Affiliation: University of Minnesota
- Measurement of islet cell antibodies in the Type 1 Diabetes Genetics Consortium: efforts to harmonize procedures among the laboratoriesPolly J Bingley
Department of Clinical Science at North Bristol, University of Bristol, Bristol, UK
Clin Trials 7:S56-64. 2010..and..
- Collection and processing of whole blood for transformation of peripheral blood mononuclear cells and extraction of DNA: the Type 1 Diabetes Genetics ConsortiumSilke Rosinger
Division of Endocrinology and Diabetes, Department of Internal Medicine, Ulm University, Ulm, Germany
Clin Trials 7:S65-74. 2010..and..
- Adiponectin, visceral fat, oxidative stress, and early macrovascular disease: the Coronary Artery Risk Development in Young Adults StudyMichael W Steffes
Department of Laboratory Medicine and Pathology, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Obesity (Silver Spring) 14:319-26. 2006..We evaluated the relationships of concentrations of adiponectin with oxidative stress and the major risk factors for and/or the presence of macrovascular disease...
- Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trialMichael W Steffes
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Diabetes Care 26:832-6. 2003..Also, continuing C-peptide (insulin) secretion is important in avoiding hypoglycemia (the major complication of intensive diabetic therapy)...
- Serum adiponectin in young adults--interactions with central adiposity, circulating levels of glucose, and insulin resistance: the CARDIA studyMichael W Steffes
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55454, USA
Ann Epidemiol 14:492-8. 2004..To study adiponectin, a circulating adipocytokine secreted by adipocytes inversely associated with diabetes and insulin resistance, and factors affecting its levels in the Coronary Artery Risk Development in Young Adults (CARDIA) study...
- Hemoglobin A1c measurements over nearly two decades: sustaining comparable values throughout the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications studyMichael Steffes
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55454, USA
Clin Chem 51:753-8. 2005..Clinical trials require assays that provide consistent results during the course of a study. The hemoglobin A1c (HbA1c) assay, a measure of chronic glycemia, is critical to the study of diabetes control and complications...
- Estimated GFR and risk of hip fracture in older men: comparison of associations using cystatin C and creatinineKristine E Ensrud
Department of Medicine, University of Minnesota, Minneapolis, MN Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN Center for Chronic Disease Outcomes Research, VA Health Care System, Minneapolis, MN Electronic address
Am J Kidney Dis 63:31-9. 2014..Whether estimated glomerular filtration rate (eGFR) based on cystatin C (eGFRcys) is superior in predicting hip fracture risk to eGFR based on creatinine (eGFRcr) or the combination (eGFR(cr-cys)) also is uncertain...
- Correlates of urinary albumin excretion in young adult blacks and whites: the Coronary Artery Risk Development in Young Adults StudyMaureen A Murtaugh
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
Am J Epidemiol 158:676-86. 2003..A risk of higher urinary albumin excretion exists at blood pressure levels below those commonly regarded as hypertension, with a greater risk among Blacks than among Whites...
- Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC)Joan E Hilner
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
Clin Trials 7:S5-S32. 2010..The initial goal was to collect 2500 affected sibling pair (ASP) families worldwide...
- Cystatin C and risk of hip fractures in older womenKristine E Ensrud
Department of Medicine, University of Minnesota, Minneapolis, MN, USA
J Bone Miner Res 28:1275-82. 2013..These findings suggest that cystatin C may be a promising biomarker for identification of older adults at high risk of hip fracture...
- Plasma F2-isoprostanes and coronary artery calcification: the CARDIA StudyMyron Gross
Department of Laboratory Medicine and Pathology, School of Medicine, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
Clin Chem 51:125-31. 2005..Oxidation of lipids in lipoproteins and cells may initiate and enhance the early development of cardiovascular disease. Method and..
- Azide and Tween-20 reduce binding to autoantibody epitopes of islet antigen-2; implications for assay performance and reproducibilityAlistair J K Williams
Clinical Science at North Bristol, Southmead Hospital, Bristol, UK
J Immunol Methods 351:75-9. 2009..We conclude that common assay reagents such as azide and Tween-20 can strongly influence IA-2A binding in an epitope-related manner, and their use may explain some of the differences between laboratories in IA-2A measurement...
