Research Topics
| P A StarrSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Treatment of dystonia with deep brain stimulationJill L Ostrem
Department of Neurology, University of California, San Francisco, California 94143, USA
Neurotherapeutics 5:320-30. 2008....- The subthalamic nucleus in primary dystonia: single-unit discharge characteristicsLauren E Schrock
Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
J Neurophysiol 102:3740-52. 2009.... 
Oscillations in sensorimotor cortex in movement disorders: an electrocorticography studyAndrea L Crowell
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
Brain 135:615-30. 2012..This is the first study of sensorimotor cortex local field potentials in the three most common movement disorders...- Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracyPhilip A Starr
Department of Neurosurgery, University of California, San Francisco, California 94143, USA
J Neurosurg 112:479-90. 2010.... - Pallidal neuronal discharge in Huntington's disease: support for selective loss of striatal cells originating the indirect pathwayPhilip A Starr
Department of Neurosurgery, University of California, San Francisco, San Francisco CA 94143, USA
Exp Neurol 211:227-33. 2008..HD GPi units showed more bursting than PD GPi units but much less oscillatory activity in the 2-35 Hz frequency range at rest. These findings are consistent with selective early loss of striatal cells originating the indirect pathway... - Stereotactic techniques and perioperative management of DBS in dystoniaPhilip A Starr
Department of Neurosurgery, UCSF, San Francisco, California, USA
Mov Disord 26:S23-30. 2011..Nevertheless, the guidelines provided may assist surgical teams in tailoring a rational approach to DBS implantation in dystonia... 
DBS and dopamine. Comment on "Does dopamine still have a leading role in advanced Parkinson's disease after subthalamic stimulation?" (Stereotact Funct Neurosurg 2008;86: 184-186)Philip A Starr
University of California San Francisco and Veteran s Affairs Medical Center, San Francisco, CA 94143, USA
Stereotact Funct Neurosurg 86:188. 2008- Implantation of deep brain stimulator electrodes using interventional MRIPhilip A Starr
Department of Neurosurgery, University of California, San Francisco, 533 Parnassus Avenue Box 0445, San Francisco, CA 94143, USA
Neurosurg Clin N Am 20:193-203. 2009..With further technical refinement, the interventional MRI method should improve the accuracy, safety, and speed of deep brain stimulator electrode placement... - Locations of movement-related cells in the human subthalamic nucleus in Parkinson's diseasePhilip V Theodosopoulos
Department of Neurosurgery, University of California, San Francisco, California 94143, USA
Mov Disord 18:791-8. 2003..Our findings are consistent with the small number of published studies on STN somatopy in the human and the nonhuman primate... - Intranigral transplantation of fetal substantia nigra allograft in the hemiparkinsonian rhesus monkeyP A Starr
Department of Neurological Surgery, University of California, San Francisco 94143, USA
Cell Transplant 8:37-45. 1999..Characteristics of the graft-host interface were variable. In one animal, reinnervation of host substantia nigra was observed, and this animal showed behavioral improvement in a reach-and-retrieval task... - Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trialWilliam J Marks
Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Lancet Neurol 9:1164-72. 2010..We aimed to assess the safety and efficacy of AAV2-neurturin in a double-blind, phase 2 randomised trial... - Single unit "pauser" characteristics of the globus pallidus pars externa distinguish primary dystonia from secondary dystonia and Parkinson's diseaseSepehr Sani
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Exp Neurol 216:295-9. 2009..The differences may reflect increased phasic input from striatal D2 receptor positive cells in primary dystonia, and are consistent with a recent model proposing that GPe provides capacity scaling for cortical input... - Physiological identification of the human pedunculopontine nucleusS A Shimamoto
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
J Neurol Neurosurg Psychiatry 81:80-6. 2010..Despite the recent introduction of PPN deep brain stimulation (DBS) for the treatment of gait disorders, little is known about its physiology in humans... - Subthalamic nucleus deep brain stimulation in primary cervical dystoniaJ L Ostrem
