W D Steers

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Mechanisms of Disease: the role of nerve growth factor in the pathophysiology of bladder disorders
    William D Steers
    Department of Urology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Nat Clin Pract Urol 3:101-10. 2006
  2. ncbi request reprint Viability and safety of combination drug therapies for erectile dysfunction
    William D Steers
    Department of Urology, University of Virginia Health System, P O Box 800422, Charlottesville, VA, USA
    J Urol 170:S20-3; discussion S23. 2003
  3. ncbi request reprint Functional electrical stimulation of bladder and bowel in spinal cord injury
    William D Steers
    Department of Urology, University of Virginia Healthcare System, Charlottesville, VA 22908, USA
    J Long Term Eff Med Implants 12:189-99. 2002
  4. ncbi request reprint Darifenacin: Pharmacology and clinical usage
    William D Steers
    Department of Urology, University of Virginia School of Medicine, University of Virginia Health System, Box 800422 Hospital Drive, Charlottesville, VA 22908, USA
    Urol Clin North Am 33:475-82, viii. 2006
  5. ncbi request reprint A simple method for teaching about voiding disorders
    William D Steers
    Department of Urology, University of Virginia, Charlottesville, VA 22908, USA
    BJU Int 97:238-42. 2006
  6. ncbi request reprint Establishing a robotics program
    William D Steers
    Department of Urology, University of Virginia, Box 800422, University of Virginia Health System, Charlottesville, VA 22908, USA
    Urol Clin North Am 31:773-80, x. 2004
  7. pmc Challenges of conducting multi-center, multi-disciplinary urinary incontinence clinical trials: experience of the urinary incontinence treatment network
    William Steers
    Department of Urology, University of Virginia, Charlottesville, VA, USA
    Neurourol Urodyn 28:170-6. 2009
  8. ncbi request reprint Voiding dysfunction in the orthotopic neobladder
    W D Steers
    University of Virginia Health System, Department of Urology, Charlottesville 22908, USA
    World J Urol 18:330-7. 2000
  9. ncbi request reprint Neural pathways and central sites involved in penile erection: neuroanatomy and clinical implications
    W D Steers
    University of Virginia, Health Sciences Center, Department of Urology, Box 800 422, Jefferson Park Avenue, Charlottesville, VA 22908 0422, USA
    Neurosci Biobehav Rev 24:507-16. 2000
  10. ncbi request reprint Clinical ease of using doxazosin in BPH patients with and without hypertension
    W D Steers
    University of Virginia Hospital West, Charlottesville, Virginia 22908, USA
    Prostate Cancer Prostatic Dis 8:152-7. 2005

Research Grants

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Mechanisms of Disease: the role of nerve growth factor in the pathophysiology of bladder disorders
    William D Steers
    Department of Urology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Nat Clin Pract Urol 3:101-10. 2006
    ..Therapies based on altered NGF levels, or changes in channel properties in afferent nerves, represent an intriguing avenue of investigation for the management of detrusor overactivity or diabetic cystopathy...
  2. ncbi request reprint Viability and safety of combination drug therapies for erectile dysfunction
    William D Steers
    Department of Urology, University of Virginia Health System, P O Box 800422, Charlottesville, VA, USA
    J Urol 170:S20-3; discussion S23. 2003
    ..However, several classes of drugs demonstrate efficacy for ED, creating the potential for pharmacological combinations preferable to implantation of a penile prosthesis...
  3. ncbi request reprint Functional electrical stimulation of bladder and bowel in spinal cord injury
    William D Steers
    Department of Urology, University of Virginia Healthcare System, Charlottesville, VA 22908, USA
    J Long Term Eff Med Implants 12:189-99. 2002
    ..Consequently, a new system is being devised in which functional electrical stimulation for incontinence in spinal cord injury can be achieved without dorsal rhizotomy...
  4. ncbi request reprint Darifenacin: Pharmacology and clinical usage
    William D Steers
    Department of Urology, University of Virginia School of Medicine, University of Virginia Health System, Box 800422 Hospital Drive, Charlottesville, VA 22908, USA
    Urol Clin North Am 33:475-82, viii. 2006
    ..This review describes the role of M3 receptors and covers the mechanism of action, pharmacokinetic properties, clinical efficacy safety and tolerability, drug interactions, and dosing guidelines for darifenacin...
