Andrea K Steck

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Secondary attack rate of type 1 diabetes in Colorado families
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes University of Colorado Health Sciences Center, 4200 East 9th Ave, Box B 140, Denver, CO 80262, USA
    Diabetes Care 28:296-300. 2005
  2. ncbi Association of non-HLA genes with type 1 diabetes autoimmunity
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
    Diabetes 54:2482-6. 2005
  3. pmc Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 58:1028-33. 2009
  4. pmc Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 34:1397-9. 2011
  5. doi rs11203203 is associated with type 1 diabetes risk in population pre-screened for high-risk HLA-DR,DQ genotypes
    Kelly Johnson
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver UCD, Aurora, CO 80045, USA
    Pediatr Diabetes 13:611-5. 2012
  6. pmc Replication and further characterization of a Type 1 diabetes-associated locus at the telomeric end of the major histocompatibility complex
    Erin E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Aurora, CO 80045, USA
    J Diabetes 3:238-47. 2011
  7. ncbi Association of the PTPN22/LYP gene with type 1 diabetes
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO, USA
    Pediatr Diabetes 7:274-8. 2006
  8. pmc Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes
    Jeesuk Yu
    University of Colorado Health Sciences Center, Aurora, Colorado, USA
    J Clin Endocrinol Metab 94:504-10. 2009
  9. pmc Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:753-8. 2012
  10. pmc Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes
    Erin E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Building M20, Aurora, CO 80045 6511, USA
    Clin Immunol 132:203-14. 2009

Collaborators

Detail Information

Publications19

  1. ncbi Secondary attack rate of type 1 diabetes in Colorado families
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes University of Colorado Health Sciences Center, 4200 East 9th Ave, Box B 140, Denver, CO 80262, USA
    Diabetes Care 28:296-300. 2005
    ..No U.S. population-specific life-table risk estimates are currently available for parents, and those for siblings (2-6% by age 20 years) are based on family studies completed before 1987...
  2. ncbi Association of non-HLA genes with type 1 diabetes autoimmunity
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
    Diabetes 54:2482-6. 2005
    ..Genes involved in the IL-4 regulatory pathway (IL-4, IL-4R, IL-13) may confer susceptibility or protection to type 1 diabetes depending on individual SNPs or specific haplotypes...
  3. pmc Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 58:1028-33. 2009
    ..We examined whether some of these alleles influence development of islet autoimmunity or progression from persistent islet autoimmunity to type 1 diabetes in children with high-risk HLA-DR,DQ genotypes...
  4. pmc Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 34:1397-9. 2011
    ..We evaluated predictors of progression to diabetes in children with high-risk HLA genotypes and persistent islet autoantibodies...
  5. doi rs11203203 is associated with type 1 diabetes risk in population pre-screened for high-risk HLA-DR,DQ genotypes
    Kelly Johnson
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver UCD, Aurora, CO 80045, USA
    Pediatr Diabetes 13:611-5. 2012
    ..To evaluate UBASH3A (rs11203203) as a predictor of persistent islet autoimmunity (IA) and type 1 diabetes (T1D)...
  6. pmc Replication and further characterization of a Type 1 diabetes-associated locus at the telomeric end of the major histocompatibility complex
    Erin E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Aurora, CO 80045, USA
    J Diabetes 3:238-47. 2011
    ..As further families have been analyzed in the Type 1 Diabetes Genetics Consortium (T1DGC), we tested replication of the association and, with more data, analyzed haplotypic associations...
  7. ncbi Association of the PTPN22/LYP gene with type 1 diabetes
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO, USA
    Pediatr Diabetes 7:274-8. 2006
    ..The goal of this study was to verify the association between type 1 diabetes (T1D) and the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene in non-Hispanic whites (NHWs) and Hispanics from Colorado...
  8. pmc Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes
    Jeesuk Yu
    University of Colorado Health Sciences Center, Aurora, Colorado, USA
    J Clin Endocrinol Metab 94:504-10. 2009
    ..There is controversy as to whether type 2 diabetes genetic susceptibility contributes to type 1 diabetes, and it is not known what proportion of islet autoantibody-negative new onset subjects have type 2 diabetes risk alleles...
  9. pmc Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:753-8. 2012
    ..Non-HLA susceptibility alleles may help estimate risk for development of type 1 diabetes in the general population. These findings require replication in different populations...
  10. pmc Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes
    Erin E Baschal
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Building M20, Aurora, CO 80045 6511, USA
    Clin Immunol 132:203-14. 2009
    ..Such common identity, specifically across the MHC, impacts type 1 diabetes susceptibility and may impact transplantation between unrelated individuals...
  11. pmc GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes
    Dongmei Miao
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado
    Diabetes 62:4174-8. 2013
    ..In conclusion, the new ECL assay identifies disease-relevant GADA by radioassay. It may help to improve the prediction and correct diagnosis of T1D among subjects positive only for GADA and no other islet autoantibodies. ..
  12. pmc Stepwise or linear decrease in penetrance of type 1 diabetes with lower-risk HLA genotypes over the past 40 years
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 60:1045-9. 2011
    ..The objective of this study was to test if the proportion of new-onset diabetic subjects with the HLA-DR3/4-DQB1*0302 genotype is decreasing over time...
  13. doi Genetic similarities between latent autoimmune diabetes and type 1 and type 2 diabetes
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Mail Stop B140, P O Box 6511, Aurora, CO 80045 6511, USA
    Diabetes 57:1160-2. 2008
  14. doi Genetics of type 1 diabetes
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045 6511, USA
    Clin Chem 57:176-85. 2011
    ..The major susceptibility locus maps to the HLA class II genes at 6p21, although more than 40 non-HLA susceptibility gene markers have been confirmed...
  15. pmc Evidence of Stage- and Age-Related Heterogeneity of Non-HLA SNPs and Risk of Islet Autoimmunity and Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young
    Brittni N Frederiksen
    Colorado School of Public Health, University of Colorado, 13001 E 17th Place, Box B119, Aurora, CO 80045, USA
    Clin Dev Immunol 2013:417657. 2013
    ..This prospective investigation of non-HLA T1D candidate loci shows that some SNPs may exhibit stage- and age-related heterogeneity in the etiology of T1D. ..
  16. pmc Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 36:2266-70. 2013
    ..We evaluated a novel electrochemiluminescent assay for insulin/proinsulin autoantibodies (ECL-IAA) as a new marker of the onset of islet autoimmunity and as a predictor of type 1 diabetes...
  17. doi The past, present, and future of genetic associations in type 1 diabetes
    Peter R Baker
    The Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045 6511, USA
    Curr Diab Rep 11:445-53. 2011
    ..In this review we highlight the advances in genetic associations in T1DM in the last several decades and how they have led to a better understanding of T1DM pathogenesis...
  18. ncbi Recent advances in insulin treatment of children
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Denver, CO, USA
    Pediatr Diabetes 8:49-56. 2007
    ..In addition, continuous glucose monitoring may teach us better ways to use insulin in children who do not have the technology available to them...
  19. doi Review on monogenic diabetes
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
    Curr Opin Endocrinol Diabetes Obes 18:252-8. 2011
    ..The goal of this review is to provide an update on the different forms of monogenic diabetes, including maturity-onset diabetes of the young (MODY) and neonatal diabetes (permanent and transient neonatal diabetes)...