nerv Ment Dis 190:219-24. 2002
    ..Moreover, the same genes that influence negative evaluation fears appear to influence a cluster of anxiety-related personality characteristics. Implications and limitations of these findings are discussed...
  31. doi request reprint Levetiracetam in generalized social anxiety disorder: a double-blind, randomized controlled trial
    Murray B Stein
    Anxiety and Traumatic Stress Disorders Research Program, University of California San Diego, 8939 Villa La Jolla Drive, Suite 200, La Jolla, CA 92037, USA
    J Clin Psychiatry 71:627-31. 2010
    ....
  32. ncbi request reprint Medication treatments for panic disorder and social phobia
    M B Stein
    Department of Psychiatry 0985, University of California, San Diego, La Jolla 92093, USA
    Depress Anxiety 7:134-8. 1998
    ..Then, three panic disorder studies which used clonazepam, clomipramine or paroxetine, and citalopram are examined. These studies serve to strengthen the empirical research base regarding which treatments are useful in these disorders...
  33. ncbi request reprint Plasma neuropeptide Y in anxiety disorders: findings in panic disorder and social phobia
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
    Psychiatry Res 59:183-8. 1996
    ..These results are convergent with prior reports of normal sympathetic nerve activity in patients with anxiety disorders...
  34. ncbi request reprint Paroxetine treatment of generalized social phobia (social anxiety disorder): a randomized controlled trial
    M B Stein
    Department of Psychiatry, University of California at San Diego, La Jolla 92093 0985, USA
    JAMA 280:708-13. 1998
    ..Earlier research has shown monoamine oxidase inhibitors or benzodiazepines to be effective in treating this condition, but neither has achieved widespread use...
  35. ncbi request reprint Genetic linkage to the serotonin transporter protein and 5HT2A receptor genes excluded in generalized social phobia
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
    Psychiatry Res 81:283-91. 1998
    ..Other 5HT receptor subtypes or indirect modulatory effects of 5HT on other neurotransmitter systems may be involved...
  36. ncbi request reprint Social phobia symptoms, subtypes, and severity: findings from a community survey
    M B Stein
    Department of Psychiatry, University of California San Diego, 8950 Villa La Jolla Dr, Suite 2243, La Jolla, CA 92037, USA
    Arch Gen Psychiatry 57:1046-52. 2000
    ....
  37. ncbi request reprint Disability and quality of life in social phobia: epidemiologic findings
    M B Stein
    Department of Psychiatry, University of California at San Diego, La Jolla, 92093 0985, USA
    Am J Psychiatry 157:1606-13. 2000
    ..The authors examined relevant data from the Ontario Health Survey Mental Health Supplement...
  38. ncbi request reprint Heritability of anxiety sensitivity: a twin study
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
    Am J Psychiatry 156:246-51. 1999
    ..In this study, the authors examined the heritability of anxiety sensitivity through use of a twin group...
  39. ncbi request reprint Fluvoxamine treatment of social phobia (social anxiety disorder): a double-blind, placebo-controlled study
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
    Am J Psychiatry 156:756-60. 1999
    ..The purpose of this study was to determine the efficacy of fluvoxamine for the treatment of social phobia (social anxiety disorder)...
  40. ncbi request reprint Gender differences in susceptibility to posttraumatic stress disorder
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
    Behav Res Ther 38:619-28. 2000
    ..g. fire, witnessing injury to others). Understanding the basis of (and parameters for) this increased susceptibility to PTSD in women compared to men following trauma exposure should be a priority for future traumatic stress research...
  41. ncbi request reprint Development of a brief diagnostic screen for panic disorder in primary care
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
    Psychosom Med 61:359-64. 1999
    ..The purpose of this study was to determine the utility of a brief screening tool for panic disorder in the primary care setting...
  42. ncbi request reprint A direct-interview family study of generalized social phobia
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
    Am J Psychiatry 155:90-7. 1998
    ..They also hypothesized that rates of avoidant personality disorder, a frequent comorbid condition, would be higher in relatives of probands with generalized social phobia...
  43. ncbi request reprint Sexual assault and physical health: findings from a population-based study of older adults
    M B Stein
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093 0985, USA
    Psychosom Med 62:838-43. 2000
    ..The objective of this study was to determine whether there is an association between self-reported sexual assault history and objective parameters of physical health in a sample of older men and women...
