H H Stedman

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Myosin gene mutation correlates with anatomical changes in the human lineage
    Hansell H Stedman
    Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 428:415-8. 2004
  2. ncbi Molecular approaches to therapy for Duchenne and limb-girdle muscular dystrophy
    H H Stedman
    Department of Surgery and Institute for Human Gene Therapy, University of Pennsylvania School of Medicine, Philadelphia 19104 6160, USA
    Curr Opin Mol Ther 3:350-6. 2001
  3. ncbi Sarcomeres are added in series to emphysematous rat diaphragm after lung volume reduction surgery
    Joseph B Shrager
    Department of Surgery, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Chest 121:210-5. 2002
  4. ncbi Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family
    Philippe R Desjardins
    Department of Surgery, School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Biol Evol 19:375-93. 2002
  5. ncbi Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema
    Dong Kwan Kim
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Respir Res 4:1. 2003
  6. ncbi A PCR-based assay for the wild-type dystrophin gene transferred into the mdx mouse
    J B Shrager
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104
    Muscle Nerve 15:1133-7. 1992
  7. ncbi Lung volume reduction surgery restores the normal diaphragmatic length-tension relationship in emphysematous rats
    J B Shrager
    Section of General Thoracic Surgery, Department of Surgery, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 121:217-24. 2001
  8. ncbi Myocardial gene delivery using molecular cardiac surgery with recombinant adeno-associated virus vectors in vivo
    J D White
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Gene Ther 18:546-52. 2011
  9. ncbi Inspiratory loading does not accelerate dystrophy in mdx mouse diaphragm: implications for regenerative therapy
    Alexander S Krupnick
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Appl Physiol 94:411-9. 2003
  10. ncbi Global cardiac-specific transgene expression using cardiopulmonary bypass with cardiac isolation
    Charles R Bridges
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, USA
    Ann Thorac Surg 73:1939-46. 2002

Research Grants

  1. Surgical Approaches to Systemic Gene Transfer
    Hansell Stedman; Fiscal Year: 2006
  2. Translational program for molecular therapeutics in DMD
    Hansell Stedman; Fiscal Year: 2007
  3. Systemic molecular therapy for muscular dystrophy
    Hansell H Stedman; Fiscal Year: 2010

Collaborators

Detail Information

Publications15

  1. ncbi Myosin gene mutation correlates with anatomical changes in the human lineage
    Hansell H Stedman
    Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 428:415-8. 2004
    ..This represents the first proteomic distinction between humans and chimpanzees that can be correlated with a traceable anatomic imprint in the fossil record...
  2. ncbi Molecular approaches to therapy for Duchenne and limb-girdle muscular dystrophy
    H H Stedman
    Department of Surgery and Institute for Human Gene Therapy, University of Pennsylvania School of Medicine, Philadelphia 19104 6160, USA
    Curr Opin Mol Ther 3:350-6. 2001
    ....
  3. ncbi Sarcomeres are added in series to emphysematous rat diaphragm after lung volume reduction surgery
    Joseph B Shrager
    Department of Surgery, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Chest 121:210-5. 2002
    ..We used a model of elastase-induced emphysema in rats to test the hypothesis that sarcomere addition occurs following LVRS...
  4. ncbi Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family
    Philippe R Desjardins
    Department of Surgery, School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Biol Evol 19:375-93. 2002
    ..One of the novel human genes is found to have introns at positions shared only with the molluscan catchin/MyHC gene, providing evidence for the structure of a pre-Cambrian ancestral gene...
  5. ncbi Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema
    Dong Kwan Kim
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Respir Res 4:1. 2003
    ....
  6. ncbi A PCR-based assay for the wild-type dystrophin gene transferred into the mdx mouse
    J B Shrager
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104
    Muscle Nerve 15:1133-7. 1992
    ..This simple technique should allow a number of basic questions related to myoblast and direct gene transfer to be addressed using the mdx mouse model...
  7. ncbi Lung volume reduction surgery restores the normal diaphragmatic length-tension relationship in emphysematous rats
    J B Shrager
    Section of General Thoracic Surgery, Department of Surgery, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 121:217-24. 2001
    ..We studied length adaptation in rat diaphragmatic muscle in an attempt to elucidate the mechanism by which diaphragmatic function improves after this controversial operation...
  8. ncbi Myocardial gene delivery using molecular cardiac surgery with recombinant adeno-associated virus vectors in vivo
    J D White
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Gene Ther 18:546-52. 2011
    ....
  9. ncbi Inspiratory loading does not accelerate dystrophy in mdx mouse diaphragm: implications for regenerative therapy
    Alexander S Krupnick
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Appl Physiol 94:411-9. 2003
    ....
  10. ncbi Global cardiac-specific transgene expression using cardiopulmonary bypass with cardiac isolation
    Charles R Bridges
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, USA
    Ann Thorac Surg 73:1939-46. 2002
    ..To address this problem, we developed a novel cannulation technique that achieves efficient isolation of the heart in situ using separate cardiopulmonary bypass (CPB) circuits for the heart and body in dogs...
  11. ncbi Regional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal model
    Valder R Arruda
    The Children s Hospital of Philadelphia, 3615 Civic Center Blvd, 302 Abramson Research Center, Philadelphia, PA 19104, USA
    Blood 105:3458-64. 2005
    ..These findings also have immediate relevance for gene transfer in patients with muscular dystrophy...
  12. ncbi Uniform scale-independent gene transfer to striated muscle after transvenular extravasation of vector
    Leonard T Su
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 112:1780-8. 2005
    ..We provide the first demonstration of uniform gene transfer to muscle fibers of an entire extremity in the dog, providing a firm foundation for further translational studies of efficacy in canine models for human diseases...
  13. ncbi Efficient myocyte gene delivery with complete cardiac surgical isolation in situ
    Charles R Bridges
    Department of Surgery of the University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 130:1364. 2005
    ....
  14. ncbi Peripheral transvenular delivery of adeno-associated viral vectors to skeletal muscle as a novel therapy for hemophilia B
    Valder R Arruda
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Blood 115:4678-88. 2010
    ..Collectively, these results demonstrate the feasibility of this approach for treatment of HB and highlight the importance of IS to prevent immune responses to the FIX transgene product...
  15. ncbi Safety of AAV factor IX peripheral transvenular gene delivery to muscle in hemophilia B dogs
    Virginia Haurigot
    Division of Hematology and Center for Cellular and Molecular Therapeutics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Mol Ther 18:1318-29. 2010
    ..In summary, this study in a large animal model of HB demonstrates that therapeutic levels of gene transfer can be safely achieved using a novel route of intravascular gene transfer to muscle...

Research Grants9

  1. Surgical Approaches to Systemic Gene Transfer
    Hansell Stedman; Fiscal Year: 2006
    ..It will also provide specific information about the rational design of strategies for systemic gene therapy in one of the most common single-gene lethal diseases in man, Duchenne Muscular Dystrophy. ..
  2. Translational program for molecular therapeutics in DMD
    Hansell Stedman; Fiscal Year: 2007
    ....
  3. Systemic molecular therapy for muscular dystrophy
    Hansell H Stedman; Fiscal Year: 2010
    ..We use a novel approach to direct gene transfer to replace the missing dystrophin protein in locomotive, respiratory and cardiac muscle in the dystrophic dog, and use a prospective, randomized study to evaluate therapeutic efficacy. ..