Roland Staud

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Peripheral and central sensitization in fibromyalgia: pathogenetic role
    Roland Staud
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Curr Pain Headache Rep 6:259-66. 2002
  2. ncbi request reprint Evidence of involvement of central neural mechanisms in generating fibromyalgia pain
    Roland Staud
    University of Florida, Division of Rheumatology and Clinical Immunology, PO Box 100221, Gainesville, FL 32610 0221, USA
    Curr Rheumatol Rep 4:299-305. 2002
  3. doi request reprint Cognitive-affective and somatic side effects of morphine and pentazocine: side-effect profiles in healthy adults
    Joseph L Riley
    Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL 32610 3628, USA
    Pain Med 11:195-206. 2010
  4. ncbi request reprint Cluster analysis of multiple experimental pain modalities
    Barbara A Hastie
    University of Florida College of Dentistry, Division of Public Health Services and Research, 1600 SW Archer Road, HSC D8 37, P O Box 100404, Gainesville, FL 32610 0404, USA
    Pain 116:227-37. 2005
  5. pmc Brain activity associated with slow temporal summation of C-fiber evoked pain in fibromyalgia patients and healthy controls
    Roland Staud
    Department of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, United States
    Eur J Pain 12:1078-89. 2008
  6. pmc Mechanical and heat hyperalgesia highly predict clinical pain intensity in patients with chronic musculoskeletal pain syndromes
    Roland Staud
    Department of Medicine, University of Florida, Gainesville, Florida 32610 0221, USA
    J Pain 13:725-35. 2012
  7. pmc Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study
    Roland Staud
    Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Pain 145:96-104. 2009
  8. ncbi request reprint Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls
    Roland Staud
    Department of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0221, USA
    Pain 118:176-84. 2005
  9. pmc Affect balance style, experimental pain sensitivity, and pain-related responses
    Kimberly T Sibille
    Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Clin J Pain 28:410-7. 2012
  10. pmc Individual differences in morphine and butorphanol analgesia: a laboratory pain study
    Kimberly T Sibille
    Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL 32610 3629, USA
    Pain Med 12:1076-85. 2011

Detail Information

Publications70

  1. ncbi request reprint Peripheral and central sensitization in fibromyalgia: pathogenetic role
    Roland Staud
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Curr Pain Headache Rep 6:259-66. 2002
    ..Therefore, recent investigations have focused on central nervous system mechanisms of pain in fibromyalgia...
  2. ncbi request reprint Evidence of involvement of central neural mechanisms in generating fibromyalgia pain
    Roland Staud
    University of Florida, Division of Rheumatology and Clinical Immunology, PO Box 100221, Gainesville, FL 32610 0221, USA
    Curr Rheumatol Rep 4:299-305. 2002
    ..Neuroglial activation has been found to play an important role in the induction and maintenance of chronic pain. These findings may have important implications for future research and the treatment of fibromyalgia pain...
  3. doi request reprint Cognitive-affective and somatic side effects of morphine and pentazocine: side-effect profiles in healthy adults
    Joseph L Riley
    Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL 32610 3628, USA
    Pain Med 11:195-206. 2010
    ....
  4. ncbi request reprint Cluster analysis of multiple experimental pain modalities
    Barbara A Hastie
    University of Florida College of Dentistry, Division of Public Health Services and Research, 1600 SW Archer Road, HSC D8 37, P O Box 100404, Gainesville, FL 32610 0404, USA
    Pain 116:227-37. 2005
    ..These findings highlight the need for future investigation to identify patterns of responses across different pain modalities in order to more accurately characterize individual differences in responses to experimental pain...
  5. pmc Brain activity associated with slow temporal summation of C-fiber evoked pain in fibromyalgia patients and healthy controls
    Roland Staud
    Department of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, United States
    Eur J Pain 12:1078-89. 2008
    ..These results suggest that enhanced neural mechanisms of TSSP in FM are reflected at all pain related brain areas, including posterior thalamus, and are not the result of selective enhancement at cortical levels...
  6. pmc Mechanical and heat hyperalgesia highly predict clinical pain intensity in patients with chronic musculoskeletal pain syndromes
    Roland Staud
    Department of Medicine, University of Florida, Gainesville, Florida 32610 0221, USA
    J Pain 13:725-35. 2012
    ....
  7. pmc Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study
    Roland Staud
    Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Pain 145:96-104. 2009
    ....
