Darko Stefanovski

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Dimensional analysis of MINMOD leads to definition of the disposition index of glucose regulation and improved simulation algorithm
    Aparna Nittala
    Max McGee National Research Center for Juvenile Diabetes and Human and Molecular Genetics Center, Medical College of Wisconsin, Children s Research Institute, Children s Hospital of Wisconsin, Milwaukee, Wl 53226, USA
    Biomed Eng Online 5:44. 2006
  2. pmc Consistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA
    Darko Stefanovski
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e18134. 2011
  3. pmc Novel canine models of obese prediabetes and mild type 2 diabetes
    Viorica Ionut
    Dept of Physiology and Biophysics, Keck School of Medicine, Univ of Southern California, 1333 San Pablo St, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 298:E38-48. 2010
  4. doi request reprint Simplified method to isolate highly pure canine pancreatic islets
    Orison O Woolcott
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Pancreas 41:31-8. 2012
  5. doi request reprint Large size cells in the visceral adipose depot predict insulin resistance in the canine model
    Morvarid Kabir
    Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    Obesity (Silver Spring) 19:2121-9. 2011
  6. pmc Portal glucose infusion-glucose clamp measures hepatic influence on postprandial systemic glucose appearance as well as whole body glucose disposal
    Dan Zheng
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Physiol Endocrinol Metab 298:E346-53. 2010
  7. pmc Exenatide sensitizes insulin-mediated whole-body glucose disposal and promotes uptake of exogenous glucose by the liver
    Dan Zheng
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Diabetes 58:352-9. 2009
  8. pmc Exenatide can reduce glucose independent of islet hormones or gastric emptying
    Viorica Ionut
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 295:E269-77. 2008
  9. pmc Greater omentectomy improves insulin sensitivity in nonobese dogs
    Maya Lottati
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Obesity (Silver Spring) 17:674-80. 2009
  10. pmc Critical role of the mesenteric depot versus other intra-abdominal adipose depots in the development of insulin resistance in young rats
    Karyn J Catalano
    Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    Diabetes 59:1416-23. 2010

Collaborators

Detail Information

Publications15

  1. pmc Dimensional analysis of MINMOD leads to definition of the disposition index of glucose regulation and improved simulation algorithm
    Aparna Nittala
    Max McGee National Research Center for Juvenile Diabetes and Human and Molecular Genetics Center, Medical College of Wisconsin, Children s Research Institute, Children s Hospital of Wisconsin, Milwaukee, Wl 53226, USA
    Biomed Eng Online 5:44. 2006
    ..Dimensional analysis of the model is up to now not available...
  2. pmc Consistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA
    Darko Stefanovski
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e18134. 2011
    ..Insulin resistance induces hyperinsulinemic compensation, which in turn maintains almost a constant disposition index. However, the signal that gives rise to the hyperinsulinemic compensation for insulin resistance remains unknown...
  3. pmc Novel canine models of obese prediabetes and mild type 2 diabetes
    Viorica Ionut
    Dept of Physiology and Biophysics, Keck School of Medicine, Univ of Southern California, 1333 San Pablo St, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 298:E38-48. 2010
    ..These models open new avenues for studying the mechanism of compensatory changes that occur in T2DM and for evaluating new therapeutic strategies to prevent progression or to treat overt diabetes...
  4. doi request reprint Simplified method to isolate highly pure canine pancreatic islets
    Orison O Woolcott
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Pancreas 41:31-8. 2012
    ..We describe and compare 2 manual isolation methods, M1 (initial) and M2 (modified), and analyze the variables associated with the outcomes, including islet yield, purity, and glucose-stimulated insulin secretion (GSIS)...
  5. doi request reprint Large size cells in the visceral adipose depot predict insulin resistance in the canine model
    Morvarid Kabir
    Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    Obesity (Silver Spring) 19:2121-9. 2011
    ..The appearance of hypertrophic adipocytes in VIS is a critical predictor of insulin resistance, supporting the deleterious effects of increased VIS adiposity in the pathogenesis of insulin resistance...
  6. pmc Portal glucose infusion-glucose clamp measures hepatic influence on postprandial systemic glucose appearance as well as whole body glucose disposal
    Dan Zheng
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Physiol Endocrinol Metab 298:E346-53. 2010
    ....
  7. pmc Exenatide sensitizes insulin-mediated whole-body glucose disposal and promotes uptake of exogenous glucose by the liver
    Dan Zheng
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Diabetes 58:352-9. 2009
    ..We aimed to investigate whether exenatide stimulates glucose turnover directly in insulin-responsive tissues dependent or independent of insulinemia...
  8. pmc Exenatide can reduce glucose independent of islet hormones or gastric emptying
    Viorica Ionut
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 295:E269-77. 2008
    ..We hypothesize that receptors in the portal vein, via a neural mechanism, increase glucose clearance independent of islet hormones...
  9. pmc Greater omentectomy improves insulin sensitivity in nonobese dogs
    Maya Lottati
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Obesity (Silver Spring) 17:674-80. 2009
    ..postsurgery: 6.7 +/- 1.2 pmol/l/mg/dl, P = 0.9). These findings provide new evidence for the deleterious role of visceral fat in insulin resistance, and suggest that a greater OM procedure may effectively improve insulin sensitivity...
  10. pmc Critical role of the mesenteric depot versus other intra-abdominal adipose depots in the development of insulin resistance in young rats
    Karyn J Catalano
    Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    Diabetes 59:1416-23. 2010
    ..However, it is unclear to what extent the portally drained mesenteric fat depot influences this susceptibility...
  11. pmc Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs
    Joyce M Richey
    Dept of Physiology, Keck School of Medicine, Univ of Southern California, 1333 San Pablo St, MMR 626, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 296:E1311-8. 2009
    ..The findings provide evidence of a peripheral effect of rimonabant to reduce adiposity and body weight, possibly through a direct effect on adipose tissue...
  12. pmc OGTT-derived measures of insulin sensitivity are confounded by factors other than insulin sensitivity itself
    Katrin Hucking
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Obesity (Silver Spring) 16:1938-45. 2008
    ....
  13. pmc Estimating hepatic glucokinase activity using a simple model of lactate kinetics
    Darko Stefanovski
    Diabetes and Obesity Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Diabetes Care 35:1015-20. 2012
    ..The ability to estimate liver GCK activity in vivo for genetic and pharmacologic studies may provide important physiologic insights into the regulation of hepatic glucose metabolism...
  14. ncbi request reprint Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action
    Viorica Ionut
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, 1333 San Pablo St, Los Angeles CA 90033, USA
    Am J Physiol Endocrinol Metab 291:E779-85. 2006
    ..In conclusion, in dogs with postprandial rises in systemic glucose and GLP-1, the hormone might not have a direct insulinotropic effect and could regulate glycemia via indirect, portohepatic-initiated neural mechanisms...
  15. pmc A better index of body adiposity
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Obesity (Silver Spring) 19:1083-9. 2011
    ..It can be used in the clinical setting even in remote locations with very limited access to reliable scales. The BAI estimates %adiposity directly...