J States

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Subhepatotoxic exposure to arsenic enhances lipopolysaccharide-induced liver injury in mice
    Gavin E Arteel
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Toxicol Appl Pharmacol 226:128-39. 2008
  2. ncbi request reprint Systems approach to identify environmental exposures contributing to organ-specific carcinogenesis
    J Christopher States
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA Electronic address
    Cancer Epidemiol 38:321-7. 2014
  3. pmc Exit from arsenite-induced mitotic arrest is p53 dependent
    Samuel C McNeely
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA
    Environ Health Perspect 114:1401-6. 2006
  4. pmc Prenatal arsenic exposure alters gene expression in the adult liver to a proinflammatory state contributing to accelerated atherosclerosis
    J Christopher States
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 7:e38713. 2012
  5. pmc Arsenic and cardiovascular disease
    J Christopher States
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky 40292, USA
    Toxicol Sci 107:312-23. 2009
  6. pmc Arsenic toxicology: translating between experimental models and human pathology
    J Christopher States
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA
    Environ Health Perspect 119:1356-63. 2011
  7. pmc Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)
    Clarisse S Muenyi
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA
    J Ovarian Res 4:9. 2011
  8. doi request reprint Arsenic exacerbates atherosclerotic lesion formation and inflammation in ApoE-/- mice
    Sanjay Srivastava
    Diabetes and Obesity Center and Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 241:90-100. 2009
  9. pmc In utero arsenic exposure induces early onset of atherosclerosis in ApoE-/- mice
    Sanjay Srivastava
    Department of Medicine, University of Louisville, Louisville, KY 40202, United States
    Reprod Toxicol 23:449-56. 2007
  10. pmc PAI-1 plays a protective role in CCl4-induced hepatic fibrosis in mice: role of hepatocyte division
    Claudia von Montfort
    Dept of Pharmacology and Toxicology, Univ of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 298:G657-66. 2010

Research Grants

  1. Arsenic Induced Miotic Arrest Associated Apoptosis
    J States; Fiscal Year: 2003
  2. Arsenic Induced Miotic Arrest Associated Apoptosis
    J Christopher States; Fiscal Year: 2004
  3. Arsenic Induced Miotic Arrest Associated Apoptosis
    J States; Fiscal Year: 2005
  4. Arsenic Induced Miotic Arrest Associated Apoptosis
    J States; Fiscal Year: 2006
  5. Effects of chemopreventive agents on DNA damage response
    J Christopher States; Fiscal Year: 2006
  6. Arsenic Induced Miotic Arrest Associated Apoptosis
    J Christopher States; Fiscal Year: 2007
  7. Arsenic Induced Miotic Arrest Associated Apoptosis
    J Christopher States; Fiscal Year: 2007
  8. Arsenic Induced Miotic Arrest Associated Apoptosis
    J Christopher States; Fiscal Year: 2009