  44. pmc A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits
    Murray B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0855, USA
    Biol Psychiatry 69:825-31. 2011
    ..We examined association of a susceptibility gene, contactin-associated protein-like 2 (CNTNAP2), for ASDs and specific language impairment with SM and social anxiety-related traits...
  45. ncbi request reprint Bringing up bashful baby. Developmental pathways to social phobia
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    Psychiatr Clin North Am 24:661-75. 2001
    ..If so, it should be possible to design early interventions to prevent the progression from phobia proneness (e.g., designated on the basis of family history) to phobic disorder...
  46. ncbi request reprint Pindolol potentiation of paroxetine for generalized social phobia: a double-blind, placebo-controlled, crossover study
    M B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0985, USA
    Am J Psychiatry 158:1725-7. 2001
    ..The effectiveness of pindolol as an adjunctive treatment to boost response to selective serotonin reuptake inhibitors (SSRIs) in patients with generalized social phobia was tested...
  47. ncbi request reprint Major depressive and post-traumatic stress disorder comorbidity in female victims of intimate partner violence
    M B Stein
    VA San Diego Healthcare System, San Diego, CA, USA
    J Affect Disord 66:133-8. 2001
    ....
  48. pmc Quality of and patient satisfaction with primary health care for anxiety disorders
    Murray B Stein
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0855, USA
    J Clin Psychiatry 72:970-6. 2011
    ..Most patients with anxiety disorders receive their care from primary care practitioners (PCPs). The purpose of this study was to evaluate quality of and patient satisfaction with primary health care for anxiety disorders...
  49. ncbi request reprint Post-traumatic stress disorder: a review of recent findings
    S Seedat
    Department of Psychiatry 0985, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA
    Curr Psychiatry Rep 3:288-94. 2001
    ....
  50. ncbi request reprint Familial aggregation of anxiety-related quantitative traits in generalized social phobia: clues to understanding "disorder" heritability?
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
    Am J Med Genet 105:79-83. 2001
    ..More extensive efforts at phenotype refinement should be undertaken before such studies proceed...
  51. ncbi request reprint Full and partial posttraumatic stress disorder: findings from a community survey
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
    Am J Psychiatry 154:1114-9. 1997
    ..Full and partial posttraumatic stress disorder (PTSD) following trauma exposure were examined in a community sample in order to determine their prevalence and their relative importance and functional significance...
  52. ncbi request reprint Social anxiety disorder and the risk of depression: a prospective community study of adolescents and young adults
    M B Stein
    Department of Psychiatry, University of California San Diego, 8950 Villa La Jolla Dr, Suite 2243, La Jolla, CA 92037, USA
    Arch Gen Psychiatry 58:251-6. 2001
    ..This has led to interest in SAD as a possible modifier of the risk and/or course of mood disorders...
  53. ncbi request reprint Obsessive-compulsive disorder in the community: an epidemiologic survey with clinical reappraisal
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0603, USA
    Am J Psychiatry 154:1120-6. 1997
    ..To examine the prevalence of obsessive-compulsive symptoms and DSM-IV obsessive-compulsive disorder (OCD), the authors conducted a telephone survey of 2,261 adults in four regions of Canada...
  54. ncbi request reprint Depression in a primary care clinic: the prevalence and impact of an unrecognized disorder
    J R McQuaid
    University of California, San Diego, USA
    J Affect Disord 55:1-10. 1999
    ..This study assesses depression among primary care patients, the relationship between depression and functioning, and how frequently depressed individuals receive mental health treatment...
  55. ncbi request reprint Use of brief psychiatric screening measures in a primary care sample
    J R McQuaid
    University of California, San Diego, USA
    Depress Anxiety 12:21-9. 2000
    ..The BAI was a relatively poor screening measure that added no significant information beyond the other measures...
  56. ncbi request reprint Profiling posttraumatic functional impairment
    Sonya B Norman
    Department of Psychiatry, University of California San Diego, and the VA San Diego Healthcare System, La Jolla, California 92093 0985, USA
    J Nerv Ment Dis 195:48-53. 2007
    ..The symptom profile can help identify traumatized individuals who may benefit from treatment but do not necessarily meet criteria for PTSD...
  57. ncbi request reprint Functional impact and health utility of anxiety disorders in primary care outpatients
    Murray B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0985, USA
    Med Care 43:1164-70. 2005
    ..The objective of this study was to examine the relative impact of anxiety disorders and major depression on functional status and health-related quality of life of primary care outpatients...