- Intra-abdominal fat and elevated urine albumin excretion in men with type 1 diabetesShalamar D Sibley
Department of Endocrinology and Diabetes, University of Minnesota, Mayo Medical Code 101, 420 Delaware St SE, Minneapolis, MN 55455, USA
Diabetes Care 30:1898-900. 2007
- The uncoupling protein 2 Ala55Val polymorphism is associated with diabetes mellitus: the CARDIA studyXinhua Yu
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
Clin Chem 51:1451-6. 2005..Uncoupling proteins (UCPs) reduce ATP generation with concomitant increased release of heat. The activities of UCPs have been related to obesity and energy metabolism...
- Gender and elevated albumin excretion in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) cohort: role of central obesityShalamar D Sibley
Department of Biostatistics, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
Am J Kidney Dis 47:223-32. 2006..These relationships have been examined less thoroughly in patients with type 1 diabetes...
- The effects of dietary patterns on urinary albumin excretion: results of the Dietary Approaches to Stop Hypertension (DASH) TrialDavid R Jacobs
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
Am J Kidney Dis 53:638-46. 2009..Dietary studies designed to decrease the urinary albumin excretion rate (AER) typically reduce protein by increasing lower protein plant foods and decreasing higher protein animal products...
- Reduced renal function and sleep-disordered breathing in community-dwelling elderly menMuna T Canales
Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Sleep Med 9:637-45. 2008..Sleep-disordered breathing (SDB) may increase the risk of cardiovascular disease (CVD) and death in chronic kidney disease (CKD). However, the association between mild reductions in renal function and SDB is uncertain...
- Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohortRodica Pop-Busui
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
J Peripher Nerv Syst 14:1-13. 2009....
- Gender- and race-specific determination of albumin excretion rate using albumin-to-creatinine ratio in single, untimed urine specimens: the Coronary Artery Risk Development in Young Adults StudyDavid R Jacobs
University of Minnesota, Division of Epidemiology, School of Public Health, Minneapolis, MN 55454, USA
Am J Epidemiol 155:1114-9. 2002..Men and Blacks have a higher albumin excretion rate than do women and Whites and may thereby have an increased risk of microvascular and macrovascular disease...
- Circulating carotenoid concentrations and incident hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) studyAtsushi Hozawa
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
J Hypertens 27:237-42. 2009..Thus, we examined the association of circulating carotenoids with hypertension, a major macrovascular disease risk factor...
- Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTAtsushi Hozawa
Division of Epidemiology and Community Health, School of Public Health, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55454, USA
Clin Chem 53:447-55. 2007..To clarify the effect of carotenoids on atherosclerotic risk factors, we examined the association of circulating carotenoids with inflammation, oxidative stress, endothelial dysfunction, and smoking...
- Factors associated with paraoxonase genotypes and activity in a diverse, young, healthy population: the Coronary Artery Risk Development in Young Adults (CARDIA) studyBharat Thyagarajan
Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota Minneapolis, MN 55454, USA
Clin Chem 54:738-46. 2008..Paraoxonase may mitigate oxidative damage and thus lower risk of macrovascular disease...
- Associations of serum carotenoid concentrations with the development of diabetes and with insulin concentration: interaction with smoking: the Coronary Artery Risk Development in Young Adults (CARDIA) StudyAtsushi Hozawa
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, 55454, USA
Am J Epidemiol 163:929-37. 2006..46 (p = 0.03); per SD increase in insulin resistance, slope = -0.14 (p = 0.01)). In CARDIA, higher serum carotenoid concentrations are associated with lower risk of diabetes and insulin resistance in nonsmokers but not in smokers...
- Lessons learned from studies of the natural history of diabetic nephropathy in young type 1 diabetic patientsJulia M Steinke
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Pediatr Endocrinol Rev 5:958-63. 2008..The longitudinal structural studies are still in analysis and this paper will mainly review the cross sectional studies that have been completed to date...
- Urinary albumin as an indicator of diabetic nephropathy lesions in Japanese type 2 diabetic patientsTatsumi Moriya
Department of Pediatrics, University of Minnesota Medical School, Minneapolis 55455, USA
Nephron 91:292-9. 2002....
- The association of cigarette smoking with self-reported disease before middle age: the Coronary Artery Risk Development in Young Adults (CARDIA) studyAtsushi Hozawa
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA
Prev Med 42:193-9. 2006..Therefore, we assessed associations between cigarette smoking and several self-reported illnesses in a prospective cohort study in healthy young adults...