  5. ncbi request reprint A simple method for teaching about voiding disorders
    William D Steers
    Department of Urology, University of Virginia, Charlottesville, VA 22908, USA
    BJU Int 97:238-42. 2006
  6. ncbi request reprint Establishing a robotics program
    William D Steers
    Department of Urology, University of Virginia, Box 800422, University of Virginia Health System, Charlottesville, VA 22908, USA
    Urol Clin North Am 31:773-80, x. 2004
    ..This article considers these factors from an academic health center standpoint and evaluates the benefits and risks of this new technology for urology departments...
  7. pmc Challenges of conducting multi-center, multi-disciplinary urinary incontinence clinical trials: experience of the urinary incontinence treatment network
    William Steers
    Department of Urology, University of Virginia, Charlottesville, VA, USA
    Neurourol Urodyn 28:170-6. 2009
    ....
  8. ncbi request reprint Voiding dysfunction in the orthotopic neobladder
    W D Steers
    University of Virginia Health System, Department of Urology, Charlottesville 22908, USA
    World J Urol 18:330-7. 2000
    ..Knowledge of the pathogenesis and identification of risk factors implies that prevention through proper design of the neobladder, meticulous surgical technique, and patient selection is paramount...
  9. ncbi request reprint Neural pathways and central sites involved in penile erection: neuroanatomy and clinical implications
    W D Steers
    University of Virginia, Health Sciences Center, Department of Urology, Box 800 422, Jefferson Park Avenue, Charlottesville, VA 22908 0422, USA
    Neurosci Biobehav Rev 24:507-16. 2000
    ..Following discussion of the anatomical substrates, a clinical correlation is then provided to confirm and reinforce these experimental observations...
  10. ncbi request reprint Clinical ease of using doxazosin in BPH patients with and without hypertension
    W D Steers
    University of Virginia Hospital West, Charlottesville, Virginia 22908, USA
    Prostate Cancer Prostatic Dis 8:152-7. 2005
    ..Based on its efficacy and pharmacokinetic and tolerability profiles, doxazosin GITS is an effective and well-tolerated treatment for normotensive and hypertensive patients with BPH...
  11. ncbi request reprint Tips on establishing a robotics program in an academic setting
    William D Steers
    Department of Urology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    ScientificWorldJournal 6:2531-41. 2006
    ..This report reviews the steps to assess, plan, initiate, and maintain a robotics program at an academic institution with the hope that other programs can benefit from lessons acquired by early adopters of this expensive technology...
  12. ncbi request reprint In vivo and in vitro investigation of the effects of sildenafil on rat cavernous smooth muscle
    H Gemalmaz
    Department of Urology, University of Virginia School of Medicine, Virginia, USA
    J Urol 165:1010-4. 2001
    ..Sildenafil enhanced the amplitude and duration of the relaxant response to electrical field stimulation in isolated corpus cavernosum tissue...
  13. ncbi request reprint 5alpha-reductase activity in the prostate
    W D Steers
    Department of Urology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Urology 58:17-24; discussion 24. 2001
    ....
  14. ncbi request reprint How can we best characterize the relationship between erectile dysfunction and benign prostatic hyperplasia?
    Raymond A Costabile
    Urology Department, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Sex Med 3:676-81. 2006
    ..However, few basic science or prospective data are available to determine the nature of the relationship between benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) and sexual dysfunction...
  15. ncbi request reprint Patient-centered goals for pelvic floor dysfunction surgery: long-term follow-up
    Kathie L Hullfish
    Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville 22908, USA
    Am J Obstet Gynecol 191:201-5. 2004
    ..This study was undertaken to describe long-term postoperative perceived achievement of subjective preoperative goals for pelvic floor dysfunction (PFD) surgery...
  16. ncbi request reprint Patient-centered goals for pelvic floor dysfunction surgery: what is success, and is it achieved?
    Kathie L Hullfish
    Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, 22908, USA
    Am J Obstet Gynecol 187:88-92. 2002
    ..The purpose of this study was to describe patient-identified goals for pelvic floor dysfunction surgical procedures and patient-reported achievement of those goals...
  17. doi request reprint Angiogenesis therapy for the treatment of erectile dysfunction
    Jeffrey J Lysiak
    Department of Urology, University of Virginia, Charlottesville, VA 22932, USA
    J Sex Med 7:2554-63. 2010
    ..With this in mind, new therapies must be developed. The treatment with angiogenic growth factors such as vascular endothelial cell growth factor (VEGF) may be one such therapy...