  8. ncbi request reprint Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls
    Roland Staud
    Department of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0221, USA
    Pain 118:176-84. 2005
    ..However, whether these exercise effects of FM patients result from abnormal descending inhibition or excessive activation of muscle nociceptive afferents needs to be addressed in future studies...
  9. pmc Affect balance style, experimental pain sensitivity, and pain-related responses
    Kimberly T Sibille
    Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Clin J Pain 28:410-7. 2012
    ..Psychological factors and experimental pain sensitivity are indicated as predictors of chronic pain onset. The current study investigated the relationship between ABS, pain sensitivity, and pain-related measures in healthy adults...
  10. pmc Individual differences in morphine and butorphanol analgesia: a laboratory pain study
    Kimberly T Sibille
    Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL 32610 3629, USA
    Pain Med 12:1076-85. 2011
    ..This laboratory study was designed to examine the contributions of sex and race to inter-individual variability in response to opioids...
  11. pmc Is the pain-reducing effect of opioid medication reliable? A psychophysical study of morphine and pentazocine analgesia
    Christopher D King
    Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA
    Pain 154:476-83. 2013
    ..These results suggest that analgesic measures are able to distinguish between active drugs. In addition, analgesic responses to morphine and pentazocine demonstrate at least moderate reliability...
  12. pmc Do past pain events systematically impact pain ratings of healthy subjects or fibromyalgia patients?
    Roland Staud
    Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    J Pain 11:142-8. 2010
    ..These results do not provide support for the strong assertion that pain rating scales are elastic, ie, being used differently depending on the severity of past pain events such as childbirth...
  13. pmc Drug response profiles to experimental pain are opioid and pain modality specific
    Lindsay L Kindler
    Comprehensive Center for Pain Research, University of Florida College of Dentistry, Gainesville, Florida, USA
    J Pain 12:340-51. 2011
    ....
  14. pmc Spatial summation of mechanically evoked muscle pain and painful aftersensations in normal subjects and fibromyalgia patients
    Roland Staud
    Department of Medicine, University of Florida, College of Medicine, Gainesville, FL 32610 0221, USA
    Pain 130:177-87. 2007
    ..The important role of MSSP for pain encoding suggests that decreasing pain in some muscle areas by local anesthetics or other means may improve overall clinical pain of FM patients...
  15. ncbi request reprint Morphine responses and experimental pain: sex differences in side effects and cardiovascular responses but not analgesia
    Roger B Fillingim
    Public Health Services and Research, University of Florida College of Dentistry, 1600 SW Archer Road, Gainesville, FL 32610 0404, USA
    J Pain 6:116-24. 2005
    ..These results suggest that sex differences in responses to morphine might depend on the pain model and/or drug dose as well as the specific end point assessed...
  16. ncbi request reprint Sex-related psychological predictors of baseline pain perception and analgesic responses to pentazocine
    Roger B Fillingim
    University of Florida College of Dentistry, Public Health Services and Research, 1600 SW Archer Road, Room D8 44A, P O Box 100404, Gainesville, FL 32610 0404, USA
    Biol Psychol 69:97-112. 2005
    ..These findings indicate sex-dependent associations of psychological factors with baseline pain perception, analgesic responses, and medication side effects...
  17. ncbi request reprint The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans
    Roger B Fillingim
    University of Florida College of Dentistry, Gainesville, FL 32610, USA
    J Pain 6:159-67. 2005
    ..The results indicate that the rare allele is associated with higher pressure pain thresholds. These results support previous contentions that OPRM1 may be a pain-relevant gene; however, replication of these findings is needed...
  18. pmc Temporal summation of second pain and its maintenance are useful for characterizing widespread central sensitization of fibromyalgia patients
    Roland Staud
    Department of Medicine, University of Florida, Gainesville, Florida 32610 0221, USA
    J Pain 8:893-901. 2007
    ..These findings demonstrate that central sensitization of FM patients is widespread and similar along the spinal neuroaxis...
  19. doi request reprint Is it all central sensitization? Role of peripheral tissue nociception in chronic musculoskeletal pain
    Roland Staud
    Department of Medicine, University of Florida College of Medicine, P O Box 100176, Gainesville, FL 32610 0221, USA
    Curr Rheumatol Rep 12:448-54. 2010
    ..This conclusion is supported by results of several studies showing that injection of local anesthetics into painful muscles normalizes somatic hyperalgesia in FM patients...