  58. ncbi request reprint Dose-dependent decrease of activation in bilateral amygdala and insula by lorazepam during emotion processing
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine and Department of Psychiatry, University of California, San Diego, USA
    Arch Gen Psychiatry 62:282-8. 2005
    ..A large body of evidence suggests that the amygdala and associated limbic structures play a critical role in the expression of anxiety and may be treatment targets for anxiolytic drugs...
  59. ncbi request reprint Social phobia: prevalence and diagnostic threshold
    A J Lang
    Department of Psychiatry, University of California San Diego and VA San Diego Healthcare System, USA
    J Clin Psychiatry 62:5-10. 2001
    ..We discuss the diagnostic threshold of social phobia and potential difficulties in differentiating this disorder from other mental disorders...
  60. ncbi request reprint Do selective serotonin re-uptake inhibitors enhance the efficacy of very brief cognitive behavioral therapy for panic disorder? A pilot study
    M B Stein
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla CA 92093 0603, USA
    Psychiatry Res 94:191-200. 2000
    ..13%; P<0.017). These findings point to the need for additional studies to confirm the effectiveness of very brief forms of CBT, and to document the circumstances in which combined treatment with an SSRI would be warranted...
  61. ncbi request reprint Associations between psychological trauma and physical illness in primary care
    Sonya B Norman
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Trauma Stress 19:461-70. 2006
    ..Awareness of the presence of the physical illnesses examined here may help with the identification and treatment of primary care patients with trauma histories...
  62. ncbi request reprint Scrutinizing the relationship between shyness and social phobia
    Denise A Chavira
    Department of Psychiatry, University of California San Diego, La Jolla 92093 0985, USA
    J Anxiety Disord 16:585-98. 2002
    ..Findings suggest that shyness and social phobia (especially the generalized type) are related constructs but not completely synonymous; an individual can be extremely shy yet not have a social phobia diagnosis...
  63. pmc Direct and indirect links between childhood maltreatment, posttraumatic stress disorder, and women's health
    Ariel J Lang
    The University of California San Diego UCSD, San Diego, CA 92108, USA
    Behav Med 33:125-35. 2008
    ..These findings should strengthen efforts directed at identifying and treating PTSD in female victims of childhood maltreatment with the aim of preventing or attenuating poor health outcomes...
  64. ncbi request reprint Double-blind, placebo-controlled assessment of combined clonazepam with paroxetine compared with paroxetine monotherapy for generalized social anxiety disorder
    Soraya Seedat
    Anxiety and Traumatic Stress Disorders Program, Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA
    J Clin Psychiatry 65:244-8. 2004
    ..Monotherapy with the benzodiazepine clonazepam is also efficacious for GSAD, but the adjunctive use of clonazepam with an SSRI to potentially improve outcomes has not been studied to date...
  65. ncbi request reprint In search of mixed anxiety-depressive disorder: a primary care study
    Adrienne J Means-Christensen
    Department of Psychiatry, University of California, San Diego, California, USA
    Depress Anxiety 23:183-9. 2006
    ..These data dispute the need for a mixed anxiety-depression category (beyond mood and anxiety syndromes currently in DSM-IV) in future editions of the DSM...
  66. ncbi request reprint Prevalence of dissociative experiences in a community sample: relationship to gender, ethnicity, and substance use
    Soraya Seedat
    Department of Psychiatry, University of California San Diego, 8950 Villa La Jolla Drive, Suite 2243, La Jolla, California 92037, USA
    J Nerv Ment Dis 191:115-20. 2003
    ..Further assessment of the link between demographic factors and the severity and expression of dissociative phenomena in nonclinical samples is warranted...
  67. ncbi request reprint Developmental antecedents of anxiety sensitivity
    Christine D Scher
    San Diego State University, San Diego, CA, USA
    J Anxiety Disord 17:253-69. 2003
    ....
  68. ncbi request reprint A polymorphism of the beta1-adrenergic receptor is associated with low extraversion
    Murray B Stein
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Biol Psychiatry 56:217-24. 2004
    ..We examined the possibility that allelic variation leading to alterations in beta(1)-adrenergic function might be present in persons with elevated social anxiety-related traits...
  69. ncbi request reprint Plasma cortisol and neuropeptide Y in female victims of intimate partner violence
    S Seedat
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA
    Psychoneuroendocrinology 28:796-808. 2003
    ..This study sought to examine baseline plasma cortisol and neuropeptide Y (NPY) levels in female victims of intimate partner violence (IPV)...