Department of Neurology, Surgical Movement Disorders, 1635 Divisadero Street, Fifth Floor, Suites 520 530, San Francisco, CA 94115, USA
Neurology 76:870-8. 2011.... - Pedunculopontine nucleus deep brain stimulation in a patient with primary progressive freezing gait disorderJill L Ostrem
Department of Neurology, University of California San Francisco, Center for the Surgical Treatment of Movement Disorders, San Francisco, CA 94143, USA
Stereotact Funct Neurosurg 88:51-5. 2010..We report here on our experience with PPN DBS in treating a 76-year-old man with medication-refractory PPFG... - Long-term benefit sustained after bilateral pallidal deep brain stimulation in patients with refractory tardive dystoniaEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Stereotact Funct Neurosurg 88:304-10. 2010..Tardive dystonia (TD) can be a highly disabling, permanent condition related to the use of dopamine-receptor-blocking medications. Our aim was to evaluate the long-term effect of bilateral pallidal deep brain stimulation (DBS) for TD... - The neurophysiology and effect of deep brain stimulation in a patient with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonismChadwick W Christine
Department of Neurology, University of California, San Francisco, CA, USA
J Neurosurg 110:234-8. 2009..This unique case has important implications for translational research that employs the MPTP-primate model for symptomatic therapy in PD... - Human/nonhuman primate AC-PC ratio--considerations for translational brain measurementsMassimo S Fiandaca
Movement Disorders Laboratory, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, San Francisco, CA 94103, USA
J Neurosci Methods 196:124-30. 2011.... - Interventional magnetic resonance guidance of deep brain stimulator implantation for Parkinson diseaseAlastair J Martin
Departments of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA
Top Magn Reson Imaging 19:213-21. 2009..Preliminary evaluation of clinical outcomes indicates comparable results to that achieved with conventional implantation methods, and the technique holds promise for substantially reducing operative durations... - Microelectrode recording in the posterior hypothalamic region in humansSepehr Sani
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 64:ons161-7; discussion ons167-9. 2009..Few reports have analyzed single unit neuronal recordings in the human PHR. We report properties of spontaneous neuronal discharge in PHR for 6 patients who underwent DBS for cluster headaches... - Software requirements for interventional MR in restorative and functional neurosurgeryAlastair J Martin
Department of Radiology and Biomedical Imaging, University of California San Francisco, Box 0628, Room L 310, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Neurosurg Clin N Am 20:179-86. 2009..An optimal software interface for iMRI requires fusion of many of the capabilities offered by these individual devices and further requires the development of tools to handle the integration and presentation of dynamically updated data... - Pallidal neuronal discharge in Parkinson's disease following intraputamenal fetal mesencephalic allograftR Mark Richardson
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143, USA
J Neurol Neurosurg Psychiatry 82:266-71. 2011.... - Surgical repositioning of misplaced subthalamic electrodes in Parkinson's disease: location of effective and ineffective leadsR Mark Richardson
Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Stereotact Funct Neurosurg 87:297-303. 2009..These results are contrasted with findings in other studies demonstrating optimal lead placement in STN border zones or neighboring white-matter tracts... - Hemorrhagic complications of microelectrode-guided deep brain stimulationDevin K Binder
Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
Stereotact Funct Neurosurg 80:28-31. 2003..We report the incidence of hemorrhage in a large series of DBS implants into the subthalamic nucleus (STN), thalamus (VIM) and internal globus pallidus (GPi)... - Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trialWilliam J Marks
Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0138, USA
Lancet Neurol 7:400-8. 2008..The aim of this study was to assess the safety, tolerability, and potential efficacy of gene delivery of the neurotrophic factor neurturin... - Minimally invasive precision brain access using prospective stereotaxy and a trajectory guideAlastair J Martin
Department of Radiology, University of California, San Francisco, California 94143, USA