  20. ncbi request reprint Ratings of experimental pain and pain-related negative affect predict clinical pain in patients with fibromyalgia syndrome
    Roland Staud
    Department of Medicine, McKnight Brain Institute, University of Florida College of Medicine, SW Archer Road, PO Box 100221, Gainesville, FL 32610 0221, USA
    Pain 105:215-22. 2003
    ..Therefore, the combination of PRNA, TP count, and WU decay may provide an excellent measure for future clinical studies of FMS patients...
  21. pmc Brain activity related to temporal summation of C-fiber evoked pain
    Roland Staud
    Department of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Pain 129:130-42. 2007
    ....
  22. ncbi request reprint Body pain area and pain-related negative affect predict clinical pain intensity in patients with fibromyalgia
    Roland Staud
    Department of Medicine, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA
    J Pain 5:338-43. 2004
    ..The combination of painful body areas, TP counts, and PRNA predicts 45% of the clinical pain intensity of FM patients. This finding might be useful for clinical evaluations of FM patients...
  23. ncbi request reprint Effects of the N-methyl-D-aspartate receptor antagonist dextromethorphan on temporal summation of pain are similar in fibromyalgia patients and normal control subjects
    Roland Staud
    Department of Medicine, McKnight Brain Institute, University of Florida, Gainesville, Florida 326100 0221, USA
    J Pain 6:323-32. 2005
    ..Thus, central pain processing of FM subjects is not different from NC in at least one important aspect, namely their NMDA receptor system responsiveness to pharmacologic inhibition by DEX...
  24. ncbi request reprint Psychophysical and neurochemical abnormalities of pain processing in fibromyalgia
    Roland Staud
    Division of Rheumatology and Clinical Immunology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0221, USA
    CNS Spectr 13:12-7. 2008
    ..Better understanding of these mechanisms and their relationship to central sensitization and clinical pain will provide new approaches for the prevention and treatment of fibromyalgia and other chronic pain syndromes...
  25. ncbi request reprint Maintenance of windup of second pain requires less frequent stimulation in fibromyalgia patients compared to normal controls
    Roland Staud
    Department of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Pain 110:689-96. 2004
    ..In addition to WU, WU-M appears to be a useful tool to study mechanisms of pain in patients with characteristics of central sensitization...
  26. ncbi request reprint Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome
    Roland Staud
    Department of Medicine, McKnight Brain Institute, University of Florida College of Medicine, 1600 SW Archer Rd, PO Box 100221, Gainesville, FL 32610 0221, USA
    Pain 102:87-95. 2003
    ..Abnormal input from muscle nociceptors appears to underlie production of central sensitization in FMS that generalizes to input from cutaneous nociceptors...
  27. ncbi request reprint Spatial summation of heat pain within and across dermatomes in fibromyalgia patients and pain-free subjects
    Roland Staud
    Department of Medicine, McKnight Brain Institute, University of Florida, College of Medicine, 1600 SW Archer Road, P O Box 100221, Gainesville, FL 32610 0221, USA
    Pain 111:342-50. 2004
    ..These results were similar for both FM and NC subjects. Thus, mechanisms of SSP, including possible inhibitory factors that limit this relevant pain mechanism, appear to be similar for both FM and NC subjects...
  28. pmc Effective connectivity among brain regions associated with slow temporal summation of C-fiber-evoked pain in fibromyalgia patients and healthy controls
    Jason G Craggs
    Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610, USA
    J Pain 13:390-400. 2012
    ..These results provide evidence for significant overlap of the fundamental brain mechanisms that process sensory and affective information related to TSSP in NC and FM groups...
  29. ncbi request reprint Mechanisms of disease: pain in fibromyalgia syndrome
    Roland Staud
    Evelyn F and William L McKnight Brain Institute and the Division of Rheumatology and Clinical Immunology, Gainesville, 32610, USA
    Nat Clin Pract Rheumatol 2:90-8. 2006
    ..An improved understanding of the mechanisms that characterize central sensitization and clinical pain will provide new approaches for the prevention and treatment of fibromyalgia and other chronic pain syndromes...
  30. ncbi request reprint Future perspectives: pathogenesis of chronic muscle pain
    Roland Staud
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0221, USA
    Best Pract Res Clin Rheumatol 21:581-96. 2007
    ....
  31. pmc Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain
    Roland Staud
    Department of Medicine, University of Florida, Gainesville, FL 32610, United States
    Eur J Pain 15:223-30. 2011
    ..The ability to sense at least some danger signals may be advantageous and ameliorate the otherwise increased morbidity and mortality of some individuals with congenital insensitivity to pain...