  70. ncbi request reprint Predictors of willingness to consider medication and psychosocial treatment for panic disorder in primary care patients
    Holly Hazlett-Stevens
    University of California, Los Angeles, CA, USA
    Gen Hosp Psychiatry 24:316-21. 2002
    ....
  71. pmc Refining the classification of children with selective mutism: a latent profile analysis
    Sharon L Cohan
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Clin Child Adolesc Psychol 37:770-84. 2008
    ..These results suggest that, although social anxiety is typically a prominent feature of SM, children with the disorder are also likely to present with communication delays and/or mild behavior problems...
  72. ncbi request reprint Sexual trauma and pregnancy: a conceptual framework
    Carie S Rodgers
    VA San Diego Healthcare System, San Diego, California 92108, USA
    J Womens Health (Larchmt) 12:961-70. 2003
    ..We suggest future directions for this area of research and discuss the clinical implications of this association, including the development of prenatal intervention and prevention programs...
  73. ncbi request reprint Comorbidity of generalized social anxiety disorder and depression in a pediatric primary care sample
    Denise A Chavira
    Department of Psychiatry, University of California San Diego, 8950 Villa La Jolla Drive, Suite 2243, La Jolla, CA 92037, USA
    J Affect Disord 80:163-71. 2004
    ..Comorbidity between adult social anxiety disorder and major depression is extensive. Considerably less information about this relationship is available among youth...
  74. doi request reprint Abbreviated brief symptom inventory for use as an anxiety and depression screening instrument in primary care
    Ariel J Lang
    Department of Psychiatry, University of California San Diego, CA, USA
    Depress Anxiety 26:537-43. 2009
    ..The feasibility of such screening, however, depends on the availability of quick, easily interpretable screening tools...
  75. ncbi request reprint Recent developments in child and adolescent social phobia
    D A Chavira
    Department of Psychiatry, University of California at San Diego, Box 0985, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
    Curr Psychiatry Rep 2:347-52. 2000
    ..Initial data regarding the use of SSRIs suggest that they may be a promising treatment option...
  76. ncbi request reprint Anterior cingulate activation in high trait anxious subjects is related to altered error processing during decision making
    Martin P Paulus
    Department of Psychiatry, University of California Sand Diego, La Jolla 92093 9116, USA
    Biol Psychiatry 55:1179-87. 2004
    ....
  77. ncbi request reprint Combined psychoeducation and treatment with selective serotonin reuptake inhibitors for youth with generalized social anxiety disorder
    Denise A Chavira
    Department of Psychiatry, University of California San Diego, La Jolla 92037, USA
    J Child Adolesc Psychopharmacol 12:47-54. 2002
    ..Findings support the need for double-blind, placebo-controlled studies of combined treatments for youth with generalized social anxiety disorder...
  78. ncbi request reprint Relationships among childhood maltreatment, PTSD, and health in female veterans in primary care
    Ariel J Lang
    VA San Diego Healthcare System, 8810 Rio San Diego Drive MC116A4Z, San Diego, CA 92108, USA
    Child Abuse Negl 30:1281-92. 2006
    ..This study examined whether current post-traumatic stress disorder (PTSD) symptoms mediate the relationship between CM and indicators of physical health and medical utilization in female veterans...
  79. ncbi request reprint Sexual dysfunction in combat veterans with post-traumatic stress disorder
    Daniel J Cosgrove
    Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103 8897, USA
    Urology 60:881-4. 2002
    ..The results of recent studies have suggested that combat veterans with PTSD experience a higher rate of sexual dysfunction than do those without PTSD...
  80. ncbi request reprint Assessment of beliefs about psychotropic medication and psychotherapy: development of a measure for patients with anxiety disorders
    Alexander Bystritsky
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Gen Hosp Psychiatry 27:313-8. 2005
    ..This study presents the psychometric properties of a brief measure to assess beliefs about psychotropic medications and psychotherapy among patients with anxiety disorders...
  81. ncbi request reprint Brief measures to screen for social phobia in primary care pediatrics
    Kelly A Bailey
    San Diego State University, La Jolla, California, USA
    J Pediatr Psychol 31:512-21. 2006
    ..To evaluate the usefulness of screening measures to detect social phobia among youth in a primary care setting...
  82. doi request reprint Prefrontal dysfunction during emotion regulation in generalized anxiety and panic disorders
    T Manber Ball
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    Psychol Med 43:1475-86. 2013
    ..e. reduce) or maintain emotional responses to negative images...