- Kidney function, albuminuria, and all-cause mortality in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) studyDavid G Warnock
Division of Nephrology, Department of Medicine, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
Am J Kidney Dis 56:861-71. 2010..Chronic kidney disease and albuminuria are associated with increased risk of all-cause mortality...
- Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications GHussam Al-Kateb
Program in Genetics and Genome Biology, The Hospital for Sick Children, TMDT Building East Tower, Rm 15 707, 101 College St, Toronto, Ontario, Canada
Diabetes 57:218-28. 2008..Despite familial clustering of nephropathy and retinopathy severity in type 1 diabetes, few gene variants have been consistently associated with these outcomes...
- Impact of creatinine calibration on performance of GFR estimating equations in a pooled individual patient databaseLesley A Stevens
Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
Am J Kidney Dis 50:21-35. 2007..Variation in performance of glomerular filtration rate (GFR) estimating equations is related to variation in calibration of the creatinine assay across clinical laboratories...
- Insulin therapy, hyperglycemia, and hypertension in type 1 diabetes mellitusIan H De Boer
Division of Nephrology, University of Washington, Box 356521, 1959 NE Pacific St, Seattle, WA 98117, USA
Arch Intern Med 168:1867-73. 2008..Diabetes mellitus and hypertension are closely linked, but the long-term blood pressure effects of glucose-lowering therapy and hyperglycemia are not clear...
- Glomerular filtration rate and albuminuria: twin manifestations of nephropathy in diabetesIan H De Boer
J Am Soc Nephrol 18:1036-7. 2007
- C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001Jerry P Palmer
Department of Medicine, University of Washington, and DVA Puget Sound Health Care System, Seattle, Washington 98108, USA
Diabetes 53:250-64. 2004..The development of therapies for addressing this important unmet clinical need will be facilitated by trials that are carefully designed with beta-cell function as determined by C-peptide measurement as the primary efficacy outcome...
- Nephropathy in diabetesMark E Molitch
Diabetes Care 27:S79-83. 2004
- Inverse effects of the PPAR(gamma)2 Pro12Ala polymorphism on measures of adiposity over 15 years in African Americans and whites. The CARDIA studyMyriam Fornage
Institute of Molecular Science, University of Texas Health Science Center at Houston, Houston TX 77030, USA
Metabolism 54:910-7. 2005..01) in African Americans but not in whites. Important roles of BMI and ethnic background in influencing the complex relationships among PPAR gamma gene variation, adiposity, and insulin resistance are suggested...
- Glycemic control, atherosclerosis, and risk factors for cardiovascular disease in individuals with diabetes: the atherosclerosis risk in communities studyElizabeth Selvin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument St, Suite 2 600, Baltimore, MD 21205, USA
Diabetes Care 28:1965-73. 2005..This study examines the relationship between A1C, carotid intima-media thickness (IMT), and traditional cardiovascular risk factors in individuals with diabetes...
- Measurement of circulating glucose concentrations: the time is now for consistency among methods and types of samplesMichael W Steffes
Clin Chem 51:1569-70. 2005
- Glycemic control and coronary heart disease risk in persons with and without diabetes: the atherosclerosis risk in communities studyElizabeth Selvin
Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2223, USA
Arch Intern Med 165:1910-6. 2005..Chronic hyperglycemia has been hypothesized to contribute to coronary heart disease (CHD), but the extent to which hemoglobin A(1c) (HbA(1c)) level, a marker of long-term glycemic control, is independently related to CHD risk is uncertain...
- The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetesMichael J Tansey
DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA
Diabetes Care 29:20-5. 2006..To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes...
- HbA1c and peripheral arterial disease in diabetes: the Atherosclerosis Risk in Communities studyElizabeth Selvin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2223, USA
Diabetes Care 29:877-82. 2006..A second aim was to investigate whether the association was stronger for severe, symptomatic disease compared with PAD assessed by low ankle-brachial index (ABI)...
- Central obesity, incident microalbuminuria, and change in creatinine clearance in the epidemiology of diabetes interventions and complications studyIan H De Boer
Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
J Am Soc Nephrol 18:235-43. 2007..In conclusion, waist circumference predicts the subsequent development of microalbuminuria in type 1 diabetes. In contrast, no association of waist circumference with decline in creatinine clearance was observed...