  32. doi request reprint Pharmacological treatment of fibromyalgia syndrome: new developments
    Roland Staud
    Department of Medicine, University of Florida, College of Medicine, Gainesville, Florida 32610 0221, USA
    Drugs 70:1-14. 2010
    ..However, new pharmacological approaches for the treatment of fibromyalgia pain and insomnia using sodium oxybate appear to be promising...
  33. ncbi request reprint Advanced continuous-contact heat pulse design for efficient temporal summation of second pain (windup)
    Roland Staud
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Pain 7:575-82. 2006
    ..The results of this study will allow more efficient use of currently available constant-contact thermodes for clinical and research applications...
  34. ncbi request reprint Experimental pain models reveal no sex differences in pentazocine analgesia in humans
    Roger B Fillingim
    University of Florida College of Dentistry, Public Health Services and Research, 1600 Southwest Archer Road, Room D8 44A, P O Box 100404, Gainesville, Florida 32610 0404, USA
    Anesthesiology 100:1263-70. 2004
    ..g., pentazocine, nalbuphine, butorphanol) among women than among men. However, evidence of sex differences in kappa-agonist-antagonist effects from studies of experimentally induced pain in humans is lacking...
  35. pmc Pain variability in fibromyalgia is related to activity and rest: role of peripheral tissue impulse input
    Roland Staud
    Department of Medicine, University of Florida, Gainesville, Florida, USA
    J Pain 11:1376-83. 2010
    ..Our findings contribute further evidence that FM pain and hyperalgesia are at least partially maintained by muscle impulse input, and that some types of exercises may be beneficial for FM...
  36. pmc Predictors of clinical pain in fibromyalgia: examining the role of sleep
    Ryan J Anderson
    Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610 0165, USA
    J Pain 13:350-8. 2012
    ..Results replicate previous research and suggest that spatial extent of pain, pain aftersensation, and negative mood play important roles in clinical pain, but sleep disturbance did not aid in its prediction...
  37. pmc Peripheral pain mechanisms in chronic widespread pain
    Roland Staud
    Division of Rheumatology and Clinical Immunology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Best Pract Res Clin Rheumatol 25:155-64. 2011
    ..Thus, a promising approach to understanding CWP is to determine whether abnormal activity of receptors in deep tissues is fundamental to the development and maintenance of this chronic pain disorder...
  38. ncbi request reprint Diffuse noxious inhibitory controls (DNIC) attenuate temporal summation of second pain in normal males but not in normal females or fibromyalgia patients
    Roland Staud
    Department of Medicine, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Pain 101:167-74. 2003
    ..Our results indicate that DNIC effects on experimental WU of second pain are gender specific, with women generally lacking this pain-inhibitory mechanism...
  39. pmc Cutaneous C-fiber pain abnormalities of fibromyalgia patients are specifically related to temporal summation
    Roland Staud
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0221, USA
    Pain 139:315-23. 2008
    ..These findings provide strong support for alterations of central pain sensitivity and not peripheral sensitization or rating bias as responsible for TSSP differences between NC and FM subjects...
  40. pmc A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity
    Chenguang Wang
    Department of Statistics, University of Florida, Gainesville, FL 32611 USA
    Mol Pain 4:13. 2008
    ..The model could have important implications for mapping complex trait genes and studying the detailed genetic architecture of sex-specific differences...
  41. ncbi request reprint Are tender point injections beneficial: the role of tonic nociception in fibromyalgia
    Roland Staud
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Curr Pharm Des 12:23-7. 2006
    ..Thus interventions aimed at reducing local FM pain seem to be effective but need to focus less on tender points but more on trigger points (TrP) and other body areas of heightened pain and inflammation...
  42. pmc Gray matter volumes of pain-related brain areas are decreased in fibromyalgia syndrome
    Michael E Robinson
    Department of Clinical and Health Psychology, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610 0221, USA
    J Pain 12:436-43. 2011
    ..Although the mechanisms for these gray matter changes are presently unclear, they may contribute to some of the core features of this chronic disorder including affective disturbances and chronic widespread pain...
  43. ncbi request reprint Predictors of clinical pain intensity in patients with fibromyalgia syndrome
    Roland Staud
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610, USA
    Curr Rheumatol Rep 6:281-6. 2004
    ..Therefore, wind-up after-sensations, tender point count, and negative affect not only seem to represent relevant pain mechanisms but also strongly emphasize their importance for fibromyalgia syndrome pain...