  18. ncbi request reprint Diagnosis and management of epididymitis
    Chad R Tracy
    Department of Urology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Urol Clin North Am 35:101-8; vii. 2008
    ..Management of epididymitis is often difficult, but relies on clinical expertise and the use of established clinical guidelines...
  19. pmc Surgical versus nonsurgical treatment of women with pelvic floor dysfunction: patient centered goals at 1 year
    Kathie L Hullfish
    Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Urol 179:2280-5; discussion 2285. 2008
    ..In women with pelvic floor dysfunction we assessed the degree to which treatment (surgical vs nonsurgical) was associated with achievement of patient centered goals, satisfaction with care and quality of life...
  20. ncbi request reprint Research frontiers in the treatment of urinary incontinence
    Adam P Klausner
    Department of Urology, University of Virginia Health System, Charlottesville, Virginia, USA
    Clin Obstet Gynecol 47:104-13. 2004
  21. ncbi request reprint Fiberoptic imaging for urologic surgery
    Jeremy B Tuttle
    University of Virginia School of Medicine, PO Box 801392, Charlottesville, VA 22908, USA
    Curr Urol Rep 10:60-4. 2009
    ..Other applications of the technology and capability will certainly be developed over time. This article reviews and assesses the potential and capabilities of the different imaging modes currently in use or development...
  22. pmc Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function
    W D Steers
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville 22908
    J Clin Invest 88:1709-15. 1991
    ..These findings provide important new evidence that parenchymal cells in the hypertrophied bladder can synthesize NGF and possibly other molecular messengers that act to alter the size and function of neurons in adult animals and man...
  23. ncbi request reprint A model for predicting motor urge urinary incontinence
    M Gray
    Department of Urology and School of Nursing at the University of Virginia, Charlottesville 22908, USA
    Nurs Res 50:116-22. 2001
    ..Additional research is recommended to test the validity and reliability of the instrument derived from this model...
  24. ncbi request reprint Neurophysiology of micturition and continence in women
    T C Chai
    University of Virginia Health Sciences Center, Department of Urology, Charlottesville 22908, USA
    Int Urogynecol J Pelvic Floor Dysfunct 8:85-97. 1997
    ..However, a brief section discussing clinical correlations will follow each of these topics to help integrate the basic science with clinical observations...
  25. ncbi request reprint Depression and incontinence
    W D Steers
    Department of Urology, University of Virginia School of Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    World J Urol 19:351-7. 2001
    ..Uncovering further evidence for such a linkage could serve as the basis for the development of genetic markers and novel therapeutic interventions for these two conditions...
  26. ncbi request reprint Colpocleisis for pelvic organ prolapse: patient goals, quality of life, and satisfaction
    K L Hullfish
    Departments of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Obstet Gynecol 110:341-5. 2007
    ..To assess patient-centered colpocleisis outcomes in women...
  27. ncbi request reprint Fiberoptic imaging of cavernous nerves in vivo
    Lisa B Boyette
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    J Urol 178:2694-700. 2007
    ..We developed a nontoxic technique that would allow high resolution, in vivo real-time imaging specifically of the cavernous nerves...
  28. ncbi request reprint RhoA-mediated Ca2+ sensitization in erectile function
    Hua Wang
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908 0736, USA
    J Biol Chem 277:30614-21. 2002
    ....
  29. ncbi request reprint Tadalafil increases Akt and extracellular signal-regulated kinase 1/2 activation, and prevents apoptotic cell death in the penis following denervation
    Jeffrey J Lysiak
    Department of Urology, University of Virginia, Charlottesville, Virginia, USA
    J Urol 179:779-85. 2008
    ..We also determined whether treatment with the phosphodiesterase-5 inhibitor tadalafil prevents apoptosis as well as the specific mechanisms involved...
  30. ncbi request reprint Postpartum depression, urge urinary incontinence, and overactive bladder syndrome: is there an association?
    Kathie L Hullfish
    University of Virginia Health System, 1215 Lee Street, Charlottesville, VA 22908, and Women s Hospital, Ann Arbor, MI 48109 0276, USA
    Int Urogynecol J Pelvic Floor Dysfunct 18:1121-6. 2007
    ..Because birth is a predictable event, further studies evaluating the causal relationships and physiologic changes linking depression and incontinence can be studied using this model...