  83. ncbi request reprint Anxiety disorders. How to recognize and treat the medical symptoms of emotional illness
    A J Lang
    Department of Psychiatry, University of California, San Diego, USA
    Geriatrics 56:24-7, 31-4. 2001
    ..Older patients may benefit from cognitive-behavioral therapy and relaxation training. Antidepresants, particularly selective serotonin reuptake inhibitors, are the preferred medical treatment...
  84. ncbi request reprint Perceived threat to life predicts posttraumatic stress disorder after major trauma: risk factors and functional outcome
    T L Holbrook
    Department of Family and Preventive Medicine, University of California, San Diego, California, USA
    J Trauma 51:287-92; discussion 292-3. 2001
    ..0001). CONCLUSION: These results provide new and provocative evidence that perceived threat to life and mechanism predict PTSD after major traumatic injury. PTSD had a prolonged and profound impact on short- and long-term outcome and QoL...
  85. ncbi request reprint An open-label, 12-week clinical and sleep EEG study of nefazodone in chronic combat-related posttraumatic stress disorder
    J C Gillin
    University of California and VA San Diego Healthcare System, 92161, USA
    J Clin Psychiatry 62:789-96. 2001
    ..To our knowledge, this is the first polysomnographic study of treatment in patients with PTSD...
  86. pmc Validation of a brief measure of anxiety-related severity and impairment: the Overall Anxiety Severity and Impairment Scale (OASIS)
    Laura Campbell-Sills
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0603, USA
    J Affect Disord 112:92-101. 2009
    ..A prior investigation with a nonclinical sample supported the reliability and validity of the OASIS; however, to date it has not been validated for use in clinical samples...
  87. ncbi request reprint Anxiety sensitivity and PTSD among female victims of intimate partner violence
    Ariel J Lang
    San Diego VA Healthcare System, San Diego, California, USA
    Depress Anxiety 16:77-83. 2002
    ..Nonetheless, AS may be an important factor to consider in treatment of individuals with PTSD...
  88. ncbi request reprint From sensory processes to conscious perception
    Justin S Feinstein
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California, San Diego, USA
    Conscious Cogn 13:323-35. 2004
    ..These results are discussed in light of a neural framework for conscious processing...
  89. ncbi request reprint Mutation screen of the GAD2 gene and association study of alcoholism in three populations
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 144:183-92. 2007
    ..The functional promoter GAD2 -243 A > G variant may influence risk for AD in some populations, or its role may be limited to susceptibility to severe AD...
  90. ncbi request reprint Habituation of attentional networks during emotion processing
    Justin S Feinstein
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California, San Diego, CA 92093, USA
    Neuroreport 13:1255-8. 2002
    ....
  91. pmc Escitalopram attenuates posterior cingulate activity during self-evaluation in healthy volunteers
    Scott C Matthews
    Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Psychiatry Res 182:81-7. 2010
    ..These results show that SSRIs change medial cortical activity and may alter self-evaluation...
  92. ncbi request reprint An insular view of anxiety
    Martin P Paulus
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92037, USA
    Biol Psychiatry 60:383-7. 2006
    ....
  93. ncbi request reprint Adult psychopathology and intimate partner violence among survivors of childhood maltreatment
    Ariel J Lang
    VA San Diego Healthcare System, CA, USA
    J Interpers Violence 19:1102-18. 2004
    ..This work underscores the importance of assessing multiple types of childhood maltreatment and of considering the cumulative effects of such experiences...
  94. pmc Issues in the assessment of social phobia: a review
    Andrea M Letamendi
    Department ofPsychology, San Diego State University, San Diego, California 82037 0855, USA
    Isr J Psychiatry Relat Sci 46:13-24. 2009
    ..This review evaluates each method by highlighting the assessment features recommended in social phobia literature, including method of administration, item content, coverage, length of scale, type of scores generated, and time frame...
  95. ncbi request reprint Anticipation of emotionally aversive visual stimuli activates right insula
    Alan Simmons
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
    Neuroreport 15:2261-5. 2004
    ..These findings indicate that common neural circuitry is involved in the anticipation of (and, perhaps, the subjective experience of anticipating) aversive affective and noxious physical stimuli...
  96. ncbi request reprint Correlates of alcohol use among anxious and depressed primary care patients
    Joanna J Arch
    Department of Psychology, University of California, Los Angeles, 90095 1563, USA
    Gen Hosp Psychiatry 28:37-42. 2006
    ..The purpose of this study is to determine the patterns of alcohol use for primary care patients with anxiety disorders and/or major depression in three urban university-affiliated outpatient clinics...