  44. pmc Attenuation of experimental pain by vibro-tactile stimulation in patients with chronic local or widespread musculoskeletal pain
    Roland Staud
    Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Eur J Pain 15:836-42. 2011
    ..Conclusions: Vibro-tactile stimulation effectively recruited analgesic mechanisms not only in NC but also in patients with chronic musculoskeletal pain, including FM. Distraction did not seem to contribute to this analgesic effect...
  45. pmc Modeling genetic imprinting effects of DNA sequences with multilocus polymorphism data
    Sheron Wen
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Algorithms Mol Biol 4:11. 2009
    ....
  46. ncbi request reprint Neurobiology of fibromyalgia syndrome
    Donald D Price
    Department of Neuroscience, University of Florida, Gainesville, Florida, USA
    J Rheumatol Suppl 75:22-8. 2005
    ..Future research needs to address the important role of abnormal nociception and/or antinociception for chronic pain in FM...
  47. ncbi request reprint Chronic widespread pain and fibromyalgia: two sides of the same coin?
    Roland Staud
    Department of Medicine, University of Florida, PO Box 100176, Gainesville, FL 32610, USA
    Curr Rheumatol Rep 11:433-6. 2009
    ..Available evidence shows that FM is associated with more severe symptoms and consequences for daily life and higher pain-severity compared with CWP...
  48. doi request reprint Characteristics of electronic visual analogue and numerical scales for ratings of experimental pain in healthy subjects and fibromyalgia patients
    Donald D Price
    Department of Neuroscience, University of Florida, College of Medicine, Gainesville, FL 32610 0221, USA
    Pain 140:158-66. 2008
    ..Finally, all three groups (total of 55 subjects) found the scales easy to use after brief instructions, though subjects strongly preferred the use of VAS-N or VAS in comparison to NUM scale...
  49. pmc Peripheral and central mechanisms of fatigue in inflammatory and noninflammatory rheumatic diseases
    Roland Staud
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Curr Rheumatol Rep 14:539-48. 2012
    ..There are several effective treatment strategies available for fatigued patients with rheumatologic disorders, including pharmacological and nonpharmacological therapies...
  50. pmc Chronic pain, perceived stress, and cellular aging: an exploratory study
    Kimberly T Sibille
    College of Dentistry, University of Florida, Gainesville, FL 32610 3628, USA
    Mol Pain 8:12. 2012
    ..However, the utility of TL as a biological marker reflecting the burden of chronic pain and psychosocial stress has not yet been explored...
  51. pmc Abnormal pain modulation in patients with spatially distributed chronic pain: fibromyalgia
    Roland Staud
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0221, USA
    Rheum Dis Clin North Am 35:263-74. 2009
    ..Long-term prospective studies that could yield insight into the role of heightened pain sensitivity and pain disinhibition for the development of chronic pain disorders like fibromyalgia in the general population are lacking, however...
  52. ncbi request reprint Predictors of clinical pain intensity in patients with fibromyalgia syndrome
    Roland Staud
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610, USA
    Curr Pain Headache Rep 9:316-21. 2005
    ..Therefore, wind-up after-sensations, tender point count, and negative affect not only seem to represent relevant pain mechanisms but also strongly emphasize their importance for fibromyalgia syndrome pain...
  53. doi request reprint Effectiveness of CAM therapy: understanding the evidence
    Roland Staud
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0221, USA
    Rheum Dis Clin North Am 37:9-17. 2011
    ..This review focuses on how to assess the effectiveness of CAM therapies for chronic musculoskeletal pains, emphasizing the role of specific and nonspecific analgesic mechanisms, including placebo...
  54. ncbi request reprint Fibromyalgia pain: do we know the source?
    Roland Staud
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville 32610 0221, USA
    Curr Opin Rheumatol 16:157-63. 2004
    ..FMS pain clearly depends on peripheral nociceptive input as well as abnormal central pain processing. This review will focus on the role of peripheral nociceptive input for pain in FMS...
  55. pmc Patient-centered outcome criteria for successful treatment of facial pain and fibromyalgia
    Lauren A Stutts
    Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA
    J Orofac Pain 23:47-53. 2009
    ....
  56. ncbi request reprint Vitamin D: more than just affecting calcium and bone
    Roland Staud
    University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Curr Rheumatol Rep 7:356-64. 2005
    ..In addition, vitamin D appears to have other important functions as a regulator of cell differentiation and cell growth...