J Magn Reson Imaging 27:737-43. 2008..To evaluate the capabilities of MR-guided "prospective stereotaxy" methods for accessing brain structures for biopsy or electrode implantation... - Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomesPhilip A Starr
Department of Neurosurgery, University of California, San Francisco 94143, USA
J Neurosurg 104:488-501. 2006.... - Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imagingAlastair J Martin
Department of Radiology, University of California, San Francisco, California 94143, USA
Magn Reson Med 54:1107-14. 2005..0 +/- 0.8 mm (range = 0.1-1.9 mm). All procedures were considered technical successes and there were no intraoperative complications; however, one patient did develop a postoperative infection... - Risk factors for hemorrhage during microelectrode-guided deep brain stimulator implantation for movement disordersDevin K Binder
Department of Neurological Surgery, Moffitt Hospital, University of California, San Francisco 94143 0112, USA
Neurosurgery 56:722-32; discussion 722-32. 2005..We analyzed the risk factors for symptomatic and asymptomatic hemorrhage in a large series of DBS implantations into the subthalamic nucleus, ventrolateral thalamus, and internal globus pallidus... - Spontaneous pallidal neuronal activity in human dystonia: comparison with Parkinson's disease and normal macaquePhilip A Starr
Dept of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, 779 Moffitt, San Francisco, CA 94143, USA
J Neurophysiol 93:3165-76. 2005.... - Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomesPhilip A Starr
Department of Neurosurgery, University of California, San Francisco, California 94143, USA
Neurosurg Focus 17:E4. 2004..Patients with juvenile-onset primary dystonia and those with the tardive form benefited greatly from this procedure, whereas benefits for most secondary dystonias and the adult-onset craniocervical form of this disorder were more modest... - Surgery of the subthalamic nucleus: use of movement-related neuronal activity for surgical navigationPhilip A Starr
Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
Neurosurgery 53:1146-9; discussion 1149. 2003..This article describes the use of movement-related cellular activity during single-unit microelectrode mapping to identify and to navigate within the motor territory of the subthalamic nucleus... - Placement of deep brain stimulators into the subthalamic nucleus or Globus pallidus internus: technical approachPhilip A Starr
University of California at San Francisco and San Francisco Veteran s Affairs Medical Center, Moffitt Hospital, San Francisco, CA 94143, USA
Stereotact Funct Neurosurg 79:118-45. 2002..Lead locations are documented by postoperative MRI in all cases... - Implantation of deep brain stimulators into the subthalamic nucleus: technical approach and magnetic resonance imaging-verified lead locationsPhilip A Starr
Department of Neurological Surgery, University of California, San Francisco 94143, USA
J Neurosurg 97:370-87. 2002..The authors present the technical approach used to implant 76 stimulators into the STNs of patients with PD and the lead locations, which were verified on postoperative magnetic resonance (MR) images... - Neuropsychological performance following staged bilateral pallidal or subthalamic nucleus deep brain stimulation for Parkinson's diseaseJohannes C Rothlind
Mental Health Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Int Neuropsychol Soc 13:68-79. 2007..Findings are discussed with reference to possible causes of neuropsychological decline and the need for further controlled studies of specific neuropsychological effects of DBS... - Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's diseaseKen Nakamura
Department of Neurology, University of California, San Francisco, CA, USA
Mov Disord 22:619-26. 2007..Our findings suggest that DBS of the STN or GPi results in a similar improvement in hand movements at short-term follow-up. Preoperative medication responsiveness predicts improvement in some but not other motor tasks... - Pallidal deep brain stimulation in patients with cranial-cervical dystonia (Meige syndrome)Jill L Ostrem
Department of Neurology, University of California, San Francisco, California 94143, USA
Mov Disord 22:1885-91. 2007..Although GPi DBS was effective in these patients, the influence of GPi DBS on nondystonic body regions deserves further investigation... - Neuronal responses to passive movement in the globus pallidus internus in primary dystoniaEdward F Chang