  97. ncbi request reprint Pain in the aftermath of trauma is a risk factor for post-traumatic stress disorder
    S B Norman
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    Psychol Med 38:533-42. 2008
    ..This study assessed pain shortly after traumatic injury (i.e. peritraumatic pain) as a risk factor for PTSD...
  98. ncbi request reprint Paroxetine CR augmentation for posttraumatic stress disorder refractory to prolonged exposure therapy
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:400-5. 2008
    ..This study prospectively examines the relative efficacy of augmentation of continued prolonged exposure therapy (PE) with paroxetine CR versus placebo for individuals remaining symptomatic despite a course of PE...
  99. ncbi request reprint Posttraumatic stress disorder symptoms influence health status of deployed peacekeepers and nondeployed military personnel
    Gordon J G Asmundson
    Faculty of Kinesiology and Health Studies, University of Regina, 3737 Wascana Parkway, Regina, Saskatchewan, Canada S4S 0A2
    J Nerv Ment Dis 190:807-15. 2002
    ..Increased alcohol use did not contribute to poorer health beyond the contribution of PTSD symptoms alone. Future research directions are discussed...
  100. doi request reprint Anxiety disorders and comorbid medical illness
    Peter P Roy-Byrne
    University of Washington School of Medicine, Seattle, WA 98195, USA
    Gen Hosp Psychiatry 30:208-25. 2008
    ..To provide an overview of the role of anxiety disorders in medical illness...
  101. ncbi request reprint A randomized, double-blind, fixed-dose comparison of paroxetine and placebo in the treatment of generalized social anxiety disorder
    Michael R Liebowitz
    New York State Psychiatric Institute and Columbia University, New York 10032, USA
    J Clin Psychiatry 63:66-74. 2002
    ..This multicenter, double-blind, placebo-controlled study was carried out to determine the effectiveness and safety of various daily dosages of paroxetine for the treatment of generalized social anxiety disorder...

Research Grants27

  1. Neural Substrates of Anticipation and Interoception in Anxiety Disorders
    Murray Stein; Fiscal Year: 2007
    ....
  2. CALM: IMPROVING PRIMARY CARE ANXIETY OUTCOMES
    Murray Stein; Fiscal Year: 2007
    ..g. instrumental variables) to examine the effects of appropriate treatment, independent of intervention assignment, on functioning and other clinical outcomes; and (2) to estimate health care costs and cost effectiveness of CALM. ..
  3. Improving Outcomes in Pharmacotherapy of Social Phobia
    Murray Stein; Fiscal Year: 2007
    ..It thus directly addresses a critical public health issue that adversely affects a substantial proportion of the population. ..
  4. Improving Outcomes and Understanding Response Heterogeneity in Anxiety Disorders
    Murray Stein; Fiscal Year: 2007
    ....
  5. Neural Substrates of Anticipation and Interoception in Anxiety Disorders
    Murray Stein; Fiscal Year: 2009
    ....
  6. Improving Outcomes in Pharmacotherapy of Social Phobia
    Murray Stein; Fiscal Year: 2009
    ..It thus directly addresses a critical public health issue that adversely affects a substantial proportion of the population. ..
  7. Pharmacological fMRI to Identify New Anxiolytics: A Human Bioassay
    Murray Stein; Fiscal Year: 2007
    ..Enhancing the development of new treatments for anxiety is a public health priority. The projects proposed in this application have the potential to achieve this important aim. ..
  8. IMPROVING CARE FOR PANIC DISORDER IN PRIMARY CARE
    Murray Stein; Fiscal Year: 2002
    ..abstract_text> ..
  9. Preventing Psychiatric Sequelae of Traumatic Injury
    Murray Stein; Fiscal Year: 2003
    ..Findings will provide justification for and information about optimal parameters (e.g., subject selection; sample size; dose and duration) for a future randomized controlled trial (RCT). ..
  10. Neural Substrates of Decision-making in Anxiety
    Murray Stein; Fiscal Year: 2006
    ..In addition, identifying dysfunctional neurocognitive processes and underlying neural substrates will enable us to better specify anxiety-based intermediate phenotypes. ..
  11. Neural Substrates of Anticipation and Interoception in Anxiety Disorders
    Murray B Stein; Fiscal Year: 2010
    ....