- Comparison of fingerstick hemoglobin A1c levels assayed by DCA 2000 with the DCCT/EDIC central laboratory assay: results of a Diabetes Research in Children Network (DirecNet) StudyWilliam V Tamborlane
Jaeb Center for Health Research, Tampa, FL 33647, USA
Pediatr Diabetes 6:13-6. 2005..The DCA 2000 + Analyzer (Bayer Inc., Tarrytown, NY, USA), which uses an immunoassay, is a very popular device for measuring HbA1c levels in pediatric diabetes practices...
- Patterns of association between PPARgamma genetic variation and indices of adiposity and insulin action in African-Americans and whites: the CARDIA StudyQi Wei
Institute of Molecular Medicine, The University of Texas Health Science Center Houston, 1825 Pressler St, Houston, TX 77030, USA
J Mol Med (Berl) 84:955-65. 2006..It underscores the role of genetic and environmental contexts in shaping the patterns of associations of PPARgamma sequence variants with metabolic traits in human populations...
- Epidemiology, heritability, and genetic linkage of C-reactive protein in African Americans (from the Jackson Heart Study)Ervin R Fox
University of Mississippi School of Medicine, Jackson, Mississippi, USA
Am J Cardiol 102:835-41. 2008..72. In conclusion, in this large population-based cohort of African Americans, circulating CRP concentration was heritable and associated with several traditional cardiovascular risk factors, particularly body mass index...
- Proteinuria and other markers of chronic kidney disease: a position statement of the national kidney foundation (NKF) and the national institute of diabetes and digestive and kidney diseases (NIDDK)Garabed Eknoyan
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Am J Kidney Dis 42:617-22. 2003
- Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetesPatricia W Mueller
Centers for Disease Control and Prevention, Diabetes and Molecular Risk Assessment Laboratory, Atlanta, Georgia, USA
J Am Soc Nephrol 17:1782-90. 2006..This overview of the GoKinD study examines in detail the power of each study component and discusses analytic challenges that investigators will face in using this resource...
- Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic ratThorsten P Degenhardt
Department of Chemistry, Animal Resource Facility, University of South Carolina, Columbia, SC 29208, USA
Kidney Int 61:939-50. 2002..In this study, we examined the effect of the AGE/ALE inhibitor pyridoxamine on chemical modification and cross-linking of collagen and development of renal disease in the streptozotocin-diabetic rat...
- Standardization of insulin immunoassays: report of the American Diabetes Association WorkgroupSantica Marcovina
Northwest Lipid Metabolism and Diabetes Research Laboratory, University of Washington, Seattle, WA, USA
Clin Chem 53:711-6. 2007..Currently, lack of standardization of insulin assays hinders efforts to achieve consistent measures for treatment guidelines...
- Relationship of family history of type 2 diabetes, hypoglycemia, and autoantibodies to weight gain and lipids with intensive and conventional therapy in the Diabetes Control and Complications TrialJonathan Q Purnell
Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
Diabetes 52:2623-9. 2003..These data support the hypothesis that increased weight gain with intensive therapy might be explained, in part, by genetic traits...
- Use of the DirecNet Applied Treatment Algorithm (DATA) for diabetes management with a real-time continuous glucose monitor (the FreeStyle Navigator)Bruce Buckingham
Pediatr Diabetes 9:142-7. 2008..The DATA provides algorithms for making diabetes management decisions using glucose values: (i) in real time which include the direction and rate of change of glucose levels, and (ii) retrospectively based on downloaded sensor data...
- Modifying Oxidative Damage in WAVEMichael Steffes; Fiscal Year: 2001..abstract_text> ..
- Modifying Oxidative Damage in WAVEMichael Steffes; Fiscal Year: 2002..abstract_text> ..
- Modifying Oxidative Damage in WAVEMichael Steffes; Fiscal Year: 2003..abstract_text> ..
- Coral: Central GFR and Biochemistry LaboratoryMichael Steffes; Fiscal Year: 2007..The study has 90% power to detect a 28% reduction in primary endpoint hazard rate. This R01 from the Clinical Coordinating Center describes the main study hypotheses and overall trial conduct. ..