  31. doi request reprint Solifenacin treatment in men with overactive bladder: effects on symptoms and patient-reported outcomes
    Steven A Kaplan
    Department of Urology, Weill Cornell Medical College, New York, New York 10065, USA
    Aging Male 13:100-7. 2010
    ..We present a post hoc analysis of PRO-based findings from the subset of men (without presumed bladder outlet obstruction [BOO]) from two large, independent, open-label trials of solifenacin...
  32. ncbi request reprint Corticotropin releasing factor: a mediator of emotional influences on bladder function
    Adam P Klausner
    Department of Urology, University of Virginia Health System, Charlottesville, Virginia, USA
    J Urol 172:2570-3. 2004
    ..We review evidence linking overactive bladder (OAB) and interstitial cystitis with anxiety and depression, and highlight the importance of corticotropin releasing factor (CRF) as a potential mediator of these conditions...
  33. ncbi request reprint An improved approach to followup care for the urological patient: drop-in group medical appointments
    Sophie G Fletcher
    Department of Urology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Urol 176:1122-6; discussion 1126. 2006
    ....
  34. ncbi request reprint Oral sildenafil in the treatment of erectile dysfunction. 1998
    Irwin Goldstein
    J Urol 167:1197-203; discussion 1204. 2002
  35. ncbi request reprint Long-term treatment with darifenacin for overactive bladder: results of a 2-year, open-label extension study
    Francois Haab
    Department d Urologie, Hopital Tenon, Paris, France
    BJU Int 98:1025-32. 2006
    ..5/15 mg once daily in patients with overactive bladder (OAB) who completed two 12-week randomized, double-blind, placebo-controlled 'feeder' studies...
  36. ncbi request reprint Efficacy and safety of tadalafil in men with erectile dysfunction with a high prevalence of comorbid conditions: results from MOMENTUS: multiple observations in men with erectile dysfunction in National Tadalafil Study in the US
    Irwin Goldstein
    Milton, MA 02186, USA
    J Sex Med 4:166-75. 2007
    ..Limited efficacy and safety data exist from open-label clinical trials of phosphodiesterase 5 inhibitors in men with erectile dysfunction (ED) and multiple comorbid (MCM) conditions, historically a difficult group to treat...
  37. pmc Is abuse causally related to urologic symptoms? Results from the Boston Area Community Health (BACH) Survey
    Carol L Link
    New England Research Institutes, Watertown, MA 02472, USA
    Eur Urol 52:397-406. 2007
    ....
  38. doi request reprint Prevalence of and risk factors for urine leakage in a racially and ethnically diverse population of adults: the Boston Area Community Health (BACH) Survey
    Sharon L Tennstedt
    New England Research Institutes, Watertown, MA 02111, USA
    Am J Epidemiol 167:390-9. 2008
    ..The authors conclude that types of and risk factors for urine leakage vary by gender and racial/ethnic group...
  39. ncbi request reprint Tachyphylaxis and phosphodiesterase type 5 inhibitors
    William D Steers
    J Urol 168:207. 2002
  40. ncbi request reprint Alterations in voiding frequency and cystometry in the clomipramine induced model of endogenous depression and reversal with fluoxetine
    Kyu Sung Lee
    Department of Urology, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Urol 170:2067-71. 2003
    ..We examined a rat model of endogenous depression caused by lowering 5-HT for effects on voiding frequency (VF) and awake cystometry (CMG), and examined the effect of reversal using the selective serotonin reuptake inhibitor fluoxetine...
  41. ncbi request reprint Editorial: use of neuronal stem cells to treat neurogenic bladder due to spinal cord injury
    William D Steers
    J Urol 170:1426. 2003
  42. ncbi request reprint A simple method for teaching about voiding disorders
    William D Steers
    BJU Int 97:1347. 2006
  43. doi request reprint Erection of the human penis and its morphological and vascular basis by Guiseppe Conti
    Sidney Glina
    Department of Urology, Instituto H Ellis, Sao Paulo, Brazil
    J Sex Med 5:262-7. 2008

Research Grants4

  1. Na Channels in Afferents after Bladder Obstruction
    William Steers; Fiscal Year: 2006
    ..Insight into these cellular processes could be exploited to develop afferent based treatments for OAB employing pharmacologic, molecular or gene based strategies. ..