  57. pmc Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions
    Roland Staud
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Expert Rev Neurother 12:577-85. 2012
    ..Such research would not only provide important information about mechanisms relevant to chronic pain but would also permit identification of individuals at high risk for future chronic pain...
  58. ncbi request reprint Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients
    Donald D Price
    Department of Oral and Maxillofacial Surgery, University of Florida College of Dentistry, Box 100416, Gainesville, FL 32610 0416, USA
    Pain 99:49-59. 2002
    ....
  59. ncbi request reprint Treatment of fibromyalgia and its symptoms
    Roland Staud
    University of Florida College of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, McKnight Brain Institute, Gainesville, FL 32610 0221, USA
    Expert Opin Pharmacother 8:1629-42. 2007
    ..Based on this evidence, a stepwise program emphasizing education, medications, exercise and cognitive therapy can be recommended...
  60. ncbi request reprint Mechanisms of acupuncture analgesia: effective therapy for musculoskeletal pain?
    Roland Staud
    University of Florida, PO Box 100221, D2 39, Gainesville, FL 32610 0221, USA
    Curr Rheumatol Rep 9:473-81. 2007
    ..Furthermore, it appears that some forms of AP are more effective for providing analgesia than others. Particularly, electro-AP seems best to activate powerful opioid and non-opioid analgesic mechanisms...
  61. pmc Pain measurement and brain activity: will neuroimages replace pain ratings?
    Michael E Robinson
    Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida Electronic address
    J Pain 14:323-7. 2013
    ..Brain imaging may help to explain pain, but replacing self-report with brain-imaging data would be philosophically and scientifically misguided and potentially harmful to pain patients...
  62. doi request reprint Evidence for shared pain mechanisms in osteoarthritis, low back pain, and fibromyalgia
    Roland Staud
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610 0221, USA
    Curr Rheumatol Rep 13:513-20. 2011
    ..Ineffective endogenous pain control and central sensitization are important features of OA, LBP, and FM patients...
  63. pmc Biology and therapy of fibromyalgia: pain in fibromyalgia syndrome
    Roland Staud
    Division of Rheumatology and Clinical Immunology, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    Arthritis Res Ther 8:208. 2006
    ..Better understanding of these mechanisms and their relationship to central sensitization and clinical pain will provide new approaches for the prevention and treatment of FM and other chronic pain syndromes...
  64. doi request reprint Sodium oxybate for the treatment of fibromyalgia
    Roland Staud
    University of Florida Medicine, 1600 SW Archer Rd, Gainesville, FL 32610 0221, USA
    Expert Opin Pharmacother 12:1789-98. 2011
    ..It is rapidly absorbed and has a plasma half-life of 30 - 60 min, necessitating twice-nightly dosing. Most of the observed effects of SXB result from binding to GABA-B receptors...
  65. ncbi request reprint Autonomic dysfunction in fibromyalgia syndrome: postural orthostatic tachycardia
    Roland Staud
    Department of Medicine, University of Florida College of Medicine, PO Box 100221, D2 39, Gainesville, FL 32610, USA
    Curr Rheumatol Rep 10:463-6. 2008
    ....
  66. ncbi request reprint Somatization does not fit all fibromyalgia patients: comment on the article by Winfield
    Roland Staud
    University of Florida, Gainesville, FL, USA
    Arthritis Rheum 46:564-5. 2002
  67. ncbi request reprint Mechanisms of acupuncture analgesia for clinical and experimental pain
    Roland Staud
    University of Florida, Department of Medicine College of Medicine, Gainesville, FL 32610 0221, USA
    Expert Rev Neurother 6:661-7. 2006
    ....
  68. ncbi request reprint Are patients with systemic lupus erythematosus at increased risk for fibromyalgia?
    Roland Staud
    Department of Medicine, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    Curr Rheumatol Rep 8:430-5. 2006
    ..Conversely, treatment of SLE-FM patients with inhibitors of NMDA or neurokinin receptors may prevent or alleviate cognitive abnormalities and chronic pain, as well as FM...
  69. pmc The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans
    Jeffrey S Mogil
    Department of Psychology, McGill University, Montreal, QC, Canada H3A 1B1
    Proc Natl Acad Sci U S A 100:4867-72. 2003
    ....
  70. pmc Long-term trials of pregabalin and duloxetine for fibromyalgia symptoms: how study designs can affect placebo factors
    Roland Staud
    Pain 136:232-4. 2008