Collaborators

Detail Information

Publications18

  1. pmc Subhepatotoxic exposure to arsenic enhances lipopolysaccharide-induced liver injury in mice
    Gavin E Arteel
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Toxicol Appl Pharmacol 226:128-39. 2008
    ..These results further suggest that arsenic levels in the drinking water may be a risk modifier for the development of chronic liver diseases...
  2. ncbi request reprint Systems approach to identify environmental exposures contributing to organ-specific carcinogenesis
    J Christopher States
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA Electronic address
    Cancer Epidemiol 38:321-7. 2014
    ..Thus, we propose a systems approach to analyze publicly available large datasets to identify candidate agents that play a role in organ-specific carcinogenesis...
  3. pmc Exit from arsenite-induced mitotic arrest is p53 dependent
    Samuel C McNeely
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA
    Environ Health Perspect 114:1401-6. 2006
    ....
  4. pmc Prenatal arsenic exposure alters gene expression in the adult liver to a proinflammatory state contributing to accelerated atherosclerosis
    J Christopher States
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 7:e38713. 2012
    ..Genes containing SREBP1 binding sites also suggest pathways for diabetes mellitus and rheumatoid arthritis, both diseases that contribute to increased cardiovascular disease in humans...
  5. pmc Arsenic and cardiovascular disease
    J Christopher States
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky 40292, USA
    Toxicol Sci 107:312-23. 2009
    ..The recent findings provide future directions for research into the cardiovascular effects of arsenic exposure...
  6. pmc Arsenic toxicology: translating between experimental models and human pathology
    J Christopher States
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA
    Environ Health Perspect 119:1356-63. 2011
    ..We propose phenotypic anchoring as a means to unify experimental observations and disease outcomes...
  7. pmc Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)
    Clarisse S Muenyi
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA
    J Ovarian Res 4:9. 2011
    ..abstract:..
  8. doi request reprint Arsenic exacerbates atherosclerotic lesion formation and inflammation in ApoE-/- mice
    Sanjay Srivastava
    Diabetes and Obesity Center and Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 241:90-100. 2009
    ..Plasma concentrations of MCP-1, IL-6 and MDA were also significantly elevated in arsenic-exposed mice. These data suggest that arsenic exposure increases oxidative stress, inflammation and atherosclerotic lesion formation...
  9. pmc In utero arsenic exposure induces early onset of atherosclerosis in ApoE-/- mice
    Sanjay Srivastava
    Department of Medicine, University of Louisville, Louisville, KY 40202, United States
    Reprod Toxicol 23:449-56. 2007
    ..These results indicate that in utero arsenic exposure induces an early onset of atherosclerosis in ApoE(-/-) mice without a hyperlipidemic diet and support the hypothesis that in utero arsenic exposure may be atherogenic in humans...
  10. pmc PAI-1 plays a protective role in CCl4-induced hepatic fibrosis in mice: role of hepatocyte division
    Claudia von Montfort
    Dept of Pharmacology and Toxicology, Univ of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 298:G657-66. 2010
    ....
  11. pmc Mitotic arrest-associated apoptosis induced by sodium arsenite in A375 melanoma cells is BUBR1-dependent
    Samuel C McNeely
    Department of Pharmacology and Toxicology, Center for Environmental Genomics and Integrative Biology, Center for Genetics and Molecular Medicine and Brown Cancer Center, University of Louisville, 570 S Preston St Suite 221, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 231:61-7. 2008
    ..These findings provide insight into the mechanism of arsenic's chemotherapeutic action and indicate a functional spindle checkpoint may be required for arsenic-sensitivity...
  12. pmc Sensitivity to sodium arsenite in human melanoma cells depends upon susceptibility to arsenite-induced mitotic arrest
    Samuel C McNeely
    Department of Pharmacology and Toxicology, University of Louisville, 570 S Preston Street, Suite 221, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 229:252-61. 2008
    ..These data suggest that arsenite has potential for treatment of solid tumors but a functional spindle checkpoint is a prerequisite for a positive response to its clinical application...
  13. pmc Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat
    David F Barker
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Drug Metab Dispos 36:2445-51. 2008
    ....
  14. pmc Arsenite-induced mitotic death involves stress response and is independent of tubulin polymerization
    B Frazier Taylor
    Department of Pharmacology and Toxicology, Center for Environmental Genomics and Integrative Biology, Center for Genetics and Molecular Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 230:235-46. 2008
    ..Thus, arsenite-induced abnormal centrosome amplification and subsequent mitotic arrest is independent of effects on tubulin polymerization and may be due to specific stresses that are protected against by HSP90 and HSP70...
  15. pmc Identification of N-acetyltransferase 2 (NAT2) transcription start sites and quantitation of NAT2-specific mRNA in human tissues
    Anwar Husain
    Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Drug Metab Dispos 35:721-7. 2007
    ..NAT2 expression in diverse human tissues provides further mechanistic support underlying associations between NAT2 genetic polymorphism, drug toxicity, and/or chemical carcinogenesis...
  16. pmc p53 suppression of arsenite-induced mitotic catastrophe is mediated by p21CIP1/WAF1
    B Frazier Taylor
    Department of Pharmacology and Toxicology, University of Louisville, 570 South Preston Street, Suite 221, Louisville, KY 40202, USA
    J Pharmacol Exp Ther 318:142-51. 2006
    ..The data indicate that p53 mediates cyclin B/CDC2 inactivation and mitotic release directly via p21CIP1/WAF1 induction...
  17. ncbi request reprint Arsenite disrupts mitosis and induces apoptosis in SV40-transformed human skin fibroblasts
    J Christopher States
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 180:83-91. 2002
    ..These results indicate that SV40-transformation sensitizes cells to arsenite-induced mitotic arrest and induction of apoptosis in the mitotic cells...
  18. ncbi request reprint Arsenite delays progression through each cell cycle phase and induces apoptosis following G2/M arrest in U937 myeloid leukemia cells
    Geniece McCollum
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    J Pharmacol Exp Ther 313:877-87. 2005
    ..Arsenic's ability to inhibit growth in any cell cycle phase may increase its value as a chemotherapeutic used together with other, more phase-selective agents, such as camptothecin...

Research Grants9

  1. Arsenic Induced Miotic Arrest Associated Apoptosis
    J States; Fiscal Year: 2003
    ....
  2. Arsenic Induced Miotic Arrest Associated Apoptosis
    J Christopher States; Fiscal Year: 2004
    ....
  3. Arsenic Induced Miotic Arrest Associated Apoptosis
    J States; Fiscal Year: 2005
    ....
  4. Arsenic Induced Miotic Arrest Associated Apoptosis
    J States; Fiscal Year: 2006
    ....
  5. Effects of chemopreventive agents on DNA damage response
    J Christopher States; Fiscal Year: 2006
    ..The results will likely illuminate a chemoprevention mechanism and also provide a deeper understanding of the mechanism of DNA damage and repair under a more physiologically relevant environmental exposure dose. ..
  6. Arsenic Induced Miotic Arrest Associated Apoptosis
    J Christopher States; Fiscal Year: 2007
    ....
  7. Arsenic Induced Miotic Arrest Associated Apoptosis
    J Christopher States; Fiscal Year: 2007
    ....
  8. Arsenic Induced Miotic Arrest Associated Apoptosis
    J Christopher States; Fiscal Year: 2009
    ....