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
J Neurophysiol 98:3696-707. 2007..There is an apparent preservation of GPi somatotopic organization in dystonia in comparison with prior studies of GPi somatotopic organization in non-human primates and humans with Parkinson's disease... - Magnetic resonance imaging of implanted deep brain stimulators: experience in a large seriesPaul S Larson
Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
Stereotact Funct Neurosurg 86:92-100. 2008..This series strongly suggests that the 0.1 W/kg recommendation for SAR may be unnecessarily low for the prevention of MRI-related adverse events... - Chronic stimulation of the posterior hypothalamic region for cluster headache: technique and 1-year results in four patientsPhilip A Starr
Departments of Neurosurgery, University of California at San Francisco, California 94143, USA
J Neurosurg 106:999-1005. 2007..Two small case series have been described. Here, the authors report their technical approach, intraoperative physiological observations, and 1-year outcomes after hypothalamic DBS in four patients with medically intractable CHs... - Induction of bradykinesia with pallidal deep brain stimulation in patients with cranial-cervical dystoniaBrian D Berman
Department of Neurology, University of California, San Francisco, Calif, USA
Stereotact Funct Neurosurg 87:37-44. 2009..More recently, it has been applied as a treatment for focal and segmental dystonias. This patient population offers an opportunity to study the effects of alteration of pallidal outflow on previously normal limb function... - Frameless stereotaxy using bone fiducial markers for deep brain stimulationKathryn L Holloway
Department of Neurosurgery, Medical College of Virginia Hospital of Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Neurosurg 103:404-13. 2005..The present study was conducted to evaluate the accuracy of a frameless system in routine clinical use... - Deep brain stimulator hardware-related infections: incidence and management in a large seriesKarl A Sillay
Department of Neurosurgery, University of California, San Francisco, California 94143 0445, USA
Neurosurgery 62:360-6; discussion 366-7. 2008..Device-related infection is a common complication of deep brain stimulator (DBS) implantation. We reviewed the incidence and management of early hardware-related infections in a large series... - Safety and tolerability of putaminal AADC gene therapy for Parkinson diseaseC W Christine
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Neurology 73:1662-9. 2009..These data prompted a clinical trial... - Surgery for Parkinson's disease: integration of neurology and neurosurgeryPhilip A Starr
Department of Neurosurgery, University of California, San Francisco, USA
Clin Neurosurg 52:202-4. 2005 - Thalamic deep brain stimulation for essential tremor: relation of lead location to outcomeEfstathios Papavassiliou
Department of Neurosurgery, University of California, San Francisco, California 94143, USA
Neurosurgery 54:1120-29; discussion 1129-30. 2004..The incidence of true physiological tolerance to the antitremor effect of thalamic DBS (defined as poor tremor control in spite of lead location within 2 mm of the optimal site) was found to be 9%... - Electrophysiological localization of the substantia nigra in the parkinsonian nonhuman primateP A Starr
Department of Neurological Surgery, University of California, San Francisco 94143, USA
J Neurosurg 93:704-10. 2000.... - Deep brain stimulation for medically intractable cluster headacheKarl A Sillay
Department of Neurosurgery, University of Wisconsin, Madison, WI 53792, USA
Neurobiol Dis 38:361-8. 2010..Recently, occipital nerve stimulation has shown efficacy, calling in question the use of DBS as a first line surgical therapy. In this report, we review the indications, techniques, and outcomes of DBS for cluster headache... - Spinal deformity and Parkinson disease: a treatment algorithmCheerag D Upadhyaya
Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
Neurosurg Focus 28:E5. 2010..The authors review the literature on the treatment of spinal deformity in patients with Parkinson disease (PD) and formulate a treatment algorithm... - First case of X-linked dystonia-parkinsonism ("Lubag") to demonstrate a response to bilateral pallidal stimulationVirgilio Gerald H Evidente
Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA
Mov Disord 22:1790-3. 2007..Bilateral pallidal DBS may be a viable option for Lubag patients with medically refractory symptoms...